MILK THISTLE SEED EXTRACT

Milk Thistle Seed extract is also used for viral hepatitis, acute and chronic hepatitis, cirrhosis, fatty liver, nutritional and metabolic disease, and cardiovascular disease.
Milk Thistle Seed extract is derived from the seeds of the Silybum marianum plant, commonly known as milk thistle. 
Milk Thistle Seed extract has been used for centuries as a herbal remedy, primarily for liver and gallbladder disorders.

CAS Number: 84604-20-6
Molecular Formula: C25H22O10
Molecular Weight: 482.43618
EINECS Number: 283-298-7

Synonyms:SILYMARIN, Silybin, 65666-07-1, Legalon, 84604-20-6, Silliver, Silybine, Flavobin Spofa, (2R,3R)-3,5,7-trihydroxy-2-[(2R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-2,3-dihydro-1,4-benzodioxin-6-yl]-2,3-dihydrochromen-4-oneSilybum marianum (L.)Gaerth;POWDERED MILK THISTLE EXTRACT (250 MG);silybummarianum(linn.)gaertn.,extract;silybummarianumextract,lady’sthistleextract;Silybum marianum, ext.;Milk Thistle Extract;Einecs 283-298-7;Extract of lady'S thistle

Milk Thistle Seed extract is prepared from the milk thistle. 
This plant belongs to the sunflower family and has been revered for thousands of years as an effective healing herb.
Milk Thistle Seed extract is popular in Europe and the United States as it is used for various liver diseases.

The active component of Milk Thistle Seed extract is a group of compounds collectively known as silymarin, which is believed to have powerful antioxidant, anti-inflammatory, and liver-protective properties. 
All kinds of reactive oxygen species can form 8 oxidation guanine a current base guanine; DNA damage, resulting in tumor, application of antioxidants, especially radical scavenging agent can prevent the occurrence of this process.
Milk Thistle Seed extract is lıkely safe for most people when taken by mouth. 

In some people, taking Milk Thistle Seed extract can cause diarrhea, nausea, intestinal gas, fullness, loss of appetite, and possibly headache. When applied to the skin: Milk thistle extract is POSSIBLY SAFE when applied directly to the skin for short periods of time.
While controlled studies demonstrating efficacy and a standardized form and concentration of silymarin are lacking, it is being used to treat a variety of liver diseases in humans and domestic companion animals (birds, dogs, cats, horses, rabbits). 
It is mostly of interest in treating chronic and acute liver disease, cirrhosis, and as a hepatoprotective agent when hepatotoxic agents are ingested (e.g., Aminita phalloide; “Death Cap Mushrooms”).

Milk Thistle Seed extract is a plant that is native to Europe and was brought to North America by early colonists. 
Milk Thistle Seed extract is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. 
The above ground parts and seeds are used to make medicine.

Milk Thistle Seed extract is taken by mouth most often for liver disorders, including liver damage caused by chemicals, alcohol, and chemotherapy, as well as liver damage caused by Amanita mushroom poisoning, nonalcoholic fatty liver disease, chronic inflammatory liver disease, cirrhosis of the liver, and chronic hepatitis. 
Some people apply milk thistle directly to the skin for skin damage caused by radiation.
Milk Thistle Seed extract has been used for 2,000 years as an herbal remedy for a variety of ailments, particularly liver, kidney, and gall bladder problems.

Several scientific studies suggest that substances in Milk Thistle Seed extract protect the liver from toxins, including certain drugs, such as acetaminophen (Tylenol), which can cause liver damage in high doses. 
Milk Thistle Seed extract has antioxidant and anti-inflammatory properties and may help the liver repair itself by growing new cells.
Milk Thistle Seed extract is a species of thistle. 

Milk Thistle Seed extract has various common names including milk thistle, blessed milk thistle, Marian thistle, Mary thistle, Saint Mary's thistle, Mediterranean milk thistle, variegated thistle, and Scotch thistle (though not to be confused with Onopordum acanthium or Cirsium vulgare). 
This species is an annual or biennial plant of the family Asteraceae.
This fairly typical thistle has red to purple flowers and shiny pale green leaves with white veins. 

Originally a native of Southern Europe through to Asia, it is now found throughout the world. 
Milk Thistle Seed extract is an upright herb that can grow to be 30 to 200 cm (12 to 79 in) tall and has an overall conical shape.
The approximate maximum base diameter is 160 cm (63 in). 

The leaves are oblong to lanceolate and 15–60 cm long and typically pinnately lobed, with spiny edges like most thistles. 
They are hairless, shiny green, with milk-white veins. 
The flower heads are 4 to 12 cm long and wide, of red-purple colour.

They flower from June to August in the North or December to February in the Southern Hemisphere (summer through autumn). 
The flower head is surrounded by bracts which are hairless, with triangular, spine-edged appendages, tipped with a stout yellow spine. 
The fruits are black achenes with a simple long white pappus, surrounded by a yellow basal ring.

A long pappus acts as a "parachute," supporting seed dispersal by wind. 
The primary active compound consists of flavonolignans like silybin, silydianin, and silychristin. 
Milk Thistle Seed extract is responsible for the extract’s medicinal properties.

Milk Thistle Seed extract acts as an antioxidant, helping to neutralize free radicals that can damage liver cells and other tissues. 
Milk Thistle Seed extract i uses and Health Benefits of Milk Thistle Seed Extract
Liver Health The most well-known use of Milk Thistle Seed extract is for its protective and regenerative effects on the liver. 

Milk Thistle Seed extract is often used to support liver detoxification by protecting liver cells from toxins, including alcohol, pollutants, and medications like acetaminophen. 
Milk Thistle Seed extract is used to treat conditions like fatty liver disease, cirrhosis, hepatitis, and liver damage caused by alcohol abuse. 
It helps in regenerating damaged liver tissue and improving liver function.

Milk Thistle Seed extract boosts the liver's antioxidant defenses by increasing glutathione levels, a potent antioxidant produced by the liver that plays a crucial role in detoxification.
Support for Gallbladder Health Milk Thistle Seed extract is also believed to support gallbladder function by promoting the production and flow of bile, which helps in digesting fats and reducing the risk of gallstones.
Antioxidant Properties Milk Thistle Seed extract's strong antioxidant properties help in protecting cells from oxidative stress, which contributes to aging, chronic diseases, and inflammation. 

By reducing oxidative stress, Milk Thistle Seed extract may slow down the aging process at the cellular level. 
Milk Thistle Seed extracts antioxidant activity may help reduce the risk of chronic diseases such as cancer and heart disease.
Anti-inflammatory Effects Milk Thistle Seed extract has anti-inflammatory properties, making it useful for conditions related to chronic inflammation.

Density: 1.144
vapor pressure: 0.004Pa at 20℃

Milk Thistle Seed extract has been used for 2,000 years as an herbal remedy for a variety of ailments, particularly liver, kidney, and gall bladder problems. 
Several scientific studies suggest that substances in milk thistle (especially a flavonoid called silymarin) protect the liver from toxins, including certain drugs, such as acetaminophen (Tylenol), which can cause liver damage in high doses. 
Milk Thistle Seed extract has antioxidant and anti-inflammatory properties and may help the liver repair itself by growing new cells.

Milk Thistle Seed extract is widely used in the treatment of viral hepatitis (particularly hepatitis C); however, studies show mixed results. 
Some studies found improvements in liver function, while others did not. 
In one study of 16 patients who didn't respond to interferon and ribavirin therapy, Milk Thistle Seed extract significantly reduced the viral load of hepatitis C. 

In 7 of the subjects, the virus decreased to undetectable levels after 14 days of therapy.
Milk Thistle Seed extract is an herbal remedy derived from the milk thistle plant, also known as Silybum marianum. 
This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Mary’s milk falling onto its leaves. 

The active ingredients in milk thistle are a group of plant compounds collectively known as silymarin.
Milk Thistle Seed extracts herbal remedy is known as milk thistle extract. 
Milk Thistle Seed extract has a high amount of silymarin that has been concentrated from the milk thistle plant. 

People are always looking for the “it” thing that promises to do wonders for their health.
Milk Thistle Seed extract is native to the Mediterranean and much of Europe to Central Asia and India; in Africa, it reaches as far south as Ethiopia. 
Milk Thistle Seed extract is possibly native near the coast of southeast England. S. marianum has been widely introduced outside its natural range, for example into North America, Hawaii, Australia, New Zealand, and Colombia where it is considered an invasive weed. 

Milk Thistle Seed extract also spreads invasively in almost all of Europe as a consequence of field cultivation.
Milk Thistle Seed extract establishes itself in sunny, warm ruderal meadows in regularly disturbed places such as rubble deposits, at the foot of south-exposed walls or villages, and on urban fallow land or cattle pastures. However, it does not prefer dry, stony soils. 
Milk Thistle Seed extract has been potentially observed to modify fire regimes in its invasive range.

Its invasion into new habitats may also be encouraged by fire.
Milk Thistle Seed extract is an adaptive crop with low requirements. 
Milk Thistle Seed extract is mainly cultivated as a medicinal plant but is also sometimes used as a food source. 

Milk Thistle Seed extract is mainly cultivated in Europe but also in Asia and North America. Milk thistle is a biennial plant; it is normally grown as an annual plant, which simplifies cultivation. 
When the main requirements of the plant are met, then the milk thistle will blossom in the first year.
Milk Thistle Seed extract is made from the seeds, which contain approximately 4–6% silymarin. 

Milk Thistle Seed extract consists of about 65–80% silymarin (a flavonolignan complex) and 20–35% fatty acids, including linoleic acid. 
Milk Thistle Seed extract is a complex mixture of polyphenolic molecules, including seven closely related flavonolignans (silybin A, silybin B, isosilybin A, isosilybin B, silychristin, isosilychristin, silydianin) and one flavonoid (taxifolin). 
Milk Thistle Seed extract, a semipurified fraction of silymarin, is primarily a mixture of 2 diastereoisomers, silybin A and silybin B, in a roughly 1:1 ratio.

Inflammatory liver conditions like non-alcoholic fatty liver disease (NAFLD) are among the conditions potentially treated by milk thistle. 
The antioxidant and anti-inflammatory properties of milk thistle seed extract make it beneficial for skin health. Protection against UV damage: Milk thistle can help protect the skin from damage caused by ultraviolet (UV) rays and environmental pollutants.

Milk Thistle Seed extracts anti-inflammatory properties can help reduce inflammation and oxidative stress, both of which are involved in skin conditions like acne and psoriasis. 
Support for Diabetes Management: Some research suggests that milk thistle may help manage type 2 diabetes by improving insulin sensitivity and reducing blood sugar levels. 
Milk Thistle Seed extract may also protect against diabetic complications due to its antioxidant effects.

Milk Thistle Seed extract may have benefits for cardiovascular health. 
Some studies suggest that it can lower LDL ("bad") cholesterol levels, which helps reduce the risk of atherosclerosis (plaque build-up in arteries) and heart disease.
Milk Thistle Seed extract is generally considered safe, there are some potential side effects and risks. 

Mild side effects like nausea, diarrhea, bloating, or gas can occur, especially if taken in high doses. 
Allergic Reactions: People allergic to plants in the Asteraceae family (e.g., ragweed, daisies, marigolds) may experience allergic reactions to milk thistle.

Milk Thistle Seed extract may interact with certain medications, including blood thinners (e.g., warfarin), cholesterol-lowering drugs (e.g., statins), and immunosuppressants.
Because Milk Thistle Seed extract has mild estrogen-like effects, it should be used with caution in individuals with hormone-sensitive conditions.

Uses Of Milk Thistle Seed extract: 
Milk Thistle Seed extract is best known for its ability to support liver function. 
Milk Thistle Seed extract is used to treat and prevent liver damage caused by alcohol abuse, chronic liver diseases (such as cirrhosis and hepatitis), non-alcoholic fatty liver disease (NAFLD), and drug-induced liver damage (e.g., acetaminophen or chemotherapy drugs).
Milk Thistle Seed extract helps in liver detoxification by promoting the regeneration of liver cells and enhancing the liver’s ability to process and remove toxins from the body.

Research shows that Milk Thistle Seed extract can improve liver function and reduce symptoms in individuals with cirrhosis, a condition where the liver becomes severely scarred. 
Milk Thistle Seed extract is also used to treat both acute and chronic hepatitis, as silymarin (the active compound) has antiviral and anti-inflammatory effects.
Milk Thistle Seed extract can reduce liver inflammation and fat accumulation in individuals with fatty liver disease, particularly non-alcoholic fatty liver disease (NAFLD).

The silymarin in milk thistle acts as a powerful antioxidant, which helps protect the body’s cells from damage caused by free radicals. 
This can reduce the risk of chronic diseases, such as cancer and heart disease.
By reducing oxidative stress, Milk Thistle Seed extract may slow down the aging process at the cellular level, supporting overall health and longevity.

Milk Thistle Seed extract has potent anti-inflammatory properties, making it beneficial for conditions related to inflammation. 
Milk Thistle Seed extract can help reduce inflammation in the liver and other organs affected by chronic diseases such as fatty liver, arthritis, and inflammatory bowel disease. 
Due to its anti-inflammatory properties, Milk Thistle Seed extract is sometimes used to treat skin conditions such as acne, eczema, and psoriasis.

Milk Thistle Seed extract helps stimulate bile production, which is important for breaking down fats during digestion. 
This makes it useful in supporting gallbladder health and preventing gallstone formation.
Studies suggest that milk thistle may help lower blood sugar levels and improve insulin sensitivity in individuals with type 2 diabetes. 

This is primarily due to its ability to reduce inflammation and oxidative stress, which are key factors in diabetes management. 
The antioxidant properties of silymarin may also help protect against complications of diabetes, such as kidney damage (diabetic nephropathy) and cardiovascular issues.
Milk Thistle Seed extract may help lower LDL (bad) cholesterol levels and increase HDL (good) cholesterol, promoting cardiovascular health. 

By reducing inflammation and preventing the oxidation of cholesterol, Milk Thistle Seed extract can lower the risk of atherosclerosis (plaque build-up in the arteries), a major risk factor for heart attacks and strokes.
Milk Thistle Seed extract's antioxidant properties help protect the skin from damage caused by ultraviolet (UV) radiation, reducing the risk of sunburn, premature aging, and even skin cancer. 
The anti-inflammatory and antioxidant properties of Milk Thistle Seed extract may also promote faster healing of wounds and improve skin conditions like acne and eczema.

Some studies suggest that Milk Thistle Seed extract may help protect healthy cells from the damaging effects of chemotherapy and radiation therapy, reducing side effects without interfering with the effectiveness of the treatments. 
Milk Thistle Seed extract’s silymarin has been studied for its potential to inhibit the growth of cancer cells, particularly in breast, prostate, and colorectal cancers. 
More research is needed, but early studies show promise.

Milk Thistle Seed extract's antioxidant and anti-inflammatory properties may also extend to brain health. 
Some research suggests that it could help protect brain cells from oxidative stress, reducing the risk of neurodegenerative diseases like Alzheimer’s and Parkinson’s. 

Some evidence suggests that Milk Thistle Seed extracte may help improve cognitive function by reducing inflammation and oxidative damage in brain cells.
Milk Thistle Seed extract may help modulate the immune response, enhancing the body’s ability to fight off infections and reducing excessive immune activity that can lead to autoimmune conditions.

Safety Profile Of Milk Thistle Seed extract:
Milk Thistle Seed extract might enhance the effects of anticoagulants like warfarin, increasing the risk of bleeding. 
Milk Thistle Seed extract can affect the metabolism of statins, potentially altering their effectiveness. 
Milk Thistle Seed extract may interact with drugs that suppress the immune system, possibly affecting their efficacy. 

Since milk thistle can lower blood sugar, it might amplify the effects of diabetes medications, leading to hypoglycemia.
While rare, very high doses of milk thistle extract may lead to liver damage. 
Excessive consumption could potentially cause liver toxicity, although this is more likely to occur with extremely high doses or long-term use.

Milk Thistle Seed extract should be used with caution or avoided during pregnancy due to its potential to stimulate uterine contractions and influence hormonal balance. 
Safety during breastfeeding has not been well-studied, so it’s best to consult with a healthcare provider before using it.