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N,N-DIETHYLFORMAMIDE = 2-HYDROXYOCTANOIC ACID = DEF
CAS Number: 617-84-5
EC Number: 210-533-2
MDL number: MFCD00003287
Linear Formula: HCON(C2H5)2 / C5H11NO
N,N-Diethylformamide is clear colorless to pale yellow liquid.
Miscible with acetone, benzene, alcohol and ether.
N,N-Diethylformamide is Industrial solvent claimed to have HIV protease inhibitory action.
N,N-Diethylformamide is clear colorless to pale yellow liquid，with ammonia-like-weak odor.
m.p-78°C，b.p.178°C，flash point 154°C，proportion 0.908(20°C).
N,N-Diethylformamide is soluble in water and alcohol.
N,N-Diethylformamide undergoes condensation with aromatic o-aminonitriles in the presence of ZnCl2 in sealed reactor to yield quinazoline-2,4(1H,3H)-dione.
N,N-Diethylformamide molecule consists of 11 Hydrogen atom(s), 5 Carbon atom(s), 1 Nitrogen atom(s) and 1 Oxygen atom(s) - a total of 18 atom(s).
Appearance: White or of- white powder or crystlline power,odorless
Solubility:
Very soluble in N,N-Dimethylformamide,
Soluble in methanol,
Sparingly soluble inglacial acetic acid,
Very slightly soluble inchloroform,
Practically insoluble in water.
Melting Point 152°C~156°C
USES and APPLICATIONS of N,N-DIETHYLFORMAMIDE:
-Plastics and polymers
-Resins
-Solvents
-Coating
-Electronics
-Polymers
-Coatings & Construction
-Pharmaceutical solvent
-Synthetic Leather
-Fiber
-Catalyst
-N,N-Diethylformamide was used in the synthesis of metal-organic frameworks.
-N,N-Diethylformamide was also used as solvent in the synthesis of porous cubic-shaped ZnO particles.
-N,N-Diethylformamide is used in the synthesis of metal-organic frameworks and Diethyltrifluoromethylamine.
-N,N-Diethylformamide is also used as solvent in the preparation of porous cubic-shaped zinc oxide particles.
-N,N-Diethylformamide is used as solvent and preservative, insect repellents etc.
-N,N-Diethylformamide is involved in the preparation of quinazoline-2,4(1H,3H)-dione by reacting with o-aminonitrile.
-Due to environmental sanctions, the use of N,N-Diethylformamide as a substitute is increasing.
-N,N-Diethylformamide is used as a solvent for synthetic leather and textiles.
-N,N-diethylformamide is a good solvent for a variety of polymers such as polyethylene, polyvinyl chloride, polyacrylonitrile, polyamide, etc., and can be used for wet spinning of synthetic fibers such as polyacrylonitrile fibers, and polyurethane Synthesis;
-N,N-Diethylformamide is used in plastic film making;
-N,N-Diethylformamide is also used as paint remover for removing paint;
-N,N-Diethylformamide can also dissolve some low-solubility pigments, giving the pigments the characteristics of dyes.
-N,N-Diethylformamide can also be used as an effective reagent for separating non-hydrocarbon components from paraffin.
-N,N-Diethylformamide has good selectivity for the solubility of isophthalic acid and terephthalic acid: the solubility of isophthalic acid in -N,N-diethylformamide is greater than that of terephthalic acid.
-N,N-Diethylformamide is used for solvent extraction in dicarboxylic acid formamide Or part of the crystallization can separate the two.
-In the petrochemical industry, N,N-Diethylformamide can be used as a gas absorbent to separate and refine gas.
-In organic reactions, N,N-Diethylformamide is not only widely used as a solvent for the reaction, but also an important intermediate in organic synthesis.
-N,N-Diethylformamide can be used to produce insecticide in the pesticide industry.
-Reagents for non-aqueous titration, solvents for vinyl resin and acetylene, organic synthesis, photometric determination, gas chromatography stationary liquid (maximum use temperature 50℃, solvent is methanol), separation and analysis of C2-C5 hydrocarbons, and can separate normal and isobutylene and cis, butene.
-Analysis of pesticide residues.
-Organic Synthesis.
-Synthesis of peptides.
-For the photographic industry.
-An excellent solvent and chemical raw material with a wide range of uses.
N,N-Diethylformamide is an excellent solvent for many polymers such as polyethylene, polyvinyl chloride, polyacrylonitrile, polyamide, etc.
-N,N-Diethylformamide can be used for wet spinning of synthetic fibers such as polyacrylonitrile fibers
-Synthesis of polyurethane
-Paint remover for removing paint
-Selective absorption of acetylene and separation and refining of butadiene
-N,N-Diethylformamide is used as a solvent in the production of artificial leather
-N,N-Diethylformamide can be used to synthesize iodosamine, doxycycline, cortisone, vitamin B6, iodoside, ququjing, pyrantel, N-formyllysin, and antitumor acid , Methoxychlor, chlorambucil, nitrosourea, furfurouracil, tranexamic acid, befenmethasone, megestrol, cholyvitamin, chlorpheniramine, etc.
-N,N-Diethylformamide is used as solvent and organic modifier in liquid chromatography, extractant and developing agent for thin layer chromatography, solvent for vinyl resin and acetylene, and solvent for non-aqueous solvent titration.
-N,N-Diethylformamide is used in organic synthesis.
-N,N-Diethylformamide is used to synthesize insecticides
-In the pharmaceutical industry
-N,N-Diethylformamide is mainly used as an industrial solvent, in the pharmaceutical industry for production, hormones, and also for the manufacture of insecticide.
PHYSICAL and CHEMICAL PROPERTIES of N,N-DIETHYLFORMAMIDE:
Molecular Weight: 101.15
XLogP3-AA: 0.5
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 1
Rotatable Bond Count: 2
Exact Mass: 101.084063974
Monoisotopic Mass: 101.084063974
Topological Polar Surface Area: 20.3 Ų
Heavy Atom Count: 7
Formal Charge: 0
Complexity: 50
Appearance Form: clear, liquid
Colour: brown
Odour: No data available
Odour Threshold: No data available
pH: No data available
Melting point/freezing point: No data available
Initial boiling point and boiling range: 176 - 177 °C - lit.
Flash point: 60 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available
Vapour pressure: No data available
Vapour density: No data available
Relative density: 0,908 g/cm3 at 25 °C
Water solubility: No data available
Partition coefficient: n-octanol/water: No data available
Auto-ignition temperature: No data available
Decomposition temperature: No data available
Viscosity: No data available
Explosive properties: No data available
Oxidizing properties: No data available
Other safety information: No data available
Melting point: 176-177°C
Boiling point: 176-177 °C (lit.)
Density: 0.908 g/mL at 25 °C (lit.)
Refractive index: n20/D 1.434(lit.)
Flash point: 141 °F
Storage temp.: Store below +30°C.
Solubility: Miscible with acetone, benzene, alcohol and ether.
pka: -0.44±0.70(Predicted)
Form: Liquid
Color: Clear colorless to pale yellow
Min. Purity Spec: >99% (GC)
Physical Form (at 20°C): Liquid
Boiling Point: 176-177°C
Flash Point: 60°C
Density: 0.9
Refractive Index: 1.433-1.435
Long-Term Storage: Store long-term in a cool, dry place
ΔfG°: 2.48 kJ/mol
ΔfH°gas: -164.58 kJ/mol
ΔfusH°: 14.02 kJ/mol
ΔvapH°: 50.30 kJ/mol
IE: 8.89 ± 0.02 eV
logPoct/wat 0.485
Pc: 3782.33 kPa
Tboil: 450.70 K
Tboil: 341.20 K
Tc: 546.52 K
Tfus: 220.58 K
Vc: 0.350 m3/kg-mol
FIRST AID MEASURES of N,N-DIETHYLFORMAMIDE:
-Description of first aid measures:
*General advice:
Consult a physician.
Show this safety data sheet to the doctor in attendance.
*If inhaled:
If breathed in, move person into fresh air.
Consult a physician.
*In case of skin contact:
Wash off with soap and plenty of water.
Consult a physician.
*In case of eye contact:
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
*If swallowed:
Rinse mouth with water.
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of N,N-DIETHYLFORMAMIDE:
-Personal precautions, protective equipment and emergency procedures:
Use personal protective equipment.
-Environmental precautions:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Contain spillage, and then collect with non-combustible absorbent material, (e.g. sand, earth, diatomaceous earth, vermiculite) and place in container for disposal according to local / national regulations.
FIRE FIGHTING MEASURES of N,N-DIETHYLFORMAMIDE:
-Extinguishing media:
--Suitable extinguishing media:
Dry powder
Dry sand
-Further information:
Use water spray to cool unopened containers.
EXPOSURE CONTROLS/PERSONAL PROTECTION of N,N-DIETHYLFORMAMIDE:
-Control parameters:
--Components with workplace control parameters:
-Exposure controls:
--Appropriate engineering controls:
Handle in accordance with good industrial hygiene and safety practice.
Wash hands before breaks and at the end of workday.
--Personal protective equipment:
*Eye/face protection
Use face shield and safety glasses.
*Skin protection
Handle with gloves.
Wash and dry hands.
Full contact:
Material: butyl-rubber
Minimum layer thickness: 0,3 mm
Break through time: 480 min
Splash contact:
Material: Nature latex/chloroprene
Minimum layer thickness: 0,6 mm
Break through time: 30 min
-Control of environmental exposure:
Prevent further leakage or spillage if safe to do so.
Do not let product enter drains.
HANDLING and STORAGE of N,N-DIETHYLFORMAMIDE:
-Conditions for safe storage, including any incompatibilities
Keep container tightly closed in a dry and well-ventilated place.
Containers which are opened must be carefully resealed and kept upright to prevent leakage.
Store in cool place.
STABILITY and REACTIVITY of N,N-DIETHYLFORMAMIDE:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
SYNONYMS:
N,N-DIETHYLFORMAMIDE
Diethylformamide
Formamide, N,N-diethyl-
Formyldiethylamine
N-Formyldiethylamine
Diethyl formamide
Diethylamid kyseliny mravenci
N,N-diethyl-formamide
UNII-D4BLP8BN9H
D4BLP8BN9H
NSC 6242
EINECS 210-533-2
Diethylamid kyseliny mravenci [Czech]
BRN 1209392
AI3-11534
diethyl-formamide
N,N-diethylormamide
formamide, diethyl-
n.n-diethylformamide
MFCD00003287
Formamide,N-diethyl-
N,N-diethyl formamide
DSSTox_CID_463
DSSTox_RID_75606
DSSTox_GSID_20463
SCHEMBL27084
N,N-Diethylformamide, 99%
WLN: VHN2&2
CHEMBL3186600
DTXSID3020463
NSC6242
CHEBI:183296
ZINC388483
NSC-6242
Tox21_200919
AKOS009156839
CS-W009551
MCULE-9053231156
NCGC00248876-01
NCGC00258473-01
AS-17885
DB-053987
D0506
D4234
FT-0629473
V2345
EN300-91618
Q4044797
Formamide, N,N-diethyl-
N,N-DiethyL
DIETHYL FORMAMIDE
N-Formyldiethylamine
n,n-diethyl-formamid
JACS-617-84-5
Diethylforamide
FORMYLDIETHYLAMINE
N,N-DIETHYLFORMAMIDE
Apixaban Impurity 174
N,N-Diethylformamide
NSC 6242
NSC-6242
NSC6242
Formamide, N,N-diethyl-
