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Myristic acid isopropyl ester is used in many applications, including pharma, food and personal care product manufacturing.
Myristic acid isopropyl ester is an ester of isopropyl alcohol myristic acid.
Myristic acid isopropyl ester is mainly used as a solubilizer, emulsifier and emollient in cosmetic and topical medicines.
CAS Number: 110-27-0
Molecular Formula: C17H34O2
Molecular Weight: 270.45
EINECS Number: 203-751-4
Synonyms: Isopropyl Myristate, Isopropyl Tetradecanoate, Tetradecanoic Acid 1-Methylethyl Ester, Myristic Acid Isopropyl Ester, Tetradecanoic Acid Isopropyl Ester, 1-Methylethyl Tetradecanoate, Propan-2-yl Tetradecanoate, Isopropylmyristate, Tetradecanoic Acid 1-Methylethyl Ester, 1-Tridecanecarboxylic Acid Isopropyl Ester, Bisomel, Estergel, Isomyst, Deltyl Extra, Deltylextra, Kesscomir, Promyr, Crodamol IPM, Crodamol I.P.M., Tegester, Wickenol 101, Sinnoester MIP, Plymouth IPM, Starfol IPM, Unimate IPM, Kessco IPM, Kessco Isopropyl Myristate, Stepan D-50, Emcol-IM, Emerest 2314, JA-FA IPM Isopropyl Myristate, 96% 25GR;IPM 100;IPM-EX;IPM-R;Radia 7730 (IPM);Isopropyl myristate Vetec(TM) reagent grade, 98%;MYRISTIC ACID ISOPROPYL ESTER MINIMU;ISO-PROPYL N-TETRADECANOATE
Myristic acid isopropyl ester is a colorless and odorless liquid with a faint odor, and miscible with vegetable oil.
Myristic acid isopropyl ester is not easy to be either hydrolyzed or become rancid.
The refractive index nD20 is 1.435~1.438, and the relative density (20°C) is 0.85~0.86.
Myristic acid isopropyl ester also finds applications as a flavoring agent in the food industry.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Myristic acid isopropyl ester is the ester of isopropyl alcohol and myristic acid.
Myristic acid isopropyl ester mainly works as an emollient in cosmetics and personal care products.
It has an oily base with low viscosity and adapts well to the skin.
Myristic acid isopropyl ester is an ester of isopropyl alcohol and myristic acid (vegetable-derived).
Low viscosity fluid non-greasy emollient, tolerates wide pH range, compatible with most surfactants.
Thanks to its low viscosity and density, it has a high spreadability.
Specific gravity 0.85 (at 20°C) superior emollient for non-greasy bath, body and baby oils.
Lubricant and compression aid for pressed powders light & non-tacky emollient for creams and lotions.
Readily adsorbed by the skin when used at high concentrations it gently lifts makeup and surface dirt.
Gives gloss and shine to hair resistant to oxidation (does not become rancid).
Myristic acid isopropyl ester is a lipophilic ester formed from the reaction of myristic acid and isopropyl alcohol.
It is listed in the CosIng database (European Commission) as an emollient, solvent, and skin-conditioning agent.
Myristic acid isopropyl ester, commonly known as isopropyl myristate, is an ester formed by the reaction of myristic acid with isopropyl alcohol.
Myristic acid isopropyl ester is a clear, colorless to pale yellow oily liquid with a mild odor and excellent spreading properties.
It is highly lipophilic and insoluble in water but readily soluble in oils, hydrocarbons, and many organic solvents.
Myristic acid isopropyl ester exhibits low viscosity and good lubricity, making it effective as an emollient and skin-conditioning agent.
It penetrates the stratum corneum easily and improves the delivery of active ingredients in topical formulations.
It provides a smooth, non-greasy feel and enhances sensory performance in cosmetic products.
Myristic acid isopropyl ester is chemically stable under normal storage conditions and shows good resistance to oxidation and hydrolysis.
It maintains clarity and consistency across a wide temperature range.
Myristic acid isopropyl ester is compatible with a wide range of cosmetic oils, waxes, silicones, and surfactants.
Myristic acid isopropyl ester is widely used in cosmetics, personal care products, and pharmaceutical topical preparations.
It is applied in creams, lotions, sunscreens, makeup, hair care products, massage oils, and dermatological formulations.
Myristic acid isopropyl ester also functions as a solvent, dispersing agent, and fragrance carrier in specialty formulations.
Melting point: ~3 °C
Boiling point: 193 °C at 20 mmHg
Density: 0.85 g/mL at 25 °C
Specific gravity: 0.855 (20/4 °C)
Vapor pressure: <1 hPa at 20 °C
Refractive index: n20/D 1.434
FEMA number: 3556 (Isopropyl myristate)
Flash point: >230 °F
Storage temperature: 2–8 °C
Solubility: <0.05 mg/L
Form: Liquid
Color: Clear
Odor: Odorless
Biological source: Synthetic (organic)
Viscosity: 4.8 cP at 25 °C
Myristic acid isopropyl ester is a clear, colorless, practically odorless liquid of low viscosity that congeals at about 5°C.
Myristic acid isopropyl ester consists of esters of propan-2-ol and saturated high molecular weight fatty acids, principally myristic acid.
Myristic acid isopropyl ester may be prepared either by the esterification of myristic acid with propan-2-ol or by the reaction of myristoyl chloride and propan-2-ol with the aid of a suitable dehydrochlorinating agent.
Myristic acid isopropyl ester a high-purity material is also commercially available, produced by enzymatic esterification at low temperature.
Myristic acid isopropyl ester is used to change the physicochemical characteristics of microsheres such as poly(lactic-co-glycolic acid) (PLGA) microspheres.
Myristic acid isopropyl ester is used as a oil phase component in the formulaton of microemulsion systems.
Myristic acid isopropyl ester is used in pharmaceutical preparations because it improves solubility and increases absorption through the skin.
External uses include a non-irritating iodine preparation for disinfecting the skin and aerosol bactericidal preparations for feminine hygiene use without irritation of the skin and mucous membranes.
Preparations for internal use include oral steroid formulations (Hirata, 1970) and anaesthetic injection solutions.
When Myristic acid isopropyl ester comes into contact with rubber, there is a drop in viscosity with concomitant swelling and partial dissolution of the rubber; contact with plastics, e.g. nylon and polyethylene, results in swelling.
Myristic acid isopropyl ester is incompatible with hard paraffin, producing a granular mixture.
It is also incompatible with strong oxidizing agents.
Myristic acid isopropyl ester is a highly refined and distilled ester obtained by the esterification of isopropyl alcohol with myristic acid.
It is a water-clear, low viscous oily liquid with a very good spreading capacity on the skin.
Myristic acid isopropyl ester is mainly used in cosmetics as an oil component for emulsions, bath oils and as a solvent for active substances.
Myristic acid isopropyl ester, also known as isopropyl myristate, is a fatty acid ester derived from the esterification of myristic acid and isopropyl alcohol.
It has a molecular structure that provides excellent spreading ability and rapid skin absorption.
It appears as a clear, colorless to pale yellow oily liquid with a faint characteristic odor.
Myristic acid isopropyl ester has low surface tension, which allows it to wet and coat surfaces efficiently.
It reduces friction and provides lubricating properties in both cosmetic and industrial applications.
It improves texture, slip, and smoothness when blended into formulations.
Myristic acid isopropyl ester is insoluble in water but highly soluble in mineral oils, vegetable oils, esters, and aromatic solvents.
It exhibits good chemical compatibility with emulsifiers, polymers, fragrances, and active ingredients.
It helps stabilize emulsions by improving oil phase uniformity.
Myristic acid isopropyl ester demonstrates good oxidative stability and maintains performance under normal light and temperature conditions.
It resists crystallization and remains fluid at low temperatures compared with long-chain fatty esters.
It supports long shelf life in properly sealed containers.
Myristic acid isopropyl ester is commonly used as a penetration enhancer in pharmaceutical topical products.
It facilitates transdermal delivery of active pharmaceutical ingredients by increasing skin permeability.
It improves bioavailability of drugs applied to the skin.
Myristic acid isopropyl ester is also used in fragrance formulations as a carrier solvent and fixative.
It helps dissolve aroma compounds and ensures even fragrance distribution.
Myristic acid isopropyl ester contributes to long-lasting scent performance in finished products.
Uses:
Myristic acid isopropyl ester is a fatty acid ester which is used as solvent in water-in-oil emulsion, oils and fatty based ointments.
The use of IPM is recommended in the Sterility Test chapter of the European, Japanese and United States Pharmacopoeia as diluent for oils and oily solutions, as well as for ointments and creams.
Indeed, its solvent properties improve the filterability of these samples.
Myristic acid isopropyl ester is known as a penetration enhancer for topical preparations.
Myristic acid isopropyl ester is a waterclear, low viscous oily liquid with a very good spreading capacity on the skin.
Myristic acid isopropyl ester is mainly used in cosmetics as an oilcomponent for emulsions, bath oils and as a solvent for active substances.
Myristic acid isopropyl ester is an emollient, moisturizer, binder, and skin softener that also assists in product penetration.
An ester of myristic acid, it is naturally occurring in coconut oil and nutmeg.
Although Myristic acid isopropyl ester is generally considered comedogenic, some ingredient manufacturers clearly specify non-comedogenicity on their data sheets.
In cosmetic and topical medicinal Preparations where good absorption through the skin is desired.
A jellied isopropyl myristate was marketed as Estergel (Merck & Co.).
Myristic acid isopropyl ester is a nongreasy emollient that is absorbed readily by the skin.
Myristic acid isopropyl ester is used as a component of semisolid bases and as a solvent for many substances applied topically.
Applications in topical pharmaceutical and cosmetic formulations include bath oils; make-up; hair and nail care products; creams; lotions; lip products; shaving products; skin lubricants; deodorants; otic suspensions; and vaginal creams.
For example, Myristic acid isopropyl ester is a self-emulsifying component of a proposed cold cream formula, which is suitable for use as a vehicle for drugs or dermatological actives; it is also used cosmetically in stable mixtures of water and glycerol.
Myristic acid isopropyl ester is used as a penetration enhancer for transdermal formulations, and has been used in conjunction with therapeutic ultrasound and iontophoresis.
It has been used in a water-oil gel prolonged-release emulsion and in various microemulsions.
Such microemulsions may increase bioavailability in topical and transdermal applications.
Myristic acid isopropyl ester has also been used in microspheres, and significantly increased the release of drug from etoposide-loaded microspheres.
Myristic acid isopropyl ester is a polar emollient and is used in cosmetic and topical pharmaceutical preparations where skin absorption is desired.
It is also used as a treatment for head lice.
Myristic acid isopropyl ester is also in flea and tick killing products for pets.
It is used to remove bacteria from the oral cavity as the non-aqueous component of the two-phase mouthwash product "Dentyl pH".
Myristic acid isopropyl ester is also used as a solvent in perfume materials, and in the removal process of prosthetic make-up.
Hydrolysis of the ester from isopropyl myristate can liberate the acid and the alcohol. The acid is theorized to be responsible for decreasing of the pH value of formulations.
Myristic acid isopropyl ester is widely used as an emollient in cosmetic and personal care formulations to soften and smooth the skin.
Myristic acid isopropyl ester improves spreadability and provides a light, non-greasy skin feel in creams, lotions, and serums.
It enhances sensory performance and consumer acceptance of finished products.
Myristic acid isopropyl ester is used as a solvent and carrier for fragrances, essential oils, and lipophilic active ingredients.
It improves solubility and stability of aromatic compounds in perfumes and cosmetic blends.
It ensures uniform distribution of active materials in formulations.
Myristic acid isopropyl ester is applied as a penetration enhancer in pharmaceutical topical products to increase skin absorption of drugs.
It improves transdermal delivery efficiency and bioavailability of active pharmaceutical ingredients.
It supports consistent therapeutic performance in dermatological preparations.
Myristic acid isopropyl ester is utilized in hair care products to improve shine, smoothness, and manageability.
It reduces friction between hair fibers and improves combing performance.
It helps prevent dryness and brittleness in treated hair.
Myristic acid isopropyl ester is incorporated into massage oils and aromatherapy blends to provide smooth glide and prolonged skin lubrication.
It reduces skin drag and improves comfort during massage treatments.
It supports even spreading of essential oils.
Myristic acid isopropyl ester is used in industrial formulations as a lubricant, plasticizer, and processing aid.
It improves flow properties and reduces surface friction in specialty coatings and polymer systems.
It supports improved processing efficiency and surface quality.
Safety Profile:
Myristic acid isopropyl ester is widely used in cosmetics and topical pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material.
Myristic acid isopropyl ester is generally considered to have low acute toxicity under normal handling conditions.
Prolonged or repeated skin contact may cause mild irritation or sensitization in sensitive individuals.
Eye contact may result in temporary redness, discomfort, and tearing.
Myristic acid isopropyl ester may cause respiratory irritation if mists or vapors are inhaled in poorly ventilated areas.
High airborne concentrations can lead to coughing or throat irritation.
Adequate ventilation is recommended during large-scale handling or spraying operations.
Myristic acid isopropyl ester may be harmful if swallowed in large quantities and can cause gastrointestinal discomfort.
Aspiration into the lungs during accidental ingestion may present a risk of chemical pneumonitis.
Medical attention should be sought if ingestion or aspiration is suspected.
Myristic acid isopropyl ester is combustible and can burn when exposed to high heat or open flame.
It should be stored away from ignition sources and strong oxidizing agents.
Containers should be kept tightly closed in a cool, dry, and well-ventilated area.
