METHANESULPHONIC ACID

Methanesulphonic acid replaces phosphoric acid in detergent formulations, thereby helping to avoid environmental phosphate pollution. 
Methanesulphonic acid is used in the preparation of polyaniline/graphene nanocomposites, which enhances its thermal and electrical properties. 
Methanesulphonic acid is utilized for electropolishing of aluminum as well as in electroplating of noble metals like gold, platinum, palladium and their alloys.

CAS Number: 75-75-2
Molecular Formula: CH4O3S
Molecular Weight: 96.11
EINECS Number: 200-898-6

Synonyms: METHANESULFONIC ACID, 75-75-2, Methylsulfonic acid, Methanesulphonic acid, Mesylic acid, Methanesulfonicacid, Sulfomethane, Kyselina methansulfonova, Methansulfonsaeure, NSC 3718, CCRIS 2783, HSDB 5004, EINECS 200-898-6, METHANE SULFONIC ACID, BRN 1446024, DTXSID4026422, MSA, UNII-12EH9M7279, CHEBI:27376, Kyselina methansulfonova [Czech], AI3-28532, NSC-3718, CH3SO3H, MFCD00007518, CH4O3S, 12EH9M7279, DTXCID806422, 22515-76-0, NSC3718, EC 200-898-6, 4-04-00-00010 (Beilstein Handbook Reference), J1.465F, ammoniummethanesulfonate, METHANESULFONIC ACID (II), METHANESULFONIC ACID [II], CH4O3S.H3N, C-H4-O3-S.H3-N, Methanesulfonic acid, ammonium salt, Methanesulfonic acid, ammonium salt (1:1), metanesulfonic acid, methansulfonic acid, MsOH, methansulphonic acid, methylsulphonic acid, 03S, methyl sulfonic acid, methyl-sulfonic acid, methane-sulfonic acid, MeSO3H, methane sulphonic acid, methanesulphonic-acid-, LACTIC ACID(DL), CH3SO2OH, H3CSO3H, WLN: WSQ1, Methanesulfonic acid solution, Methanesulfonic acid, 99.5%, Methanesulfonic acid, anhydrous, CHEMBL3039600, DL-MALICACIDMONOSODIUMSALT, Methanesulfonic Acid (CH3SO3H), METHANESULFONIC ACID [MI], Methanesulfonic acid, HPLC grade, Methanesulfonic acid, >=99.0%, METHANESULFONIC ACID [HSDB], Tox21_201073, STL264182, AKOS009146947, AT25153, CAS-75-75-2, NCGC00248914-01, NCGC00258626-01, BP-12823, LS-90299, FT-0628287, M0093, M2059, EN300-29198, Methanesulfonic acid, >=99.0%, ReagentPlus(R), Methanesulfonic acid, for HPLC, >=99.5% (T), A934985, Q414168, J-521696, Methanesulfonic acid, Vetec(TM) reagent grade, 98%, F1908-0093, Z281776238, InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4

Methanesulphonic acid has a role as an Escherichia coli metabolite. 
Methanesulfonic acid (MsOH) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH. 
Methanesulphonic acid is the simplest of the alkylsulfonic acids (R−S(=O)2−OH). 

Salts and esters of Methanesulphonic acid are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate). 
Methanesulphonic acid is hygroscopic in its concentrated form. 
Methanesulphonic acid is a strong organic acid. 

The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities. 
Methanesulphonic acid can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).
Methanesulphonic acid solution is used virtually in all electronic applications involving tin or tin-alloy plating from non fluoborate systems. 

Methanesulphonic acid is considered a particularly suitable supporting electrolyte for electrochemical applications, where it stands as an environmentally friendly alternative to other acid electrolytes used in plating processes.
Methanesulphonic acid is also a primary ingredient in rust remover and descaler. 
Methanesulphonic acid is recommended in formulation for removing rust from ceramic, tiles and porcelain surfaces which are usually susceptible to acid attack.

Methanesulphonic acid or methanesulfonic acid (British English) is an organic sulfuric acid colorless liquid with the molecular formula CH3SO3H and the structure H3C-S(=O)2-OH. 
Methanesulphonic acid, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures. 
Methanesulphonic acid has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa),  the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃). 

Methanesulphonic acid is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene. 
Methanesulphonic acid will not subject to decomposition in boiling water and hot alkaline solution. 
Methanesulphonic acid also has strong corrosion effect against the metal iron, copper and lead.

Methanesulphonic acid is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methanesulphonic acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations. 
Beyond that, Methanesulphonic acid is used as a starting material for the preparation of methanesulfonyl chloride.

Methanesulphonic acid is a strong organic acid widely used as a catalyst for esterification and alkylation. 
Strong acid, biodegradable, non-oxidizing and non-foaming, compatible with oxidant and biocide.
Methanesulphonic acid, also known as methylsulfonic acid or methane sulfonate, is a strong organic acid with the chemical formula CH3SO3H. 

Methanesulphonic acid is a colorless, odorless liquid that is highly soluble in water. 
Methanesulphonic acid is classified as a sulfonic acid because it has a sulfonyl (SO3H) functional group attached to a methyl (CH3) group.
Methanesulphonic acid is often used as a substitute for sulfuric acid (H2SO4) in various chemical processes because it is less corrosive and volatile. 

Methanesulphonic acid is commonly employed as a catalyst, acidifier, or pH adjuster in organic synthesis, electroplating, and other industrial applications. 
Methanesulphonic acid mild and non-oxidizing nature makes it useful in situations where strong acids like sulfuric acid may be too harsh.
Methanesulphonic acid  refers to the concentration of MSA in a solution. 

In this case, Methanesulphonic acid means that the solution contains 70% by weight of pure MSA, with the remaining 30% typically being water. 
Different concentrations of Methanesulphonic acid can be prepared depending on the specific application's requirements.
Methanesulphonic acid undergoes biodegradation by forming CO2 and sulphate. 

Methanesulphonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methanesulphonic acid solution has been considered a model electrolyte for electrochemical processes.
Methanesulphonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl. 

Methanesulphonic acid is an alkanesulfonic acid and a one-carbon compound. 
Methanesulphonic acid is a conjugate acid of a methanesulfonate.
Methanesulphonic acid is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.

Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
vapor density: 3.3 (vs air)
vapor pressure: 1 mm Hg ( 20 °C)
refractive index: n20/D 1.429(lit.)
Flash point: >230 °F
storage temp.: 2-8°C
solubility: water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
form: Solution
color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible: with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024

Methanesulphonic acid should be stored in a cool, dry place away from incompatible materials. 
Methanesulphonic acid should be kept in containers made of materials resistant to acids, such as glass or certain plastics.
Methanesulphonic acid is often used as a milder and safer alternative to mineral acids like sulfuric acid (H2SO4) and hydrochloric acid (HCl) in laboratory settings and industrial processes. 

Its reduced corrosiveness and lower volatility make it a preferred choice in situations where worker safety and equipment preservation are essential.
Methanesulphonic acid is compatible with a wide range of organic compounds, which makes it useful in various organic syntheses and reactions. 
Methanesulphonic acid can serve as a solvent, acid catalyst, or reagent in reactions involving a variety of functional groups.

Like other acids, Methanesulphonic acid can be neutralized with bases such as sodium hydroxide (NaOH) or potassium hydroxide (KOH) to form salts, for instance, sodium methane sulfonate or potassium methane sulfonate.
In the pharmaceutical industry, Methanesulphonic acid is used in the production of certain pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
Its high purity and low residue levels are advantageous in drug manufacturing.

Methanesulphonic acid can be used in analytical chemistry techniques such as ion chromatography, where it serves as a highly stable and inert mobile phase component for separating ions in solution.
Methanesulphonic acid is less likely to corrode or react with metals, which is advantageous when it is used in metal-related applications like electroplating.
Methanesulphonic acid is generally recognized as safe (GRAS) when used in food and pharmaceutical applications within established guidelines.
 
Methanesulphonic acid is essential to ensure compliance with local regulations and quality standards when using MSA in various industries.
Methanesulphonic acid, it is important to follow the appropriate regulations for hazardous materials, including labeling, packaging, and safety precautions, to prevent accidents and ensure worker safety.
Methanesulphonic acid can be obtained through the nitrate oxidation of thiocyanate methyl. 

Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃. 
Methanesulphonic acid is a strong, odorless and less corrosive acid. 
Methanesulphonic acid is not harmful to systems, employees, customers, waste management or the environment when used in chemical synthesis, metal refinement or industrial cleaning. 

Methanesulphonic acid can be used sparingly and saves energy. 
Additional advantages are the high solubility of Methanesulphonic acids salts, its lack of color and the fact that it is readily biodegradable (according to OECD Directive 301 A). 
The acid strength of the organic methane sulphonic acid is between that of carboxylic acids and strong mineral acids. 

Since methane sulphonic acid is odorless, Methanesulphonic acid may also be used in odor-sensitive applications. 
Methanesulphonic acids lack of smell also increases safety at work because it does not produce any acrid fumes. 
Methanesulphonic acid is very suitable for neutralisation of vegetable oils with high FFA content.

Methanesulphonic acid is a strong acid with a pKa (acid dissociation constant) of about -1.9, making it significantly more acidic than acetic acid (vinegar) or many other common organic acids. 
Methanesulphonic acid is highly soluble in water, which makes it suitable for various aqueous processes and reactions.

Uses Of Methanesulphonic acid:
Methanesulphonic acid is used as a catalyst in a variety of organic reactions, including esterification, etherification, and alkylation reactions.
Methanesulphonic acid is employed in the electroplating industry to improve the quality of metal coatings.
Methanesulphonic acid is used in the synthesis of pharmaceuticals and fine chemicals.

Methanesulphonic acid's used for dyeing textiles and leather.
Methanesulphonic acid can be used in the oil and gas industry for acidizing reservoirs.
Methanesulphonic acid is a versatile acid catalyst in various organic reactions, such as esterification, etherification, and alkylation. 

Methanesulphonic acid facilitates chemical reactions by donating protons (H+) to reactants, enabling the formation of new bonds and the synthesis of desired compounds.
Methanesulphonic acid is used in the electroplating industry to improve the quality of metal coatings. 
Methanesulphonic acid can be employed as an additive in electroplating baths to enhance the deposition of metal layers onto surfaces, providing improved adhesion and uniformity.

Methanesulphonic acid finds application in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). 
Its high purity and low residue levels are advantageous in drug manufacturing processes where the presence of impurities can be detrimental.
Methanesulphonic acid is utilized in the dyeing of textiles and leather. 

Methanesulphonic acid serves as a strong acid to help fix dyes onto fabric or leather surfaces, enhancing colorfastness and dye adherence.
In the oil and gas industry, Methanesulphonic acid can be used for acidizing reservoirs. 
Methanesulphonic acid helps improve the permeability of rock formations in oil and gas wells by dissolving mineral deposits and increasing the flow of hydrocarbons.

Methanesulphonic acid is used as a component of mobile phases in ion chromatography, a technique employed for separating and analyzing ions in solution. 
Its stability and low reactivity make it suitable for this purpose.
Methanesulphonic acid is often used in research laboratories as a milder alternative to stronger mineral acids like sulfuric acid or hydrochloric acid. 

Methanesulphonic acid can be employed for tasks such as acid-catalyzed reactions or pH adjustments in various experiments.
Methanesulphonic acid is sometimes used as a pH adjuster and acidulant in certain food products. 
Methanesulphonic acids use is regulated to ensure food safety and quality.

Methanesulphonic acid has been used in photography, particularly in the preparation of photographic developers.
Methanesulphonic acid can be found in some cleaning products where its acidity helps in removing mineral deposits, scale, and stains.

Methanesulphonic acid is employed in polymerization reactions, including the production of certain types of resins, plastics, and polymeric materials. 
Its acidic nature can initiate and control polymerization processes.
Methanesulphonic acid is useful for synthesizing various organic compounds, including fragrances, flavors, and specialty chemicals. 

Methanesulphonic acid can be involved in reactions that create valuable intermediates for these industries.
Methanesulphonic acid can be used for descaling and removing oxide layers from metal surfaces, preparing them for subsequent treatments or coatings.
Methanesulphonic acid can be used for pH adjustment and water treatment processes, particularly in situations where a strong acid is needed to neutralize alkaline water or control the pH of industrial wastewater.

Methanesulphonic acid finds use in electronics manufacturing for cleaning and etching printed circuit boards (PCBs) and other electronic components.
Methanesulphonic acid can be used in the production of adhesives and sealants, where it can act as a curing agent or catalyst.
In the oil refining industry, Methanesulphonic acid can be used as a catalyst or acid in certain refining processes to improve the quality of petroleum products.

Methanesulphonic acid is used as a reagent in various chemical analyses and assays, especially when a strong acid is required for sample preparation or digestion.
Methanesulphonic acid is sometimes used for pH adjustment in industrial processes where precise control of acidity is necessary.
Methanesulphonic acid can be used in biotechnology and molecular biology applications, such as DNA and RNA purification and protein purification processes.

Methanesulphonic acid is a raw material for medicine and pesticide. 
Methanesulphonic acid can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
Methanesulphonic acid can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry. 

Methanesulphonic acid can also be applied to oxidation.
Methanesulphonic acid has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings. 
One of the major advantages of Methanesulphonic acid over sulfuric acid is that it is not an oxidizing species.

Methanesulphonic acid solution is used virtually in all electronic applications involving tin or tin-alloy plating from non fluoborate systems. 
Methanesulphonic acid replaces phosphoric acid in detergent formulations, thereby helping to avoid environmental phosphate pollution. 
Methanesulphonic acid is used in the preparation of polyaniline/graphene nanocomposites, which enhances its thermal and electrical properties. 

Methanesulphonic acid is utilized for electropolishing of aluminum as well as in electroplating of noble metals like gold, platinum, palladium and their alloys.
Methanesulphonic acid is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents. 

Methanesulphonic acid is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters. 
Methanesulphonic acid reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex. 
It finds application in batteries, because of its purity and chloride absence. 

In pharmaceutical industry, Methanesulphonic acid is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan. 
Methanesulphonic acid is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
Methanesulphonic acid is involved in the deprotection of peptides.

Safety Profile Of Methanesulphonic acid: 
Proper safety measures, including the use of appropriate protective gear like gloves and goggles, should be followed when working with Methanesulphonic acid.
Environmental Considerations: 
Methanesulphonic acid is considered to be less environmentally harmful than many other strong acids, especially when it comes to disposal. 

Methanesulphonic acid is less likely to produce environmentally damaging byproducts when handled and disposed of properly.
Poison by ingestion and intraperitoneal routes. 
Methanesulphonic acid may be corrosive to skin, eyes, and mucous membranes. 

Explosive reaction with ethyl vinyl ether. 
Incompatible with hydrogen fluoride. 

When heated to decomposition Methanesulphonic acid emits toxic fumes of SOx. 
While Methanesulphonic acid is considered less hazardous than some other strong acids like sulfuric acid, it is still corrosive and should be handled with care.