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EC / List no.: 220-250-6
CAS no.: 2687-91-4
Mol. formula: C6H11NO
N-Ethylpyrrolidone (NEP) as an aprotic and highly polar organic solvent is completely miscible with water and is used as a replacement for N-Methylpyrrolidone (NMP) in many application fields such as the coatings industry and cleaning applications due to its very similar solvent properties.
Further application fields for N-Ethylpyrrolidone (NEP) include the pharmaceutical and electronic industries.
N-Ethylpyrrolidone is a special polar solvent for cleaning of metals, glasses and plastics; for pretreating of plastics, for polyurethane dispersions and for high polar resins and resin production
N-Ethylpyrrolidone is used in plastic coatings, for water-borne coatings, and for electro insulation coatings.
N-Ethylpyrrolidone (NEP) as an aprotic and highly polar organic solvent is completely miscible with water and is used as a replacement for N-Methylpyrrolidone (NMP) in many application fields such as the coatings industry and cleaning applications due to its very similar solvent properties.
Further application fields for NEP include the pharmaceutical and electronic industries.
N-Ethylpyrrolidone is a polar, aprotic, organic solvent that is completely miscible with water and dissolves many plastics like polyvinylpyrrolidone (PVP) and polyether sulfone (PES).
Description and uses:N-Ethylpyrrolidone and its derivatives are used as Intermediates for the synthesis of agrochemicals, pharmaceuticals, textile auxiliaries, plasticizers, polymer solvent, stabilizers, specialty inks and as a nylon precursor.
N-Ethylpyrrolidone is used as a solvent for paint stripping and resins, cleaner for polymeric residues, metal finishing, printed circuit board manufacturing, SBR latex production, pigment dispersant, extraction of acetylene and butadiene, dehydration of natural gas, lube oil processing.
N-Ethylpyrrolidone (NEP) is a clear, almost colorless liquid.It can be used for the following applications:
Microelectronics
Ethylpyrrolidone can be used as solvent in photoresist stripper formulations.
Electronics
Ethylpyrrolidone can be used in electrolyte formulations for electrolytic capacitors.
Cryogenic applications
Due to its low freezing point, ethylpyrrolidone is used as solvent in cryogenic reaction conditions.
Pharmaceuticals
Ethylpyrrolidone can be used as raw material for the production of several antipsychotics and Antibiotics.
Solvent for diclofenac in topical formulations, solvent in acne remedies.
Transdermal transport enhancer.
Lithographic printing
Ethylpyrrolidone can be used in dampening water for lithographic printing plates.
Jet printing ink
Ethylpyrrolidone is used in the formulation of jet printing ink.
Other
Liquid cleaning composition.
Solvent for radical polymerisation inhibitor.
Composition of detergent for liquid crystal cell.
Applications/uses
Industrial electronics
Paints & coatings
Pharmaceutical chemicals
Process solvents
N-Ethylpyrrolidone (NEP) as an aprotic and highly polar organic solvent is used as a replacement for N-Methylpyrrolidone (NMP) in cleaning applications due to its very similar solvent properties
Description: N-Ethylpyrrolidone-2 (NEP) Is a colorless to yellow liquid, with an amine like odor.
It is miscible in water and soluble in other organic solvents.
Applications: Intermediate used in the production of Cosmetic industry, Paint and printing ink industry, Paint strippers, Pharmaceuticals and Solvent/cleaner for polymeric residual
N- Ethyl Pyrrolidone is used in the following products: anti-freeze products, coating products, lubricants and greases, adhesives and sealants, air care products, non-metal-surface treatment products, inks and toners, leather treatment products, polishes and waxes and washing & cleaning products.
Other release to the environment of N- Ethyl Pyrrolidone is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
N- Ethyl Pyrrolidone is used in the following products: washing & cleaning products, coating products, laboratory chemicals and polymers.
N- Ethyl Pyrrolidone is used in the following products: laboratory chemicals.
Release to the environment of N- Ethyl Pyrrolidone can occur from industrial use: formulation of mixtures, manufacturing of the substance and formulation in materials.
N- Ethyl Pyrrolidone is used in the following products: laboratory chemicals, coating products, polymers, washing & cleaning products, water treatment chemicals and photo-chemicals.
N- Ethyl Pyrrolidone is used in the following areas: formulation of mixtures and/or re-packaging.
N- Ethyl Pyrrolidone is used for the manufacture of: chemicals.
Release to the environment of N- Ethyl Pyrrolidone can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid, of substances in closed systems with minimal release and as an intermediate step in further manufacturing of another substance (use of intermediates).
Household & Commercial/Institutional Products
Information on 1 consumer products that contain Ethyl Pyrrolidone in the following categories is provided:
• Home Maintenance
Uses
• General adhesives and binding agents for a variety of uses
• Relatived to the maintenance and repair of automobiles, products for cleaning and caring for automobiles (auto shampoo, polish/wax, undercarriage treatment, brake grease)
• Various types of paint for various uses
• Related to all forms of cleaning/washing, including cleaning products used in the home, laundry detergents, soaps, de-greasers, spot removers, etc; such as drycleaning, laundry, soap, window/floor, etc
• Detergents with wide variety of applications
• Fillers for paints, textiles, plastics, etc
• General adhesives and binding agents for a variety of uses
• If applied entry is related to the manufacturing process for the product, widely applied
• General term which includes clothes, shoes, backpacks/purses/luggage, jewelry, pet apparel, etc.; more specific terms (e.g. clothing, footwear, handwear)
• Drug product, or related to the manufacturing of drugs; modified by veterinary, animal, or pet if indicated by source
• Related to manufacturing for export
• Furniture, or the manufacturing of furniture (can include chairs and tables, and more general furniture such as mattresses, patio furniture, etc.)
• Inks used for printing or writing
• Leather products, and products/chemicals used in the process of tanning and dressing leather
• Related to metals - manufacturing of metals, casting of metals, production of metals, surface treatment of metals, etc
• Plastic products, industry for plastics, manufacturing of plastics, plastic additives
• Raw materials used in a variety of products and industries (e.g. in cosmetics, chemical manufacturing, production of metals, etc)
• Rubber products (e.g. tires) and their manufacture
• Textiles used for clothing or furniture upholstery, processes related to textiles (e.g. softeners, antiwrinkle agents), or the processing/manufacturing of textiles
• Soaps, includes personal care products for cleansing the hands or body, and soaps/detergents for cleaning products, homes, etc
• Related to photography, film, photographic equipment, photographic laboraties, photochemicals, and developing of photographs
• Paint removers, graffiti removers, or general solvents
• Paint and varnish removers
Industry Uses
• Intermediates
• Paint additives and coating additives not described by other categories
• Processing aids, not otherwise listed
• Solvents (for cleaning and degreasing)
• Solvents (which become part of product formulation or mixture)
Consumer Uses
• Paints and coatings
• Pharmaceutical
• Plastic and rubber products not covered elsewhere
General Manufacturing Information
Industry Processing Sectors
• Paint and coating manufacturing
• Pharmaceutical and medicine manufacturing
• Plastic material and resin manufacturing
• Printing ink manufacturing
• Textiles, apparel, and leather manufacturing
• Transportation equipment manufacturing
• Wholesale and retail trade
N-Ethyl Pyrrolidone (NEP, CAS No.2687-91-4) are widely used in industrial and professional applications including process chemicals, coatings, adhesives, agricultural chemicals, electronics, pigment dispersions and paint stripping and cleaning.
In Europe the only supported uses of NMP are in industrial and professional applications.
Workers may be exposed to N-Ethyl Pyrrolidone during such activities such as product transfer, repackaging, formulation, laboratory activities or as use as a component in professional or industrial products.
Whilst the exposure to N-Ethyl Pyrrolidone in manufacturing facilities is considered low because of enclosed process, storage and handling operations, worker exposure can still potentially occur during operations such as
product transfer, product sampling, or maintenance repair activities on product containing systems.
N-Ethyl Pyrrolidone are solvents that are miscible with water.
Depending on the application, N-Ethyl Pyrrolidone is used generally as an organic solvent, intermediate or surfactant in a range of industrial and consumer applications.
Products in Canada that contain N-Ethyl Pyrrolidone and that may be available to the general population include paint strippers.
As a replacement for NEP may be used in similar products as those identified for NMP.
Both substances are used in Canada in cosmetics and in certain food packaging materials.
N-Ethyl Pyrrolidone is a kind of organic synthesis intermediates,used for a variety of chemical synthesis,can also be used as an organic solvent,is mainly used in oil refining and the manufacture of gunpowder,lithium batteries,medicine,dyes pesticides,chemicals,paint,heat resistant high molecular weight polymer resin and adhesive,coating of degreasing agent,epoxy resin glue edge resection,acetylene,butadiene extraction,gas desulfurization,pesticide,synethetic fiber spinning medium,pigment dispersion etc.
Character:
N-Ethyl Pyrrolidone is colorless and transparent liquid,has the weak alkaline,boiling point:212ºC,is a strong polar organic solvent,with water and organic solvents miscible in any proportion.
N-Ethyl Pyrrolidone is a transdermal absorption-enhancing compound and mechanism of its effect on multilammellar liposome of stratum corneum lipid has been studied.
1-Ethyl-2-pyrrolidinone , its cas register number is 2687-91-4.
It also can be called N-Ethylpyrrolidinone ; NEP ; and N-Ethyl-2-pyrrolidone.
N-Ethyl Pyrrolidone is an organic compound consisting of a 5-membered lactam.
N-Ethyl Pyrrolidone is a colorless liquid, although impure samples can appear yellow.
N-Ethyl Pyrrolidone is miscible with water and with most common organic solvents.
N-Ethyl Pyrrolidone also belongs to the class of dipolar aprotic solvents such as dimethylformamide and dimethyl sulfoxide.
N-Ethyl Pyrrolidone is used in the petrochemical and plastics industries as a solvent, exploiting its nonvolatility and ability to dissolve diverse materials.
Preparation
N-Ethyl Pyrrolidone is produced industrially by a typical ester-to-amide conversion, by treating butyrolactone with methylamine.
Alternative routes include the partial hydrogenation of N-methylsuccinimide and the reaction of acrylonitrile with methylamine followed by hydrolysis.
About 20,000 to 30,000 tons are produced annually
Applications
N-Ethyl Pyrrolidone is used to recover certain hydrocarbons generated in the processing of petrochemicals, such as the recovery of 1,3-butadiene and acetylene.
N-Ethyl Pyrrolidone is used to absorb hydrogen sulfide from sour gas and hydrodesulfurization facilities.
Its good solvency properties have led to NMP's use to dissolve a wide range of polymers.
Specifically, it is used as a solvent for surface treatment of textiles, resins, and metal coated plastics or as a paint stripper.
N-Ethyl Pyrrolidone is also used as a solvent in the commercial preparation of polyphenylene sulfide.
In the pharmaceutical industry, N-methyl-2-pyrrolidone is used in the formulation for drugs by both oral and transdermal delivery routes.
N-Ethyl Pyrrolidonet is also used heavily in lithium ion battery fabrication, as a solvent for electrode preparation, though there is much effort to replace it with solvents of less environmental concern, like water.
SYNONYMS:
1-ethyl-2-pyrrolidinon
1-ethyl-pyrrolidin-2-one
2-Pyrrolidinone, 1-ethyl-
Agsol Ex 2
ethyl-2-pyrrolidone
N-Ethyl-2-pyrrolidinone
N-Ethylpyrrolidinone
N-Ethylpyrrolidone
1-ETHYL-2-PYRROLIDINONE
1-ETHYL-2-PYRROLIDONE
1-Ethyl-2-pyrrolidone 98%
DGTP 100MM PH7.0 BIOTECHNOLOGY GRADE
PROTEIN ASSAY BRADFORD METHOD BIOTECH GR
NEP N-Ethyl-2-azapentanone
1-Ethyl-2-pyrrolidinone for synthesis
NEP, N-Ethyl-2-pyrrolidone
ethyl-pyrrolidinone
1-Ethyl-2-pyrrolidinone(NEP)
N-Ethyl Pyrrolidone (NMP)
2-(methoxymethyl)oxolane
Amisulpride Impurity 6
NEP crystal
Sodium aminosalicylate Impurity 6
N-ETHYL-ALPHA-PYRROLIDONE
N-ETHYL-2-PYRROLIDONE
N-ETHYL-2-AZAPENTANONE
NEP
1-Ethyl-2-pyrrolidinone,98%
1-Ethylpyrrolidin-2-on
N-Ethyl-a-pyrrolidone
N-Ethyl-2-pyrrolidon
N-ETHYL-|á-PYRROLIDONE
N-Efhyl-2-Pyrrolidone
N-Second base-pyrrole alkane and ketone
Ethyl Pyrrolidone
39 kDa protein kinase
CAK1
CDK-activating kinase
CDKN7
Anti-DDR1 (AB2) antibody produced in rabbit
Anti-DDR1 (AB1) antibody produced in rabbit
discoidin domain receptor 1
Drd1
Anti-CDK7, C-Terminal antibody produced in rabbit
D(1A) dopamine receptor
Anti-PYK2, C-Terminal antibody produced in rabbit
IUPAC NAMES:
1- etilpirrolin-2-one
1-Ethyl-2-pyrrolidinon
1-Ethyl-2-pyrrolidinone
1-Ethyl-2-pyrrolidone
1-ETHYLPYRROLIDIN-2-ONE
1-Ethylpyrrolidin-2-one
1-ethylpyrrolidin-2-one
1-ethylpyrrolidin-2-one
1-ETHYLPYRROLIDIN-2-ONE-
2-Pyrrolidinone, 1-ethyl-
N ethyl pyrrolidone
N- ethyl pyrrolidone
N-Ethyl-2-Pyrrolidon
N-Ethyl-2-pyrrolidone
N-ethyl-2-pyrrolidone
N-ethyl-2-pyrrolidone; 1-ethylpyrrolidin-2-one
n-ethyl-pyrrolidone
N-ethylpyrrolidone
