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CAS: 75-75-2
MF: CH4O3S
MW: 96.11
EINECS: 200-898-6
Description
Methylsulfonic acid is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methylsulfonic acid in large quantities.
Methylsulfonic acid undergoes biodegradation by forming CO2 and sulphate.
Methylsulfonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous Methylsulfonic acid has been considered a model electrolyte for electrochemical processes.
Methylsulfonic acid is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl.
Methylsulfonic acid has a role as an Escherichia coli metabolite.
Methylsulfonic acid is an alkanesulfonic acid and a one-carbon compound.
Methylsulfonic acid is a conjugate acid of a methanesulfonate.
Methylsulfonic acid is a strong organic acid.
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of Methylsulfonic acid in large quantities.
Methylsulfonic acid undergoes biodegradation by forming CO2 and sulphate.
Methylsulfonic acid is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
Methane Sulphonic Acid is a clear liquid that can be colourless, pale yellow or pale brown.
Methylsulfonic acid has low endotoxin making it suitable for parenteral applications.
Methylsulfonic acid has many uses in the pharmaceutical industry including as a buffering agent, pH modifier and stabilising agent.
Methylsulfonic acid Chemical Properties
Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
Vapor density: 3.3 (vs air)
Vapor pressure: 1 mm Hg ( 20 °C)
Refractive index: n20/D 1.429(lit.)
Fp: >230 °F
Storage temp.:2-8°C
Solubility water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
Form: Solution
Color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024
Stability: Stable. Moisture sensitive. Incompatible with amines, bases, water, common metals.
Releases a substantial amount of heat when diluted with water (add acid to water with care if diluting).
InChIKey: AFVFQIVMOAPDHO-UHFFFAOYSA-N
CAS DataBase Reference: 75-75-2(CAS DataBase Reference)
NIST Chemistry Reference: CH3SO3H(75-75-2)
EPA Substance Registry System: Methylsulfonic acid (75-75-2)
Methylsulfonic acid, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures.
Methylsulfonic acid has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa), the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃).
Methylsulfonic acid is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene.
Methylsulfonic acid will not subject to decomposition in boiling water and hot alkaline solution.
Methylsulfonic acid also has strong corrosion effect against the metal iron, copper and lead.
Methylsulfonic acid is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.
Methylsulfonic acid is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations.
Beyond that, Methylsulfonic acid is used as a starting material for the preparation of methanesulfonyl chloride.
Uses
Methylsulfonic acid is a raw material for medicine and pesticide.
Methylsulfonic acid can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
Methylsulfonic acid can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry.
Methylsulfonic acid can also be applied to oxidation.
Methylsulfonic acid is a strong organic acid used in numerous applications ranging from chemical and biofuel synthesis to industrial cleaning and metal surface treatment in the electronics industry.
Methylsulfonic acidis used as an acid catalyst in organic reactions because it is a non-volatile, strong acid that is soluble in organic solvents.
Methylsulfonic acid is convenient for industrial applications because it is liquid at ambient temperature, while the closely related p-toluenesulfonic acid (PTSA) is solid.
However, in a laboratory setting, solid PTSA is more convenient.
Methylsulfonic acid can be used in the generation of borane (BH3) by reacting methanesulfonic acid with NaBH4 in an aprotic solvent such as THF or DMS, the complex of BH3 and the solvent is formed.
Production Method
Methylsulfonic acid, the simplest alkanesulfonic acid, is a hygroscopic colorless liquid or white solid, depending on whether the ambient temperature is greater or less than 20 ºC.
Methylsulfonic acid is very soluble in water and oxygenated solvents, but sparingly soluble in most hydrocarbons.
In aqueous solution, Methylsulfonic acid is a strong acid (completely ionized).
Methylsulfonic acid’s acidity and solubility properties make it industrially valuable as a catalyst in organic reactions, particularly polymerization.
In many applications, Methylsulfonic acid's advantage over concentrated sulfuric acid is that it has similar acid strength but is not an oxidant.
The first report of Methylsulfonic acid synthesis was in a 1950 patent awarded to John C. Snyder and Aristid V. Grosse of Houdry Process Corp. (subsequently acquired by Air Products).
They heated methane and sulfur trioxide to 200–325 ºC under pressure in the presence of a mercury catalyst.
BASF currently produces the acid via a two-step process in which methanol and elemental sulfur react to give dimethyl disulfide, which is then oxidized to the final product.
Synonyms
METHANESULFONIC ACID
75-75-2
Methylsulfonic acid
Methanesulphonic acid
Mesylate
Mesylic acid
Kyselina methansulfonova
Sulfomethane
Methansulfonsaeure
NSC 3718
CH3SO3H
MFCD00007518
CHEBI:27376
22515-76-0
MSA
NSC-3718
12EH9M7279
ammoniummethanesulfonate
CCRIS 2783
Kyselina methansulfonova [Czech]
HSDB 5004
EINECS 200-898-6
BRN 1446024
METHANE SULFONIC ACID
AI3-28532
UNII-12EH9M7279
metanesulfonic acid
methansulfonic acid
MsOH
methansulphonic acid
methylsulphonic acid
03S
methyl sulfonic acid
methyl-sulfonic acid
methane-sulfonic acid
MeSO3H
methane sulphonic acid
methanesulphonic-acid-
LACTIC ACID(DL)
ammonium methanesulphonate
CH3SO2OH
H3CSO3H
DSSTox_CID_6422
WLN: WSQ1
EC 200-898-6
DSSTox_RID_78109
Methane Sulfonic Acid 99%
Methanesulfonic acid solution
DSSTox_GSID_26422
4-04-00-00010 (Beilstein Handbook Reference)
Methanesulfonic acid, 99.5%
Methanesulfonic acid, anhydrous
CHEMBL3039600
DL-MALICACIDMONOSODIUMSALT
DTXSID4026422
METHANESULFONIC ACID [II]
METHANESULFONIC ACID [MI]
Methanesulfonic acid, HPLC grade
NSC3718
Methanesulfonic acid, >=99.0%
METHANESULFONIC ACID [HSDB]
Tox21_201073
STL264182
Methane Sulfonic Acid, 70% Solution
AKOS009146947
AT25153
J1.465F
CAS-75-75-2
NCGC00248914-01
NCGC00258626-01
BP-12823
DB-075013
FT-0628287
M0093
M2059
Methanesulfonic acid, >=99.0%, ReagentPlus(R)
Methanesulfonic acid, for HPLC, >=99.5% (T)
A934985
Methanesulfonic acid solution, 70 wt. % in H2O
Q414168
J-521696
Methanesulfonic acid, Vetec(TM) reagent grade, 98%
F1908-0093
Z940713430
Methanesulfonic acid solution, 4 M (with 0.2% (w/v) tryptamine)
Methanesulfonic acid concentrate, 0.1 M CH3SO3H in water (0.1N), eluent concentrate for IC
Methanesulfonic acid, PharmaGrade, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production
