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MONOMERIC CARBODIIMIDE

 

Monomeric carbodiimide is used to extend the usage life of polymers under hot and humid conditions.
Monomeric carbodiimide is used as a crosslinker in aqueous resins, such as polyurethane dispersions or acrylic dispersions.
Monomeric carbodiimide is primarily used as an anti-hydrolysis agent or hydrolysis stabilizer in various polymer systems.


CAS Number: 2162-74-5
EC Number: 218-487-5
Chemical Name: Bis(2,6-diisopropylphenyl)carbodiimide
Molecular Formula C25H34N2 
Molecular Weight 362.56 

SYNONYMS:
Bis(2,6-diisopropylphenyl)carbodiimide, Carbo D, Stabaxol I, N,N'-Methanediylidenebis(2,6-diisopropylaniline), N,N'-bis(2,6-diisopropylphenyl)carbodiimide, 2,2',6,6'-Tetraisopropyldiphenylcarbodiimide, N,N'-bis[2,6-di(propan-2-yl)phenyl]methanediimine, Carbodiimide, bis(2,6-diisopropylphenyl)- (7CI,8CI), N,N'-Methanetetraylbis(2,6-bis(1-methylethyl)benzenamine), Benzenamine, N,N'-methanetetraylbis(2,6-bis(1-methylethyl)-), Stabilizer 7000, DIPPC, carbod, HS-700F, Staboxol, staboxol1, HRstab-409, RARECHEM AQ A4 0133, Bis(2,6-diisopropylp, STABILIZER 7000 / 7000 F, RARECHEM AQ A4 0133, STABILIZER 7000 / 7000 F, Stabilizer 7000, N,N'-Bis(2,6-diisopropylphenyl)carbodiimide, Benzenamine, N,N-methanetetraylbis2,6-bis(1-methylethyl)-, (2,6-diisopropylphenyl)-[(2,6-diisopropylphenyl)iminomethylene]amine, N,N'-bis[2,6-di(propan-2-yl)phenyl]methanediimine, Bis(2,6-diisopropylphenyl)carbodiimide ,98%, Bis(2,6-diisopropylphenyl)carbodiimide, Staboxol 1, Carbo D, YPK27Z98PL, DTXSID5051862, 2,2',6,6'-Tetraisopropyldiphenylcarbodiimide, EINECS 218-487-5, UNII-YPK27Z98PL, Carbodiimide, bis(2,6-diisopropylphenyl)-, N,N'-Methanetetraylbis(2,6-bis(1-methylethyl)benzenamine), Benzenamine, N,N'-methanetetraylbis(2,6-bis(1-methylethyl)-, BIS(2,6-DIISOPROPYLPHENYL)-CARBODIIMIDE, EC 218-487-5, Benzenamine, N,N'-methanetetraylbis[2,6-bis(1-methylethyl)-, DTXCID3030420, Carbodiimide, bis(2,6-diisopropylphenyl)-(7CI,8CI), 218-487-5, 2162-74-5, N,N'-Methanediylidenebis(2,6-diisopropylaniline), (2,6-diisopropylphenyl)carbodiimide, MFCD00082211, N,N'-bis[2,6-bis(propan-2-yl)phenyl]methanediimine, C25H34N2, Maybridge1_004202, SCHEMBL134760, HMS553G24, AKOS015915473, FB16104, bis(2,6-di-2-propylphenyl)carbodiimide, bis-(2,6-diisopropylphenyl)carbodiimide, AS-10072, SY035749, DB-119014, B2756, CS-0154311, NS00007917, EN300-256163, O12007, N,N/'-bis[2,6-di(propan-2-yl)phenyl]methanediimine, N,N'-bis[2,6-di(propan-2-yl)phenyl]methanediimine, Q27894368, N-{N-[2,6-bis(propan-2-yl)phenyl]carboximidoyl}-2,6-bis(propan-2-yl)aniline, Monomeric carbodiimide, Stabaxol® I, 2,2',6,6'-Tetraisopropyldiphenylcarbodiimide, N,N'-Bis(2,6-diisopropylphenyl)carbodiimide, N,N'-Methanediylidenebis(2,6-diisopropylaniline), benzenamine, N,N'-methanetetraylbis(2,6-bis(1-methylethyl)-, carbo D, carbodiimide, bis(2,6-diisopropylphenyl)- (7CI,8CI), N,N'-bis[2,6- di(propan-2-yl)phenyl]methanediimine, staboxol 1, 2,2',6,6'- tetraisopropyldiphenylcarbodiimide

Monomeric carbodiimide belongs to the class of carbodiimides, which are known for their ability to facilitate the formation of peptide bonds and other condensation reactions.
With its advanced formula, Monomeric carbodiimide acts as a powerful anti-hydrolysis agent, effectively preventing moisture-induced degradation of PLA.


This ensures the longevity and durability of PLA-based products, making it an ideal choice for various applications.
Crafted with precision, this powder monomeric carbodiimide anti-hydrolysis agent is tailored to meet the high standards of the industry.
Monomeric carbodiimide's professional-grade formulation guarantees exceptional results, providing enhanced resistance against hydrolysis and maintaining the integrity of PLA materials over time.


Bis(2,6-diisopropylphenyl)carbodiimide, also known as monomeric carbodiimide.
Monomeric carbodiimide, also known by its UNII identifier YPK27Z98PL, is a chemical compound used in various applications, including biochemistry and organic synthesis.


Monomeric carbodiimide is an organic compound characterized by the functional group –N=C=N–, where two nitrogen atoms are double-bonded to a central carbon atom.
Monomeric carbodiimide is typically a low-molecular-weight, reactive intermediate used in various chemical synthesis processes.


Monomeric carbodiimide differs from polymeric carbodiimides in structure, with monomeric forms being small, discrete molecules rather than chain-forming polymers.
Monomeric carbodiimide is often aliphatic or aromatic and can be synthesized via dehydrosulfurization of thioureas or dehydration of ureas.


Monomeric carbodiimide is moisture-sensitive and tends to react readily with carboxylic acids and other nucleophiles.
Monomeric carbodiimides are usually liquids or low-melting solids with varying reactivity based on their substituents.

USES and APPLICATIONS of MONOMERIC CARBODIIMIDE:
Monomeric carbodiimide is primarily used as an anti-hydrolysis agent or hydrolysis stabilizer in various polymer systems.
Its applications include: Enhancing the hydrolytic stability of thermoplastic resins such as polyester polyurethane, PLA, PET/PBT, elastomers, adhesives, and coating systems.


Monomeric carbodiimide is used to extend the usage life of polymers under hot and humid conditions.
Monomeric carbodiimide is used as a crosslinker in aqueous resins, such as polyurethane dispersions or acrylic dispersions.
Monomeric carbodiimide is primarily used as an anti-hydrolysis agent or hydrolysis stabilizer in various polymer systems.


Monomeric carbodiimide is used to enhance the hydrolytic stability of thermoplastic resins such as polyester polyurethane, PLA, PET/PBT, elastomers, adhesives, and coating systems.
Monomeric carbodiimide is used to extend the usage life of polymers under hot and humid conditions.


Monomeric carbodiimide is used as a crosslinker in aqueous resins, such as polyurethane dispersions or acrylic dispersions.
Whether you're involved in 3D printing, packaging, or any other industry utilizing PLA, Monomeric carbodiimide is a must-have solution.
Its remarkable features make Monomeric carbodiimide a reliable choice for manufacturers and professionals seeking to optimize the performance and lifespan of PLA-based products.


Monomeric carbodiimide acts as an anti-hydrolysis agent.
Monomeric carbodiimide has distinctly reduced content of volatile components for polyester polymers (PET, PBT, TPE), polyamide, thermoplastics polyester polyurethanes (TPU) and millable urethane rubber.


Monomeric carbodiimide is very suitable for extrusion of monofilaments.
Monomeric carbodiimide's recommend dosage is 1.5 to 2.5 pbw for polyester, polyamide, and thermoplastic polyurethanes.
Monomeric carbodiimide is used as an anti-hydrolysis agent.


Monomeric carbodiimide helps prevent polymer degradation.
Monomeric carbodiimide is compatible with PET, PBT, PA, CO-PET, PU, TPU, CPU, TPEE, EVA, PLA, PHA, PBS, PTT.
Monomeric carbodiimide can effectively extend the usage life of polymers under hot and high humid conditions.


Monomeric carbodiimide is widely used as a coupling agent in organic synthesis, particularly for peptide bond formation.
Monomeric carbodiimide reacts with carboxylic acids to form O-acylisourea intermediates, facilitating the formation of amide bonds with amines.
This application is fundamental in the synthesis of peptides and proteins in both research and pharmaceutical industries.


Monomeric carbodiimide serves as a stabilizer in polyurethane formulations, reacting with carboxylic acid groups to scavenge moisture and extend shelf life.
In polymer chemistry, monomeric carbodiimide is used to modify or crosslink polymers, enhancing heat resistance and mechanical strength.


Monomeric carbodiimide is employed in the production of coatings, adhesives, and sealants where improved durability and hydrolytic stability are desired.
In the pharmaceutical industry, Monomeric carbodiimide acts as an intermediate in the synthesis of active pharmaceutical ingredients (APIs) and drug delivery materials.


Due to its strong dehydrating properties, Monomeric carbodiimide is also used in reactions requiring water removal or moisture sensitivity.
Monomeric carbodiimide offers high reactivity and versatility, making it an essential reagents in both laboratory and industrial-scale chemistry.


-Applications of Monomeric carbodiimide in Biochemistry and Medical Research:
In biochemistry and medical research, Monomeric carbodiimide is utilized for the synthesis and modification of biomolecules, such as proteins and peptides.

Its ability to form peptide bonds under mild conditions makes Monomeric carbodiimide an essential tool in peptide synthesis, allowing researchers to create complex peptides and proteins with high precision.
This capability is crucial for producing therapeutic peptides and understanding protein function and interactions at a molecular level.

CHEMICAL PROPERTIES AND USES OF MONOMERIC CARBODIIMIDE:
Monomeric carbodiimide is characterized by its high reactivity, which makes it a valuable reagent in the synthesis of peptides, esters, and other organic compounds.

Monomeric carbodiimide's chemical structure, featuring two bulky 2,6-diisopropylphenyl groups, enhances its selectivity and reduces side reactions, making it particularly useful in sensitive biochemical applications.
Monomeric carbodiimide is often employed in coupling reactions, where it mediates the formation of new bonds between molecules, a process critical in the synthesis of complex biomolecules and pharmaceuticals.

✅ BENEFITS AND CHARACTERISTICS OF MONOMERIC CARBODIIMIDE:
Hydrolysis Resistance:
Monomeric carbodiimide improves resistance to hydrolytic degradation in polymers, especially under high temperature and humidity.

Processing Flexibility:
Monomeric carbodiimide can be dissolved in polyester polyol or added to pre-polymers with terminal OH groups.

Compatibility:
Monomeric carbodiimide is suitable for various polymer systems, including PET, PBT, PA, CO-PET, PU, TPU, CPU, TPEE, EVA, PLA, PHA, PBS, and PTT.

Efficiency:
An addition of 0.5 parts by weight to 100 parts by weight of polyester polyol approximately doubles the resistance to hydrolysis.

As an anti-hydrolysis stabilizer which can be applied in PET, PBT, PA, PU, TPU, TPEE, EVA, PBAT, PLA, PHA, PBS, PTT and other materials, Monomeric carbodiimide can inhibit the hydrolysis of such materials effectively and stabilize their initial mechanical properties.

PHYSICAL and CHEMICAL PROPERTIES of MONOMERIC CARBODIIMIDE:
Appearance: White to off-white crystalline solid
Melting Point: Approximately 33–35 °C
Boiling Point: Approximately 122–124 °C
Density: 1.325 g/cm³
Flash Point: 87 °C
Solubility: Soluble in organic solvents; insoluble in water
Stability: Stable under recommended storage conditions 
Chemical Name: Bis(2,6-diisopropylphenyl)carbodiimide
CAS Number: 2162-74-5

EC Number: 218-487-5
CBNumber: CB1347186
Molecular Formula: C25H34N2
Molecular Weight: 362.56
MDL Number: MFCD00082211
MOL File: 2162-74-5.mol
Melting point: 51 °C
Boiling point: 152–162 °C (Press: 0.05 Torr)

Density: 0.95±0.1 g/cm³ (Predicted)
Vapor pressure: 0.006 Pa at 20 °C
Flash point: 197 °C
Storage temp.: 2–8 °C
Form: Powder to lump
Color: White to almost white
Water Solubility: 50 μg/L at 20 °C
InChIKey: XLDBGFGREOMWSL-UHFFFAOYSA-N
LogP: 6.2 at 30 °C
CAS DataBase Reference: 2162-74-5

FDA UNII: YPK27Z98PL
EPA Substance Registry System: Benzenamine, N,N'-methanetetraylbis[2,6-bis(1-methylethyl)- (2162-74-5)
Physical Condition (20 °C): Thick
CAS No: 2162-74-5
Reaxys Registry Number: 2675165
PubChem Substance ID: 87558238
Appearance: White to almost white powder to lump
Purity (with Total Nitrogen): min. 98.0%

Melting point: 50.0 to 54.0 °C
Features (reference)
Melting Point: 51 °C
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Soluble in: water, 0.0001861 mg/L @ 25 °C (est)
Melting point: 51 °C
Boiling point: 152–162 °C (Press: 0.05 Torr)
Density: 0.95±0.1 g/cm³ (Predicted)

Vapor pressure: 0.006 Pa at 20 °C
Fp: 197 °C
Storage temp.: 2–8 °C
Form: Powder to lump
Color: White to almost white
Water Solubility: 50 μg/L at 20 °C
InChIKey: XLDBGFGREOMWSL-UHFFFAOYSA-N
LogP: 6.2 at 30 °C
CAS DataBase Reference: 2162-74-5
EPA Substance Registry System: Benzenamine, N,N'-methanetetraylbis[2,6-bis(1-methylethyl)- (2162-74-5)

Appearance: White to off-white crystalline solid
Melting Point: Approximately 50–54 °C
Solubility: Soluble in organic solvents; insoluble in water
Stability: Stable under recommended storage conditions
Storage Conditions: Store in a cool, dry, well-ventilated area away from incompatible substances
Molecular Formula / Molecular Weight: C25H34N2 = 362.56
Physical State (20 deg.C): Solid
Storage Temperature: Room Temperature (Recommended in a cool and dark place, <15 °C)

CAS RN: 2162-74-5
Reaxys Registry Number: 2675165
PubChem Substance ID: 87558238
Molecular Weight: 362.5 g/mol
XLogP3-AA: 9.1
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 2
Rotatable Bond Count: 6
Exact Mass: 362.272199093 Da
Monoisotopic Mass: 362.272199093 Da

Topological Polar Surface Area: 24.7 Ų
Heavy Atom Count: 27
Formal Charge: 0
Complexity: 419
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: No

FIRST AID MEASURES of MONOMERIC CARBODIIMIDE:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of MONOMERIC CARBODIIMIDE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of MONOMERIC CARBODIIMIDE:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of MONOMERIC CARBODIIMIDE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of MONOMERIC CARBODIIMIDE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of MONOMERIC CARBODIIMIDE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Possibility of hazardous reactions:
No data available

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