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Motherwort (leonurus japonicus) extract, which has been isolated from the leaves of Cadaba fruticosa, has been shown, by comparison of its hydrochloride and the NMR spectrum, to be stachydrine.
Motherwort (leonurus japonicus) extract is an amino acid betaine that is L-proline zwitterion in which both of the hydrogens attached to the nitrogen are replaced by methyl groups.
Motherwort (leonurus japonicus) extract has a role as a food component, a plant metabolite and a human blood serum metabolite.
CAS Number: 471-87-4
Molecular Formula: C7H14NO2
Molecular Weight: 144.19
EINECS Number: 207-445-1
Synonyms: stachydrine, 471-87-4, proline betaine, L-proline betaine, (S)-1,1-Dimethylpyrrolidin-1-ium-2-carboxylate, methyl hygrate betaine, N,N-dimethyl-L-proline, (2S)-1,1-dimethylpyrrolidin-1-ium-2-carboxylate, (S)-2-Carboxylato-1,1-dimethylpyrrolidinium, L-stachydrine, Prestwick-08G03, CHEBI:35280, (2S)-1,1-dimethylpyrrolidinium-2-carboxylate, S1L688345C, Pyrrolidinium, 2-carboxy-1,1-dimethyl-, inner salt, (2S)-, UNII-S1L688345C, (-)-Stachydrine, EINECS 207-445-1, CADABINE, N,N-dimethyl L-proline(2s)-1,1-dimethylpyrrolidinium-2-carboxylate;(Pyrrolidinium, 2-carboxy-1,1-dimethyl-, innersalt, (2S)-;Methyl hygrate betaine;(S)-2-Carboxy-1,1-dimethylpyrrolidinium hydroxide inner salt;1-Methylproline methylbetaine;Cadabine;(2S)-1,1-Dimethyl-2-carboxylatopyrrolidin-1-ium;(2S)-2-Carboxylato-1,1-dimethylpyrrolidin-1-ium
Motherwort (leonurus japonicus) extract is a N-methyl-L-alpha-amino acid, an alkaloid and an amino-acid betaine.
Motherwort (leonurus japonicus) extract is functionally related to a L-prolinium.
It is a conjugate base of a N,N-dimethyl-L-prolinium.
Motherwort (leonurus japonicus) extract is an enantiomer of a D-proline betaine.
Motherwort (leonurus japonicus) extract is derived from the leaves and stems of the Leonurus japonicus plant, which belongs to the mint family (Lamiaceae).
This herb is traditionally used in various forms of herbal medicine, particularly in Chinese medicine, where it's known as "yi mu cao."
Motherwort (leonurus japonicus) extract is a plant that grows about 1 meter in height.
The parts that grow above the ground are used to make medicine.
Motherwort (leonurus japonicus) extract has anti-inflammatory and antioxidant effects.
Motherwort (leonurus japonicus) extract might also help fight bacteria and stimulate the uterus.
People use motherwort to prevent or stop bleeding.
Motherwort (leonurus japonicus) extract is also used for heart failure, symptoms of menopause, high blood pressure, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
Employed by the ancient Greeks to reduce anxiety during childbirth, motherwort (Leonurus cardiaca) is primarily used as a tea or tincture for its potential medicinal properties.
Also called lion’s tail, motherwort is an upright, prickly bush with dark green leaves and furry purple or pink flowers (1Trusted Source).
Motherwort (leonurus japonicus) extract’s native to Asia and Southeastern Europe but can now be found worldwide.
In the United States, Motherwort (leonurus japonicus) extract’s considered an invasive species.
Unlike some other herbs in the mint family, Motherwort (leonurus japonicus) extract has an unpleasant smell and bitter flavor.
This article reviews motherwort, including its potential benefits and side effects.
Leonurus cardiaca, known as motherwort, is an herbaceous perennial plant in the mint family, Lamiaceae.
Other common names include throw-wort, lion's ear, and lion's tail.
Motherwort (leonurus japonicus) extract's tail is also a common name for Leonotis leonurus, and lion's ear, a common name for Leonotis nepetifolia.
Originally from Central Asia and southeastern Europe, Motherwort (leonurus japonicus) extract is now found worldwide, spread largely due to its use as a herbal remedy.
Motherwort (leonurus japonicus) extract has a squarish stem which is clad in short hairs and is often purplish, especially near the nodes.
The opposite leaves have serrated margins and are palmately lobed with long petioles; basal leaves are wedge shaped with three points while the upper leaves have three to five.
They are slightly hairy above and greyish beneath.
Flowers appear in leaf axils on the upper part of the plant and have three-lobed bracts.
The calyx of each flower is bell-shaped and has five lobes.
The corolla is irregular, 8 to 12 mm (0.3 to 0.5 in) long, fused, long-tubed with two lips.
The upper lip is convex and covered with white hairs and the lower lip is three-lobed and downward-curving and spotted with red.
The flowers are pink to lilac in colour often with furry lower lips.
There are four protruding stamens, two short and two longer, and the fruit is a four-chambered schizocarp.
Motherwort (leonurus japonicus) extract is probably native to the southeastern part of Europe and central Asia where it has been cultivated since ancient times.
Its natural habitat is beside roadsides, in vacant fields, waste ground, rubbish dumps and other disturbed areas.
This plant prefers well drained soil and a partly shady location.
Introduced to North America as a bee foraging plant and to attract bumble bees, this perennial herb is now considered invasive.
Motherwort (leonurus japonicus) extract is hardy in USDA climate zones 4–8.
Melting point: 235°C
Boiling point: 261.28°C (rough estimate)
Density: 1.1095 (rough estimate)
refractive index: 1.4150 (estimate)
storage temp.: 2-8°C
solubility: Water: 100 mg/mL (698.42 mM); DMSO: 100 mg/mL (698.42 mM)
form: Solid
color: White to off-white
Among other chemical constituents, it also contains stachydrine,[8] bitter iridoid glycosides (leonuride), diterpenoids, flavonoids (including rutin and quercetin), tannins, volatile oils, and vitamin A.
Motherwort (leonurus japonicus) extract is extracted from the leaves of Motherwort and has demonstrated various bioactivities for the treatment of fibrosis, cardiovascular diseases, cancers, uterine diseases, brain injuries, and inflammation.
Such as leonurine, which is believed to have cardioprotective properties.
Motherwort (leonurus japonicus) extracts have antioxidant and anti-inflammatory effects.
These are associated with anti-microbial and anti-inflammatory activities.
Motherwort (leonurus japonicus) extract has been used for centuries to treat cardiovascular conditions.
Motherwort (leonurus japonicus) extract, in particular, is thought to improve blood circulation, relax blood vessels, and support overall heart health.
Motherwort (leonurus japonicus) extract is commonly used to regulate menstrual cycles, relieve menstrual pain, and treat other gynecological conditions like uterine bleeding and postpartum recovery.
The herb is used to calm nerves and reduce anxiety or restlessness.
Motherwort (leonurus japonicus) extract has been traditionally used to reduce inflammation and as an antioxidant.
Motherwort (leonurus japonicus) extract is available in various supplement forms, such as tinctures, capsules, and teas, often marketed for heart health, women's health, and stress relief.
In some cultures, Motherwort (leonurus japonicus) extract is applied topically for wound healing and to reduce inflammation.
Uses Of Motherwort (leonurus japonicus) extract:
Motherwort (leonurus japonicus) extract is used for various ethnobotany and ethnomedicinal uses.
Motherwort (leonurus japonicus) extract can also be used to promote healthy neural development in an unborn baby, as well as to determine the differential effects of post-weaning diet and maternal obesity on mouse liver and brain metabolomes.
Historically, Motherwort (leonurus japonicus) extract is known as a heart tonic.
It may help regulate heart rhythms, reduce palpitations, and lower blood pressure.
The active compound leonurine in motherwort can promote better blood circulation and help prevent clot formation, supporting overall heart function.
Motherwort (leonurus japonicus) extract is sometimes used to reduce high blood pressure (hypertension).
Motherwort (leonurus japonicus) extract is often used to regulate the menstrual cycle.
It can help with irregular periods, delayed menstruation, or scanty menstrual flow.
Motherwort (leonurus japonicus) extract is known to alleviate menstrual cramps and discomfort by relaxing the uterus.
In traditional Chinese medicine, motherwort is used to promote recovery after childbirth, especially to reduce postpartum bleeding and assist uterine contraction.
Motherwort (leonurus japonicus) extract can help ease symptoms associated with menopause, such as anxiety, palpitations, and hot flashes.
Motherwort (leonurus japonicus) extract is traditionally used as a mild sedative and relaxant, helping to reduce anxiety, stress, and tension.
Its calming properties are also used to promote restful sleep and reduce insomnia caused by stress or anxiety.
Motherwort (leonurus japonicus) extract has anti-inflammatory properties and may be useful in reducing inflammation associated with various conditions.
The extract contains flavonoids that act as antioxidants, helping to protect cells from oxidative stress and damage.
Motherwort (leonurus japonicus) extract can help stimulate digestive processes, promoting better digestion and reducing indigestion or bloating.
Some studies suggest that motherwort may have antimicrobial and antifungal effects, making it useful for treating minor infections.
Motherwort (leonurus japonicus) extract is believed to reduce uterine muscle contractions, making it useful in conditions where excess uterine contractions occur, such as dysmenorrhea (painful periods).
In some traditional practices, motherwort is applied to wounds to reduce swelling and promote healing due to its anti-inflammatory and antimicrobial properties.
Motherwort (leonurus japonicus) extract can act as a mild diuretic, helping the body eliminate excess fluid.
Safety Profile Of Motherwort (leonurus japonicus) extract:
Motherwort (leonurus japonicus) extract has been traditionally used to stimulate uterine contractions, making it unsafe for use during pregnancy.
Motherwort (leonurus japonicus) extract may increase the risk of miscarriage or premature labor.
Due to its effects on the uterus, it is strictly advised that pregnant women avoid Motherwort (leonurus japonicus) extract, especially in the first and second trimesters.
Motherwort (leonurus japonicus) extract may have blood-thinning properties, increasing the risk of excessive bleeding.
This can be hazardous for individuals with bleeding disorders (e.g., hemophilia) or those taking blood thinners like warfarin or aspirin.
Due to its anticoagulant effects, Motherwort (leonurus japonicus) extract should not be taken before or after surgery as it could lead to increased bleeding.
Motherwort (leonurus japonicus) extract is known to lower blood pressure, which may be beneficial for individuals with hypertension but dangerous for those who already have low blood pressure.
It may exacerbate symptoms of hypotension, such as dizziness, fainting, or fatigue.
Although motherwort is often used as a heart tonic, it can interact with certain heart conditions.
Individuals with specific cardiovascular issues, such as arrhythmias or congestive heart failure, should use it with caution and under medical supervision, as its effects on heart rate and rhythm are not fully predictable.
Some people may be allergic to plants in the mint family (Lamiaceae), which includes Motherwort (leonurus japonicus) extract.
Allergic reactions may manifest as skin irritation, rashes, or respiratory issues like difficulty breathing.
