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Methyl salicylate (Methyl 2-hydroxybenzoate) is the methyl ester of salicylic acid and is a clear aromatic liquid with the characteristic sweet, minty and wintergreen-like odor associated with natural wintergreen oil.
Methyl salicylate (Methyl 2-hydroxybenzoate) is used as a fragrance ingredient, flavoring substance, topical salicylate active, solvent and intermediate in specialty chemical manufacture.
Methyl salicylate (Methyl 2-hydroxybenzoate) combination of strong odor impact, moderate organic-solvent compatibility and chemically reactive ester and phenolic functionality makes it valuable across fragrance, flavor, pharmaceutical and industrial applications.
CAS Number: 119-36-8
Molecular Formula: C8H8O3
Molecular Weight: 152.15 g/mol
EINECS Number: 204-317-7
Synonyms: Methyl salicylate, Methyl 2-hydroxybenzoate, Methyl o-hydroxybenzoate, Salicylic acid methyl ester, Methyl salicylate ester, Benzoic acid 2-hydroxy methyl ester, 2-Hydroxybenzoic acid methyl ester, Methyl 2-hydroxybenzoate, 2-Carbomethoxyphenol, Oil of wintergreen, Wintergreen oil synthetic, Synthetic wintergreen oil, Gaultheria oil synthetic, Betula oil synthetic, FEMA 2745, JECFA Flavor Number 899.
Methyl salicylate (Methyl 2-hydroxybenzoate) belongs to the salicylate and hydroxybenzoate ester families.
Methyl salicylate (Methyl 2-hydroxybenzoate) structure contains a benzene ring bearing an ortho hydroxyl group and a methyl ester group derived from salicylic acid.
This ortho relationship strongly influences odor, polarity, intramolecular hydrogen bonding and chemical behavior.
Methyl salicylate (Methyl 2-hydroxybenzoate) is commonly known as methyl salicylate or oil of wintergreen when used in fragrance and flavor contexts.
Natural wintergreen oil can contain very high proportions of methyl salicylate, while synthetic methyl salicylate is manufactured as a defined chemical substance.
Methyl salicylate (Methyl 2-hydroxybenzoate) commercial users should distinguish pure methyl salicylate from natural botanical oils that may contain additional minor constituents.
Methyl salicylate (Methyl 2-hydroxybenzoate) has a strong and highly recognizable wintergreen odor.
Methyl salicylate (Methyl 2-hydroxybenzoate) odor is sweet, minty, phenolic and medicinal and is perceptible at relatively low concentration.
This high odor potency makes dosage control especially important in fragrances, flavors and household-care products.
The molecular formula C8H8O3 corresponds to one aromatic ring, one phenolic hydroxyl group and one methyl ester group.
Methyl salicylate (Methyl 2-hydroxybenzoate) phenolic hydroxyl can participate in hydrogen bonding, while the ester group contributes polarity and hydrolytic reactivity.
These functional groups distinguish methyl salicylate from non-hydroxylated benzoate esters such as methyl benzoate.
Methyl salicylate (Methyl 2-hydroxybenzoate) intramolecular hydrogen bonding can occur between the ortho phenolic hydroxyl and the ester carbonyl.
This interaction influences molecular conformation, volatility and partitioning behavior.
Methyl salicylate (Methyl 2-hydroxybenzoate) also helps explain why methyl salicylate has a distinctive physicochemical profile compared with positional hydroxybenzoate isomers.
Methyl salicylate (Methyl 2-hydroxybenzoate) is a liquid at ordinary room temperature.
Methyl salicylate (Methyl 2-hydroxybenzoate) melting point is approximately -9 to -7 °C, allowing it to remain fluid under most normal storage and processing conditions.
Cold environments below this range can cause crystallization, which is generally reversible upon controlled warming.
The boiling point is approximately 222–224 °C at atmospheric pressure.
Methyl salicylate (Methyl 2-hydroxybenzoate) relatively high boiling point gives methyl salicylate lower volatility than many common fragrance solvents and low-boiling organic esters.
Methyl salicylate (Methyl 2-hydroxybenzoate) still has sufficient vapor pressure to contribute strongly to odor and aroma perception.
Methyl salicylate (Methyl 2-hydroxybenzoate) density is approximately 1.17 g/mL at 25 °C.
Methyl salicylate is therefore denser than water even though it has only limited aqueous solubility.
This density difference can influence phase separation and bottom-layer formation in uncontrolled oil-water mixtures.
Methyl salicylate (Methyl 2-hydroxybenzoate) refractive index is approximately 1.536–1.537 at 20 °C.
This parameter is commonly used as an identity and quality-control characteristic for aromatic fragrance and flavor chemicals.
A significant deviation can indicate contamination, dilution or incorrect material.
Methyl salicylate (Methyl 2-hydroxybenzoate) viscosity is relatively low.
Representative data place dynamic viscosity at approximately 1.5 mPa·s at 25 °C.
This allows easy pumping, metering and incorporation into liquid fragrance, flavor and industrial formulations.
Methyl salicylate (Methyl 2-hydroxybenzoate) is only slightly soluble in water.
Representative solubility values are approximately 0.7 g/L at around 30 °C, although values vary with temperature and method.
The material is much more compatible with ethanol, ether, oils and many other organic solvents.
Methyl salicylate (Methyl 2-hydroxybenzoate) limited water solubility is important in formulation.
Direct addition to an aqueous product can create droplets, haze or phase separation unless an appropriate solubilizer, surfactant or co-solvent is present.
Hydroalcoholic systems generally accommodate methyl salicylate more readily than purely aqueous systems.
Methyl salicylate (Methyl 2-hydroxybenzoate) ethanol is a particularly useful solvent.
Methyl salicylate is compatible with ethanol at room temperature and can therefore be incorporated readily into many fragrance and personal-care systems.
This compatibility also supports use in flavor concentrates and laboratory formulations.
Methyl salicylate (Methyl 2-hydroxybenzoate) partition behavior of methyl salicylate is moderately lipophilic.
Methyl salicylate (Methyl 2-hydroxybenzoate) logP is around the low-to-mid 2 range, indicating preference for organic phases while retaining some polar character.
This helps the substance interact with skin lipids, fragrance oils and organic formulation components.
Methyl salicylate (Methyl 2-hydroxybenzoate) has a flash point around the 100 °C region depending on test method.
Methyl salicylate (Methyl 2-hydroxybenzoate) is therefore combustible but considerably less volatile and less easily ignited than low-boiling solvents such as acetone or ethanol.
Fire precautions remain necessary during heated processing and bulk storage.
Methyl salicylate (Methyl 2-hydroxybenzoate) autoignition temperature is substantially higher than the flash point.
Published reference data place autoignition in the approximately 450 °C region.
This does not remove the need to control ignition sources when the material is heated or dispersed as mist.
Physical Form: Liquid
Appearance: Clear colorless to pale-yellow liquid
Chemical Family: Salicylate Ester / Hydroxybenzoate Ester
Chemical Name: Methyl 2-hydroxybenzoate
Boiling Point: approximately 222–224 °C
Melting Point: approximately -9 to -7 °C
Density: approximately 1.17 g/mL at 25 °C
Refractive Index: approximately 1.536–1.537 at 20 °C
Viscosity: approximately 1.5 mPa·s at 25 °C
Water Solubility: low, approximately 0.7 g/L at around 30 °C
Ethanol Solubility: miscible / readily soluble
Methyl salicylate (Methyl 2-hydroxybenzoate) can be produced by esterification of salicylic acid with methanol.
Methyl salicylate (Methyl 2-hydroxybenzoate) catalysis promotes conversion of the carboxylic-acid group into the methyl ester while the ortho phenolic hydroxyl remains intact.
Purification then removes excess methanol, water, catalyst residues and unreacted salicylic acid.
Methyl salicylate (Methyl 2-hydroxybenzoate) industrial product quality depends strongly on purity.
Residual salicylic acid can influence acidity, odor and color and may be undesirable in fragrance, pharmaceutical or flavor applications.
The Certificate of Analysis should therefore be reviewed for assay, acid value, color and related impurities.
Methyl salicylate (Methyl 2-hydroxybenzoate) color is especially important for fragrance and cosmetic applications.
High-purity methyl salicylate should normally be clear and colorless or only faintly yellow.
Darkening can indicate oxidation, contamination or thermal degradation.
Methyl salicylate (Methyl 2-hydroxybenzoate) odor quality must also be controlled.
A chemically high assay does not automatically guarantee an acceptable fragrance profile if trace impurities create harsh, burnt or phenolic off-notes.
Organoleptic quality therefore remains important for fragrance- and flavor-grade material.
Methyl salicylate (Methyl 2-hydroxybenzoate) can hydrolyze under sufficiently strong acidic or alkaline conditions.
Hydrolysis produces salicylic acid and methanol.
This reaction is generally slow under ordinary neutral storage conditions but becomes more important at elevated temperature or extreme pH.
Methyl salicylate (Methyl 2-hydroxybenzoate) strong base promotes ester saponification.
Alkaline systems can therefore convert methyl salicylate into salicylate salts rather than maintaining the intact ester.
Long-term stability testing is recommended when the product is used in strongly alkaline formulations.
Methyl salicylate (Methyl 2-hydroxybenzoate) strong acid can also promote hydrolysis under suitable conditions.
The rate depends on temperature, water activity and acid concentration.
Acidic formulations should therefore be checked for odor and chemical stability over their intended shelf life.
Because of body mass and exposure differences, relatively small quantities can represent a substantial salicylate dose.
Bulk and finished medicinal products should be stored securely away from children.
Methyl salicylate (Methyl 2-hydroxybenzoate) use on damaged skin can increase absorption.
Cuts, abrasions, dermatitis or other barrier damage can change the amount entering systemic circulation.
Medicinal labels should therefore be followed precisely.
Methyl salicylate (Methyl 2-hydroxybenzoate) occlusion can also increase dermal delivery.
Methyl salicylate (Methyl 2-hydroxybenzoate) covering a methyl-salicylate-containing preparation with impermeable materials can raise skin hydration and absorption.
Such use should occur only if specifically directed by an approved product instruction.
Methyl salicylate (Methyl 2-hydroxybenzoate) heating pads, hot-water bottles or intense external heat should not be combined casually with topical salicylate products.
This risk is relevant to end-product labeling rather than ordinary fragrance use.
Methyl salicylate is metabolized primarily to salicylic acid.
Combined exposure from other salicylates can therefore increase total systemic salicylate burden.
This is one reason regulatory safety assessment considers multiple salicylate sources.
Methyl salicylate (Methyl 2-hydroxybenzoate) cosmetic formulations can contain salicylates from fragrance mixtures, botanical extracts and other ingredients simultaneously.
Total exposure should therefore be assessed rather than evaluating added methyl salicylate in isolation.
Wintergreen oil is particularly important because it may contain very high methyl salicylate concentration.
Methyl salicylate (Methyl 2-hydroxybenzoate) current EU cosmetic restrictions are category specific.
Different maximum concentrations apply to hydroalcoholic fragrances, hand wash, rinse-off products, lip products, eye products, aerosols and other categories.
The current Annex III entry should therefore be checked for every formulation.
For example, current EU provisions permit substantially different levels in hydroalcoholic fragrance and hand-wash products than in eye makeup or aerosol deodorant.
These differences reflect variation in exposure route and systemic dose.
A generic statement such as “safe up to X% in cosmetics” would therefore be technically misleading.
Methyl salicylate (Methyl 2-hydroxybenzoate) is also classified in the EU as a reproductive toxicant Category 2.
This classification has direct consequences for risk communication and some regulatory uses.
Industrial users should rely on the latest CLP classification and SDS rather than older fragrance-industry summaries.
Methyl salicylate (Methyl 2-hydroxybenzoate) also has an Acute Toxicity Category 4 classification under current EU harmonized information.
The exact hazard statements and exposure routes should be taken from the current SDS.
This is especially important because supplier documentation can differ between jurisdictions.
Methyl salicylate (Methyl 2-hydroxybenzoate) aquatic Chronic Category 3 classification is also relevant in the EU framework.
Waste material and concentrated spills should therefore not be discharged uncontrolled.
Wastewater treatment requirements depend on local permits and total discharge concentration.
Methyl salicylate (Methyl 2-hydroxybenzoate) food-grade handling requires prevention of cross-contamination.
Flavor manufacturing facilities should use clean dedicated equipment and documented traceability.
A technical grade should not be substituted into food manufacture merely because the CAS number is identical.
Methyl salicylate (Methyl 2-hydroxybenzoate) pharmaceutical-grade handling requires even tighter control.
Identity, assay, related substances and manufacturing documentation may be governed by pharmacopoeial or internal pharmaceutical specifications.
Reference standards and production grades should not be treated as interchangeable.
Methyl salicylate (Methyl 2-hydroxybenzoate) fragrance-grade quality also requires traceability.
Odor profile, color and impurity content can affect finished perfume character.
Current IFRA or customer requirements should be considered where the material is part of a fragrance compound.
Methyl salicylate (Methyl 2-hydroxybenzoate) storage should be cool and dry.
Containers should remain tightly closed and protected from excessive heat and direct sunlight.
Clean compatible packaging helps prevent color change, contamination and odor degradation.
Methyl salicylate (Methyl 2-hydroxybenzoate) can freeze or crystallize in very cold environments because its melting point lies around -9 to -7 °C.
Crystallization does not necessarily indicate chemical degradation.
Controlled warming and homogenization can restore the liquid state if permitted by the supplier.
Methyl salicylate (Methyl 2-hydroxybenzoate) heating should remain moderate.
Direct high-temperature surfaces can create local decomposition or color formation even when the bulk product remains below its boiling point.
Gentle controlled warming is preferable if cold material requires remelting.
Methyl salicylate (Methyl 2-hydroxybenzoate) Safety Data Sheet should take precedence for hazard classification, PPE, first aid, transport, firefighting and disposal.
The Technical Data Sheet should be reviewed separately for assay, density, refractive index, color, odor and storage specifications.
Methyl salicylate (Methyl 2-hydroxybenzoate) a batch-specific Certificate of Analysis should be checked whenever Methyl salicylate (Methyl 2-hydroxybenzoate) is used in fragrance, flavor, pharmaceutical or high-purity chemical applications.
Methyl salicylate (Methyl 2-hydroxybenzoate) oxidation can also affect product quality.
Although methyl salicylate is reasonably stable under normal conditions, prolonged exposure to heat, light or reactive oxidants can create color and odor changes.
Methyl salicylate (Methyl 2-hydroxybenzoate) storage in clean tightly closed packaging helps preserve quality.
Uses Of Methyl salicylate (Methyl 2-hydroxybenzoate):
Methyl salicylate (Methyl 2-hydroxybenzoate) is widely used as a fragrance ingredient.
Methyl salicylate (Methyl 2-hydroxybenzoate) powerful wintergreen character provides a distinctive sweet, minty and medicinal note that can be recognized at relatively low concentration.
It is used in fragrance compositions where freshness, herbal character or a characteristic salicylate profile is desired.
Perfume compositions can use Methyl salicylate (Methyl 2-hydroxybenzoate) as both a character note and a modifier.
Methyl salicylate (Methyl 2-hydroxybenzoate) blends well with mint, herbal, floral, spicy and medicinal accords depending on concentration.
Overuse can dominate the fragrance because of its strong odor intensity.
Methyl salicylate (Methyl 2-hydroxybenzoate) fine fragrance can use low concentrations for complexity.
Methyl salicylate can contribute green, wintergreen or floral-salicylate nuances without making the entire fragrance smell explicitly medicinal.
Its dosage must be optimized carefully because the transition from subtle modifier to dominant note can occur rapidly.
Methyl salicylate (Methyl 2-hydroxybenzoate) functional fragrances represent another major use.
Household cleaners, detergents, air-care products, polishes and waxes can incorporate methyl salicylate into fragrance compositions.
The material can reinforce a fresh, clean or medicinal sensory impression in these products.
Methyl salicylate (Methyl 2-hydroxybenzoate) air-care systems can use wintergreen-style fragrance accords.
Methyl salicylate provides a highly recognizable aromatic signature and can support mint, pine or herbal fragrance themes.
Volatility and compatibility with the carrier system should be verified in the finished air-care format.
Methyl salicylate (Methyl 2-hydroxybenzoate) polishes and waxes can also use methyl salicylate as a fragrance ingredient.
The odor can mask base-material odors and provide a traditional clean or treated-surface character.
Methyl salicylate (Methyl 2-hydroxybenzoate) solvent interaction with waxes and resins should be assessed in the complete formulation.
Methyl salicylate (Methyl 2-hydroxybenzoate) household cleaning products represent another established application.
Floor cleaners, multipurpose cleaners and specialty cleaners may use wintergreen fragrance profiles for sensory differentiation.
Methyl salicylate (Methyl 2-hydroxybenzoate) concentration must remain within applicable fragrance and regulatory restrictions.
Methyl salicylate (Methyl 2-hydroxybenzoate) personal-care products can also contain methyl salicylate as fragrance.
Shampoos, rinse-off skin products, hand washes and selected leave-on cosmetics can use it within current legal limits.
Methyl salicylate (Methyl 2-hydroxybenzoate) permitted concentration varies significantly between product categories and jurisdiction.
Methyl salicylate (Methyl 2-hydroxybenzoate) hydroalcoholic fragrances represent a specific EU-regulated category.
Methyl salicylate may be used subject to category-specific concentration restrictions and labeling requirements.
Regulatory assessment should therefore be performed before transferring a fragrance formula between markets.
Methyl salicylate (Methyl 2-hydroxybenzoate) is also used as a flavoring substance.
Its characteristic wintergreen taste can contribute to mint, wintergreen and medicinal-style flavor profiles.
Methyl salicylate (Methyl 2-hydroxybenzoate) is recognized by the US FDA as a flavoring agent or adjuvant.
Methyl salicylate (Methyl 2-hydroxybenzoate) confectionery is one potential flavor application.
Wintergreen candies, mints and chewing products can use very small controlled amounts to create the characteristic profile.
Flavor-grade quality and appropriate legal use levels are essential because concentrated methyl salicylate is toxic.
Methyl salicylate (Methyl 2-hydroxybenzoate) chewing gum can use wintergreen flavors.
The long-lasting aromatic profile can complement mint oils and cooling ingredients.
Dosage should be established by professional flavor formulation rather than direct addition of technical-grade material.
Oral-care flavors are another possible application.
Wintergreen notes have historically been associated with toothpastes, mouth-care and breath-freshening products.
Cosmetic or oral-care regulatory restrictions must be considered separately from food flavor authorization.
Pharmaceutical flavoring can also use methyl salicylate in selected products.
Its strong wintergreen profile can help mask unpleasant medicinal tastes in suitable formulations.
Pharmaceutical use requires appropriately qualified grade and regulatory documentation.
Methyl salicylate (Methyl 2-hydroxybenzoate) is also well known as a topical pharmaceutical salicylate.
Methyl salicylate (Methyl 2-hydroxybenzoate) is used in rubefacient and counterirritant-type products intended for temporary relief of minor muscle and joint discomfort.
This pharmaceutical role must be clearly distinguished from low-concentration fragrance or flavor use.
Methyl salicylate (Methyl 2-hydroxybenzoate) topical analgesic formulations can contain methyl salicylate together with menthol, camphor or other active ingredients.
The combination produces a characteristic cooling, warming or counterirritant sensory effect depending on the formulation.
Dosage and labeling must follow the medicinal regulations applicable to the target market.
Methyl salicylate (Methyl 2-hydroxybenzoate) creams can use methyl salicylate as part of an oil phase or solubilized active system.
The formulation must provide uniform distribution and controlled skin delivery.
Excessive local concentration should be avoided because methyl salicylate can be absorbed through skin.
Methyl salicylate (Methyl 2-hydroxybenzoate) qintments are another traditional dosage form.
A lipophilic base can dissolve or disperse methyl salicylate effectively and prolong contact with the skin.
The vehicle strongly influences absorption and should therefore be considered during safety assessment.
Methyl salicylate (Methyl 2-hydroxybenzoate) liniments have historically used methyl salicylate.
These liquid or semi-liquid topical preparations are designed to be rubbed onto the skin over muscles or joints.
Concentration must remain within permitted medicinal limits and should never be extrapolated from fragrance-use levels.
Methyl salicylate (Methyl 2-hydroxybenzoate) sports rubs are another familiar application.
Methyl salicylate contributes both characteristic odor and pharmacological salicylate activity.
The product must therefore be treated as a medicinal formulation when used for therapeutic claims.
Methyl salicylate (Methyl 2-hydroxybenzoate) patches can also deliver methyl salicylate.
In a patch system, the active is retained within an adhesive or matrix and released toward the skin over time.
Controlled-release behavior, skin exposure and adhesion must all be validated.
Methyl salicylate (Methyl 2-hydroxybenzoate) is readily absorbed through the skin.
After absorption it is hydrolyzed substantially to salicylic acid, which then undergoes further metabolism.
Methyl salicylate (Methyl 2-hydroxybenzoate) systemic conversion is one of the major reasons topical concentration and exposed surface area require careful control.
Methyl salicylate (Methyl 2-hydroxybenzoate) large-area application can substantially increase systemic exposure.
Occlusion, heat, damaged skin and repeated application can further increase absorption.
Topical medicinal products should therefore follow approved dose instructions rather than consumer intuition.
Methyl salicylate (Methyl 2-hydroxybenzoate) heating pads should not be combined casually with methyl-salicylate-containing products.
Elevated temperature can increase skin permeability and drug absorption.
The label and approved instructions of the finished medicinal product should always take precedence.
Methyl salicylate (Methyl 2-hydroxybenzoate) is also used as a chemical intermediate.
The ester and phenolic groups provide multiple routes for derivatization.
Methyl salicylate (Methyl 2-hydroxybenzoate) makes the material useful in synthesis of salicylate derivatives, specialty aromatics and pharmaceutical intermediates.
Methyl salicylate (Methyl 2-hydroxybenzoate) hydrolysis is one potential route.
Conversion back to salicylic acid can provide a controlled intermediate step within specific synthetic sequences.
In most industrial cases, direct salicylic acid feedstock is more economical if salicylic acid itself is the target.
Methyl salicylate (Methyl 2-hydroxybenzoate) phenolic hydroxyl can undergo etherification.
Alkylation or other substitution at this site allows preparation of functionalized aromatic intermediates.
Reaction conditions must be controlled to avoid competing ester hydrolysis.
Methyl salicylate (Methyl 2-hydroxybenzoate) acylation is another possibility.
The hydroxyl group can be converted into esters or other derivatives under suitable reaction conditions.
This expands the range of salicylate-derived specialty chemicals accessible from methyl salicylate.
Methyl salicylate (Methyl 2-hydroxybenzoate) electrophilic aromatic substitution chemistry can also be performed on the aromatic ring.
The hydroxyl and ester groups direct substitution behavior and influence regioselectivity.
Methyl salicylate can therefore serve as an intermediate in more complex aromatic synthesis.
Methyl salicylate (Methyl 2-hydroxybenzoate) nitration and halogenation are examples of possible aromatic transformations.
Such reactions require controlled conditions because the aromatic ring already contains strongly directing substituents.
Industrial use depends on target molecule, safety and economic route selection.
Methyl salicylate (Methyl 2-hydroxybenzoate) can also serve as a solvent or solvent-like medium in selected specialty applications.
Its moderate polarity and high boiling point allow dissolution of some organic materials without rapid evaporation.
This role is more specialized than its fragrance and pharmaceutical uses.
Methyl salicylate (Methyl 2-hydroxybenzoate) high boiling solvents are useful where extended open time is required.
Methyl salicylate (Methyl 2-hydroxybenzoate) evaporates much more slowly than low-boiling esters and alcohols.
Residual odor and regulatory concerns limit its use as a general-purpose industrial solvent.
Methyl salicylate (Methyl 2-hydroxybenzoate) can also be used in analytical chemistry.
Methyl salicylate (Methyl 2-hydroxybenzoate) well-defined aromatic ester structure makes it suitable as a reference compound or standard in chromatographic and spectroscopic work.
Analytical use requires high-purity grades with traceable documentation.
Methyl salicylate (Methyl 2-hydroxybenzoate) reference standards are available for pharmaceutical and laboratory testing.
These grades are intended for instrument calibration, identification and assay procedures rather than ordinary manufacturing.
They should not be confused with bulk commercial flavor, fragrance or technical grades.
Methyl salicylate is also useful in research involving salicylate metabolism.
Its conversion to salicylic acid provides a model pathway for ester hydrolysis and systemic salicylate exposure.
Research applications should use grades appropriate to the analytical objective.
Methyl salicylate (Methyl 2-hydroxybenzoate) has also been studied in ecological and plant-communication contexts.
Methyl salicylate occurs naturally in various plants and can act as a volatile signal or attractant in certain biological systems.
These functions are distinct from its industrial fragrance or pharmaceutical uses.
In agricultural research, Methyl salicylate (Methyl 2-hydroxybenzoate) has been studied for effects on insect behavior.
Methyl salicylate (Methyl 2-hydroxybenzoate) volatile can act as an attractant or signaling compound for some insect species.
Any practical agricultural use requires regulatory authorization specific to the product and region.
Methyl salicylate (Methyl 2-hydroxybenzoate) occurs naturally in wintergreen and related botanical sources.
Gaultheria species can produce oils with very high methyl salicylate content.
Natural-origin claims should therefore distinguish botanical wintergreen oil from synthetically manufactured methyl salicylate.
Natural and synthetic Methyl salicylate (Methyl 2-hydroxybenzoate) are chemically the same principal molecule.
Methyl salicylate (Methyl 2-hydroxybenzoate) impurity profiles, trace aroma components and documentation can nevertheless differ.
A flavor or fragrance formulator should therefore specify whether natural-source or synthetic material is required.
Methyl salicylate (Methyl 2-hydroxybenzoate) synthetic manufacture offers strong consistency.
Purity, color, odor intensity and batch-to-batch composition can be controlled independently of agricultural variability.
This makes synthetic methyl salicylate attractive where reproducibility is more important than natural-origin positioning.
Methyl salicylate (Methyl 2-hydroxybenzoate) natural wintergreen oil provides a broader aromatic profile.
Minor botanical components can subtly alter the odor compared with highly purified synthetic methyl salicylate.
The two materials should therefore be compared sensorially before substitution in a fine fragrance or flavor.
Methyl salicylate (Methyl 2-hydroxybenzoate) can also be used as a fragrance component in soaps.
Methyl salicylate (Methyl 2-hydroxybenzoate) odor survives sufficiently well in many soap bases to contribute a characteristic wintergreen note.
Strong alkalinity and long-term storage stability should nevertheless be checked because ester hydrolysis is possible.
Methyl salicylate (Methyl 2-hydroxybenzoate) detergent fragrances can use methyl salicylate in suitable compositions.
The wintergreen note can reinforce herbal, pine, mint and medicinal accords.
Compatibility with surfactants, oxidants and bleaching systems should be evaluated during accelerated stability testing.
Methyl salicylate (Methyl 2-hydroxybenzoate) fabric-care products can also include the material as part of fragrance.
The extent of deposition on fabric depends on the complete perfume system and delivery technology.
Methyl salicylate itself should not be assumed to provide substantive deposition without formulation support.
Methyl salicylate (Methyl 2-hydroxybenzoate) industrial odorants or masking compositions may also use it.
Its strong characteristic odor can dominate weaker process odors and provide a recognizable sensory marker.
Occupational exposure and regulatory classification must still be considered at industrial concentrations.
Methyl salicylate (Methyl 2-hydroxybenzoate) cosmetic use requires particular care in the European Union.
Current restrictions vary by category and are substantially tighter in certain leave-on or aerosol products than in rinse-off categories.
Formulators should therefore review the exact Annex III limit applicable to the finished product category.
Methyl salicylate (Methyl 2-hydroxybenzoate) some EU product categories permit only very low concentrations.
Eye makeup, aerosol hair products and deodorant aerosols can have especially restrictive limits compared with hand wash or hydroalcoholic fragrance categories.
A universal cosmetic use level should therefore never be quoted for methyl salicylate.
Methyl salicylate (Methyl 2-hydroxybenzoate) current provisions prohibit use in preparations for children under six years of age except for specified toothpaste circumstances.
The exact legal text and transition provisions should be checked before market placement.
Methyl salicylate (Methyl 2-hydroxybenzoate) fragrance allergen labeling can also be relevant.
Methyl salicylate is subject to disclosure requirements above defined thresholds in leave-on and rinse-off cosmetic products.
Label compliance should therefore be assessed together with maximum-use restrictions.
The presence of Methyl salicylate (Methyl 2-hydroxybenzoate) from natural wintergreen oil must also be counted.
A cosmetic containing wintergreen essential oil may already contain substantial methyl salicylate even if no synthetic methyl salicylate was added separately.
Formulators must calculate the total concentration from all ingredient sources.
Methyl salicylate (Methyl 2-hydroxybenzoate) food and flavor use requires similarly careful grade control.
The FDA recognizes methyl salicylate as a flavoring agent or adjuvant and lists FEMA number 2745 and JECFA flavor number 899.
Commercial food use should rely on flavor-grade material and applicable regional limits or good-manufacturing-practice requirements.
Methyl salicylate (Methyl 2-hydroxybenzoate) flavor dosage is normally very low.
The strong wintergreen character can become harsh or medicinal if overused.
Professional sensory evaluation is therefore essential for food and beverage development.
Methyl salicylate (Methyl 2-hydroxybenzoate) can be used in mint-flavored confectionery.
Methyl salicylate (Methyl 2-hydroxybenzoate) characteristic sensory profile works particularly well with peppermint, spearmint and cooling agents.
The final flavor should remain balanced so that wintergreen does not overpower sweetness or freshness.
Methyl salicylate (Methyl 2-hydroxybenzoate) beverage applications are more specialized.
Limited water solubility means the ingredient typically requires flavor emulsions, ethanol or other approved carriers.
Clouding, ring formation and phase separation should be evaluated during shelf-life testing.
Methyl salicylate (Methyl 2-hydroxybenzoate) oral-care formulations can use wintergreen character for freshness.
Toothpaste, mouthwash and breath-care products can incorporate methyl salicylate through fragrance or flavor systems.
Regulatory classification of these products varies between markets and can place them under cosmetic, drug or other legal frameworks.
Methyl salicylate (Methyl 2-hydroxybenzoate) toothpaste formulations require compatibility with abrasives and surfactants.
Calcium carbonate, silica, fluoride salts and detergents can change flavor release and stability.
The complete oral-care base should therefore be used during sensory optimization.
Methyl salicylate (Methyl 2-hydroxybenzoate) mouthwash typically uses hydroalcoholic or solubilized aqueous systems.
Methyl salicylate can be incorporated effectively when the solvent or surfactant system maintains clarity.
The final concentration should meet both flavor requirements and the relevant cosmetic or therapeutic regulation.
Methyl salicylate (Methyl 2-hydroxybenzoate) pharmaceutical manufacturing requires an appropriate pharmaceutical grade.
A technical or fragrance-grade product can share the same CAS number but may not satisfy pharmaceutical impurity or quality-system requirements.
Grade selection should therefore be based on intended regulatory use rather than chemical identity alone.
Methyl salicylate (Methyl 2-hydroxybenzoate) flavor-grade and fragrance-grade material also differ in documentation.
Food manufacturers may require FEMA, JECFA or regulatory compliance statements, while fragrance users may prioritize IFRA-related information and odor quality.
Methyl salicylate (Methyl 2-hydroxybenzoate) a single commercial grade should not automatically be assumed suitable for every market.
Methyl salicylate (Methyl 2-hydroxybenzoate) industrial buyers should review assay.
High-purity commercial methyl salicylate is generally supplied close to or above 99% assay depending on grade.
Exact specification should be confirmed from the supplier's TDS and Certificate of Analysis.
Methyl salicylate (Methyl 2-hydroxybenzoate) value is another important purchasing parameter.
Residual salicylic acid can increase acidity and may indicate incomplete esterification or hydrolysis.
Methyl salicylate (Methyl 2-hydroxybenzoate) low acid value is desirable in high-quality fragrance, pharmaceutical and technical grades.
Methyl salicylate (Methyl 2-hydroxybenzoate) water content should also be controlled.
Excess water can affect hydrolytic stability and downstream formulation behavior.
Karl Fischer moisture analysis may be useful where low water content is critical.
Methyl salicylate (Methyl 2-hydroxybenzoate) density provides another simple incoming test.
Values around 1.17 g/mL at 25 °C are expected for high-purity material.
Methyl salicylate (Methyl 2-hydroxybenzoate) combined density and refractive-index measurement can identify many gross quality deviations rapidly.
Methyl salicylate (Methyl 2-hydroxybenzoate) odor should be evaluated alongside instrumental tests.
Trace impurities can affect fragrance quality even when assay remains high.
A retained approved reference sample can support consistent organoleptic incoming inspection.
The broad application profile of Methyl salicylate (Methyl 2-hydroxybenzoate) therefore includes fragrances, wintergreen flavors, oral-care products, topical pharmaceutical preparations, analytical standards and specialty chemical synthesis.
Methyl salicylate (Methyl 2-hydroxybenzoate) principal technical strengths are high odor impact, recognizable wintergreen character, compatibility with many organic phases and reactive salicylate ester chemistry.
The intended application should always determine grade selection because fragrance, food, pharmaceutical and technical requirements differ substantially.
Safety Profile Of Methyl salicylate (Methyl 2-hydroxybenzoate):
Methyl salicylate (Methyl 2-hydroxybenzoate) is a biologically active salicylate and should not be treated as a benign fragrance oil simply because it has a familiar wintergreen odor.
Current EU classification includes acute toxicity concerns and reproductive-toxicity classification together with chronic aquatic hazard.
Methyl salicylate (Methyl 2-hydroxybenzoate) current supplier-specific Safety Data Sheet should therefore be reviewed before industrial handling.
Methyl salicylate (Methyl 2-hydroxybenzoate) can be toxic if swallowed in significant quantity.
Once absorbed, it is rapidly converted to salicylic acid and can produce systemic salicylate toxicity.
Concentrated raw material must therefore be kept away from food, drink and unauthorized consumer access.
Methyl salicylate (Methyl 2-hydroxybenzoate) dermal exposure is also important.
Methyl salicylate (Methyl 2-hydroxybenzoate) can pass through skin and contribute to systemic salicylate dose.
This is especially relevant during prolonged contact, large-area exposure or contact under occlusive conditions.
Methyl salicylate (Methyl 2-hydroxybenzoate) skin absorption makes glove selection important during manufacturing.
Suitable chemical-resistant gloves should be used for bulk transfer, sampling and formulation operations.
Contaminated gloves or clothing should be replaced rather than worn for prolonged periods.
Methyl salicylate (Methyl 2-hydroxybenzoate) eye contact should be prevented.
Methyl salicylate is recognized as an eye irritant and concentrated liquid can produce significant discomfort.
Safety glasses or goggles are appropriate during splash-risk operations.
Methyl salicylate (Methyl 2-hydroxybenzoate) is also regarded as a weak skin sensitizer in humans by the European Scientific Committee on Consumer Safety.
Repeated exposure can therefore produce allergic responses in susceptible individuals.
Good industrial hygiene should minimize repeated skin contact.
Methyl salicylate (Methyl 2-hydroxybenzoate) inhalation exposure is generally lower than with highly volatile solvents because methyl salicylate has a relatively high boiling point.
Heated processing, spraying or aerosol generation can nevertheless produce inhalable vapor or mist.
Local exhaust should be considered where these operations occur.
Methyl salicylate (Methyl 2-hydroxybenzoate) is combustible.
Its relatively high flash point reduces ignition risk at ordinary room temperature but does not eliminate fire hazard when heated.
Bulk storage should remain separated from strong ignition sources.
Methyl salicylate (Methyl 2-hydroxybenzoate) fire can generate carbon monoxide, carbon dioxide and irritating aromatic decomposition products.
Firefighters should use appropriate respiratory protection in a substantial chemical fire.
Containers exposed to heat should be cooled where this can be performed safely.
Methyl salicylate (Methyl 2-hydroxybenzoate) strong oxidizing agents should be avoided.
Oxidizers can react with aromatic organic materials and increase fire or decomposition risk.
Chemical segregation should follow the current SDS.
Methyl salicylate (Methyl 2-hydroxybenzoate) strong bases can promote saponification.
Uncontrolled contamination with alkali can convert methyl salicylate into salicylate salts and methanol while generating heat depending on conditions.
Storage containers should therefore remain chemically clean.
Methyl salicylate (Methyl 2-hydroxybenzoate) strong acids can also accelerate hydrolysis under heated aqueous conditions.
Such chemistry is useful in controlled synthesis but undesirable during storage.
Contamination by reactive chemicals should be prevented.
Methyl salicylate (Methyl 2-hydroxybenzoate) can create a slippery surface.
Liquid should be contained and collected using compatible absorbent material.
Waste should be placed in properly labeled containers for disposal according to local regulations.
Methyl salicylate (Methyl 2-hydroxybenzoate) large spills should not be flushed directly into drains.
Current EU classification includes chronic aquatic hazard concerns.
Environmental release should therefore be minimized even though the substance is used in consumer fragrance and flavor applications at low levels.
Methyl salicylate (Methyl 2-hydroxybenzoate) food-use authorization does not imply that concentrated methyl salicylate is safe to consume directly.
Flavor substances are used at carefully controlled concentrations that are far below the quantity contained in a bulk raw-material container.
Concentrated material should always be handled as an industrial chemical.
Methyl salicylate (Methyl 2-hydroxybenzoate) topical pharmaceutical use similarly does not imply unlimited dermal safety.
Approved medicinal products control concentration, dosage, application area and frequency.
Using concentrated methyl salicylate directly on skin can result in serious systemic exposure.
Methyl salicylate (Methyl 2-hydroxybenzoate) Procurement and Technical Support:
Ataman Kimya supports customers looking for Methyl salicylate (Methyl 2-hydroxybenzoate) with dependable supply solutions and relevant technical information for industrial and formulation requirements.
Additional support can be provided regarding product specifications, available documentation, and the evaluation of suitable product options based on the intended application.
