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Monoethylamine HCl is a chemical used in various chemical organic synthesis and biological research.
Monoethylamine HCl is utilized in various industrial and laboratory processes.
Monoethylamine HCl is used as a raw material for organic synthesis.
CAS Number: 557-66-4
EC Number: 209-795-0
MDL Number: MFCD00012885
IUPAC Name: Ethanamine hydrochloride
Molecular Formula: C2H7N.ClH / C2H8ClN
Molecular Weight: 81.55 g/mol
SYNONYMS:
Ethylamine hydrochloride, Ethylamine HCl, Ethanamine hydrochloride, Ethylamine monohydrochloride, Ethylamine hydrochloride, 557-66-4, Ethylammonium chloride, Ethanamine, hydrochloride, ETHYLAMINE HCl, Monoethylammonium chloride, 70CJ09IE3A, Ethanamine, hydrochloride (1:1), DTXSID8060323, DTXCID4041943, 209-182-8, Ethanamine hydrochloride, ethanamine;hydrochloride, ethyl amine hydrochloride, MFCD00012885, ETHYLAMINE, HYDROCHLORIDE, Ethylamine,hydrochloride, Ethylaminehydrochloride, Ethylamine Hydrochloride-d3, EINECS 209-182-8, UNII-70CJ09IE3A, ethanamine HCl, ethanamine-HCl, Ethylammonium Chloride, Monoethylammonium Chloride, N-Ethylammonium Chloride, ethylamine HCl salt, ethyl amine HCl salt, ethylamine hydochloride, ethylamine hydrochlorid, ethylamine hydrochoride, EtNH2-HCl, EtNH2.HCl, NH2Et.HCl, ethyl ammonium chloride, Aminoethane hydrochloride, N-ethylamine hydrochloride, ethanamine hydrochloric acid, hydrogen chloride ethanamine, ethan-1-amine hydrochloride, ethylamine hydrochloride salt, SCHEMBL126107, Ethylamine hydrochloride, 98%, N-ETHYLAMMONIUM CHLORIDE, SCHEMBL3656174, PCA58512, ETHYLAMINE HYDROCHLORIDE [MI], AKOS005259815, FE36995, DB-050362, E0205, Q27265860, F2191-0276, N-Ethylammonium chloride, Ethylammonium chloride, Monoethylammonium chloride, ETHYLAMINE HCL, MONOETHYLAMINE HCL, ETHYLAMMONIUM CHLORIDE, ETHYLAMINE HYDROCHLORIDE, Ethylamine,hydrochloride, ETHANAMINE HYDROCHLORIDE, Ethylamine Hydrochloride, monoethylammoniumchloride, AMINOETHANE HYDROCHLORIDE, Ethanamine, hydrochloride, Monoethylamine Hydrochloride, MONOETHYLAMINE HYDROCHLORIDE, monoethylammoniumchloride, ETHYLAMINE HCL, ETHYLAMINE HYDROCHLORIDE, ETHYLAMMONIUM CHLORIDE, ETHANAMINE HYDROCHLORIDE, MONOETHYLAMINE HCL, AMINOETHANE HYDROCHLORIDE, MONOETHYLAMINE HYDROCHLORIDE, ETHYLAMINE HCL, ETHYLAMMONIUM CHLORIDE, EACl, ETHANAMINE HYDROCHLORIDE, MONOETHYLAMINE HYDROCHLORIDE, MonethylamineHCl, MONOETHYLAMINE HCL, CH3CH2NH3Cl (EACl), Ethylammoniumchlorid, ETHYLAMINE HYDROCHLORIDE
Monoethylamine HCl is a white to off-white crystals.
Monoethylamine HCl is a chemical used in various chemical organic synthesis and biological research.
USES and APPLICATIONS of MONOETHYLAMINE HCL:
Monoethylamine HCl is used for organic synthesis.
Monoethylamine HCl is used as a raw material for organic synthesis.
Monoethylamine HCl's free base ethylamine is used in the diethyldiazene, dimethylolethyltriazone, ethylcyanopyrolidone disperse and 1,3-diethylthiourea.
Monoethylamine HCl is a precursor used for the preparation of benzilnitrate, detergents, rayon, rocket propellant and alkyl isocyanates, which finds application in the manufacture of pharmaceuticals.
Monoethylamine HCl is a chemical used in various chemical organic synthesis and biological research.
Monoethylamine HCl is utilized in various industrial and laboratory processes.
Organic Synthesis: Monoethylamine HCl is used as a reagent in the synthesis of pharmaceuticals and agrochemicals.
Chemical Intermediate: Monoethylamine HCl serves as a precursor in the production of ethylamine and other derivatives.
Analytical Chemistry: Monoethylamine HCl is employed in the preparation of standard solutions and calibration curves.
Laboratory Reactions: Monoethylamine HCl is utilized in reactions requiring a mild base.
Monoethylamine HCl is a chemical used in various chemical organic syntheses and biological studies.
Monoethylamine HCl is used in production of resins and rubber latex; also used in oil refining and organic syntheses.
Monoethylamine HCl is used as a raw material for organic synthesis.
Monoethylamine HCl's free base ethylamine is used in the diethyldiazene, dimethylolethyltriazone, ethylcyanopyrolidone disperse and 1,3-diethylthiourea.
Monoethylamine HCl is a precursor used for the preparation of benzilnitrate, detergents, rayon, rocket propellant and alkyl isocyanates, which finds application in the manufacture of pharmaceuticals.
CONTEXTUAL SIGNIFICANCE IN CHEMICAL AND PHARMACEUTICAL SCIENCES OF MONOETHYLAMINE HCL:
Monoethylamine HCl is a versatile intermediate in organic synthesis.
Monoethylamine HCl is frequently used as a starting material or a building block in the production of more complex molecules.
In the pharmaceutical industry, Monoethylamine HCl serves as a precursor in the synthesis of various active pharmaceutical ingredients (APIs).
For instance, Monoethylamine HCl is employed in the manufacture of certain anesthetic medications.
Monoethylamine HCl's utility extends to material science, where it has been used in the development of organic-inorganic hybrid materials, such as precursors for perovskite solar cells.
In broader chemical applications, Monoethylamine HCl's free base, ethylamine, is used in the creation of dyestuffs, resins, and as a stabilizer for rubber latex.
Monoethylamine HCl provides a convenient, solid, and water-soluble source for the ethylamine moiety for these synthetic processes.
✅ BENEFITS AND CHARACTERISTICS OF MONOETHYLAMINE HCL:
*Purity:
High purity grades available for sensitive applications.
*Reactivity:
Moderate reactivity suitable for controlled reactions.
*Solubility:
Excellent solubility in polar solvents.
*Storage:
Stable under dry, cool conditions.
CHEMICAL PROPERTIES OF MONOETHYLAMINE HCL:
*Basicity:
Monoethylamine HCl acts as a weak base.
*Reactivity:
Monoethylamine HCl can form salts with acids; undergoes nucleophilic substitution reactions.
*Stability:
Monoethylamine HCl is stable under standard conditions; sensitive to moisture.
PURIFICATION METHODS OF MONOETHYLAMINE HCL:
Crystallise the hydrochloride from absolute EtOH or MeOH/CHCl3, wash with dry ether and dry it in a vacuum.
Monoethylamine HCl is the salt of ethylamine and hydrochloric acid.
Monoethylamine HCl is a basic compound with a high affinity for water.
Monoethylamine HCl has been shown to have anti-inflammatory properties, which may be due to its ability to inhibit prostaglandin synthesis.
Monoethylamine HCl also has an important role in the formation of polymers such as cellulose and can be used to prepare other chemicals such as ethyl alcohol.
HISTORICAL PERSPECTIVES IN CHEMICAL SYNTHESIS AND RESEARCH OF MONOETHYLAMINE HCL:
The parent compound, ethylamine, has historical preparation methods dating back to the mid-20th century, including synthesis from ethyl iodide and liquid ammonia (B1221849) (1947) and from ethanol (B145695) and ammonia (1952).
Monoethylamine HCl is a common and stable derivative of ethylamine.
Historically, the hydrochloride salt has been a staple in organic synthesis laboratories.
A common purification method for the compound involves crystallization from absolute ethanol or a methanol (B129727)/chloroform mixture, followed by washing with dry ether and vacuum drying.
The synthesis of Monoethylamine HCl is straightforward and can be achieved by treating ethylamine with hydrochloric acid.
Monoethylamine HCl's consistent use as a fundamental reagent underscores its long-standing importance in chemical research and development.
ADVANCED SYNTHETIC METHODOLOGIES FOR MONOETHYLAMINE HCL AND DERIVATIVES:
Established Synthetic Routes and Their Evolution
The synthesis of Monoethylamine HCl and its derivatives has evolved, with various methods being established for their preparation.
These routes range from direct acid-base reactions to more complex multi-step syntheses for substituted analogs.
REACTION OF ETHYLAMINE WITH HYDROCHLORIC ACID
The most direct method for preparing Monoethylamine HCl is the acid-base reaction between ethylamine and hydrochloric acid.
In this reaction, ethylamine, a base, accepts a proton from hydrochloric acid.
The lone pair of electrons on the nitrogen atom of ethylamine attacks a proton (H⁺) from hydrochloric acid, forming the ethylammonium (B1618946) cation (C₂H₅NH₃⁺) and the chloride anion (Cl⁻).
These ions then combine to form the salt, this compound (C₂H₅NH₃Cl).
This straightforward and efficient reaction is widely used for the synthesis of this fundamental compound.
MULTI-STEP SYNTHESES OF SUBSTITUTED MONOETHYLAMINE HCL:
The synthesis of substituted Monoethylamine HCl often requires multi-step reaction sequences to introduce various functional groups onto the ethylamine backbone or an aromatic ring.
IUPAC NAME AND SYNONYMS OF MONOETHYLAMINE HCL:
The internationally recognized IUPAC name for Monoethylamine HCl is ethanamine;hydrochloride.
In scientific literature and commercial catalogs, it is also known by several synonyms.
COMMON SYNONYMS OF MONOETHYLAMINE HCL:
Ethylammonium (B1618946) chloride.
Ethanamine, hydrochloride.
Aminoethane hydrochloride.
Monoethylammonium chloride.
ETHYLAMINE HCl.
PHYSICAL and CHEMICAL PROPERTIES of MONOETHYLAMINE HCL:
Chemical Name: Ethylamine Hydrochloride
Molecular Formula: C₂H₇ClN
Molecular Weight: 81.55 g/mol
CAS Number: 557-66-4
EC Number: 209-795-0
IUPAC Name: Ethanamine hydrochloride
SMILES Notation: Cl.CC[NH₂]
InChI Key: QXJYQJZVQXKZQK-UHFFFAOYSA-N
PubChem CID: 11198
UN Number: UN 1152
Appearance: White to off-white crystalline solid
Odour: Slight amine-like odour
Melting Point: ~150°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water and ethanol
Density: ~1.2 g/cm³
pH: Approximately 5–6 in aqueous solution
Hygroscopic: Yes
Reactivity: Stable under normal conditions; reacts with acids to form salts
Molecular Weight: 81.54 g/mol
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 0
Exact Mass: 81.0345270 Da
Monoisotopic Mass: 81.0345270 Da
Topological Polar Surface Area: 26 Ų
Heavy Atom Count: 4
Formal Charge: 0
Complexity: 2.8
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 2
Compound Canonicalized: Yes
Molecular Formula / Molecular Weight: C2H7N·HCl = 81.54
Physical State (20 deg.C): Solid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15°C)
Store Under Inert Gas: Store under inert gas
Condition to Avoid: Air Sensitive,Hygroscopic
CAS RN: 557-66-4
Reaxys Registry Number: 3589312
PubChem Substance ID: 87569493
MDL Number: MFCD00012885
CBNumber: CB5133635
Molecular Formula: C2H8ClN
Molecular Weight: 81.54
MDL Number: MFCD00012885
MOL File: 557-66-4.mol
Melting Point: 107-108 °C(lit.)
Boiling Point: 95.79°C (rough estimate)
Density: 1,22 g/cm3
Refractive Index: 1.4202 (estimate)
Storage Temp.: Store below +30°C.
Solubility: soluble
Form: Solid
Color: White to Off-White
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 14,3762
BRN: 3589312
Stability: Hygroscopic
CAS DataBase Reference: 557-66-4(CAS DataBase Reference)
FDA UNII: 70CJ09IE3A
EPA Substance Registry System: Ethylamine hydrochloride (557-66-4)
UNSPSC Code: 12352107
NACRES: NA.22
Linear Formula: C2H5NH2 · HCl
CAS Number: 557-66-4
Molecular Weight: 81.54
Beilstein: 3589312
EC Number: 209-182-8
MDL Number: MFCD00012885
UNSPSC Code: 12352107
PubChem Substance ID: 24853934
Physical State: Crystalline
Color: Beige
Odor: No data available
Melting Point/Freezing Point: Melting point/range: 107 - 108 °C - lit.
Initial Boiling Point and Boiling Range: No data available
Flammability (Solid, Gas): No data available
Upper/Lower Flammability or Explosive Limits: No data available
Flash Point: No data available
Autoignition Temperature: No data available
Decomposition Temperature: No data available
pH: No data available
Viscosity, Kinematic: No data available
Viscosity, Dynamic: No data available
Water Solubility: No data available
Partition Coefficient n-octanol/water: No data available
Vapor Pressure: No data available
Density: No data available
Relative Density: No data available
Relative Vapour Density: No data available
Particle Characteristics: No data available
Explosive Properties: No data available
Oxidizing Properties: No data available
Other Safety Information: No data available
CAS No: 557-66-4
Product Code: FE36995
MDL No: MFCD00012885
Chemical Formula: C2H7N·HCl
Molecular Weight: 81.54 g/mol
SMILES: CCN.Cl
CAS: 557-66-4
EINECS: 209-182-8
InChI: InChI=1/C2H7N.ClH/c1-2-3;/h2-3H2,1H3;1H
Molecular Formula: C2H8ClN
Molar Mass: 81.54
Density: 1,22 g/cm3
Melting Point: 107-108°C(lit.)
Boiling Point: 95.79°C (rough estimate)
Water Solubility: soluble
Solubility: soluble
Vapor Pressure: 1130mmHg at 25°C
Appearance: Solid
Color: White to Off-White Sticky to
Merck: 14,3762
BRN: 3589312
Storage Condition: Store below +30°C.
Sensitive: Hygroscopic
Refractive Index: 1.4202 (estimate)
Physical and Chemical Properties: Melting point 105-108°C
Water-Soluble: soluble
Use: For Organic synthesis
CAS: 557-66-4
MF: C2H8ClN
MW: 81.54
EINECS: 209-182-8
Mol File: 557-66-4.mol
Ethylamine hydrochloride Chemical Properties
Melting Point: 107-108 °C(lit.)
Boiling Point: 95.79°C (rough estimate)
Density: 1,22 g/cm3
Refractive Index: 1.4202 (estimate)
Storage Temp.: Store below +30°C.
Solubility: soluble
Water Solubility: soluble
Sensitive: Hygroscopic
Merck: 143,762
BRN: 3589312
CAS DataBase Reference: 557-66-4
FIRST AID MEASURES of MONOETHYLAMINE HCL:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available
ACCIDENTAL RELEASE MEASURES of MONOETHYLAMINE HCL:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of MONOETHYLAMINE HCL:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of MONOETHYLAMINE HCL:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of MONOETHYLAMINE HCL:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.
STABILITY and REACTIVITY of MONOETHYLAMINE HCL:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available
