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Momordica C. (bitter melon) extract, commonly known as bitter melon or bitter gourd, is a tropical and subtropical vine in the Cucurbitaceae family, widely cultivated for its edible fruit.
Momordica C. (bitter melon) extract of bitter melon is derived from various parts of the plant, including the fruit, seeds, leaves, and vines.
Momordica C. (bitter melon) extract is known for its medicinal properties and has been used in traditional medicine, particularly in Asia, Africa, and the Caribbean.
CAS Number: 91590-76-0
Molecular Formula: C30H48O4
Molecular Weight: 472.7
Synonyms:Momordicine I, Momordicin I, 91590-76-0, GLXC-13590, FS-7484, 1ST177535(+)-Momordicin I;(10α)-3β,7β,23-Trihydroxy-19-norlanosta-5,24-diene-9β-carbaldehyde;3β,7β,23-Trihydroxycucurbita-5,24-dien-19-al;Momordicin I;Momordicine I;Kuguaglycoside G aglycon;Momordicine II aglycone;19-Norlanosta-5,24-diene-9-carboxaldehyde, 3,7,23-trihydroxy-, (3β,7β,9β,10α,24R)-
Momordica C. (bitter melon) extract is a vine originally from India and other Asian countries.
It has been traditionally used to treat diabetes.
Momordica C. (bitter melon) extract contains a chemical that acts like insulin to help reduce blood sugar levels.
People commonly use Momordica C. (bitter melon) extract for diabetes, osteoarthritis, athletic performance, and many other conditions, but there is no good scientific evidence to support these uses.
Momordica C. (bitter melon) extract is sometimes called bitter gourd.
Momordica C. (bitter melon) extract a compound believed to help regulate blood sugar levels.
Momordica C. (bitter melon) extract a peptide that mimics insulin, potentially aiding in glucose management.
Momordica C. (bitter melon) extracts with anti-diabetic properties.
Known for their antioxidant activity.
Momordica C. (bitter melon) extract has been extensively studied for its hypoglycemic (blood sugar-lowering) properties, especially in managing type 2 diabetes.
The high content of flavonoids and phenolic compounds helps neutralize harmful free radicals.
May help reduce inflammation in the body.
Momordica C. (bitter melon) extract has shown potential in fighting infections caused by viruses and bacteria.
Momordica C. (bitter melon) extract is low in calories and rich in fiber, which may assist in weight management.
Often used in traditional and alternative medicine for its role in managing insulin sensitivity and blood glucose levels.
Known to support digestion and may be used as a remedy for various gastrointestinal issues.
Due to its high antioxidant content, Momordica C. (bitter melon) extract may strengthen the immune system.
These include momordicine, which gives the bitter melon its characteristic bitterness and contributes to its medicinal benefits.
Momordica C. (bitter melon) extract, a key compound known for its anti-diabetic effects.
Momordica C. (bitter melon) extracts are also linked to anti-inflammatory and cholesterol-lowering effects.
Momordica C. (bitter melon) extract has numerous glycosides, such as momordin, which help in various biological functions, including sugar metabolism.
Momordica C. (bitter melon) extract, contribute to the hypoglycemic activity of bitter melon and have shown potential for anti-cancer effects in laboratory studies.
Momordica C. (bitter melon) extracts are effective in reducing oxidative stress and inflammation in the body, which can lead to better heart health, cancer prevention, and overall cell health.
Momordica C. (bitter melon) extract have insulin-like properties, helping to lower blood glucose by acting directly on peripheral tissues.
Momordica C. (bitter melon) extract has been used in traditional medicine for centuries, and different parts of the plant are used for various ailments:
Boiling point: 592.4±50.0 °C(Predicted)
Density: 1.11±0.1 g/cm3(Predicted)
solubility: Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form: Powder
pka: 13.73±0.70(Predicted)
Momordica C. (bitter melon) extract, clinical efficacy, adverse effects, drug interactions, and place in therapy of bitter melon are described.
Momordica C. (bitter melon) extract is an alternative therapy that has primarily been used for lowering blood glucose levels in patients with diabetes mellitus.
Momordica C. (bitter melon) extract is known as "Karela" and is used to treat diabetes, digestive issues, and as a tonic for the liver.
Momordica C. (bitter melon) extract is believed to “clear heat,” “cool the blood,” and treat dysentery, acne, and other inflammatory conditions.
Used as a remedy for intestinal worms, wounds, skin infections, and fevers.
Several studies have examined bitter melon extract's role in lowering blood glucose levels.
Momordica C. (bitter melon) extract, such as charantin and polypeptide-p, mimic insulin or enhance the action of insulin, improving glucose uptake by cells and reducing insulin resistance.
Some clinical trials suggest that bitter melon can reduce fasting blood glucose levels in individuals with type 2 diabetes.
A study published in the Journal of Ethnopharmacology showed that participants who consumed bitter melon juice experienced a moderate reduction in blood glucose levels compared to the placebo group.
Momordica C. (bitter melon) extract has demonstrated potential in inhibiting the growth of certain cancer cells.
Studies on pancreatic, breast, and colon cancer cells have shown that bitter melon extract can induce apoptosis (programmed cell death) and inhibit cancer cell proliferation.
This is believed to be due to its high content of bioactive triterpenoids and glycosides.
Momordica C. (bitter melon) extract may affect the regulation of several pathways involved in cancer development, including the AMP-activated protein kinase (AMPK) pathway, which plays a key role in cell metabolism and growth.
Momordica C. (bitter melon) extract’s ability to lower blood sugar may also contribute to improved fat metabolism, helping with weight management.
Momordica C. (bitter melon) extract contains fiber and has a low calorie count, which helps in promoting satiety and reducing caloric intake.
By helping regulate blood sugar and cholesterol levels, bitter melon can support cardiovascular health.
Its anti-inflammatory and antioxidant properties reduce the risk of plaque formation in arteries, lowering the chance of atherosclerosis and related heart diseases.
Momordica C. (bitter melon) extract has demonstrated efficacy against bacterial and viral infections.
It contains antibacterial compounds that may be effective against Staphylococcus aureus and Escherichia coli, and antiviral compounds that have shown activity against HIV and herpes viruses in vitro.
Momordica C. (bitter melon) extract is commonly available in capsules, tablets, and liquid forms, standardized to contain specific amounts of active ingredients like charantin or polypeptide-p.
The fresh juice of Momordica C. (bitter melon) extract is consumed in various cultures as a health tonic, particularly for diabetes management and digestive health.
Momordica C. (bitter melon) extract is sometimes used in creams and ointments to treat skin conditions like eczema, psoriasis, and minor wounds due to its anti-inflammatory properties.
Dried bitter melon fruit or leaves are used to make herbal teas, which are believed to aid in digestion and detoxification.
Momordica C. (bitter melon) extract has many potential health benefits, there are some possible side effects and interactions to consider:
Since Momordica C. (bitter melon) extract can lower blood sugar, people taking medications for diabetes should be cautious of hypoglycemia (dangerously low blood sugar levels).
Some people experience stomach pain, diarrhea, or nausea after consuming bitter melon extract, especially in large amounts.
Momordica C. (bitter melon) extract is not recommended for pregnant women, as some animal studies suggest it may stimulate uterine contractions, potentially leading to miscarriage.
Uses Of Momordica C. (bitter melon) extract:
Momordica C. (bitter melon) extract is popular for managing type 2 diabetes.
Its compounds like charantin and polypeptide-p help lower blood glucose levels by mimicking insulin or enhancing its action.
Momordica C. (bitter melon) extract is a growing concern, bitter melon is often incorporated into diets or supplements to help regulate blood sugar naturally.
Momordica C. (bitter melon) extract aids in digestion and is used to treat various gastrointestinal issues such as constipation, indigestion, and bloating.
In traditional medicine, it’s believed to cleanse the stomach and intestines.
Its low-calorie content and high fiber help promote weight loss by reducing appetite and improving fat metabolism.
This makes Momordica C. (bitter melon) extract useful in diets aimed at reducing obesity, a growing health issue in many regions, including Türkiye.
Thanks to its antioxidant and anti-inflammatory properties, bitter melon extract supports the immune system.
Momordica C. (bitter melon) extract is sometimes used to combat colds, flu, and infections.
Research suggests that bitter melon extract may inhibit the growth of cancer cells, particularly in breast, colon, and pancreatic cancers.
Its use as a natural remedy to complement cancer treatments is being explored worldwide.
Momordica C. (bitter melon) extract is used in creams and ointments to treat skin conditions such as eczema, acne, and psoriasis, as well as for healing wounds due to its antimicrobial properties.
Momordica C. (bitter melon) extract helps lower cholesterol levels and reduce blood pressure, contributing to better cardiovascular health.
As heart disease remains a leading cause of death globally, natural remedies like bitter melon are gaining attention for preventive care.
Momordica C. (bitter melon) extract is traditionally used to reduce inflammation, which can help with conditions like arthritis or other inflammatory diseases.
In summary, Momordica C. (bitter melon) extract offers multiple health benefits, ranging from managing blood sugar to improving digestion and supporting skin health.
However, consulting with a healthcare provider is essential before using it, especially for those on medication.
Momordica C. (bitter melon) extract helps improve insulin sensitivity and reduces insulin resistance, a major cause of type 2 diabetes.
Studies show that consuming bitter melon extract can significantly lower fasting blood sugar levels.
This makes it a popular supplement among those seeking natural ways to control diabetes without pharmaceuticals.
Momordica C. (bitter melon) extract enhances the uptake of glucose into cells, which helps maintain lower blood sugar levels after meals.
Safety Profile Of Momordica C. (bitter melon) extract:
One of the primary concerns with bitter melon extract, especially for individuals taking diabetes medications such as insulin or other hypoglycemic agents, is the risk of hypoglycemia (excessively low blood sugar)
Some people may experience digestive discomfort when using Momordica C. (bitter melon) extract, particularly at high doses.
Excessive consumption of bitter melon extract may pose a risk of liver toxicity.
Some animal studies have suggested that high doses can affect liver function, leading to elevated liver enzymes and potential damage to liver cells.
Though these effects are rare in humans, Momordica C. (bitter melon) extract’s important to use the extract cautiously and avoid excessive intake.
