N-ETHYL PROPYLAMINE

N-Ethyl propylamine is also capable of forming hazardous derivatives, such as N-nitroso compounds, when it reacts with nitrosating agents, which are often carcinogenic. 
N-Ethyl propylamine is volatile, flammable, and has a strong ammonia-like odor, which makes exposure noticeable but also hazardous if not controlled. 
N-Ethyl propylamine is a chemically versatile secondary amine with important applications in organic synthesis, but it must be treated carefully due to its flammability, toxicity, and potential to form highly hazardous compounds.

CAS Number: 20193-20-8
Molecular Formula: C5H13N
Molecular Weight: 87.16
EINECS Number: 243-573-4

Synonyms: ethyl(nitroso)propylamine, N-Ethyl-N-nitroso-1-propanamide, 1-Propanamide, N-ethyl-N-nitroso-, NNitroso ethyl propylamine, 1Propanamide, NethylNnitroso, 867-022-8, RefChem:829967, 25413-61-0, N-Nitrosoethyl-N-propylamine, N-ethyl-N-propylnitrous amide, N-Ethyl-N-nitroso-1-propanamine, N-Ethyl-N-nitrosopropylamine, 1-Propanamine, N-ethyl-N-nitroso-, N- Nitroso N-Ethyl N-Propyl Amine, Propylamine, N-ethyl-N-nitroso-, Propylethylnitrosamine, 7Z64MW6LXM, N-Nitroso-athyl-n-propylamin, N-ethyl-N-propyl-nitrous amide, SCHEMBL11525062, DTXSID00948276, SRYOEGQUUQSLBH-UHFFFAOYSA-N, N-Nitroso N-Ethyl N-Propyl Amine, 1-Ethyl-2-oxo-1-propylhydrazine #, MFCD00015803, AKOS006280818, G77426, EN300-1296535, N-ETHYLPROPYLAMINE;N-Ethyl-1-propaneamine;1-propanamine,N-ethyl;1-Propanamine,N-ethyl-;Ethylpropylamine;ethyl-propyl-amine;N,N-Ethylpropylamine;n-ethyl-1-propanamin

N-Ethyl propylamine is an organic compound that belongs to the class of secondary amines, meaning that the nitrogen atom is bonded to two different alkyl groups, in this case, an ethyl group (–CH₂CH₃) and a propyl group (–CH₂CH₂CH₃). 
N-Ethyl propylamine is a colorless to pale yellow liquid with a strong, ammonia-like odor and is generally miscible with water and many organic solvents, which makes it relatively easy to handle in laboratory settings.
N-Ethyl propylamine has the formula C₅H₁₃N, and its structure features a nitrogen atom attached to a short chain ethyl group and a slightly longer propyl chain, giving it both basic properties and the ability to participate in nucleophilic reactions. 

N-Ethyl propylamine is often used as a building block in organic synthesis, including the preparation of pharmaceuticals, agrochemicals, and other nitrogen-containing compounds.
From a safety perspective, N-Ethyl propylamine is flammable and can cause severe irritation to the skin, eyes, and respiratory tract if inhaled or contacted. 
It should be handled with proper personal protective equipment, such as gloves and goggles, and stored in a cool, well-ventilated area away from oxidizing agents to prevent accidental reactions.

N-Ethyl propylamine, as a secondary aliphatic amine, serves as a key intermediate in the production of more complex nitrogen-containing chemicals. 
Its structure—comprising an ethyl and a propyl group bonded to nitrogen—makes it sufficiently reactive to participate in a variety of chemical reactions, such as alkylation, acylation, and nitrosation, without being as sterically hindered as tertiary amines. 
Because of this, it is widely used in synthetic organic chemistry, particularly in the manufacture of pharmaceuticals, where introducing specific alkylamine moieties can significantly alter the biological activity of a drug molecule. 

Additionally, N-Ethyl propylamine finds applications in the production of agrochemicals, rubber chemicals, and corrosion inhibitors, where its basicity and solubility allow it to function both as a reactant and a catalyst.
One of the most critical aspects of N-Ethylpropylamine’s chemistry is its ability to form N-nitroso derivatives, such as N-Ethyl-N-nitrosopropylamine, through reaction with nitrosating agents like nitrous acid. 

These N-nitroso compounds are of significant concern because they are highly toxic and carcinogenic, capable of causing DNA damage and mutagenic effects in living organisms. 
The formation of these compounds can occur unintentionally in industrial settings, particularly when amines are exposed to nitrites under acidic conditions, making careful process control, storage, and waste management essential.

Melting point    -75°C (estimate)
Boiling point    80-85°C
Density    0,72 g/cm3
vapor pressure    86hPa at 20℃
refractive index    1.3950-1.3980
Flash point    80-85°C
storage temp.    Refrigerator
solubility    Chloroform, Ethyl Acetate
pka    10.76±0.19(Predicted)
form    Liquid
Specific Gravity    0.748
color    Colourless

N-Ethyl propylamine is a secondary aliphatic amine, meaning it has a nitrogen atom bonded to two carbon-containing groups and one hydrogen atom. 
This molecular arrangement gives it basic chemical properties, allowing it to act as a proton acceptor in chemical reactions. 
Its boiling point is relatively low, which makes it a volatile liquid under standard conditions. 

Because of its small size and moderate polarity, it is soluble in both water and many organic solvents, including alcohols, ethers, and hydrocarbons, which makes it useful as a versatile intermediate in chemical syntheses.
In organic chemistry, N-Ethyl propylamine is often used as a starting material or reagent to introduce ethyl or propyl groups into larger molecules. 
It is commonly employed in the synthesis of amines, amides, and N-substituted nitrogen compounds, which are critical in producing pharmaceuticals, dyes, rubber accelerators, and agrochemicals. 

N-Ethyl propylamine nucleophilic nitrogen atom allows it to react with electrophiles, such as acyl chlorides or alkyl halides, under controlled conditions, forming a wide variety of functionalized nitrogen-containing products.
From a safety perspective, N-Ethyl propylamine is flammable and chemically reactive. 
Direct contact can result in skin burns or severe eye irritation, while inhalation of its vapors can lead to respiratory discomfort, coughing, or dizziness. 

Because of these hazards, handling N-Ethylpropylamine requires strict laboratory safety protocols, including working in a fume hood, using gloves and eye protection, and storing it away from acids, oxidizers, and sources of ignition.
Inhalation can lead to respiratory irritation, headaches, or dizziness, while prolonged skin contact can cause chemical burns or dermatitis. 
From a regulatory standpoint, handling this compound often requires adherence to strict occupational exposure limits, fume hood use, and protective equipment, as well as proper storage in tightly sealed containers away from oxidizers, acids, and sources of ignition.

N-Ethyl propylamine is a chemically versatile secondary amine that is highly valuable in industrial and laboratory synthesis but poses significant health and environmental hazards, especially when it reacts to form nitrosamines. 
Its dual nature—as a useful chemical building block and a potential precursor to dangerous derivatives—makes it a compound that must be treated with both technical precision and rigorous safety protocols.

Uses Of N-Ethyl propylamine:
N-Ethyl propylamine is used in the synthesis of neuraminidase inhibitors as well as non-peptide CRF-1 antagonists.
N-Ethyl propylamine has several important uses in chemical synthesis and industrial applications, primarily because it is a secondary amine with a reactive nitrogen atom capable of participating in a wide variety of chemical reactions. 
One of its most significant applications is as a building block in organic synthesis, where it is used to construct more complex nitrogen-containing molecules, such as pharmaceutical intermediates, agrochemicals, and specialty chemicals. 

Its chemical reactivity allows it to undergo alkylation, acylation, and condensation reactions, which makes it highly versatile for modifying molecular structures in drug development or in the synthesis of fine chemicals.
In the pharmaceutical industry, N-Ethyl propylamine is often employed to introduce ethyl and propyl amine moieties into drug candidates, which can improve their solubility, bioavailability, and pharmacological activity. 

N-Ethyl propylamine also serves as a precursor for the synthesis of N-nitroso compounds, which, while toxic, are sometimes used in chemical research to study mutagenicity or as intermediates in laboratory-scale reactions under highly controlled conditions.
Beyond pharmaceuticals, N-Ethyl propylamine finds use in the production of rubber chemicals, corrosion inhibitors, and dyes, where its basic nitrogen atom can interact with other chemical species to create functionalized additives that enhance material properties, prevent degradation, or act as catalysts. 

In some cases, it is also used as a solvent or co-solvent in organic reactions due to its moderate polarity and miscibility with both water and organic solvents.
However, because of its reactivity with nitrosating agents, one of its uses must be strictly controlled: it can react to form N-nitroso derivatives, which are potent carcinogens. 
This means that in industrial and laboratory applications, its use is always accompanied by careful monitoring, ventilation, and storage precautions to avoid accidental formation of toxic byproducts.

N-Ethyl propylamine is primarily used as a chemical intermediate, a reactive building block for pharmaceuticals and agrochemicals, and in the manufacture of functional additives, but its applications require strict safety measures due to its potential to form highly hazardous derivatives.
N-Ethyl propylamine is widely used in industrial and laboratory chemical synthesis due to its reactive secondary amine structure, which allows it to act as a nucleophile in numerous chemical reactions, including alkylation, acylation, and condensation processes. 

This makes it an essential intermediate in the synthesis of more complex organic molecules, such as pharmaceutical compounds, agrochemicals, and specialty chemical products. 
In the pharmaceutical industry specifically, it is utilized to introduce ethyl and propyl groups onto nitrogen atoms in drug molecules, which can improve the drug’s solubility, metabolic stability, and overall pharmacokinetic properties, thereby enhancing its therapeutic potential.
N-Ethyl propylamine is employed as a precursor for nitrogen-containing functional derivatives, including N-nitroso compounds, which, although toxic and potentially carcinogenic, are sometimes used in controlled laboratory experiments to study chemical reactivity, mutagenicity, or as intermediates in research-scale organic synthesis. 

Its ability to act as both a base and a nucleophile also makes it valuable in the production of rubber accelerators, corrosion inhibitors, and dyes, where it helps create functional additives that improve material durability, chemical resistance, or color properties.
N-Ethyl propylamine’s solubility in water and organic solvents allows it to be used as a co-solvent or reaction medium in certain chemical transformations, providing a suitable environment for reactions that require moderate polarity or compatibility with both hydrophilic and hydrophobic components. 
In industrial formulations, it can also serve as a reactive agent in the synthesis of surfactants and emulsifiers, where the nitrogen atom’s reactivity enables the formation of stable, functional chemical bonds.

Safety Profile Of N-Ethyl propylamine:
N-Ethyl propylamine is a flammable and volatile liquid with a strong, ammonia-like odor. 
It has a low flash point, meaning it can ignite easily when exposed to sparks, open flames, or high temperatures. 
N-Ethyl propylamine is also chemically reactive, particularly with oxidizers, acids, or nitrosating agents, which can lead to hazardous reactions, including fires, explosions, or formation of toxic compounds. 

Because of its volatility, inhalation exposure is a real risk if proper containment or ventilation is not used.
N-Ethyl propylamine can cause severe irritation to the skin, eyes, and respiratory tract. 
Direct contact may result in chemical burns, dermatitis, or eye damage, while inhalation of its vapors can produce coughing, shortness of breath, dizziness, nausea, or headaches. 

Prolonged or repeated exposure increases the risk of more serious health effects. 
Its toxicological risk is amplified by the fact that it can be converted into N-nitroso derivatives, such as N-Ethyl-N-nitrosopropylamine, which are potent carcinogens capable of causing DNA damage and increasing the risk of cancer in humans and animals.

N-Ethyl propylamine is also a hazardous substance for the environment, particularly aquatic ecosystems. 
If released into water bodies, it can increase local toxicity, harm aquatic life, and disrupt ecological balance due to its basicity and chemical reactivity. 
Proper disposal and spill containment are therefore critical to prevent environmental contamination.