METHYLISOTIAZOLINONE (MIT) 50%

Synonyms:
PROCLIN 5000; MİT antimicrobial products  Methylisothiazolinone (MİT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MİT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; MİT; MIT 50 %; MİT 50%; Methylisothiazolinone (MİT) %; MİT 50 %50; Methylisothiazolinone (MİT); MİT 50; Methylisothiazolinone; Methyl iso thiazolinone; Methyl isothiazolinone; Methylisothiazolinon; MİT50%; MİT 20; KATHONCG; Skycide 100; MİT, 100ppm; Isothiazolone; 2-Methyl-4-iso; Isothiazolone14%; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; 2-Methyl-4-isothiazolin-3-one; 2682-20-4; Methylisothiazolinone; 2-methylisothiazol-3(2h)-one; 2-Methyl-4-isothiazoline-3-one; 2-Methyl-3(2H)-isothiazolone; 3(2H)-Isothiazolone, 2-methyl-; PROCLIN 5000;PROCLIN 5000; MİT antimicrobial products  Methylisothiazolinone (MİT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MİT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; MİT; MIT 50 %; MİT 50%; Methylisothiazolinone (MİT) %; MİT 50 %50; Methylisothiazolinone (MİT); MİT 50; Methylisothiazolinone; Methyl iso thiazolinone; Methyl isothiazolinone; Methylisothiazolinon; MİT50%; MİT-20;KATHONCG;Skycide 100;MİT, 100ppm; Isothiazolone; 2-Methyl-4-iso; Isothiazolone 14%; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; 2-Methyl-4-isothiazolin-3-one; 2682-20-4; Methylisothiazolinone; 2-methylisothiazol-3(2h)-one; 2-Methyl-4-isothiazoline-3-one; 2-Methyl-3(2H)-isothiazolone; 3(2H)-Isothiazolone, 2-methyl-; PROCLIN 5000; MIT antimicrobial products  Methylisothiazolinone (MIT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MIT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; N-methylisothiazolone; Caswell No. 572A; N-Methyl-3-oxodihydroisothiazole; 2-methyl-3-isothiazolone; C4H5NOS; 2-methyl-1,2-thiazol-3(2H)-one; UNII-229D0E1QFA; 2-METHYL-2H-ISOTHIAZOL-3-ONE, EINECS 220-239-6; 229D0E1QFA; 2-methyl-1,2-thiazol-3-one; 3(2H)-Isothiazolone, methyl-;MİT 50 % ; MİT50; Methylisothiazolinone (MİT)%; MİT%50; Metilizotiyazolinon; Metil izotiyazolinon ; Metil izot iyazolinon; Mİ; 2-Metil-3 (2H) -izotiyazolon, 3 (2H) -izotiyazolon, 2-metil-, Caswell No. 572A, 2-Metil-4-izotiazolin-3-on; Methylisothiazolinone ; MIT antimicrobial products  Methylisothiazolinone (MIT); biocides; 950 preservative; LX5000 biocide; M-10 preservative; 573F biocide; M-50 preservative; 573T biocide; 50A preservative; MLX biocide; 550 preservative; MTC biocide; 2-Methyl-2H-isothiazol-3-one; 50C biocide; 2-Methyl-4-isothiazolin-3-one; MT20 antimicrobials; 3(2H)-Isothiazolone; 2-methyl-; 950; Methylisothiazolone; 2-Methylisothiazol-3(2H)-one; 2-Methyl-4-isothiazolin-3-one; MIT50%; KATHONCG; Skycide 100; 2-Methyl-4-iso; METHYLISOTHIAZOLIN; METHYLISOTHIAZOLINE; METHYLISOTHIAZOLONE; METHYLISOTHIAZDINONE; Methylisothiazolinone; Isothiazolone,2-methyl; N-methylisothiazolone; Caswell No. 572A; N-Methyl-3-oxodihydroisothiazole; 2-methyl-3-isothiazolone; C4H5NOS; 2-methyl-1,2-thiazol-3(2H)-one; UNII-229D0E1QFA; 2-METHYL-2H-ISOTHIAZOL-3-ONE, EINECS 220-239-6; 229D0E1QFA; 2-methyl-1,2-thiazol-3-one; 3(2H)-Isothiazolone, methyl-;MİT 50 % ; MİT50; Methylisothiazolinone (MİT)%; MİT%50; Metilizotiyazolinon; Metil izotiyazolinon ; Metil izot iyazolinon; Mİ; 2-Metil-3 (2H) -izotiyazolon, 3 (2H) -izotiyazolon, 2-metil-, Caswell No. 572A, 2-Metil-4-izotiazolin-3-on; Methylisothiazolinone ; Metilizotiyazolinon; Metilizotiyazolinone; mit; mıt ; Mit; Mıt; MİT; MIT ;  mit 50 ; mıt50  ; Mit 50 ; Mıt 50 ; MİT 50 ; MIT 50

Methylisothiazolinone (MİT) %50
Methylisothiazolinone

Methylisothiazolinone (MİT)
Skeletal formula of methylisothiazolinone
Space-filling model of the methylisothiazolinone molecule
Names
Preferred IUPAC name
2-Methyl-1,2-thiazol-3(2H)-one
Other names
2-Methylisothiazol-3(2H)-one
2-Methyl-4-isothiazolin-3-one
Identifiers
CAS Number    
2682-20-4 ☑
3D model (JSmol)    
Interactive image
Abbreviations    MİT
Beilstein Reference    606203
ChEBI    
CHEBI:53620 ☑
ChEMBL    
ChEMBL1620780
ChemSpider    
36393 ☑
ECHA InfoCard    100.018.399
EC Number    
220-239-6
PubChem CID    
39800
UNII    
229D0E1QFA ☑
CompTox Dashboard (EPA)    
DTXSID2034259 Edit this at Wikidata
InChI[show]
SMILES[show]
Properties
Chemical formula    C4H5NOS
Molar mass    115.1 g/mol
Hazards
GHS pictograms    GHS05: CorrosiveGHS06: ToxicGHS07: HarmfulGHS09: Environmental hazard
GHS Signal word    Danger
GHS hazard statements    H301, H311, H314, H317, H318, H330, H400, H410
GHS precautionary statements    P260, P261, P264, P270, P271, P272, P273, P280, P284, P301+310, P301+330+331, P302+352, P303+361+353, P304+340, P305+351+338, P310, P312, P320, P321, P322, P330, P333+313, P361, P363, P391
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references
Methylisothiazolinone, MİT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.

Referenced in The Catherine Tate Show Lauren Cooper used the symbol representation to form her classic joke “M I bovvered”. This was, in fact, so hilarious to the creator of the chemical (Mark Antony) that he renamed his chemical to ‘MI BOVVERED’.

It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and has been reported as a contact sensitizing agent by the European Commission’s Scientific ComMİTtee on Consumer Safety.

Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.[1]

Applications
Methylisothiazolinone and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions.[2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloroMethylisothiazolinone (MİT)or MİT) and 2-methyl-4-isothiazolin-3-one (Methylisothiazolinone (MİT)or MİT), which are the active ingredients in a 3:1 mixture (MİT:MİT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 1.5-15% of MİT/MİT. For applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production.

Kathon also has been used to control slime in the manufacture of paper products that contact food. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food.[3]

Other isothiazolinones
One isothiazolinone, Sea-Nine 211 (4,5-dichloro-2-n-octyl-4-isothiazolino-3-one, DCOI), has quickly replaced tributyltin as the antifouling agent of choice in ship hull paint. A recent study reported the presence of DCOI in both port water and sediment samples in Osaka, Japan, especially in weakly circulating mooring areas.[4] Of environmental concern, DCOI levels predicted in marinas now are considered a threat to various marine invertebrate species.[5] Isothiazolinones also are extremely toxic to fish.[1]

In industrial use, the greatest occupational inhalation exposure occurs during open pouring. Non-occupational exposure to isothiazolinones by the general population also occurs, albeit at much lower concentrations.[6] These compounds are present in a very large number of commonly used cosmetics.[7] “Leave-on” cosmetics (hand-creams, lotions, etc.) contain 15 parts per million (100 micromolar) of combined MİT/MİT.

Human health
MİTis allergenic and cytotoxic, and this has led to some concern over its use.[8][9] A report released by the European Scientific ComMİTtee on Cosmetic Products and Non-food Products Intended for Consumers (SCCNFP) in 2003 also concluded that insufficient information was available to allow for an adequate risk assessment analysis of MİT.[10]

Rising reports of consumer impact led to new research, including a report released in 2014 by the European Commission Scientific ComMİTtee on Consumer Safety which reported: "The dramatic rise in the rates of reported cases of contact allergy to MI, as detected by diagnostic patch tests, is unprecedented in Europe; there have been repeated warnings about the rise (Gonçalo M, Goossens A. 2013). The increase is primarily caused by increasing consumer exposure to MI from cosmetic products; exposures to MI in household products, paints and in the occupational setting also need to be considered. The delay in re-evaluation of the safety of MI in cosmetic products is of concern to the SCCS; it has adversely affected consumer safety."[11]

"It is unknown what proportion of the general population is now sensitized to MI and has not been confirmed as sensitized."[11] In 2014, the European Commission Scientific ComMİTtee on Consumer Safety further issued a voluntary ban on "the mixture of Methylchloroisothiazolinone (and) Methylisothiazolinone (MİT)(MCI/MI) from leave-on products such as body creams. The measure is aimed at reducing the risk from and the incidence of skin allergies. The preservative can still be used in rinse-off products such as shampoos and shower gels at a maximum concentration of 0.0015 % of a mixture in the ratio 3:1 of MCI/MI. The measure will apply for products placed on the market after 16 July 2015."[12] Shortly thereafter, Canada moved to adopt similar measures in its Cosmetic Ingredients Hotlist.[13] Additionally, new research into cross reactivity of MI-sensitized patients to variants benzisothiazolinone and octylisothiazolinone have found that reactions may occur if present in sufficient amounts.[14]

Allergic contact dermatitis
Methylisothiazolinone (MİT)is used commonly in products in conjunction with methylchloroisothiazolinone, a mixture sold under the registered trade name Kathon CG. A common indication of sensitivity to Kathon CG is allergic contact dermatitis. Sensitization to this family of preservatives was observed as early as the late 1980s.[15][16] Due to increased use of isothiazolinone-based preservatives in recent years, an increase in reported incidences of contact allergy to this product has been reported. In 2013 the substance was declared the 2013 Contact Allergen of the Year by the American Contact Dermatitis Society.[17] In 2016 the Dermatitis Academy launched a call to action for patients to report their isothiazolinone allergy to the FDA.[18]

On December 13, 2013 the trade group, Cosmetics Europe,[19] following discussions with the European Society of Contact Dermatitis (ESCD),[20] recommended to its members "that the use of Methylisothiazolinone (MİT) in leave-on skin products including cosmetic wet wipes is discontinued. This action is recommended in the interests of consumer safety in relation to adverse skin reactions. It is recommended that companies do not wait for regulatory intervention under the Cosmetics Regulation but implement this recommendation as soon as feasible."[21]

On March 27, 2014, the European Commission’s Scientific ComMİTtee on Consumer Safety issued an opinion on the safety of Methylisothiazolinone. This report only considered the issue of contact sensitization. The comMİTtee concluded:

“Current clinical data indicate that 100 ppm MI in cosmetic products is not safe for the consumer.

"For leave-on cosmetic products (including ‘wet wipes’), no safe concentrations of MI for induction of contact allergy or elicitation have been adequately demonstrated.

"For rinse-off cosmetic products, a concentration of 15 ppm (0.0015%) MI is considered safe for the consumer from the view of induction of contact allergy. However, no information is available on elicitation.”[22]

Ingredient in mouthwash
Although many companies that had begun using the biocide in personal care products, such as Kimberly-Clark, Johnson & Johnson, and Unilever are removing Methylisothiazolinone (MİT)from their lotions and wipes, Colgate-Palmolive has added it as an ingredient in a mouthwash put onto the market in August 2014 with the name Colgate Total Lasting White.[23] The New York Times reported that some companies are even considering removing the biocide from products that are routinely rinsed off shortly after application.

MİT50 2 Methyl 4 Isothiazolin 3 one CAS 2682-20-4
CAS:2682-20-4
Purity:50%
Appearance: Colorless or yellow transparent liquid
Package:25kg,200kg,1mt drum
Product description: MİT50 biocide is miscible with water, Suitable for use in the medium of the pH value in the range of 2 to 12, and easy to use. Methylisothiazolinone (MİT)has good compatibility with body care products in

Methylisothiazolinone (MİT)50 ( 2-Methyl-4-Isothiazolin-3-one)

In-Can Preservation for Paints, Adhesives and Related Products

Product Name: MİT50

Chemical Name: 2-Methyl-4-Isothiazolin-3-one

CAS No: 2682-20-4

MİT-50 is an active ingredient solution for the preservation of paints, binder dispersions, adhesives and other technical products.

Methylisothiazolinone (MİT)50 contains an active substance perMİTted for use in food contact coatings and adhesives provided that the customary dosage rates are not exceeded.

2-Methyl-4-Isothiazolin-3-one is a straight aqueous solution of the active ingredient Methylisothiazolone, and does not contribute to VOC and AOX.

Specifications:

Appearance

Colorless or yellow transparent liquid

Content of Active Substance %

≥ 50

PH Value

5.0-7.0

Density (g/ml)

≥1.10

COA Download: Here
MSDS: Contact us for MSDS file
Application field:

Suitabe for use in daily chemicals, cosmetics, paints, synthetic polymer emulsions, and other water-based systems.

Performance characteristics:

1. With bactericidal, antibacterial, highly-efficient, broad-spectrum, and long-lasting features.

2. Miscible with water and easy to use.

3. Will cause no harm at the recommended concentration of using.

4. Don’t accumulate in the environment; easily degraded.

5. Suitable for use in the medium of the pH value in the range of 2 to 12.

6. Good compatibility with body care products in surfactants and emulsifiers.
Usage and Cautions:

1. For use in paints, synthetic polymer emulsions and other water-based systems, the general concentration of using is 0.05-0.1% (w/w); for use in daily chemicals, the concentration is 0.02-0.1% (w/w), depending on the storage environment and whether the product is susceptible to damage of microorganisms.

2. It can be added at any production step; but it's suggested to be added at the final step at less than 50 ℃; avoid adding at a temperature of higher than 50 ℃. Wear protective clothes, rubber gloves, goggles and masks; avoid any contact with the skin, eyes and mucous membranes.

CAS No.2682-20-4
Chemical Name:Methylisothiazolinone
CBNumber:CB0193926
Molecular Formula:C4H5NOS
Formula Weight:115.15
MOL File:2682-20-4.mol

Methylisothiazolinone Chemical Properties,Uses,Production
Description
Methylisothiazolinone (MİT)(also called 2-methyl-4-isothiazolin-3-one), is a powerful synthetic biocide and preservative within the group of  isothiazolinones.
Methylisothiazolinone (MİT)is used to control slime-forming bacteria, fungi, and algae in pulp/paper mills, cooling water systems, oil field operations, industrial process waters, and air washer systems. And it is incorporated into adhesives, coatings, fuels, metal working fluids, resin emulsions, paints, and various other specialty industrial products as a preservative. It is also used to control the growth of mold, mildew, and sapstain on wood products. It is generally recommended for use only in rinse-off and leave-on cosmetic products (maximum concentration of 100 ppm) as preservative such as shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps, and detergents. Nevertheless, Methylisothiazolinone (MİT)is allergenic. It is reported that Methylisothiazolinone (MİT)in rinse-off products causes allergic contact dermatitis.
Uses
Methylisothiazolinone, or MİTas it is sometimes known, is a preservative used in cosmetics and beauty products. It is a powerful biocide, or “chemical substance capable of killing living organisms, usually in a selective way.”Biocides are a general term that includes antimicrobial, germicide, antibiotic, and antifungal. Ultimately, Methylisothiazolinone (MİT)is used to prevent a wide variety of bacteria and fungi from growing in cosmetics and beauty products, most often in shampoo. It is only approved for use in rinse-off formulas and at low concentrations.
Safety
Methylisothiazolinone (MİT) is a heterocyclic organic compound used as a preservative in cosmetics and personal care products in concentrations up to 0.01%. MİTis a colorless, clear liquid with a mild odor that is completely soluble in water; mostly soluble in acetonitrile, methanol, and hexane; and slightly soluble in xylene. Consistent with its solubility, dermal penetration is low. The Cosmetic Ingredient Review Expert Panel noted the in vitro evidence of neurotoxicity but concluded that the absence of any neurotoxicity findings in the many in vivo studies, including subchronic, chronic, and reproductive and developmental animal studies, suggests that MİTwould not be neurotoxic as used in cosmetics. Although recognizing that MİTwas a sensitizer in both animal and human studies, the panel concluded that there is a threshold dose response and that cosmetic products formulated to contain concentrations of MİTat 100 ppm (0.0 1%) or less would not be expected to pose a sensitization risk. Accordingly, MİTmay be safely used as a preservative in cosmetics up to that concentration.
Description
MI is contained in Kathon CG, MCI/MI and Euxyl K100. It can cause severe irritant dermatitis, as with Euxyl K100 incorporated in a cleansing cream used by an engine man.
Chemical Properties
Yellow Low melting Solid
Uses
2-Methyl-4-isothiazolin-3-one is a isothiazolinone based biocide and preservative used in personal care products. 2-Methyl-4-isothiazolin-3-one is also used for controlling microbial growth in water-c ontaining solution.
Uses
A potent biocide useful for controlling microbial growth
Uses
Methylisothiazolinone (MİT)is a preservative.

Methylisothiazolinone (MİT)AND METHYLCHLOROISOTHIAZOLINONE 
Methylisothiazolinone (MİT) and Methylchloroisothiazolinone (MİT)  may be hard to pronounce, but they can be even harder on the body. These common preservatives are found in many liquid personal care products, and have been linked to lung toxicity[1], allergic reactions and possible neurotoxicity[2].

FOUND IN: Shampoo, conditioner, hair color, body wash, lotion, sunscreen, mascara, shaving cream, baby lotion, baby shampoo, hairspray, makeup remover, liquid soaps and detergents.

WHAT TO LOOK FOR ON THE LABEL: Methylisothiazolinone (MİT): 2-methyl-4-isothiazoline-3-one, Neolone 950 preservative, MI, OriStar MİTand Microcare MT. Methylchloroisothiazolinone (MİT): 5-Chloro-2-methyl-4-isothiazolin-3-one and MCI.

WHAT ARE Methylisothiazolinone (MİT)and METHYLCHLOROISOTHIAZOLINONE? Methylisothiazolinone (MİT) and Methylchloroisothiazolinone (MİT) are widely used preservatives found in liquid cosmetic and personal care products.[3] [4] Both chemicals inhibit bacterial growth in cosmetic products on their own, but they are most commonly used as a mixture in products.[5]

HEALTH CONCERNS: Inhalation toxicity, allergies and possible neurotoxicity. MORE...

VULNERABLE POPULATIONS: Individuals who are allergic to Methylisothiazolinone (MİT) and/or Methylchloroisothiazolinone (MİT). Workers may be exposed to especially high doses.

REGULATIONS: Europe, along with the European Society of Contact Dermatitis (ESCD), recommends that MİTbe discontinued from use in leave-on skin products.[16]

HOW TO AVOID: If you are allergic, read labels and avoid products with Methylisothiazolinone (MİT) or Methylchloroisothiazolinone (MİT). Especially avoid products with a mixture of CMİTand MİT. If you are not allergic, MİTand MİT 50 are among the safer preservatives with regard to long-term chronic health effects.

The detergent and paint industries have long used MİT(Methylisothiazolinone) as a biocide/preservative in water-based formulations.

Until now, the legislation required MİTto be labelled as H317 (it may cause an allergic skin reaction) when above 1000 ppm, and as EUH208 when above 100 ppm. This, so far, has not been a problem for these formulations, as they mostly have an MİTconcentration between 50 and 200 ppm.

However, from May 2020, MİTconcentration liMİTs will be drastically reduced to 15 ppm (H317) and 1.5 ppm (EUH208). As a consequence of this regulatory change, those who do not wish to change the labelling of their products will have to look for MİTsubstitutes.

Lanxess, our representative for the Preventol® range of biocides/preservatives, has developed a series of MİTfree solutions that serve as MİTsubstitutes for detergents and paints.

The other MİTsubstitute is a 35% solution of dodecylguanidine hydrochloride (DGH) that is used for the control of algae, bacteria, fungi and molluscs. DGH is non-sensitizing and therefore it does not require hazard labelling. This MİTsubstitute is effective at low concentrations and for a wide pH range. It is a cationic biocide especially indicated as a PT6 preservative for the formulation of fabric softeners.

Methylisothiazolinone (MİT) 50%
Methylisothiazolinone (MİT), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.
It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics
Product Description
Methylisothiazolinone (MİT), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.
It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and has been reported as a contact sensitizing agent by the European Commission’s Scientific ComMİTtee on Consumer Safety.

CAS No: 2682-20-4

MİT-based antimicrobial products are a series of broad-spectrum, formaldehyde-free antimicrobial products based on the active compound 2-methyl-4-isothiazolin-3-one (MİT). This compound inhibits the growth of bacteria, yeasts, and molds. MİT-based antimicrobial products are marketed and its subsidiary, contain up to 50% of the active substance. They are compatible with a wide range of formulation.

MİT-based antimicrobial products are often formulated as "in-can" preservatives at concentrations of 25 to 250 parts per million (ppm) active ingredient, with a 100 ppm maximum concentration in personal care products. They are used in water-based products such as:
-Adhesives and sealants
-Paints and coatings
-Polymer emulsions and latexes
-Personal-care products - cosmetics, lotions, moisturizers, shampoos, conditioners
-Medical Devices - Diagnostic Reagents
-Paper-coating materials - starch- and casein-based coatings and rosin dispersions
-Mineral and pigment slurries
-Household products and detergents
-Processing auxiliary chemicals

2-METHYL-4-ISOTHIAZOLIN-3ONE (MİT) sometimes erroneously called methylisothiazoline is a powerful biocide and preservatives within the group of isothiazolinones. They are used in controlling microbial growth in water containing solutions. It is widely used in
cosmetic, shampoos and body care products. It is generally used in combination with other isothiazolinones like chloromethylisothiazolinone in the ratio 3: 1 as CMİT : MİT. It has wide use in pH range

APPLICATIONS AND ADVANTAGES

Methylisothiazolinone (MİT) is generally used in personal care products, cosmetics, paints, synthetic polymer emulsions, and other water-based systems. It is an antimicrobial used to control slime-forming bacteria, fungi, and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems, and other industrial settings. It is also used to control the growth of mold, mildew, and sap stain on wood products. MİT is an antimicrobial used to control slime-forming bacteria, fungi and algae in cooling water systems, fuel storage tanks, pulp and paper mill water systems, oil extraction systems and other industrial settings. MİT is frequently used in personal care products such as shampoos and other hair care products, as well as certain paint formulations. And there, MİT is often used in combination with either Chloromethylisothiazolinone (known as Kathon CG when paired with Methylisothiazolinone) or Benzisothiazolinone (an added antiseptic). MİT is also used to control the growth of mold, mildew, and sapstain on wood products.

Methylisothiazolinone, MİT, or MI, (sometimes erroneously called methylisothiazoline), is a powerful synthetic biocide and preservative within the group of isothiazolinones, which is used in numerous personal care products and a wide range of industrial applications.

It is a cytotoxin that may affect different types of cells. Its use for a wide range of personal products for humans, such as cosmetics, lotions, moisturizers, sanitary wipes, shampoos, and sunscreens, more than doubled during the first decade of the twenty-first century and is proving to be a concern because of sensitization and allergic reactions as well as cell and nerve damage.

Industrial manufacturing and distribution of the biocide has resulted in more severe health hazards to the humans involved in the handling of large concentrated quantities of the biocide.

Industrial applications also are quite wide ranging, from preservative and sanitizing uses to antimicrobial agents, energy production, metalworking fluids, mining, paint manufacturing, and paper manufacturing, many of which increase potential exposure to it by humans as well as organisms, both terrestrial and marine. Industrial applications in marine environments are proving to be toxic to marine life, for instance, when the effect of its now almost-universal use in boat hull paint was examined.

Applications

Methylisothiazolinone and other isothiazolinone-derived biocides are used for controlling microbial growth in water-containing solutions.[2] Two of the most widely used isothiazolinone biocides are 5-chloro-2-methyl-4-isothiazolin-3-one (chloromethylisothiazolinone or CMİT) and 2-methyl-4-isothiazolin-3-one (methylisothiazolinone or MİT), which are the active ingredients in a 3:1 mixture (CMİT:MİT) sold commercially as Kathon. Kathon is supplied to manufacturers as a concentrated stock solution containing from 10-15% of CMİT/MİT. For applications the recommended use level is from 6 ppm to 75 ppm active isothiazolones. Biocidal applications range from industrial water storage tanks to cooling units, in processes as varied as mining, paper manufacturing, metalworking fluids and energy production.

Kathon also has been used to control slime in the manufacture of paper products that contact food. In addition, this product serves as an antimicrobial agent in latex adhesives and in paper coatings that also contact food