N,N-Dimethyl-N-ethanolamine is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA).
N,N-Dimethyl-N-ethanolamine holds tertiary amine and primary alcohol groups as functional groups.
N,N-Dimethyl-N-ethanolamine has been used in the treatment of attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia.
CAS Number: 108-01-0
Molecular Formula: C4H11NO
Molecular Weight: 89.14
EINECS Number: 203-542-8
Synonyms: 2-(Dimethylamino)ethanol, Deanol, N,N-Dimethylethanolamine, 108-01-0, Dimethylethanolamine, Dimethylaminoethanol, 2-DIMETHYLAMINOETHANOL, Norcholine, DMAE, Bimanol, Liparon, Varesal, N,N-Dimethylaminoethanol, Propamine A, DMEA, Ethanol, 2-(dimethylamino)-, (2-Hydroxyethyl)dimethylamine, Kalpur P, Dimethylmonoethanolamine, Dimethylaminoaethanol, N,N-Dimethyl-2-hydroxyethylamine, Amietol M 21, N,N-Dimethyl-2-aminoethanol, N-Dimethylaminoethanol, Texacat DME, N,N-Dimethyl ethanolamine, 2-(N,N-Dimethylamino)ethanol, Dimethyl(hydroxyethyl)amine, Dimethylaethanolamin, Dimethyl(2-hydroxyethyl)amine, 2-(Dimethylamino)-1-ethanol, N-(2-Hydroxyethyl)dimethylamine, Demanol, Demanyl, N,N-Dimethyl-N-(2-hydroxyethyl)amine, (Dimethylamino)ethanol, beta-Hydroxyethyldimethylamine, beta-Dimethylaminoethyl alcohol, 2-(Dimethylamino) ethanol, 2-Dwumetyloaminoetanolu, 2-Dimethylamino-ethanol, N,N-Dimethyl-N-(beta-hydroxyethyl)amine, NSC 2652, CCRIS 4802, N-(Dimethylamino)ethanol, Oristar dmae, HSDB 1329, N,N-Dimethyl(2-hydroxyethyl)amine, Tegoamin DMEA, EINECS 203-542-8, Dabco DMEA, UNII-2N6K9DRA24, 2-(dimethylamino)ethan-1-ol, Deanol [BAN], BRN 1209235, 2N6K9DRA24, DIMETHYL MEA, AI3-09209, CHEBI:271436, NSC-2652, N,N'-Dimethylethanolamine, 2-(dimethylamino)-ethanol, (CH3)2NCH2CH2OH, CHEMBL1135, .beta.-(Dimethylamino)ethanol, .beta.-Hydroxyethyldimethylamine, .beta.-Dimethylaminoethyl alcohol, DTXSID2020505, NSC2652, EC 203-542-8, Phosphatidyl-N-dimethylethanolamine, Deanol (BAN), MFCD00002846, n-(2-hydroxyethyl)-n,n-dimethylamine, N,N-DIMETHYLAMINOETHANOL (DMAE), NCGC00159413-02, Tonibral, N,N-Dimethyl-N-(.beta.-hydroxyethyl)amine, DEANOL (MART.), DEANOL [MART.], DTXCID00505, rexolin, CAS-108-01-0, Dimethylaethanolamin [German], Dimethylamino ethanol, Dimethylaminoaethanol [German], 2-Dwumetyloaminoetanolu [Polish], 2-Dimethylamino ethanol, UN2051, Ethanol, 2-dimethylamino-, N,N-Dimethyl-N-ethanolamine, 2-dimethylamino, N,N Dimethyl 2 hydroxyethylamine, Jeffcat DMEA, Dimethylethanoiamine, Toyocat -DMA, dimethyl ethanolamine, dimethyl-ethanolamine, DIMETHOL, Paresan (Salt/Mix), dimethyl ethanol amine, THANCAT DME, 2-dimethyamino-ethanol, n,n-dimethylethanolamin, Biocoline (Salt/Mix), beta-dimethylaminoethanol, N,N dimethylaminoethanol, DEANOL [WHO-DD], DEANOL [MI], N,N-dimethyl-ethanolamine, N,N-dimethylamino ethanol, N,N-dimethylethanol amine, N,N-dimethylethanol-amine, (n,n-dimethylamino)ethanol, 2-Hydroxyethyldimethylamine, 2-Dimethylaminoethanol [UN2051] [Corrosive], beta-(Dimethylamino)ethanol, beta -(dimethylamino)ethanol, DIMETHYL MEA [INCI], Dimethylaminoaethanol(german), N,N-Dimethylethanolamine (2-Dimethylaminoethanol), Choline chloride (Salt/Mix), Luridin chloride (Salt/Mix), beta -hydroxyethyldimethylamine, N,N-Dimethylethanolamine/DMEA, beta -dimethylaminoethyl alcohol, DMAE1549, 2-(N,N-dimethyl amino)ethanol, 2-(N,N-dimethylamino) ethanol, N-hydroxyethyl-N,N-dimethylamine, 2-(N,N-dimethyl amino) ethanol, beta -(dimethylamino)ethyl alcohol, 2-hydroxy-N,N-dimethylethanaminium, B-DIMETHYLAMINOETHYL ALCOHOL, WLN: Q2N1 & 1, 2-Dimethylaminoethanol, >=99.5%, BCP22017, CS-M3462, N,N-Dimethyl-beta-hydroxyethylamine, .beta.-(Dimethylamino)ethyl alcohol, N, N-Dimethyl(2-hydroxyethyl)amine, Tox21_113163, Tox21_201821, Tox21_302844, BDBM50060526, N,N-Dimethyl-beta -hydroxyethylamine, N,N-Dimethylaminoethanol, redistilled, 2-(DIMETHYLAMINO)ETHYL ALCOHOL, AKOS000118738, N,N-Dimethyl-.beta.-hydroxyethylamine, DB13352, N,N-DIMETHYLETHANOLAMINE [HSDB], RP10040, UN 2051, N, N-Dimethyl-N-(2-hydroxyethyl)amine, NCGC00159413-03, NCGC00256454-01, NCGC00259370-01, BP-13447, N,N-Dimethyl-N-(beta -hydroxyethyl)amine, N, N-Dimethyl-N-(beta -hydroxyethyl)amine, D0649, NS00001173, D07777, DIMETHYLAMINOETHANOL, (CORROSIVE LIQUID), 2-Dimethylaminoethanol [UN2051] [Corrosive
N,N-Dimethyl-N-ethanolamine has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.
N,N-Dimethyl-N-ethanolamine and comes with molecular formula of C4H11NO and molecular weight of 89.13624.
N,N-Dimethyl-N-ethanolamine works as anti-depressive agent and is also used for treating movement disorders.
N,N-Dimethyl-N-ethanolamine holds tertiary amine and primary alcohol groups as functional groups.
N,N-Dimethyl-N-ethanolamine has been used in the treatment of attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia.
However, results of several studies were inconclusive and a systematic review could not confirm the positive effects of N,N-Dimethyl-N-ethanolamine or other cholinergic compounds in patients with TD.
N,N-Dimethyl-N-ethanolamine is a tertiary amine that is ethanolamine having two N-methyl substituents.
N,N-Dimethyl-N-ethanolamine has a role as a curing agent and a radical scavenger.
N,N-Dimethyl-N-ethanolamine is a tertiary amine and a member of ethanolamines.
N,N-Dimethyl-N-ethanolamine is commonly referred to as 2-(dimethylamino)ethanol, dimethylaminoethanol (DMAE) or dimethylethanolamine (DMEA).
N,N-Dimethyl-N-ethanolamine holds tertiary amine and primary alcohol groups as functional groups.
N,N-Dimethyl-N-ethanolamine has been used in the treatment of attention deficit-hyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia.
N,N-Dimethyl-N-ethanolamine has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.
N,N-Dimethyl-N-ethanolamine is bifunctional, containing both a tertiary amine and primary alcohol functional groups.
N,N-Dimethyl-N-ethanolamine is a colorless viscous liquid.
N,N-Dimethyl-N-ethanolamine is used in skin care products for improving skin tone and also taken orally as a nootropic.
N,N-Dimethyl-N-ethanolamine is prepared by the ethoxylation of dimethylamine.
N,N-Dimethyl-N-ethanolamine, commonly known as Deanol, is a chemical compound with the molecular formula C4H11NO.
N,N-Dimethyl-N-ethanolamine is an organic compound that belongs to the class of alkanolamines.
N,N-Dimethyl-N-ethanolamine is a tertiary amine and has two methyl groups attached to the nitrogen atom, along with an ethyl group attached to the carbon adjacent to the nitrogen.
N,N-Dimethyl-N-ethanolamine is used as a curing agent for polyurethanes and epoxy resins.
N,N-Dimethyl-N-ethanolamine is a precursor to other chemicals, such as the nitrogen mustard 2-dimethylaminoethyl chloride.
The acrylate ester, N,N-Dimethyl-N-ethanolamine acrylate is used as a flocculating agent.
Related compounds are used in gas purification, e.g. removal of hydrogen sulfide from sour gas streams.
N,N-Dimethyl-N-ethanolamine is an organic chemical compound from the group of alkylated amino alcohols .
N,N-Dimethyl-N-ethanolamine is closely related to the neurotransmitter acetylcholine via choline (the trimethylethanolammonium cation).
N,N-Dimethyl-N-ethanolamine is an intermediate product of the chemical and pharmaceutical industries .
N,N-Dimethyl-N-ethanolamine is miscible with water, ethanol, benzene, ether and acetone.
N,N-Dimethyl-N-ethanolamine is a white powder providing 37% DMAE.
Animal tests show possible benefit for improving spatial memory and working memory.
N,N-Dimethyl-N-ethanolamine is produced industrially by reacting dimethylamine with ethylene oxide at temperatures of 125-160 ° C and pressures of 15-30 bar in the presence of catalytic amounts of water in liquid-cooled double-jacket tube reactors.
N,N-Dimethyl-N-ethanolamine is an organic compound with the formula (CH3)2NCH2CH2OH.
N,N-Dimethyl-N-ethanolamine is bifunctional, containing both a tertiary amine and primary alcohol functional groups.
N,N-Dimethyl-N-ethanolamine is a colorless viscous liquid.
N,N-Dimethyl-N-ethanolamine is used in skin care products for improving skin tone and also taken orally as a nootropic.
N,N-Dimethyl-N-ethanolamine is prepared by the ethoxylation of dimethylamine.
N,N-Dimethyl-N-ethanolamine is an amino alcohol.
N,N-Dimethyl-N-ethanolamine is the main product formed during the amination of ethylene glycol by dimethylamine on alumina supported copper in a continuous fixed-bed reactor.
N,N-Dimethyl-N-ethanolamine has been reported to be the putative precursor of acetylcholine.
N,N-Dimethyl-N-ethanolamine is effect as a skin-firming and anti-wrinkle agent has been studied.
Microwave spectrum of N,N-Dimethyl-N-ethanolamine has been investigated.
N,N-Dimethyl-N-ethanolamine is effect as an organic additive on deposition and anti-reflective properties of porous CaF2 has been studied.
Removal of the benzyl ester groups by transesterification with N,N-Dimethyl-N-ethanolamine from benzyl protected tripeptides has been reported.
N,N-Dimethyl-N-ethanolamine is a transparent, pale yellow liquid and primary alcohol that is used as a building block for the synthesis of cationic flocculants and ion exchange resins.
N,N-Dimethyl-N-ethanolamine is also used used as a chemical intermediate for pharmaceuticals, dyes, corrosion inhibitors, and emulsifiers and as an additive to boiler water, paint removers, and amino resins.
N,N-Dimethyl-N-ethanolamine is an organic compound with the formula (CH3)2NCH2CH2OH.
N,N-Dimethyl-N-ethanolamine is bifunctional, containing both a tertiary amine and primary alcohol functional groups.
N,N-Dimethyl-N-ethanolamine is a colorless viscous liquid.
N,N-Dimethyl-N-ethanolamine is used in skin care products.
N,N-Dimethyl-N-ethanolamine is prepared by the ethoxylation of dimethylamine.
N,N-Dimethyl-N-ethanolamine is a precursor to other chemicals, such as the nitrogen mustard 2-dimethylaminoethyl chloride.
The acrylate ester is used as a flocculating agent.Related compounds are used in gas purification, e.g. removal of hydrogen sulfide from sour gas streams.
N,N-Dimethyl-N-ethanolamine is a white powder providing 37% DMAE.
Deanol is commonly referred to as 2-(dimethylamino)ethanol, N,N-Dimethyl-N-ethanolamine or dimethylethanolamine (DMEA).
N,N-Dimethyl-N-ethanolamine holds tertiary amine and primary alcohol groups as functional groups.
N,N-Dimethyl-N-ethanolamine has been used in the treatment of attention deficithyperactivity disorder (ADHD), Alzheimer's disease, autism, and tardive dyskinesia.
N,N-Dimethyl-N-ethanolamine has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.
N,N-Dimethyl-N-ethanolamine appears as a clear colorless liquid with a fishlike odor.
N,N-Dimethyl-N-ethanolamine is a tertiary amine that is ethanolamine having two N-methyl substituents.
N,N-Dimethyl-N-ethanolamine has a role as a curing agent and a radical scavenger.
N,N-Dimethyl-N-ethanolamine is a tertiary amine and a member of ethanolamines.
N,N-Dimethyl-N-ethanolamine is a compound that many people believe can positively affect mood, enhance memory, and improve brain function.
N,N-Dimethyl-N-ethanolamine’s also thought to have benefits for aging skin.
While there aren’t many studies on N,N-Dimethyl-N-ethanolamine, advocates believe it may have benefits for several conditions, including: attention deficit hyperactivity disorder (ADHD).
N,N-Dimethyl-N-ethanolamine is naturally produced in the body.
N,N-Dimethyl-N-ethanolamine’s also found in fatty fish, such as salmon, sardines, and anchovies.
N,N-Dimethyl-N-ethanolamine is thought to work by increasing production of acetylcholine (Ach), a neurotransmitter that’s crucial for helping nerve cells send signals.
Ach helps regulate many functions controlled by the brain, including REM sleep, muscle contractions, and pain responses.
N,N-Dimethyl-N-ethanolamine may also help prevent the buildup of a substance called beta-amyloid in the brain.
Too much beta-amyloid has been linked to age-related decline and memory loss.
N,N-Dimethyl-N-ethanolamine’s impact on Ach production and beta-amyloid buildup may make it beneficial for brain health, especially as age.
N,N-Dimethyl-N-ethanolamine can be synthesized through the reaction of dimethylamine with ethylene oxide.
This reaction results in the formation of a tertiary amine, where two methyl groups are attached to the nitrogen atom and an ethyl group is attached to the adjacent carbon.
N,N-Dimethyl-N-ethanolamine finds various industrial applications due to its properties as a versatile amine.
N,N-Dimethyl-N-ethanolamine is commonly used as a catalyst or a reactant in chemical reactions, particularly in the synthesis of pharmaceuticals, pesticides, and corrosion inhibitors.
In cosmetics and personal care products, N,N-Dimethyl-N-ethanolamine is utilized as an ingredient in formulations such as skin care products, hair care products, and toiletries.
N,N-Dimethyl-N-ethanolamine can act as a pH adjuster, emulsifier, or conditioning agent in these formulations.
N,N-Dimethyl-N-ethanolamine has gained attention in the field of nootropics and cognitive enhancement.
Some individuals use Deanol-containing supplements for its potential to improve cognitive function, memory, and focus.
However, scientific evidence supporting these claims is limited, and more research is needed to determine its effectiveness and safety for cognitive enhancement purposes.
N,N-Dimethyl-N-ethanolamine is regulated by various regulatory bodies, including the U.S. Food and Drug Administration (FDA) and the European Chemicals Agency (ECHA).
N,N-Dimethyl-N-ethanolamine is important to adhere to regulations and guidelines regarding its use in different applications to ensure safety and compliance.
While Deanol is generally regarded as safe when used in accordance with regulations and guidelines, it is essential to handle it with care due to its potential hazards.
Proper safety precautions, such as wearing appropriate personal protective equipment and following handling instructions, should be observed when working with this compound.
Research on N,N-Dimethyl-N-ethanolamine continues to explore its potential applications and properties. Studies may focus on its chemical reactivity, biological effects, and
potential uses in various industries, contributing to ongoing advancements in science and technology.
N,N-Dimethyl-N-ethanolamine has previously been investigated as a stimulant and treatment for several neurological diseases, including tardive dyskinesia (TD), Alzheimer’s disease (AD) and senile dementia.
First, application of N,N-Dimethyl-N-ethanolamine to human healthy volunteers dates back to the 1960s when N,N-Dimethyl-N-ethanolamine was reported to exert stimulating effects comparable to amphetamine.
Murphree et al. (1960) described improved concentration, increased muscle tone and changed sleeping habits in healthy males (21–26 years) with an intake of 10–20 mg N,N-
Dimethyl-N-ethanolamine (or Deanol) daily for 2–3 weeks compared to a placebo group.
In later studies, N,N-Dimethyl-N-ethanolamine was hypothesized as an acetylcholine (ACh) precursor and therefore tested in diseases that are considered to be linked to the cholinergic system.
N,N-Dimethyl-N-ethanolamine is a tertiary amine that is ethanolamine having two N-methyl substituents.
N,N-Dimethyl-N-ethanolamine is colorless or slightly yellow liquid with ammonia odor.
N,N-Dimethyl-N-ethanolamine has a role as a curing agent and a radical scavenger.
N,N-Dimethyl-N-ethanolamine is a tertiary amine and a member of ethanolamines.
N,N-Dimethyl-N-ethanolamine is an organic compound with the formula (CH3)2NCH2CH2OH.
The synthesis of N,N-Dimethyl-N-ethanolamine by the ethylene oxide method is obtained by the ammonification of dimethylamine with ethylene oxide, which is distilled, refined and dehydrated.
N,N-Dimethyl-N-ethanolamine has been also used as an ingredient in skin care, and in cognitive function- and mood-enhancing products.
In addition, in vivo experiments showed that N,N-Dimethyl-N-ethanolamine is not methylated to choline and does not alter brain ACh levels.
Interestingly, in both acute and chronic seizure models in rats, a conjugate of N,N-Dimethyl-N-ethanolamine and valproate (DEVA) was shown to be more potent than valproate alone, potentially by facilitation of valproate transport via the blood brain barrier.
Melting point: −70 °C(lit.)
Boiling point: 134-136 °C(lit.)
Density: 0.886 g/mL at 20 °C(lit.)
vapor density: 3.03 (vs air)
vapor pressure: 100 mm Hg ( 55 °C)
refractive index: n20/D 1.4294(lit.)
Flash point: 105 °F
storage temp.: Store below +30°C.
solubility: alcohol: miscible(lit.)
form: Liquid
pka: pK1:9.26(+1) (25°C)
color: Clear colorless to pale yellow
Odor: Amine like
PH Range: 10.5 - 11.0 at 100 g/l at 20 °C
PH: 10.5-11 (100g/l, H2O, 20℃)
explosive limit 1.4-12.2%(V)
Water Solubility: miscible
FreezingPoint: -59.0℃
Sensitive: Hygroscopic
Merck: 14,2843
BRN: 1209235
Stability: Stable. Flammable. Incompatible with oxidizing agents, copper, copper alloys, zinc, acids, galvanised iron. Hygroscopic.
InChIKey: UEEJHVSXFDXPFK-UHFFFAOYSA-N
LogP: -0.55 at 23℃
N,N-Dimethyl-N-ethanolamine belongs to the ontological category of tertiary amine in the ChEBI Ontology tree.
The United Nations designated GHS hazard class pictogram is Flammable;Corrosive;Irritant, and the GHS signal word is DangerThe storage condition is described as Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
N,N-Dimethyl-N-ethanolamine use and application categories indicated by third-party sources: Fire Hazards -> Corrosives, Flammable - 2nd degree.
However, this does not mean N,N-Dimethyl-N-ethanolamine can be used or applied in the same or a similar way.
N,N-Dimethyl-N-ethanolamine has been studied for its potential biological effects, including its interaction with neurotransmitter systems in the brain.
Some research suggests that it may modulate levels of acetylcholine, a neurotransmitter involved in memory and cognition.
However, the exact mechanisms of action and their significance in cognitive function are still not fully understood.
Upon ingestion, N,N-Dimethyl-N-ethanolamine is metabolized in the body.
N,N-Dimethyl-N-ethanolamine undergoes processes such as oxidation and conjugation, leading to the formation of various metabolites.
Understanding its metabolic pathways is important for assessing its safety and potential health effects.
While N,N-Dimethyl-N-ethanolamine is generally considered safe when used appropriately, excessive intake or exposure may lead to adverse effects.
Some reported side effects include gastrointestinal disturbances, such as nausea and stomach upset.
Additionally, there have been concerns about potential liver toxicity associated with high doses, although more research is needed to confirm these effects.
N,N-Dimethyl-N-ethanolamine may interact with other substances, medications, or supplements.
Individuals taking medications or supplements should consult healthcare professionals before using N,N-Dimethyl-N-ethanolamine-containing products to avoid potential interactions or adverse effects.
N,N-Dimethyl-N-ethanolamine is available in various formulations, including oral supplements, topical creams, and liquid solutions.
The concentration and form of N,N-Dimethyl-N-ethanolamine in these products may vary, influencing its absorption, bioavailability, and effectiveness.
Despite its potential benefits, research on Deanol faces challenges, including variability in study designs, inconsistent findings, and a lack of standardized protocols.
Addressing these challenges is essential for advancing scientific understanding and establishing evidence-based recommendations regarding its use.
Regulatory agencies evaluate the safety and efficacy of N,N-Dimethyl-N-ethanolamine-containing products based on scientific evidence.
Compliance with regulatory requirements ensures that N,N-Dimethyl-N-ethanolamine meet quality standards and are safe for consumer use.
Consumers should be aware of the limitations of available evidence and exercise caution when using Deanol-containing products, particularly those marketed for cognitive enhancement.
Consulting healthcare professionals and reputable sources can help individuals make informed decisions about its use.
In cosmetics, N,N-Dimethyl-N-ethanolamine is often incorporated into formulations targeting skin care and hair care products.
N,N-Dimethyl-N-ethanolamine can act as a pH adjuster, emulsifier, or humectant, contributing to the stability, texture, and moisturizing properties of these products.
Some formulations may claim to have firming or toning effects on the skin due to N,N-Dimethyl-N-ethanolamine's potential to enhance skin elasticity.
While the exact mechanisms underlying N,N-Dimethyl-N-ethanolamine's purported cognitive-enhancing effects are not fully understood, some hypotheses suggest that it may influence cholinergic neurotransmission.
Cholinergic pathways play a crucial role in memory, attention, and learning processes.
N,N-Dimethyl-N-ethanolamine's interaction with these pathways may modulate neurotransmitter levels and neuronal activity, affecting cognitive function.
Ongoing research continues to explore N,N-Dimethyl-N-ethanolamine's potential therapeutic applications and mechanisms of action.
Studies may investigate its effects on neuroplasticity, neuroprotection, and neurotransmitter systems to elucidate its role in cognitive function and neurological disorders.
Additionally, clinical trials assessing N,N-Dimethyl-N-ethanolamine's efficacy and safety in specific populations, such as older adults or individuals with cognitive impairments, are warranted.
Amines are chemical bases.
They neutralize acids to form salts plus water.
These acid-base reactions are exothermic.
The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base.
Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides.
Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.
N,N-Dimethyl-N-ethanolamine may react vigorously with oxidizing materials.
N,N-Dimethyl-N-ethanolamine is used as a corrosion inhibitor; pharmaceutical intermediate; in making dyestuffs, textiles, pharmaceuticals; emulsifiers in paints and coatings.
Also, N,N-Dimethyl-N-ethanolamine has been used as a medication in the treatment ofbehavioral problems of children.
When administered orally, N,N-Dimethyl-N-ethanolamine acetamidobenzoate (the therapeutic salt formulation) has been shown to cross the blood-brain barrier (HSDB 1988).
Two other studies have examined the pharmacokinetics of dimethylaminoethanol in rats and healthy adults.
N,N-Dimethyl-N-ethanolamine is a chemical that can be converted into choline.
Choline is involved in a series of reactions that form acetylcholine, a chemical that is found in the brain and other areas of the body.
N,N-Dimethyl-N-ethanolamine is a "neurotransmitter" that helps nerve cells communicate.
N,N-Dimethyl-N-ethanolamine is used for attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, autism, and other conditions, but there is no good scientific evidence to support these uses.
N,N-Dimethyl-N-ethanolamine is an aminoalcohol.
N,N-Dimethyl-N-ethanolamine has been submitted to the National Cancer Institute (NCI) for testing and evaluation and the Cancer Chemotherapy National Service Center (NSC) number is 2652.
N,N-Dimethyl-N-ethanolamine is sometimes included as an ingredient in combination products, alongside other compounds purported to have cognitive-enhancing effects.
These products may contain vitamins, minerals, antioxidants, or herbal extracts, aiming to synergistically improve cognitive function.
However, the efficacy of such combinations should be evaluated through rigorous scientific research.
N,N-Dimethyl-N-ethanolamine-containing products marketed for cognitive enhancement often attract public interest, particularly among individuals seeking ways to support brain health and cognitive performance.
N,N-Dimethyl-N-ethanolamine is important for consumers to critically evaluate marketing claims and seek evidence-based information from reliable sources when considering the use of these products.
Regulatory agencies oversee the safety and labeling of N,N-Dimethyl-N-ethanolamine-containing products to ensure compliance with regulations.
Manufacturers are responsible for conducting safety assessments, adhering to labeling requirements, and providing accurate information to consumers.
Regulatory oversight helps safeguard public health and prevent misleading claims or unsafe practices in the marketplace.
Educational resources, such as scientific literature, reputable websites, and healthcare professionals, can provide valuable information about N,N-Dimethyl-N-ethanolamine and its potential effects.
Consumers and healthcare providers can use these resources to make informed decisions about its use, weighing potential benefits against risks and considering individual health
needs and preferences.
Uses:
N,N-Dimethyl-N-ethanolamine is used in gas purification.
In certain chemical reactions, N,N-Dimethyl-N-ethanolamine can function as a catalyst, accelerating the rate of reaction without being consumed in the process.
N,N-Dimethyl-N-ethanolamine facilitates the conversion of reactants into desired products and may enhance reaction efficiency in various industrial processes.
N,N-Dimethyl-N-ethanolamine is incorporated into cosmetic formulations, including skin care products, hair care products, and toiletries.
N,N-Dimethyl-N-ethanolamine can serve multiple functions in these formulations, such as adjusting pH, emulsifying ingredients, and providing moisturizing or conditioning effects.
N,N-Dimethyl-N-ethanolamine is a common ingredient in some dietary supplements marketed for cognitive enhancement or brain health.
These supplements often claim to support memory, focus, and mental clarity, although scientific evidence supporting these claims is limited and controversial.
N,N-Dimethyl-N-ethanolamine is studied for its potential therapeutic effects in various health conditions, including neurodegenerative disorders and cognitive impairments.
Research explores its mechanisms of action, pharmacokinetics, and potential benefits as a treatment adjunct or therapeutic agent.
N,N-Dimethyl-N-ethanolamine can be used as an additive in polymer formulations to impart desired properties, such as enhanced flexibility, adhesion, or resistance to degradation.
N,N-Dimethyl-N-ethanolamine may improve the performance of polymeric materials in applications ranging from adhesives and coatings to plastics and composites.
N,N-Dimethyl-N-ethanolamine serves as a solvent or co-solvent, facilitating the dissolution of substances and aiding in the production of formulations or chemical mixtures.
N,N-Dimethyl-N-ethanolamine is solvent properties make it valuable in applications such as cleaning, degreasing, and extraction processes.
N,N-Dimethyl-N-ethanolamine can act as a surfactant, lowering the surface tension between two substances and promoting their mixing or dispersion.
N,N-Dimethyl-N-ethanolamine finds application in formulations such as detergents, emulsifiers, foaming agents, and dispersants in various industrial and household products.
N,N-Dimethyl-N-ethanolamine may be used as a dyeing assistant, leveling agent, or softening agent to improve the processing and quality of textile materials.
N,N-Dimethyl-N-ethanolamine can enhance dye uptake, uniformity of coloration, and fabric handle, contributing to the production of high-quality textiles.
N,N-Dimethyl-N-ethanolamine is utilized in gas treatment processes, particularly in the removal of acidic gases such as hydrogen sulfide (H2S) and carbon dioxide (CO2) from natural gas and biogas streams.
N,N-Dimethyl-N-ethanolamine can react with acidic components to form stable salts or complexes, thereby purifying the gas for various industrial applications.
In the printing industry, N,N-Dimethyl-N-ethanolamine may be incorporated into ink formulations as a solvent or additive to enhance print quality, adhesion, and drying characteristics.
N,N-Dimethyl-N-ethanolamine can help optimize ink performance and improve the printing process in applications such as offset printing, flexography, and gravure printing.
N,N-Dimethyl-N-ethanolamine is sometimes added to metalworking fluids, such as cutting oils and coolants, to improve lubricity, thermal stability, and corrosion protection during machining, grinding, and metal forming operations.
N,N-Dimethyl-N-ethanolamine enhances tool life, surface finish, and overall machining efficiency in metalworking processes.
In photographic applications, Deanol may be used in the formulation of developers, fixing agents, and other processing chemicals.
N,N-Dimethyl-N-ethanolamine plays a role in the development and stabilization of photographic images, contributing to the production of high-quality prints in traditional and digital photography.
N,N-Dimethyl-N-ethanolamine can serve as a catalyst or blowing agent in the production of polyurethane foams.
N,N-Dimethyl-N-ethanolamine promotes the polymerization reaction and facilitates the formation of cellular structures, leading to the production of flexible or rigid foams with desired properties such as density, resilience, and thermal insulation.
In water treatment and detergent formulations, N,N-Dimethyl-N-ethanolamine may act as a sequestering agent or chelating agent, binding to metal ions and preventing their precipitation or interference with chemical processes.
N,N-Dimethyl-N-ethanolamine helps improve water quality, prevent scale formation, and enhance the performance of cleaning products.
N,N-Dimethyl-N-ethanolamine is used in the synthesis of synthetic resins, including epoxy resins, polyurethane resins, and acrylic resins.
N,N-Dimethyl-N-ethanolamine contributes to the polymerization process, crosslinking reactions, or resin modification, leading to the production of resins with specific properties suitable for coatings, adhesives, and composite materials.
In coatings and paint formulations, N,N-Dimethyl-N-ethanolamine may be employed as a coalescing agent or viscosity modifier in waterborne systems.
N,N-Dimethyl-N-ethanolamine aids in film formation, film integrity, and flow properties, allowing for the production of environmentally friendly coatings with excellent performance and durability.
N,N-Dimethyl-N-ethanolamine can be utilized in wood preservation treatments to enhance the resistance of timber and wood products against decay, fungi, and insects.
N,N-Dimethyl-N-ethanolamine penetrates wood fibers, inhibits microbial growth, and prolongs the service life of wood structures in outdoor or humid environments.
N,N-Dimethyl-N-ethanolamine may have additional applications in diverse industries, including adhesives, sealants, lubricants, agricultural chemicals, and electronic materials.
N,N-Dimethyl-N-ethanolamine is multifunctional properties and compatibility with various substrates make it valuable in addressing specific performance requirements across different industrial sectors.
N,N-Dimethyl-N-ethanolamine is bitartrate salt is sold as a dietary supplement.
N,N-Dimethyl-N-ethanolamine has been also used as an ingredient in skin care.
N,N-Dimethyl-N-ethanolamine is used in Mood-enhancing products.
N,N-Dimethyl-N-ethanolamine serves as a precursor or intermediate in the synthesis of various chemicals, including pharmaceuticals, agrochemicals, and specialty chemicals.
N,N-Dimethyl-N-ethanolamine is utilized in organic synthesis reactions due to its amine functionality, contributing to the formation of complex molecules.
N,N-Dimethyl-N-ethanolamine is employed as a component in corrosion inhibitor formulations, particularly in industries where metal corrosion poses a significant challenge.
N,N-Dimethyl-N-ethanolamine helps mitigate corrosion by forming a protective layer on metal surfaces, thereby extending the lifespan of equipment and infrastructure.
N,N-Dimethyl-N-ethanolamine is also used as an intermediate for active pharmaceutical ingredients and dyes.
N,N-Dimethyl-N-ethanolamine serves as a curing agent for polyurethanes and epoxy resins.
Further, N,N-Dimethyl-N-ethanolamine is used as an additive to boiler water.
In addition to this, N,N-Dimethyl-N-ethanolamine is used therapeutically as a CNS stimulant.
MEA (DMAE) is also known as N,N-Dimethyl-N-ethanolamine.
Studies indicate skin-firming properties, and an ability to reduce the appearance of fine lines and wrinkles as well as dark circles under the eyes.
N,N-Dimethyl-N-ethanolamine is considered anti-aging, and antiinflammatory, and has exhibited free-radical scavenging activity.
N,N-Dimethyl-N-ethanolamine may be employed as a ligand in the copper-catalyzed amination of aryl bromides and iodides.
N,N-Dimethyl-N-ethanolamine is used as a chemical intermediate for antihistamines and local anesthetics; as a catalyst for curing epoxy resins and polyurethanes; and as a pH control agent for boiler water treatment.
However, N,N-Dimethyl-N-ethanolamine in the salt form, (i.e. dimethylaminoethanol acetamidobenzoate) is primarily utilized therapeutically as an antidepressant.
N,N-Dimethyl-N-ethanolamine is used as an aid for dispersing color pigments in water-based paints .
Furthermore, N,N-Dimethyl-N-ethanolamine is required as an intermediate product or starting material for the production of dyes , emulsifiers , corrosion inhibitors , textile auxiliaries, cosmetics and pharmaceuticals .
N,N-Dimethyl-N-ethanolamine is said to have a variety of positive effects, including nootropic effects , but there is a lack of clear evidence for this.
One author reports increased lucid dreams after using N,N-Dimethyl-N-ethanolamine.
N,N-Dimethyl-N-ethanolamine may be used as a ligand in the copper-catalyzed amination of aryl bromides and iodides.
N,N-Dimethyl-N-ethanolamine is used in the following products: laboratory chemicals, coating products, polymers, fillers, putties, plasters, modelling clay, lubricants and greases and adhesives and sealants.
N,N-Dimethyl-N-ethanolamine is used in the following areas: building & construction work, offshore mining and municipal supply (e.g. electricity, steam, gas, water) and sewage treatment.
N,N-Dimethyl-N-ethanolamine is used as corrosion inhibitor, anti-scaling agent, paint additive, coating additive and solids separation agent.
N,N-Dimethyl-N-ethanolamine is used for the manufacture of: fabricated metal products, machinery and vehicles, mineral products (e.g. plasters, cement) and metals.
Other release to the environment of N,N-Dimethyl-N-ethanolamine is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.
N,N-Dimethyl-N-ethanolamine is used in the following products: polymers, coating products, fillers, putties, plasters, modelling clay and inks and toners.
Release to the environment of N,N-Dimethyl-N-ethanolamine can occur from industrial use: formulation of mixtures, manufacturing of the substance, formulation in materials, in the production of articles and as an intermediate step in further manufacturing of another substance (use of intermediates).
N,N-Dimethyl-N-ethanolamine is used in the following products: polymers, coating products and paper chemicals and dyes.
N,N-Dimethyl-N-ethanolamine has an industrial use resulting in manufacture of another substance (use of intermediates).
N,N-Dimethyl-N-ethanolamine is used in the following areas: formulation of mixtures and/or re-packaging and building & construction work.
N,N-Dimethyl-N-ethanolamine is used for the manufacture of: chemicals, pulp, paper and paper products, fabricated metal products, machinery and vehicles and plastic products.
Release to the environment of N,N-Dimethyl-N-ethanolamine can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, formulation in materials, for thermoplastic manufacture and as processing aid.
N,N-Dimethyl-N-ethanolamine is a precursor to other chemicals, such as the nitrogen mustard 2-dimethylaminoethyl chloride.
Safety Profile:
N,N-Dimethyl-N-ethanolamine causes increased blood pressure.
N,N-Dimethyl-N-ethanolamine can cause stomach upset, headaches & muscle tension.
Can lead to drowsiness, confusion and irritability.
Moderately toxic by ingestion, inhalation, skin contact, intraperitoneal, and subcutaneous routes.
A skin and severe eye irritant.
Used medically as a central nervous system stimulant.
N,N-Dimethyl-N-ethanolamine is classified as a mild skin irritant and a severe eye irritant.
Doses as high as 1200 mg daily produce no serious side effects and a single dose of 2500 mg taken in a suicide attempt had no adverse effects.
Inhalation of the vapor or mist can cause irritation to the upper respiratory tract.
Asthmatic symptoms have been reported.
Flammable liquid when exposed to heat or flame; can react vigorously with oxidzing materials.
Ignites spontaneously in contact with cellulose nitrate of high surface area.
To fight fire, use alcohol foam, foam, CO2, dry chemical.