N-CHLORO-P-TOLUENESULFONAMIDE

N-Chloro-p-toluenesulfonamide is a chlorinated sulfonamide compound used as an oxidizing and chlorinating agent in chemical processing and laboratory applications.
N-Chloro-p-toluenesulfonamide is closely related to Chloramine-T chemistry, and N-Chloro-p-toluenesulfonamide can act as a convenient source of “active chlorine” for controlled oxidative and chlorination reactions.
N-Chloro-p-toluenesulfonamide must be handled carefully because N-Chloro-p-toluenesulfonamide is an oxidizer, can irritate skin and eyes, and can release chlorine-containing gases under acidic or incompatible conditions.

CAS Number: 144-86-5
EC Number: Not consistently assigned (supplier and inventory dependent)
Molecular Formula: C7H8ClNO2S
Molecular Weight: 205.66 g/mol

Synonyms: N-Chloro-p-toluenesulfonamide, Tosylchloramide, p-Toluenesulfonamide N-chloro-, N-Chloro-4-methylbenzenesulfonamide, N-Chlorotoluene-p-sulfonamide, Chlorinated p-toluenesulfonamide, Active Chlorine Sulfonamide, Tosyl Chloramide, N-Chloro Tosylamide, N-Chloro-p-toluenesulfonamide Oxidant, N-Chloro-p-toluenesulfonamide Chlorinating Agent, Chloramine-T Related Compound, N-Chloro-p-toluenesulfonamide, N-chloro-p-toluenesulfonamide, N-CHLORO-P-TOLUENESULFONAMIDE, N-Chloro-p-toluenesulfonamide (chloramine-T related) (use context), N-Chloro-4-methylbenzenesulfonamide, N-chloro-4-methylbenzenesulfonamide, 4-Methylbenzenesulfonamide, N-chloro-, N-Chloro-4-methylbenzenesulfonamide sodium salt (Chloramine-T) (related), N-Chloro-p-toluenesulfonamide sodium salt (Chloramine-T) (related), p-Toluenesulfonamide, N-chloro- (generic), p-Toluenesulfonamide N-chloro (variant), N-Chloro p-toluenesulfonamide (no hyphen variant), N-Chloro-p-toluene sulfonamide (spacing variant), N-Chloro p-toluene sulfonamide (spacing variant), N-Chloro-para-toluenesulfonamide, N-chloro-para-toluenesulfonamide, para-Toluenesulfonamide, N-chloro-, 4-Methylbenzenesulfonamide, N-chloro-, p-CH3C6H4SO2NHCl (formula-style), p-CH3C6H4SO2NClH (formula-style), p-Tolylsulfonamide, N-chloro-, p-Tolylsulfonamide N-chloro (variant), N-Chloro-para-tolylsulfonamide, N-chloro-4-toluenesulfonamide (variant), N-Chloro-toluenesulfonamide (p-isomer) (descriptive)

APPLICATIONS

N-Chloro-p-toluenesulfonamide is used as an oxidizing reagent in organic synthesis to perform selective oxidation steps under controlled conditions.
N-Chloro-p-toluenesulfonamide is incorporated into laboratory protocols where a stable solid oxidant is preferred for convenience and dosing accuracy.
N-Chloro-p-toluenesulfonamide is used in small-scale synthesis routes to support clean reaction profiles in compatible solvent systems.

N-Chloro-p-toluenesulfonamide is used as a mild chlorinating agent to introduce chlorine functionality in selected organic transformations.
N-Chloro-p-toluenesulfonamide is incorporated into electrophilic chlorination reactions where controlled chlorine delivery is needed.
N-Chloro-p-toluenesulfonamide is used in method development as an alternative chlorine source in compatible chemistries.

N-Chloro-p-toluenesulfonamide is used in bromination and iodination support chemistry in some systems by generating reactive halogen species in situ.
N-Chloro-p-toluenesulfonamide is incorporated into oxidative halogenation reactions to improve control and reduce handling of more volatile halogen reagents.
N-Chloro-p-toluenesulfonamide is used in analytical reagent applications where halogen-based derivatization is required.

N-Chloro-p-toluenesulfonamide is used in research as a reagent for preparing N-chloro intermediates and testing oxidative mechanisms.
N-Chloro-p-toluenesulfonamide is incorporated into screening studies for oxidation catalysts and halogen-transfer reactions.
N-Chloro-p-toluenesulfonamide is used in teaching laboratories for demonstrations of controlled oxidation and active-chlorine chemistry in safe, supervised formats.

N-Chloro-p-toluenesulfonamide is used in disinfection-related chemistry concepts where active chlorine release is required in controlled, regulated contexts.
N-Chloro-p-toluenesulfonamide is incorporated into specialty cleaning and sanitizing formulations only when the final product design, regulations, and safety controls are appropriate.
N-Chloro-p-toluenesulfonamide is used in industrial hygiene and maintenance chemistry as a chlorine donor in niche, controlled-use applications.

N-Chloro-p-toluenesulfonamide is used in water-treatment and process-water maintenance concepts in certain applications where controlled oxidizing capacity is needed and permitted.
N-Chloro-p-toluenesulfonamide is incorporated into pilot studies to evaluate microbial control strategies in compatible systems.
N-Chloro-p-toluenesulfonamide is used where stable solid oxidizers simplify logistics compared with more unstable chlorine sources.

N-Chloro-p-toluenesulfonamide is used in pharmaceutical and fine chemical intermediate synthesis where selective oxidation or chlorination steps are required.
N-Chloro-p-toluenesulfonamide is incorporated into multi-step synthesis routes where reagent stability and reproducibility are important.
N-Chloro-p-toluenesulfonamide is used in route scouting to reduce variability in halogen-transfer steps.

N-Chloro-p-toluenesulfonamide is used in laboratory cleaning protocols for glassware and surfaces in limited, controlled contexts where oxidative cleaning is required.
N-Chloro-p-toluenesulfonamide is incorporated into specialty cleaning solutions where compatibility with materials and safety procedures are confirmed.
N-Chloro-p-toluenesulfonamide is used to support removal of certain organic residues through oxidation when appropriate.

N-Chloro-p-toluenesulfonamide is used in quality control laboratories as a reference reagent for titration and active-chlorine related testing methods in compatible procedures.
N-Chloro-p-toluenesulfonamide is incorporated into standardized tests where consistent oxidizing capacity is needed for repeatability.
N-Chloro-p-toluenesulfonamide is valued because N-Chloro-p-toluenesulfonamide provides a stable, weighable active-chlorine oxidant for controlled chemical transformations and specialty applications.

N-Chloro-p-toluenesulfonamide is used as a chlorinating agent in organic synthesis.
N-Chloro-p-toluenesulfonamide supports controlled introduction of chlorine into suitable substrates.
N-Chloro-p-toluenesulfonamide helps enable selective chlorination under mild laboratory conditions.

N-Chloro-p-toluenesulfonamide is used as an oxidizing agent in synthetic chemistry.
N-Chloro-p-toluenesulfonamide supports oxidation of selected functional groups in controlled reactions.
N-Chloro-p-toluenesulfonamide helps provide reproducible oxidant strength in small-scale synthesis.

N-Chloro-p-toluenesulfonamide is used as an electrophilic chlorine source for halogenation reactions.
N-Chloro-p-toluenesulfonamide supports chlorination of activated aromatic systems in some routes.
N-Chloro-p-toluenesulfonamide helps generate chlorinated intermediates for fine chemical production.

N-Chloro-p-toluenesulfonamide is used in preparation of sulfonamide derivatives in medicinal chemistry.
N-Chloro-p-toluenesulfonamide supports synthesis routes where N-chloro sulfonamides serve as intermediates.
N-Chloro-p-toluenesulfonamide helps create building blocks for further functionalization.

N-Chloro-p-toluenesulfonamide is used in synthesis of N-sulfonyl imines and related nitrogen-containing intermediates in some methods.
N-Chloro-p-toluenesulfonamide supports oxidation-chlorination sequences that generate reactive nitrogen species.
N-Chloro-p-toluenesulfonamide helps enable subsequent nucleophilic additions in research chemistry.

N-Chloro-p-toluenesulfonamide is used in preparation of chloramine-T type reagents and related oxidants.
N-Chloro-p-toluenesulfonamide supports standardization and reagent benchmarking in laboratory work.
N-Chloro-p-toluenesulfonamide helps provide a stable, weighable solid oxidant for routine use.

N-Chloro-p-toluenesulfonamide is used in analytical chemistry as an oxidant in iodometric and related titration methods.
N-Chloro-p-toluenesulfonamide supports oxidation steps that enable quantitation of reductants.
N-Chloro-p-toluenesulfonamide helps provide sharp endpoints in properly designed titration systems.

N-Chloro-p-toluenesulfonamide is used in bromination and iodination methods via halogen exchange concepts in some protocols.
N-Chloro-p-toluenesulfonamide supports in situ generation of active halogen species in controlled experiments.
N-Chloro-p-toluenesulfonamide helps create reactive halogenating conditions without handling elemental halogens directly.

N-Chloro-p-toluenesulfonamide is used in disinfection and sanitization formulations in laboratory and institutional contexts.
N-Chloro-p-toluenesulfonamide supports controlled release of active chlorine in aqueous solutions.
N-Chloro-p-toluenesulfonamide helps reduce microbial load on surfaces when used under approved protocols.

DESCRIPTION

N-Chloro-p-toluenesulfonamide is a chlorinated sulfonamide that can act as an “active chlorine” donor, enabling oxidation and chlorination reactions under controlled conditions.
N-Chloro-p-toluenesulfonamide is often discussed alongside Chloramine-T chemistry, and the sodium salt form is commonly used in similar active-chlorine applications, but N-Chloro-p-toluenesulfonamide refers to the non-sodium form.
N-Chloro-p-toluenesulfonamide is typically supplied as a crystalline solid, and N-Chloro-p-toluenesulfonamide should be protected from moisture and incompatible contaminants to maintain stability.

N-Chloro-p-toluenesulfonamide can react with acids to release chlorine-containing species, so N-Chloro-p-toluenesulfonamide must not be mixed with acids, ammonia, reducers, or incompatible organics without controlled procedures.
N-Chloro-p-toluenesulfonamide is an oxidizer, and N-Chloro-p-toluenesulfonamide can accelerate combustion of combustible materials under certain conditions.
N-Chloro-p-toluenesulfonamide handling should emphasize contamination control, dry tools, appropriate PPE, and avoidance of heat sources that could increase decomposition risk.

N-Chloro-p-toluenesulfonamide should be stored in tightly closed containers in a cool, dry, well-ventilated area away from direct sunlight.
N-Chloro-p-toluenesulfonamide should be kept away from reducing agents, acids, bases, amines, and metal salts that may catalyze decomposition.
N-Chloro-p-toluenesulfonamide should be used with good laboratory and industrial hygiene practices and disposed of according to local hazardous waste requirements.

N-Chloro-p-toluenesulfonamide is a chlorine-releasing sulfonamide compound commonly known as chloramine-T.
N-Chloro-p-toluenesulfonamide is typically supplied as a white to off-white crystalline powder.
N-Chloro-p-toluenesulfonamide provides active chlorine and functions as an oxidizing and chlorinating reagent.

N-Chloro-p-toluenesulfonamide is soluble in water, forming solutions that release oxidizing chlorine species.
N-Chloro-p-toluenesulfonamide reactivity depends on pH, concentration, and organic load in solution.
N-Chloro-p-toluenesulfonamide can generate chlorinated byproducts when reacting with organic compounds.

N-Chloro-p-toluenesulfonamide is used in laboratories because it is a stable, weighable solid oxidant.
N-Chloro-p-toluenesulfonamide can substitute for less stable hypochlorite solutions in some protocols.
N-Chloro-p-toluenesulfonamide can enable controlled chlorination without handling chlorine gas.

N-Chloro-p-toluenesulfonamide should be kept away from reducing agents, acids, and combustible materials.
N-Chloro-p-toluenesulfonamide can release chlorine or other reactive species under acidic conditions.
N-Chloro-p-toluenesulfonamide requires strict segregation and compatible storage because it is an oxidizer.

N-Chloro-p-toluenesulfonamide can irritate skin, eyes, and respiratory tract, and sensitization is possible with exposure.
N-Chloro-p-toluenesulfonamide handling requires gloves, goggles, dust control, and good ventilation.
N-Chloro-p-toluenesulfonamide safe use depends on following supplier SDS guidance and local regulations.

PROPERTIES

Chemical Formula: C7H8ClNO2S
Molecular Weight: 205.66 g/mol
Common Name: N-Chloro-p-toluenesulfonamide
Chemical Type: Chlorinated sulfonamide; oxidizing and chlorinating reagent
Appearance: White to off-white crystalline solid (grade dependent)
Odor: Slight characteristic odor (grade dependent)
Solubility: Limited water solubility; solubility depends on pH and solvent system (system dependent)
Oxidizing Capacity: Active-chlorine donor behavior (use and matrix dependent)
Reactivity: Reacts with acids and reducing agents; avoid incompatible mixtures
Stability: Stable under dry, cool storage; decomposition risk increases with heat, contamination, and incompatible chemicals
Hazard Profile: Oxidizer and irritant; avoid dust inhalation and contact
Storage Temperature: 15–25°C, dry, tightly closed, well ventilated
Shelf Life: Typically 24–36 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if dust is inhaled.
Seek medical attention if respiratory irritation persists.
Avoid breathing dust during handling and transfer.

Skin Contact:
Remove contaminated clothing and wash skin with soap and water.
Seek medical advice if irritation develops or persists.
Wash contaminated clothing before reuse.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention promptly if irritation persists.

Ingestion:
Rinse mouth with water and seek medical attention.
Do not induce vomiting unless directed by medical personnel.
Never give anything by mouth to an unconscious person.

Note to Physicians:
Treat symptomatically.
Consider oxidizer exposure and potential irritation to mucous membranes.
Provide supportive care based on exposure route and symptoms.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves, safety glasses or goggles, and protective clothing.
Avoid generating dust and avoid inhalation of fine particles.
Keep away from acids, reducing agents, ammonia, and combustible materials.

Ventilation:
Use local exhaust or general ventilation where dust may be generated.
Avoid confined spaces if reactions could release chlorine-containing fumes.
Maintain good airflow during weighing, charging, and mixing operations.

Storage:
Store in tightly closed containers in a cool, dry, well-ventilated place.
Protect from moisture, heat, and direct sunlight.
Segregate from acids, reducers, amines, and organic combustible materials.

Spill and Leak Procedures:
Avoid dust generation and collect spilled material using non-sparking tools.
Place collected material into suitable containers for disposal according to local regulations.
Clean residues with methods that avoid incompatible cleaners and prevent release to drains if required by site rules.

Handling Precautions:
Do not mix N-Chloro-p-toluenesulfonamide with acids or incompatible chemicals because hazardous gases can be released.
Use contamination control and dedicated tools to reduce decomposition risk and maintain consistent oxidizing performance.
Rotate stock using FIFO practices and keep containers sealed to preserve stability and predictable reactivity.