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N-ETHYLMORPHOLINE
N-Ethylmorpholine is a component of the buffer used in basic peptide separation through anion-exchange chromatography. Further, it acts as a catalyst in the preparation of polyurethane foam. It is used to produce preservatives, emulsifiers and coating. This product is soluble in water and alcohol, so it also can be used as intermediate of solvent, catalysts, dye, pharmaceuticals and surfactant. Meantime, it is also used in organic synthesis.
Cas No.: 100-74-3
Synonyms:
4-Ethylmorpholine, N-ETHYLMORPHOLINE, 100-74-3, Morpholine, 4-ethyl, Ethylmorpholine, N-Ethylmorfolin, N-ethyl morpholine, UNII-ECM0G991FQ, NSC 6110, N-ethyl-morpholine, 4-ethyl-morpholine, ECM0G991FQ, MFCD00006177, N-Ethylmorpholine, 99%, N-Ethylmorfolin [Czech], CCRIS 4818, HSDB 1644, EINECS 202-885-0, BRN 0102969, AI3-24288, N-ethylmopholine, N-ethyhnorpholine, Texacat NEM, Toyocat NEM, 4-ethylmorpholirie, Dabco NEM, 4-Ethylmorpholine, 97%, DSSTox_CID_5312, ACMC-2097sb, SCHEMBL3167, DSSTox_RID_77745, DSSTox_GSID_25312, WLN: T6N DOTJ A2, O1CCN(CC1)C[C], 4-27-00-00023 (Beilstein Handbook Reference), KSC174M5J, CHEMBL3561880, DTXSID5025312, CTK0H4654, KS-00000VBI, NSC6110, NSC-6110, Tox21_201103, ANW-14361, SBB060634, ZINC20230620, AKOS015901076, 4-Ethylmorpholine, >=97.0% (GC), MCULE-6162178461, NCGC00248922-01, NCGC00258655-01, CAS-100-74-3, SC-65091, E0145, FT-0618417, ST51046780, 8373-EP2295409A1, 8373-EP2316824A1, 28037-EP2308838A1, 28037-EP2311808A1, 28037-EP2311829A1, 28037-EP2314588A1, Q2676918, W-108942, 4-Ethylmorpholine, BioXtra, suitable for protein sequencing, >=99.5% (GC), 6LB
Specific Gravity 0.9
Water 0.3% max. (K.F.)
Flash Point 27°C
Infrared Spectrum Authentic
Quantity 100mL
Refractive Index 1.4400 to 1.4420
Packaging Glass bottle
Melting Point -63.0°C
Boiling Point 139.0°C
Density 0.9000g/mL
Color Brown-Gray to Cream
CAS Min % 98.5
CAS Max % 100.0
Assay Percent Range 98.5% min. (GC)
Beilstein 27, 6
Fieser 01,383
Solubility Information Solubility in water: miscible with water. Other solubilities: soluble in alcohol,ether,acetone and benzene
Formula Weight 115.17
Physical Form Powder
Percent Purity 99%
Chemical Name or Material N-Ethylmorpholine, 99%
N-ethyl morpholine appears as a colorless liquid with a strong ammonia-like odor. Severely irritates skin, eyes, and mucous membranes. Moderately soluble in water and less dense than water. Flash point 83°F .
Colorant Term used for colorants, dyes, or pigments; includes colorants for drugs, textiles, personal care products (cosmetics, tatoo inks, hair dye), food colorants, and inks for printing;
Fuel General fuels, fuel additives, motor/automotive fuels
Manufacturing, building material, wood Wood used as a building material, wood preservatives
Manufacturing, chemical General term used only when the only information known from the source is 'chemical,' typically related to manufacturing of chemicals, or laboratory chemicals
Manufacturing, plastics Plastic products, industry for plastics, manufacturing of plastics, plastic additives
Manufacturing, raw material Raw materials used in a variety of products and industries (e.g. in cosmetics, chemical manufacturing, production of metals, etc)
Manufacturing, rubber Rubber products (e.g. tires) and their manufacture
Plastics Plastic products, industry for plastics, manufacturing of plastics, plastic additives
Process_regulator Accelerators, activators, oxidation agents, reducing agents, etc
Rubber Rubber products (e.g. tires) and their manufacture
Ethylmorpholine is a colorless liquid with an ammonia-like odor. Colorless, flammable liquid with an ammonia-like odor. Experimentally determined detection and recognition odor threshold concentrations were 400 μg/m3 (85 ppbv) and 1.2 mg/m3 (250 ppbv), respectively. Catalyst in polyurethane foam production. Intermediate for dyestuffs, pharmaceuticals; rubber accelerators and emulsifying agents; solvent for dyes, resins, oils; catalyst in making polyurethane foams.
A colorless liquid with a strong ammonia-like odor. Severely irritates skin, eyes, and mucous membranes. Moderately soluble in water and less dense than water. Flash point 83°F. Highly flammable. Moderately soluble in water. N-Ethylmorpholine can react vigorously with oxidizing materials. N-Ethylmorpholine dissolves LiAlH4.
N-Ethylmorpholine function
1)Commonly used as solvents for oils and resins, also used as intermediates for organic synthesis, etc.
2)Produces preservatives, emulsifiers and coatings. This product is soluble in water, alcohol, and ether, and can be used as an intermediate for solvents, catalysts, dyes, medicines, and surfactants.
3)In the polyurethane industry, N-ethylmorpholine is used as a catalyst for polyester-polyurethane soft block foam.
Health
Exposure limit(s) NIOSH REL: TWA 5 ppm (23 mg/m3) [skin] OSHA PEL: TWA 20 ppm (94 mg/m3) [skin] IDLH 100 ppm
Poison_Class 4
Exposure effects Effects may be delayed.
Ingestion May cause gastrointestinal irritation with nausea, vomiting and diarrhea. Ingestion of large amounts may cause CNS depression.
Inhalation Aspiration may lead to pulmonary edema. Vapors may cause dizziness or suffocation. May cause burning sensation in the chest.
Skin May cause irritation and dermatitis. May cause cyanosis of the extremities.
Eyes May cause chemical conjunctivitis and corneal damage.
First aid
Ingestion Do NOT induce vomiting. If victim is conscious and alert, give 2-4 cupfuls of milk or water. Get medical aid immediately. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation Get medical aid immediately. Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. DO NOT use mouth-to-mouth respiration.
Skin Get medical aid. Flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Remove contaminated clothing and shoes.
Eyes Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid immediately.
The IUPAC name of this chemical is 4-ethylmorpholine. With the CAS registry number 100-74-3, it is also named as Morpholine, 4-ethyl-. The product's categories are protein sequencing; protein structural analysis; reagents for protein sequencing; building blocks; heterocyclic building blocks; morpholines. It is colorless liquid with a strong ammonia-like odor. N-Ethylmorpholine can react vigorously with oxidizing materials. To fight fire, use alcohol foam, foam, CO2, dry chemical. When heated to decomposition this chemical emits toxic fumes of NOx. It is obtained by the reaction of morpholine and dibromoethane.
The other characteristics of this product can be summarized as: (1)ACD/LogP: 0.20; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -2; (4)ACD/LogD (pH 7.4): -0.32; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 9.32; (9)#H bond acceptors: 2; (10)#H bond donors: 0; (11)#Freely Rotating Bonds: 1; (12)Index of Refraction: 1.435; (13)Molar Refractivity: 32.94 cm3; (14)Molar Volume: 126.1 cm3; (15)Polarizability: 13.06×10-24 cm3; (16)Surface Tension: 26.9 dyne/cm; (17)Enthalpy of Vaporization: 37.69 kJ/mol; (18)Vapour Pressure: 6.36 mmHg at 25°C; (19)Exact Mass: 115.099714; (20)MonoIsotopic Mass: 115.099714; (21)Topological Polar Surface Area: 12.5; (22)Heavy Atom Count: 8.
Uses of N-Ethylmorpholine: It is used to produce preservatives, emulsifiers and coating. This product is soluble in water and alcohol, so it also can be used as intermediate of solvent, catalysts, dye, pharmaceuticals and surfactant. Meantime, it is also used in organic synthesis.
This product is soluble in water, alcohol and ether. It can be used as an intermediate in solvents, catalysts, dyes, pharmaceuticals and surfactants. It can also be used in the production of preservatives, emulsifiers and coatings.
When you are using this chemical, please be cautious about it as the following:
It is flammable, so people should keep it away from sources of ignition. And it is harmful in contact with skin and if swallowed. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If you want to contact this product, you must wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
