MSA 70%

MSA 70% or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH3SO3H and structure H3C−S(=O)2−OH. 
MSA 70% is also a primary ingredient in rust remover and descaler. 
MSA 70% is recommended in formulation for removing rust from ceramic, tiles and porcelain surfaces which are usually susceptible to acid attack.

CAS Number: 75-75-2
Molecular Formula: CH4O3S
Molecular Weight: 96.11
EINECS Number: 200-898-6

Synonyms: METHANESULFONIC ACID, 75-75-2, Methylsulfonic acid, Methanesulphonic acid, Mesylic acid, Methanesulfonicacid, Sulfomethane, Kyselina methansulfonova, Methansulfonsaeure, NSC 3718, CCRIS 2783, HSDB 5004, EINECS 200-898-6, METHANE SULFONIC ACID, BRN 1446024, DTXSID4026422, MSA, UNII-12EH9M7279, CHEBI:27376, Kyselina methansulfonova [Czech], AI3-28532, NSC-3718, CH3SO3H, MFCD00007518, CH4O3S, 12EH9M7279, DTXCID806422, 22515-76-0, NSC3718, EC 200-898-6, 4-04-00-00010 (Beilstein Handbook Reference), J1.465F, ammoniummethanesulfonate, METHANESULFONIC ACID (II), METHANESULFONIC ACID [II], CH4O3S.H3N, C-H4-O3-S.H3-N, Methanesulfonic acid, ammonium salt, Methanesulfonic acid, ammonium salt (1:1), metanesulfonic acid, methansulfonic acid, MsOH, methansulphonic acid, methylsulphonic acid, 03S, methyl sulfonic acid, methyl-sulfonic acid, methane-sulfonic acid, MeSO3H, methane sulphonic acid, methanesulphonic-acid-, LACTIC ACID(DL), CH3SO2OH, H3CSO3H, WLN: WSQ1, Methanesulfonic acid solution, Methanesulfonic acid, 99.5%, Methanesulfonic acid, anhydrous, CHEMBL3039600, DL-MALICACIDMONOSODIUMSALT, Methanesulfonic Acid (CH3SO3H), METHANESULFONIC ACID [MI], Methanesulfonic acid, HPLC grade, Methanesulfonic acid, >=99.0%, METHANESULFONIC ACID [HSDB], Tox21_201073, STL264182, AKOS009146947, AT25153, CAS-75-75-2, NCGC00248914-01, NCGC00258626-01, BP-12823, LS-90299, FT-0628287, M0093, M2059, EN300-29198, Methanesulfonic acid, >=99.0%, ReagentPlus(R), Methanesulfonic acid, for HPLC, >=99.5% (T), A934985, Q414168, J-521696, Methanesulfonic acid, Vetec(TM) reagent grade, 98%, F1908-0093, Z281776238, InChI=1/CH4O3S/c1-5(2,3)4/h1H3,(H,2,3,4

MSA 70% is the simplest of the alkylsulfonic acids (R−S(=O)2−OH). 
Salts and esters of MSA 70% are known as mesylates (or methanesulfonates, as in ethyl methanesulfonate). 
MSA 70% is hygroscopic in its concentrated form. 

MSA 70% can dissolve a wide range of metal salts, many of them in significantly higher concentrations than in hydrochloric acid (HCl) or sulfuric acid (H2SO4).
MSA 70% solution is used virtually in all electronic applications involving tin or tin-alloy plating from non fluoborate systems. 
MSA 70% replaces phosphoric acid in detergent formulations, thereby helping to avoid environmental phosphate pollution. 

MSA 70%, the simplest alkanesulfonic acid, is a colorless or slightly brown oily liquid, appearing as solid at low temperatures. 
MSA 70% has a melting temperature of 20 °C, the boiling point of 167 °C (13.33 kPa), 122 °C (0.133 kPa),  the relative density of 1.4812 (18 ℃) and refractive index 1.4317 (16 ℃). 
MSA 70% is soluble in water, alcohol and ether, insoluble in alkanes, benzene and toluene. 

MSA 70% will not subject to decomposition in boiling water and hot alkaline solution. 
MSA 70% also has strong corrosion effect against the metal iron, copper and lead.
MSA 70% is a colourless or light yellow liquid having a melting point of 20° C, is a strong acid acting corroding but not oxidizing.

MSA 70% is used in the electroplating industry and for organic syntheses, in particular as a catalyst for alkylations, esterifications, and polymerizations. 
Beyond that, MSA 70% is used as a starting material for the preparation of methanesulfonyl chloride.
MSA 70% is a strong organic acid widely used as a catalyst for esterification and alkylation. 

Strong acid, biodegradable, non-oxidizing and non-foaming, compatible with oxidant and biocide.
MSA 70%, also known as methylsulfonic acid or methane sulfonate, is a strong organic acid with the chemical formula CH3SO3H. 
MSA 70% is a colorless, odorless liquid that is highly soluble in water. 

MSA 70% is classified as a sulfonic acid because it has a sulfonyl (SO3H) functional group attached to a methyl (CH3) group.
MSA 70% is often used as a substitute for sulfuric acid (H2SO4) in various chemical processes because it is less corrosive and volatile. 
MSA 70% is commonly employed as a catalyst, acidifier, or pH adjuster in organic synthesis, electroplating, and other industrial applications. 

MSA 70% mild and non-oxidizing nature makes it useful in situations where strong acids like sulfuric acid may be too harsh.
MSA 70%  refers to the concentration of MSA in a solution. 
In this case, MSA 70% means that the solution contains 70% by weight of pure MSA, with the remaining 30% typically being water. 

Different concentrations of MSA 70% can be prepared depending on the specific application's requirements.
MSA 70% is used in the preparation of polyaniline/graphene nanocomposites, which enhances its thermal and electrical properties. 
MSA 70% is utilized for electropolishing of aluminum as well as in electroplating of noble metals like gold, platinum, palladium and their alloys.

MSA 70% is considered a particularly suitable supporting electrolyte for electrochemical applications, where it stands as an environmentally friendly alternative to other acid electrolytes used in plating processes.
MSA 70% is a strong organic acid. 
The chemical oxidation of dimetyl sulfide in the atmosphere leads to the formation of MSA in large quantities. 

MSA 70% undergoes biodegradation by forming CO2 and sulphate. 
MSA 70% is considered a green acid as it is less toxic and corrosive in comparison to mineral acids.
The aqueous MSA 70% solution has been considered a model electrolyte for electrochemical processes.

MSA 70% is an alkanesulfonic acid in which the alkyl group directly linked to the sulfo functionality is methyl. 
MSA 70% has a role as an Escherichia coli metabolite. 
MSA 70% is an alkanesulfonic acid and a one-carbon compound. 

MSA 70% is a conjugate acid of a methanesulfonate.
MSA 70% is produced predominantly by oxidizing methylthiol or dimethyl disulfide using nitric acid, hydrogen peroxide, chlorine or by employing electrochemical processes.

Melting point: 17-19 °C (lit.)
Boiling point: 167 °C/10 mmHg (lit.)
Density: 1.475-1.485 g/mL at 20 °C 1.481 g/mL at 25 °C (lit.)
vapor density: 3.3 (vs air)
vapor pressure: 1 mm Hg ( 20 °C)
refractive index: n20/D 1.429(lit.)
Flash point: >230 °F
storage temp.: 2-8°C
solubility: water: soluble1,000 g/L at 20°C
pka: -2.6(at 25℃)
form: Solution
color: brown
Specific Gravity: 1.48 (18/4℃)
Water Solubility: Miscible with water. Slightly miscible with benzene and toluene. Immiscible: with paraffins.
λmax λ: 240-320 nm Amax: <0.4
Sensitive: Light Sensitive & Hygroscopic
Merck: 14,5954
BRN: 1446024

MSA 70% is a strong acid with a pKa (acid dissociation constant) of about -1.9, making it significantly more acidic than acetic acid (vinegar) or many other common organic acids. 
MSA 70% is highly soluble in water, which makes it suitable for various aqueous processes and reactions.
MSA 70% should be stored in a cool, dry place away from incompatible materials. 

MSA 70% should be kept in containers made of materials resistant to acids, such as glass or certain plastics.
MSA 70% is often used as a milder and safer alternative to mineral acids like sulfuric acid (H2SO4) and hydrochloric acid (HCl) in laboratory settings and industrial processes. 
Its reduced corrosiveness and lower volatility make it a preferred choice in situations where worker safety and equipment preservation are essential.

MSA 70% is compatible with a wide range of organic compounds, which makes it useful in various organic syntheses and reactions. 
MSA 70% can serve as a solvent, acid catalyst, or reagent in reactions involving a variety of functional groups.
Like other acids, MSA 70% can be neutralized with bases such as sodium hydroxide (NaOH) or potassium hydroxide (KOH) to form salts, for instance, sodium methane sulfonate or potassium methane sulfonate.

In the pharmaceutical industry, MSA 70% is used in the production of certain pharmaceutical intermediates and active pharmaceutical ingredients (APIs).
Its high purity and low residue levels are advantageous in drug manufacturing.
MSA 70% can be used in analytical chemistry techniques such as ion chromatography, where it serves as a highly stable and inert mobile phase component for separating ions in solution.

MSA 70% is less likely to corrode or react with metals, which is advantageous when it is used in metal-related applications like electroplating.
MSA 70% is generally recognized as safe (GRAS) when used in food and pharmaceutical applications within established guidelines.
 
MSA 70% is essential to ensure compliance with local regulations and quality standards when using MSA in various industries.
MSA 70%, it is important to follow the appropriate regulations for hazardous materials, including labeling, packaging, and safety precautions, to prevent accidents and ensure worker safety.

Production method Of MSA 70%:
MSA 70% can be obtained through the nitrate oxidation of thiocyanate methyl. 
Nitric acid and negative water are heated carefully to 80-88 °C with fractional addition of methyl thiocyanate and the temperature being automatically rose to about 105 ℃. 
After the reaction becomes mild, the reaction was heated to 120 ° C and reacted for 5 hours to obtain a crude product. 

The crude product was diluted with exchanged water and adjusted to pH 8-9 by addition of 25% barium hydroxide solution and filtered. 
The filtrate is condensed to until crystalline precipitation. 
The crystal is washed by methanol to remove the nitrate to obtain the barium methanesulfonate. 

It is then added to the exchanged water to boiling, add sulfuric acid for decomposition while it is hot, filter and the filtrate was concentrated under vacuum to no water to obtain the finished product.
Another method is that the methyl isothiourea sulfate is successively subject to chlorination, oxidation and hydrolysis to derive the finished product. 

Methyl isothiourea sulfate was added to the water; and the chlorine is sent into at 20-25 ° C to until phenomenon such as solution color is turned into yellow; oil layer emerges in the bottom of the bottle; the temperature drop and large number of residual chlorine is discharged from the exhaust pipe; this indicates the end point of the reaction. 
The reaction solution was extracted with chloroform. 

After drying, the extract was distilled at 60-62 ° C under normal pressure to remove the chloroform, and then further subject to distillation under reduced pressure. 
Collect the 60-65 °C (2.67 kPa) fraction was to obtain the methanesulfonyl chloride. 

Add the base drop wise under stirring to 80 ℃ hot water and maintain the heat hydrolysis for about 2h, to until the reaction liquid droplets completely disappear. 
The reaction solution was concentrated under reduced pressure to a syrupy form, diluted with water, and concentrated under reduced pressure to until no more water was distilled off to obtain methanesulfonic acid.

MSA 70% is a strong, odorless and less corrosive acid. 
MSA 70% is not harmful to systems, employees, customers, waste management or the environment when used in chemical synthesis, metal refinement or industrial cleaning. 
MSA 70% can be used sparingly and saves energy. 

Additional advantages are the high solubility of MSA 70%s salts, its lack of color and the fact that it is readily biodegradable (according to OECD Directive 301 A). 
The acid strength of the organic methane sulphonic acid is between that of carboxylic acids and strong mineral acids. 
Since methane sulphonic acid is odorless, MSA 70% may also be used in odor-sensitive applications. 

MSA 70%s lack of smell also increases safety at work because it does not produce any acrid fumes. 
MSA 70% is very suitable for neutralisation of vegetable oils with high FFA content.

Uses Of MSA 70%:
MSA 70% is used as a catalyst in a variety of organic reactions, including esterification, etherification, and alkylation reactions.
MSA 70% is employed in the electroplating industry to improve the quality of metal coatings.
MSA 70% is used in the synthesis of pharmaceuticals and fine chemicals.

MSA 70%'s used for dyeing textiles and leather.
MSA 70% can be used in the oil and gas industry for acidizing reservoirs.
MSA 70% is a versatile acid catalyst in various organic reactions, such as esterification, etherification, and alkylation. 

MSA 70% facilitates chemical reactions by donating protons (H+) to reactants, enabling the formation of new bonds and the synthesis of desired compounds.
MSA 70% is used in the electroplating industry to improve the quality of metal coatings. 
MSA 70% can be employed as an additive in electroplating baths to enhance the deposition of metal layers onto surfaces, providing improved adhesion and uniformity.

MSA 70% finds application in the synthesis of pharmaceutical intermediates and active pharmaceutical ingredients (APIs). 
Its high purity and low residue levels are advantageous in drug manufacturing processes where the presence of impurities can be detrimental.

MSA 70% is utilized in the dyeing of textiles and leather. 
MSA 70% serves as a strong acid to help fix dyes onto fabric or leather surfaces, enhancing colorfastness and dye adherence.
In the oil and gas industry, MSA 70% can be used for acidizing reservoirs. 

MSA 70% helps improve the permeability of rock formations in oil and gas wells by dissolving mineral deposits and increasing the flow of hydrocarbons.
MSA 70% is used as a component of mobile phases in ion chromatography, a technique employed for separating and analyzing ions in solution. 
Its stability and low reactivity make it suitable for this purpose.

MSA 70% is often used in research laboratories as a milder alternative to stronger mineral acids like sulfuric acid or hydrochloric acid. 
MSA 70% can be employed for tasks such as acid-catalyzed reactions or pH adjustments in various experiments.
MSA 70% is sometimes used as a pH adjuster and acidulant in certain food products. 

MSA 70%s use is regulated to ensure food safety and quality.
MSA 70% has been used in photography, particularly in the preparation of photographic developers.
MSA 70% can be found in some cleaning products where its acidity helps in removing mineral deposits, scale, and stains.

MSA 70% is employed in polymerization reactions, including the production of certain types of resins, plastics, and polymeric materials. 
Its acidic nature can initiate and control polymerization processes.
MSA 70% is useful for synthesizing various organic compounds, including fragrances, flavors, and specialty chemicals. 

MSA 70% can be involved in reactions that create valuable intermediates for these industries.
MSA 70% can be used for descaling and removing oxide layers from metal surfaces, preparing them for subsequent treatments or coatings.
MSA 70% can be used for pH adjustment and water treatment processes, particularly in situations where a strong acid is needed to neutralize alkaline water or control the pH of industrial wastewater.

MSA 70% finds use in electronics manufacturing for cleaning and etching printed circuit boards (PCBs) and other electronic components.
MSA 70% can be used in the production of adhesives and sealants, where it can act as a curing agent or catalyst.
In the oil refining industry, MSA 70% can be used as a catalyst or acid in certain refining processes to improve the quality of petroleum products.

MSA 70% is used as a reagent in various chemical analyses and assays, especially when a strong acid is required for sample preparation or digestion.
MSA 70% is sometimes used for pH adjustment in industrial processes where precise control of acidity is necessary.
MSA 70% can be used in biotechnology and molecular biology applications, such as DNA and RNA purification and protein purification processes.

MSA 70% is a raw material for medicine and pesticide. 
MSA 70% can also be used as dehydrating agent, curing accelerator for coating, treating agent for fiber, solvent, catalysis, and esterification as well as polymerization reaction.
MSA 70% can be used as solvent, alkylation, catalyst of esterification and polymerization, also used in medicine and electroplating industry. 

MSA 70% can also be applied to oxidation.
MSA 70% has been developed as an esterification catalyst in place of sulfuric acid for the synthesis of resins in paints and coatings. 
One of the major advantages of MSA 70% over sulfuric acid is that it is not an oxidizing species.

MSA 70% solution is used virtually in all electronic applications involving tin or tin-alloy plating from non fluoborate systems. 
MSA 70% replaces phosphoric acid in detergent formulations, thereby helping to avoid environmental phosphate pollution. 
MSA 70% is used in the preparation of polyaniline/graphene nanocomposites, which enhances its thermal and electrical properties. 

MSA 70% is utilized for electropolishing of aluminum as well as in electroplating of noble metals like gold, platinum, palladium and their alloys.
MSA 70% is used as a catalyst in organic reactions namely esterification, alkylation and condensation reactions due to its non- volatile nature and solubility in organic solvents. 

MSA 70% is also involved in the production of starch esters, wax oxidate esters, benzoic acid esters, phenolic esters, or alkyl esters. 
MSA 70% reacts with sodium borohydride in presence of polar solvent tetrahydrofuran to prepare borane-tetrahydrofuran complex. 
It finds application in batteries, because of its purity and chloride absence. 

In pharmaceutical industry, MSA 70% is used for the manufacturing of active pharmaceutical ingredients like telmisartan and eprosartan. 
MSA 70% is useful in ion chromatography and is a source of carbon and energy for some gram-negative methylotropic bacteria.
MSA 70% is involved in the deprotection of peptides.

Safety Profile Of MSA 70%:
MSA 70% is considered less hazardous than some other strong acids like sulfuric acid, it is still corrosive and should be handled with care.
Proper safety measures, including the use of appropriate protective gear like gloves and goggles, should be followed when working with MSA 70%.
MSA 70% is considered to be less environmentally harmful than many other strong acids, especially when it comes to disposal. 

MSA 70% is less likely to produce environmentally damaging byproducts when handled and disposed of properly.
Poison by ingestion and intraperitoneal routes. 
MSA 70% may be corrosive to skin, eyes, and mucous membranes. 

Explosive reaction with ethyl vinyl ether. 
Incompatible with hydrogen fluoride. 
When heated to decomposition MSA 70% emits toxic fumes of SOx.