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Monoisopropanolamine also acts as a co-solvent in formulations where water and oil-based components need to be blended smoothly, such as in coatings, cleaning agents, and cosmetic products.
Monoisopropanolamine’s also valued for helping formulate more strong items with improved low temperature performance as well as reduced discoloration.
Monoisopropanolamine is the organic compound with the formula CH3CH(OH)CH2NH2.
CAS Number: 78-96-6
Molecular Formula: C3H9NO
Molecular Weight: 75.11
EINECS Number: 201-162-7
Synonyms: 1-Aminopropan-2-ol, 1-AMINO-2-PROPANOL, Isopropanolamine, Monoisopropanolamine, Threamine, DL-1-Amino-2-propanol, 2-Hydroxypropylamine, 2-Propanol, 1-amino-, 1-Methyl-2-aminoethanol, 2-Hydroxypropanamine, 2-Amino-1-methylethanol, 1-Amino-2-hydroxypropane, 2-Hydroxy-1-propylamine, Mono-iso-propanolamine, alpha-Aminoisopropyl alcohol, CCRIS 2284, 2-Hydroxy-1-propanamine, HSDB 5224, beta-Aminoisopropanol, NSC 3188, AI3-14653, UE40BY1BZW, EINECS 201-162-7, BRN 0605275, DTXSID9021764, CHEBI:19030, NSC-3188, (2-HYDROXY-2-METHYLETHYL)AMINE, DTXCID901764, FEMA NO. 3965, EC 201-162-7, 4-04-00-01665 (Beilstein Handbook Reference), 1-AMINO-2-PROPANOL [FHFI], 1-AMINO-2-PROPANOL [HSDB], 1Aminopropan2ol, 2hydroxypropylamine, 2Hydroxypropanamine, 2Propanol, 1amino, 1Methyl2aminoethanol, 2Amino1methylethanol, 2Hydroxy1propylamine, 1Amino2hydroxypropane, alphaAminoisopropyl alcohol, 2-Hydroxy-1-methylethanol, ISOPROPANOLAMINE [INCI], 201-162-7, (2S)-1-aminopropan-2-ol, RefChem:429211, 78-96-6, Amino-2-propanol, Mipa, (+/-)-1-Amino-2-propanol, 1-amino-propan-2-ol, (RS)-1-amino-2-propanol, MFCD00008139, .alpha.-Aminoisopropyl alcohol, (RS)-1-Amino-2-hydroxypropane, (+/-)-Isopropanolamine, D-1-amino-2-propanol, D-1-aminopropan-2-ol, DL-Isopropanolamine, 2-Propanol, 1-amino- (8CI,9CI), 1674-56-2, 2-Propanol, 1-amino-, (.+/-.)-, (R)-(-)-Isopropanolamine, (S)-(+)-Isopropanolamine, UNII-UE40BY1BZW, 2-Propanol, 1-amino-, (R)-, 2-Propanol, 1-amino-, (S)-, Aminopropan-2-ol, 1-amino-2 propanol, 3-amino-2-propanol, 3-aminopropan-2-ol, 2-hydroxy-propylamine, 2-hydroxypropyl-amine, 1-Aminoisopropylalcohol, 1-Aminopropanol-(2), 1-amino-propane-2-ol, 1-Amin-iso-proylalcohol, rac-1-amino-2-propanol, 2-hydroxy-1-aminopropane, Amino-2-propanol, 93%, bmse000305, SCHEMBL9387, (rac)-1-amino-2-propanol, racemic 1-amino-2-propanol, 1-amino-2(R,S)-propanol, WLN: Z1YQ1, SCHEMBL68249, (2rs)-1-amino-2-propanol, 1-amino-2-Hydroxypropanamine, (2RS) 1-amino-2-propanol, SCHEMBL502679, SCHEMBL873233, 2-hydroxy-2-methyl-ethylamine, propane, 1-amino-2-hydroxy-, CHEMBL326602, orb1962263, SCHEMBL1140446, SCHEMBL2835744, SCHEMBL2852882, SCHEMBL5688779, 1-Aminopropan-2-ol (Standard), SCHEMBL10478084, SCHEMBL11898270, SCHEMBL22283791, NSC3188, (.+/-.)-1-Amino-2-propanol, BCP08083, HY-W015969R, Tox21_301704, BBL027685, DL-1-Amino-2-propanol, >=90%, STL308732, AKOS000120495, AKOS016042334, CS-W016685, HY-W015969, SB44651, SB44696, SB83757, CAS-78-96-6, NCGC00257540-01, 1-AMINO-2-PROPANOL, (+/-)-, DB-013106, A0406, A1229, A5358, NS00007157, EN300-20160, C05771, G75932, (+/-)-1-Amino-2-propanol, analytical standard, Q161580, F2190-0369, Z104477092, (?)-1-Amino-2-propanol, 94%, remainder 2-amino-1-propanol, MONOISOPROPANOLAMINE;MIPA;THREAMINE;RARECHEM AL BW 2385;(+/-)-1-AMINO-2-PROPANOL;1-AMINO-2-PROPANOL;1-AMINOISOPROPANOL;1-AMINOISOPROPYL ALCOHOL
Monoisopropanolamine is an amino alcohol.
Monoisopropanolamine serves as an emulsifier and stabilizer, improving oil solubility, foam control, and color stabilization in formulations.
It’s frequently used to neutralize fatty acids as well as sulfonates.
Monoisopropanolamine is also used as a corrosion inhibitor in water based metalworking fluids as well as an intermediate in synthetic chemistry for foaming agents, herbicides, coatings & also surfactants.
Compared to conventional ethanolamines, Monoisopropanolamine offers superior thermal as well as oxidative stability.
This makes it ideal for demanding processing conditions.
Monoisopropanolamine is a versatile amino alcohol.
Monoisopropanolamine distinguishes itself from other ethanolamines with improved heat/color stability, enhanced oil solubility & also favorable physical handling characteristics—qualities that optimize product performance while keeping costs manageable.
Monoisopropanolamine, also known as 1 amino 2 propanol (CAS Number 78 96 6), is a primary alkanolamine derived from isopropanol.
Monoisopropanolamine is a clear, colorless liquid with a mild ammonia like odor.
As the lowest molecular weight isomer among isopropanolamines, Monoisopropanolamine provides effective basicity—raising pH and neutralizing acids—while also functioning as a buffering agent and chemical intermediate.
Monoisopropanolamine, is an organic chemical compound that belongs to the family of alkanolamines, which are molecules containing both alcohol (-OH) and amine (-NH₂) functional groups.
Structurally, it is a clear to slightly yellow, viscous liquid with a mild ammonia-like odor, and it is highly soluble in water as well as in many polar organic solvents.
Its chemical structure gives it a dual nature: the alcohol group imparts hydrophilic (water-attracting) properties, while the amine group makes it basic and capable of neutralizing acids.
Because of this unique combination of properties, Monoisopropanolamine is widely used as a pH adjuster, neutralizing agent, and emulsifier in a variety of industrial and consumer applications.
In chemical manufacturing, it can serve as an intermediate in producing surfactants, corrosion inhibitors, and agrochemicals.
Monoisopropanolamine is extensively used across multiple industries including coatings, metalworking, agrochemicals as well as personal care.
Monoisopropanolamines combination of neutralizing strength, emulsification capability, corrosion inhibition as well as solvent properties makes it a valuable intermediate as well as functional additive.
A colorless liquid with a slight ammonia-like odor less dense than water and soluble in water.
Corrosive to metals and tissue vapors are heavier than air.
Produces toxic oxides of nitrogen during combustion.
Monoisopropanolamine is used in plastics, paints, cutting oils, and specialized cleaning compounds.
A basic chemical used in many applications serving as an emulsifier, stabilizer, chemical intermediate, and a neutralizer that achieves basicity, buffering, and alkalinity objectives.
Monoisopropanolamine is a liquid product at room temperature, providing neutralization of acidic component and pH contribution to the formulations.
Monoisopropanolamine-based formulations can offer better color and heat stability and improved oil solubility than conventional ethanolamines.
Monoisopropanolamine is a specialty alkanolamine that acts as a neutralizers for water-based coatings
Monoisopropanolamine acts as an emulsifier, stabilizer, chemical intermediate, and neutralizer.
Monoisopropanolamine is GMO- and BSE-free.
Monoisopropanolamine neutralizes fatty acids and sulfonic acid-based surfactants.
Monoisopropanolamine exhibits good solubilizing property for oil and fat.
It offers low formulation cost as well as heat and color stability.
Monoisopropanolamine is used for paint strippers and waterborne coatings.
Monoisopropanolamine is REACH and TSCA compliant.
Melting point: -2 °C (lit.)
Boiling point: 160 °C (lit.)
Density: 0.973 g/mL at 25 °C (lit.)
Vapor density: 2.6 (vs air)
Vapor pressure: <1 mm Hg (20 °C)
Refractive index: n20/D 1.4478 (lit.)
FEMA: 3965 | 1-AMINO-2-PROPANOL
Flash point: 165 °F
Storage temp.: 2-8 °C
Solubility: DMSO : 250 mg/mL (3328.45 mM; Need ultrasonic)
pKa: 12.92 ± 0.35 (Predicted)
Form: Liquid
Color: Clear
pH: 11.3 (10 g/L, H₂O, 20 °C)
Odor: Slight ammonia odor
Odor type: Fishy
Biological source: Synthetic
Explosive limit: 1.9-10.4% (V)
Water solubility: Freely soluble
Freezing point: 1.4 °C
Sensitive: Hygroscopic
JECFA Number: 1591
BRN: 605275
Stability: Stable. Substances to be avoided include strong oxidizing agents. Combustible. Hygroscopic.
InChIKey: HXKKHQJGJAFBHI-UHFFFAOYSA-N
LogP: -0.93 at 23 °C
Surface tension: 37.6 mN/m at 293.15 K
Any amino alcohol that is propan-2-ol substituted by an amino group at position 1.
The term isopropanolamine may also refer more generally to the additional homologs diisopropanolamine (DIPA) and triisopropanolamine (TIPA).
Monoisopropanolamine is chiral.
Monoisopropanolamine can be prepared by the addition of aqueous ammonia to propylene oxide.
A basic chemical used in many applications serving as an emulsifier, stabilizer, chemical intermediate, and a neutralizer that achieves basicity, buffering, and alkalinity objectives.
Monoisopropanolamine is a liquid product at room temperature, providing neutralization of acidic component and pH contribution to the formulations.
Monoisopropanolamine-based formulations can offer better color and heat stability and improved oil solubility than conventional ethanolamines.
Monoisopropanolamine is a specialty alkanolamine that acts as a neutralizers for water-based coatings
A colorless liquid with a slight ammonia-like odor less dense than water and soluble in water.
Produces toxic oxides of nitrogen during combustion used in plastics, paints, cutting oils, and specialized cleaning compounds.
Monoisopropanolamine is an aminoalcohol amines are chemical bases.
They neutralize acids to form salts plus water these acid-base reactions are exothermic.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
Monoisopropanolamine is known for its ability to react with fatty acids to form amine salts, which are used as emulsifying and thickening agents in both industrial processes and personal care formulations.
Due to its basicity and surface activity, it plays an important role in adjusting formulation stability, foaming characteristics, and product performance in systems ranging from water-based paints to liquid detergents.
Uses Of Monoisopropanolamine:
Synthetic and semisynthetic machine lubricating/cutting oil formulations have included isopropanolamine, diisopropanolamine, and triethanolamine, together with nitrites; consequently the EPA has promulgated standards regarding the composition of cutting fluids.
Monoisopropanolamine is typically used in metalworking fluid, waterborne coatings, personal care products, and in the production of titanium dioxide and polyurethanes.
Monoisopropanolamine is an intermediate in the synthesis of a variety of pharmaceutical drugs.
Monoisopropanolamine is metabolised to aminoacetone by the enzyme (R)-aminopropanol dehydrogenase.
Used as an emulsifier, stabilizer, chemical intermediate, and a neutralizer in personal care, pharmaceuticals, metalworking products, and water borne coatings. Possesses acid neutralization.
Monoisopropanolamine, is valued for its unique combination of an alcohol group and an amine group within the same molecule, a structural feature that allows it to perform several different chemical and physical roles in various industrial and commercial applications.
One of its most common uses is as a neutralizing agent in formulations containing acidic components, such as coatings, paints, inks, and adhesives, where it helps control pH, improve product stability, and prevent unwanted corrosion in metal packaging or application equipment.
In the cosmetics and personal care industry, Monoisopropanolamine is widely incorporated into creams, lotions, hair conditioners, and shaving products, where it functions not only as a pH adjuster but also as an emulsifying aid that stabilizes mixtures of water and oils, thereby improving the texture, consistency, and shelf-life of the product.
When reacted with fatty acids such as myristic acid or lauric acid, Monoisopropanolamine produces amine soaps, which are highly effective emulsifiers and foaming agents in both skin-care products and household cleaning formulations.
In the industrial cleaning sector, Monoisopropanolamine is often used in degreasers, detergents, and all-purpose cleaners, where its surfactant-forming ability enhances the removal of oils, greases, and particulate soils from hard surfaces.
Its capacity to improve the wetting of surfaces and to reduce surface tension makes it particularly effective in cleaning metal machinery, automotive parts, and food processing equipment.
The agrochemical industry makes extensive use of Monoisopropanolamine as a neutralizing or solubilizing agent in the preparation of herbicide and pesticide formulations.
By forming water-soluble salts with acidic active ingredients, Monoisopropanolamine helps these chemicals dissolve evenly in spray solutions, ensures a more uniform distribution over crop surfaces, and enhances their chemical stability during storage.
In addition, Monoisopropanolamine serves as a chemical intermediate in the production of corrosion inhibitors, cement grinding aids, textile finishing agents, and water treatment chemicals.
In cement grinding, for example, small amounts of MIPA can be added to milling operations to prevent particle agglomeration, improve flow characteristics, and increase overall grinding efficiency.
In metalworking fluids, Monoisopropanolamine-based additives help reduce friction, protect against rust, and extend the lifespan of cutting tools.
The combination of these properties — pH control, emulsification, solubilization, and chemical reactivity — makes Monoisopropanolamine a multipurpose ingredient that bridges the needs of industries as varied as personal care, agriculture, coatings, and heavy manufacturing, often allowing for the reduction or replacement of multiple separate additives in a single, cost-effective formulation.
Monoisopropanolamine is used to study the effect of temperature and water content on the molecular structure and hydrogen bonding of amino-2-propanol, which has been examined by Fourier transform near-infrared (FT-NIR) spectroscopy.
Also used in used in the synthesis of protein kinase CK2 inhibitors used in the treatment of neoplasia and other infective diseases.
Monoisopropanolamine can be used as a reactant to prepare:
Monoisopropanolamine by oxidative carbonylation reaction using Pd(OAc)2/I2 catalyst.
Bio-based polyurethanes by reacting with epoxidized soybean oil via ring-opening and amidation reaction.
Monoisopropanolamine can also be used as a solvent as well as a template to synthesize layered aluminophosphate containing a racemic mixture of isopropanolamine.
Safety Profile Of Monoisopropanolamine:
Poison by intraperitoneal route, moderately toxic by ingestion and skin contact.
A skin andsevere eye irritant, moderately flammable in presence ofheat, flame, sparks, powerful oxidizers.
Ignites on contactwith cellulose nitrate of high surface area.
When Monoisopropanolamine comes into contact with the eyes, it can produce serious irritation, pain, watering, and redness, and higher concentrations have the potential to cause long-lasting damage to the corneal surface, resulting in blurred vision or other visual disturbances.
Inhalation of Monoisopropanolamine vapors, mists, or aerosols, especially in poorly ventilated environments or during industrial processing, can irritate the nose, throat, and lungs, causing coughing, sore throat, chest tightness, and in some cases, difficulty breathing.
Repeated inhalation over time may contribute to chronic respiratory irritation or sensitization in particularly sensitive individuals.
