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MONTANOX 40 DF is a trade name for a nonionic surfactant, commonly identified as PEG-40 Hydrogenated Castor Oil.
MONTANOX 40 DF is derived from castor oil and ethoxylated to form polyethylene glycol esters of hydrogenated castor oil.
MONTANOX 40 DF type of surfactant is known for its emulsifying and solubilizing properties, making it useful in various formulations.
CAS Number: 9005-66-7
Molecular Formula: C12H18O11
Molecular Weight: 338.26472
Synonyms: 9005-66-7, 2-[(2R)-2-[(2R,3R,4R)-3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate, Crillet 2, Glycosperse p-20, Crill 7, Durfax 60, Radiasurf 7145, Emsorb 6910, Nissan Nonion PT-221, UNII-4NR71FN0IA, UNII-STI11B5A2X, 4NR71FN0IA, Sorbimacrogol palmitate 300, STI11B5A2X, CCRIS 701, HSDB 1928, HMFKFHLTUCJZJO-OQUNMALSSA-N, POLYSORBATE 40,POLYOXYETHYLENE SORBITAN MONOPALMITATE,POLYOXYETHYLENE GLYCOL SORBITAN MONOPALMITATE,POLYOXYETHYLENE (20) SORBITAN MONOPALMITATE,POLYSORBATE40,NF,Sorbitanmonopalmitat, ethoxiliert, EO 20 mol,TWEEN 40,TWEEN NO 40
MONTANOX 40 DF acts as hydrophilic o/w emulsifier, for all types of application and texture.
MONTANOX 40 DF is used in make-up removal, deodorant, hair, suncare, make-up, facial cleansing gels, tonics, shampoos, etc.
MONTANOX 40 DF is a nonionic surfactant and emulsifier often used in pharmaceuticals, foods, and cosmetics.
This synthetic compound is a viscous, water-soluble yellow liquid.
MONTANOX 40 DF is derived from polyethoxylated sorbitan and oleic acid.
The hydrophilic groups in this compound are polyethers also known as polyoxyethylene groups, which are polymers of ethylene oxide.
In the nomenclature of polysorbates, the numeric designation following polysorbate refers to the lipophilic group, in this case, the oleic acid (see polysorbate for more detail).
The critical micelle concentration of MONTANOX 40 DF in pure water is reported as 0.012 mM.
It is made from hydrogenated castor oil that has undergone ethoxylation, meaning it has been reacted with ethylene oxide to improve its water solubility.
As a nonionic surfactant, it does not carry a charge, making it stable in a wide range of pH and electrolytic conditions.
MONTANOX 40 DF has good solubility in both water and oil, which allows it to act as a bridge between water-based and oil-based components.
MONTANOX 40 DF is used in formulations of creams, lotions, shampoos, and conditioners to emulsify oils in water-based products.
Helps solubilize oil-soluble ingredients, such as essential oils, fragrances, or active ingredients in aqueous formulations.
Improves the texture and consistency of lotions, gels, and creams.
MONTANOX 40 DF is used to improve the solubility of hydrophobic active ingredients in pharmaceutical formulations like topical creams or oral solutions.
Can be used in the food industry to stabilize oil-in-water emulsions, commonly in processed foods, sauces, and beverages.
Acts as a surfactant and emulsifier in cleaning agents, helping to remove oils, greases, and dirt from surfaces.
MONTANOX 40 DF is used in textile processing as a wetting agent and emulsifier to improve fabric handling and dye uptake.
Helps to emulsify and stabilize agrochemical formulations, improving the spread and penetration of pesticides or herbicides.
Generally considered to be of low toxicity and safe for use in personal care products.
At typical concentrations, MONTANOX 40 DF is not known to cause significant skin or eye irritation.
Being derived from castor oil, it is considered biodegradable, reducing its long-term impact on the environment.
MONTANOX 40 DF is derived from castor oil, which is a renewable resource, and it is biodegradable, reducing its long-term environmental impact.
This makes it more favorable in industries focused on sustainability and eco-friendly formulations.
MONTANOX 40 DF is considered non-toxic for typical cosmetic, pharmaceutical, and food use.
It has been deemed safe for human use by major regulatory bodies such as the FDA and Cosmetic Ingredient Review (CIR) panel.
While generally safe, it may cause mild irritation if used in very high concentrations, especially on sensitive skin.
However, in typical product formulations, it is diluted to safe levels.
MONTANOX 40 DF may cause some eye irritation if undiluted, but this is rare at typical concentrations used in consumer products.
MONTANOX 40 DF has a low potential for causing allergic reactions, making it suitable for sensitive skin products, though patch testing is always recommended in cosmetics.
MONTANOX 40 DF is approved for use in various cosmetic and pharmaceutical formulations globally.
It is listed in Cosmetic Ingredient Review (CIR) reports and European Union regulations, with concentration limits ensuring safe usage.
MONTANOX 40 DF is also recognized as safe in certain food applications, where it is used as an emulsifier in compliance with regulatory standards.
It is compliant with the Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH) in Europe, ensuring that it meets environmental and health safety requirements.
Melting point: 0.1 °C
Boiling point: 797.89°C (rough estimate)
Density: 1.083 g/mL at 25 °C(lit.)
refractive index: n20/D 1.47(lit.)
Flash point: >230 °F
storage temp.: Store below +30°C.
solubility: Miscible with water, with anhydrous ethanol, with ethyl acetate and with methanol, practically insoluble in fatty oils and in liquid paraffin.
form: viscous liquid
Specific Gravity: 1.090 (25/4℃)
color: Light yellow to Yellow to Orange
Water Solubility: 100 g/L
Hydrophilic-Lipophilic Balance (HLB): 15.6
MONTANOX 40 DF, as well known as Tween 80, is a non-ionic detergent used for selective protein extraction and isolation of nuclei from mammalian cell lines and as a stabilizer and emulsifier.
A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by a palmitoyl group.
MONTANOX 40 DF is formed by the ethoxylation of hydrogenated castor oil.
The number 40 refers to the average number of ethylene oxide units added to the hydrogenated castor oil, improving its water solubility.
Typically appears as a viscous liquid or a soft solid, depending on the exact composition and temperature.
Readily soluble in water and oil, making it an ideal emulsifier in formulations requiring the combination of oil-based and water-based components.
MONTANOX 40 DF is commonly used to stabilize oil-in-water emulsions in complex cosmetics such as BB creams, foundations, and sunscreens, ensuring consistent distribution of active ingredients and other components.
It can solubilize essential oils and fragrances into water-based products like perfumes, body mists, and toners, making them clear and stable.
MONTANOX 40 DF is used in facial cleansers and micellar waters, where it helps remove makeup and impurities by emulsifying oils and dirt, leaving skin clean without excessive drying.
In shampoos and conditioners, it improves foam quality, acts as a conditioning agent, and helps solubilize other conditioning ingredients like silicones or oils.
Helps dissolve and remove makeup, including waterproof cosmetics, from the skin.
MONTANOX 40 DF can enhance the permeation of active pharmaceutical ingredients (APIs) across the skin, which is useful in topical treatments like creams for dermatological conditions or pain relief.
In certain cases, MONTANOX 40 DF can be used to solubilize hydrophobic drugs in oral suspensions or solutions, improving the bioavailability of drugs that are otherwise poorly soluble in water.
It can be found in certain processed foods and beverages, where it helps blend fats or oils into water-based systems.
This is especially useful in creamy dressings, sauces, and flavored beverages.
MONTANOX 40 DF may also be used to stabilize fat-soluble vitamins (like vitamin A, D, E, and K) in aqueous solutions, ensuring even distribution in fortified drinks or supplements.
MONTANOX 40 DF is effective in liquid detergents and household cleaners as it helps emulsify and remove grease, oils, and dirt from various surfaces, improving cleaning efficiency.
In products where foam is desired, such as car shampoos or laundry detergents, it helps stabilize the foam to improve the overall performance of the product.
MONTANOX 40 DF is used in textile formulations as a wetting agent, helping water and dyes to spread more evenly across fabric surfaces.
This improves the uptake of dyes and enhances color consistency during the dyeing process.
In leather finishing, it can be used to help spread conditioning or protective agents uniformly across the leather surface, improving the softness and durability of the finished product.
MONTANOX 40 DF helps pesticides, herbicides, and fungicides disperse evenly when sprayed onto crops, ensuring better coverage and penetration of the active ingredients into the plants.
This results in more efficient pest and disease control.
Can be used in fertilizer formulations to ensure even distribution of nutrients in the soil.
Uses:
Pharmaceutic aid (surfactant)Note—Graphic formula same as for Polysorbate 20, except that R is (C15H31)COO.
MONTANOX 40 DF is an emulsifier and stabilizer of essential oils in water.
MONTANOX 40 DF is also a detergent and employed in a variety of cleansing and moisturizing preparations.
MONTANOX 40 DF is a non-ionic surfactant used as an inner antistatic agent.
MONTANOX 40 DF is used as an emulsifier in foods, though research suggests it may "profoundly impact intestinal microbiota in a manner that promotes gut inflammation and associated disease states."
For example, in ice cream, polysorbate is added up to 0.5% (v/v) concentration to make the ice cream smoother and easier to handle, as well as increasing its resistance to melting.
Adding polysorbate prevents milk proteins from completely coating the fat droplets.
This allows them to join in chains and nets, which hold air in the mixture, and provide a firmer texture that holds its shape as the ice cream melts.
MONTANOX 40 DF is also used as a surfactant in soaps and cosmetics (including eyedrops), or a solubilizer, such as in a mouthwash.
The cosmetic grade of polysorbate 80 may have more impurities than the food grade.
MONTANOX 40 DF is a surfactant and solubilizer used in a variety of oral and topical pharmaceutical products.
MONTANOX 40 DF is also an excipient that is used to stabilize aqueous formulations of medications for parenteral administration, and used as an emulsifier in the making of the antiarrhythmic amiodarone.
It is also used as an excipient in some European and Canadian influenza vaccines.
Influenza vaccines contain 2.5 μg of polysorbate 80 per dose.
MONTANOX 40 DF is found in many vaccines used in the United States, including the Janssen COVID-19 vaccine.
MONTANOX 40 DF is used in the culture of Mycobacterium tuberculosis in Middlebrook 7H9 broth.
It is also used as an emulsifier in the estrogen-regulating drug Estrasorb.
MONTANOX 40 DF is also used in granulation for stabilization of drugs and excipients when IPA binding.
Some mycobacteria contain a type of lipase (enzyme that breaks up lipid molecules); when these species are added to a mixture of MONTANOX 40 DF and phenol red, they cause the solution to change color, so this is used as a test to identify the phenotype of a strain or isolate.
On RODAC agar plates used in microbiological control, MONTANOX 40 DF counteracts disinfectants often found on sampled surfaces, thereby allowing the microbes found on these surfaces to grow.
Topical drug formulations to enhance skin penetration of active ingredients.
MONTANOX 40 DF oral formulations for solubilizing hydrophobic drugs.
MONTANOX 40 DF emulsifier in processed foods, sauces, and beverages.
MONTANOX 40 DF stabilizer for fat-soluble vitamins in aqueous solutions.
MONTANOX 40 DF surfactant in liquid detergents and household cleaners.
Foam stabilizer for products requiring foaming.
Wetting agent in textile processing to improve dye uptake.
MONTANOX 40 DF conditioning agent in leather treatment to enhance softness.
Adjuvant in pesticides to improve coverage and penetration.
MONTANOX 40 DF emulsifier in fertilizers for even nutrient distribution.
MONTANOX 40 DF stabilizes oil-in-water emulsions in creams, lotions, and moisturizers, allowing the mixture of water and oil-based ingredients.
Commonly used in formulations like BB creams, foundations, and sunscreens to maintain consistency and improve texture.
Solubilizes oil-soluble ingredients, such as fragrances, essential oils, and vitamins in products like body sprays, shower gels, and hair serums.
MONTANOX 40 DF enhances the viscosity of products like gels, creams, and lotions, providing a more luxurious feel on the skin.
Reduces surface tension in facial cleansers and shampoos, aiding in the removal of dirt, oil, and makeup.
Improves the spreadability and overall feel of hair care products, making hair smoother and easier to manage.
MONTANOX 40 DF is used in creams, ointments, and gels to enhance the absorption of active ingredients through the skin, making it effective for treatments like pain relief and dermatological applications.
Helps in drug delivery through skin patches, ensuring a steady release of medication over time.
MONTANOX 40 DF employed in suspensions and solutions to solubilize hydrophobic drugs, improving their bioavailability in oral medications.
Stabilizes oil-in-water emulsions in processed foods like sauces, dressings, and dairy products to improve texture and mouthfeel.
MONTANOX 40 DF prevents the separation of fat-soluble vitamins and other nutrients in beverages and fortified foods, ensuring even distribution and effectiveness.
Enhances the delivery of flavors in food formulations, helping to maintain flavor consistency in products like flavored drinks and desserts.
MONTANOX 40 DF is used in liquid detergents and surface cleaners to emulsify and remove grease, oils, and dirt from various surfaces.
In products that benefit from foaming action, such as car shampoos and laundry detergents, it helps maintain foam quality for better cleaning performance.
MONTANOX 40 DF reduces excessive foam during industrial cleaning processes, improving efficiency and reducing waste.
Acts as a wetting agent, ensuring dyes and chemicals spread evenly across fabric surfaces, leading to better color consistency during dyeing.
MONTANOX 40 DF is used in leather treatments to improve softness and flexibility, enhancing the quality of finished leather goods.
MONTANOX 40 DF reduces static electricity in synthetic fibers, improving handling during manufacturing processes.
Enhances the efficacy of pesticides by ensuring even coverage on crops, improving the penetration of active ingredients into plant tissues.
MONTANOX 40 DF is used to emulsify and stabilize liquid fertilizers, ensuring uniform distribution and application.
Helps stabilize oil-in-water emulsions in paints and coatings, improving the uniformity of color and texture in finished products.
MONTANOX 40 DF enhances the wetting properties of paints and inks, ensuring better adhesion and spreadability on surfaces.
Incorporated into wound dressings and ointments to promote moisture retention and enhance the delivery of healing agents.
MONTANOX 40 DF is used as a lubricant in medical devices to reduce friction and enhance patient comfort.
MONTANOX 40 DF is a versatile ingredient with applications spanning multiple industries. Its primary roles include:
Emulsifying, solubilizing, and conditioning properties in skincare and hair care products.
MONTANOX 40 DF enhancing drug delivery in topical and oral formulations.
Stabilizing emulsions and fortifying products with nutrients.
Serving as a surfactant and foam stabilizer for improved cleaning efficiency.
MONTANOX 40 DF facilitating dye uptake and conditioning leather products.
Improving pesticide efficacy and fertilizer distribution.
Stabilizing emulsions and enhancing performance.
Safety Profile:
MONTANOX 40 DF can cause irritation upon contact with skin and eyes.
Protective gear should be worn to avoid direct exposure.
Inhalation of dust or aerosols may lead to respiratory irritation or other respiratory issues, especially in poorly ventilated areas.
The surfactant properties may pose risks to aquatic life if released into the environment.
MONTANOX 40 DF is essential to prevent it from entering water bodies.
If ingested, it can be harmful, potentially causing gastrointestinal irritation and other health issues.
Although stable under normal conditions, it should be kept away from strong oxidizers to prevent any adverse reactions.
Personal Protective Equipment (PPE): Use gloves, goggles, and masks when handling the product.
Ensure adequate ventilation in areas where the product is used.
In case of skin contact, wash thoroughly with soap and water.
If MONTANOX 40 DF gets into the eyes, rinse immediately with plenty of water and seek medical attention if irritation persists.
