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CAS Number: 127-19-5
Molecular Formula: C4H9NO
Molecular Weight: 87.12
EC Number: 204-826-4
MDL number: MFCD00008686
PubChem Substance ID: 329751718
IUPAC Name: N,N-dimethylacetamide
APPLICATIONS
N,N-Dimethylacetamide (DMAc) has been employed as an organic solvent for the liquid-phase exfoliation of pristine graphene from bulk graphite.
N,N-Dimethylacetamide may be used to compose the solvent system along with lithium chloride (LiCl) for the dissolution of commercial rayon grade cellulose.
Moreover, N,N-Dimethylacetamide solvent mixtures have been used for the preparation of chitin, cellulose and polyimide fibers and films.
N,N-Dimethylacetamide may be used in the preparation of α-lithio N,N-dimethylacetamide.
Further, N,N-Dimethylacetamide along with palladium chloride forms an efficient catalytic system for the oxidation of several internal olefins to carbonyl compounds without undergoing isomerization.
N,N-Dimethylacetamide is used as a solvent for many organic reactions, resins, polymers, crystallization, and purification.
[N,N-Dimethylacetamide is used as a solvent in plastics, resins, and gums.
Also, N,N-Dimethylacetamide is used as a catalyst and paint remover.
N,N-Dimethylacetamide is also used in synthetic fiber and resin industries.
N,N-Dimethylacetamide is used as a solvent in elastane fiber factories.
Furhtermore, N,N-Dimethylacetamide is solvent in industrial applications.
N,N-Dimethylacetamide is solvent for plastics, resins, gums, and electrolytes; catalyst; paint remover; high-purity solvent for crystallization and purification.
N,N-Dimethylacetamide is used to dissolve polyacrylonitrile, polyvinyl chloride, polyamides, polyimides, cellulose derivatives, styrenes, and linear polyesters; manufacturing of films and fibers; booster solvent in coatings and adhesives formulations.
Moreover, N,N-Dimethylacetamide is electrolytic solvent; formation of dimethylacetamide complexes; chemical reaction medium and catalyst
SOME USES OF N,N-Dimethylacetamide:
Flame retardants
Functional fluids (closed systems)
Functional fluids (open systems)
Intermediates
Laboratory chemicals
Processing aids, not otherwise listed
Solvent for polyimide manufacturing
Solvents (which become part of product formulation or mixture)
Apparel and footwear care products
Paints and coatings
Photographic supplies, film, and photo chemicals
Plastic and rubber products not covered elsewhere
N,N-Dimethylacetamide is used as a polar solvent in organic synthesis as well as in reactions involving strong bases such as sodium hydroxide.
Additionally, N,N-Dimethylacetamide is also used as a solvent for fibers like polyacrylonitrile, spandex, as an excipient in drugs viz. vumon, busulfex and in the adhesive industry.
N,N-Dimethylacetamide finds application as a reaction medium in the production of pharmaceuticals, agrochemicals, dyes and plasticizers.
N,N-Dimethylacetamide is widely used in polymer industry due to its high solving power for high molecular-weight polymers and synthetic resins.
Furthermore, N,N-Dimethylacetamide plays an important role as a catalyst in various reactions viz. cyclization, halogenation, cynidation, alkylation and dehydrogenation and increases the yield of main products.
N,N-Dimethylacetamide is also used as an extracting agent for oil and gases, in paint removers, in the production of photo-resist stripping compounds and as booster solvent in coatings.
N,N-Dimethylacetamide (DMAC) is mainly used as synthetic fibers (acrylonitrile) and polyurethane spinning synthetic polyamide resin and a solvent, but also N,N-Dimethylacetamide is used for separating styrene from the C8 fraction extractive distillation solvent, and it is widely used in the aspects of polymer films, coatings and medicine. Currently, N,N-Dimethylacetamide is used to synthesize a large number of antibiotics and pesticides in the pharmaceutical and pesticide.
The catalyst can also be used for the reaction, electrolytic solvent, paint scavengers and various crystalline solvent adducts and complexes.
N,N-Dimethylacetamide is used as the reaction solvent of pharmaceutical synthesis, synthetic fiber spinning solvents and synthetic resins, photographic chemicals chromogenic agent solvents, paints and other solvents, catalyst.
N,N-Dimethylacetamide is also commercial solvent especially for textile fibers.
In addition to that, N,N-Dimethylacetamide is primarily used as an industrial solvent and intermediate in the manufacture of pharmaceuticals, fine chemicals, agrochemicals, polymers, and resins.
N,N-Dimethylacetamide is also used as a spinning solvent in the production of fibers of various polymers, including acrylic, polyurethane, polyurea copolymer, and meta-aramid.
Moreover, this aprotic dipolar solvent is also used in X-ray and photographic products and in the production of polyimide films.
The polyimide films are produced for a variety of industries, including consumer electronics, solar photovoltaic and wind energy, aerospace, automotive, and industrial applications.
N,N-Dimethylacetamide has other minor uses, including removal of ink, stripping of paint, and also for laboratory use.
N,N-Dimethylacetamide is used in all analytical laboratories as a major component of mobile phase in High Performance Liquid Chromatography (HPLC) and in Liquid Chromatography - Mass Spectrometry.
Also, N,N-Dimethylacetamide is solvent for many organic reactions and in industrial applications. dimethylacetamide is an important industrial solvent for polyacrylonitrile, vinyl resins, cellulose derivatives, styrene polymers and linear polyesters.
N,N-Dimethylacetamide is a useful as a medium for strong bases such as sodium hydroxide.
In addition, N,N-Dimethylacetamideis commonly used as a solvent for fibers or in the adhesive industry.
N,N-Dimethylacetamide is also employed in the production of pharmaceuticals and plasticizers as a reaction medium.
The solvent for GPC secures absorbances after heating considering the heat decoloration of the solvent at solubilization/analysis of the polymers.
N,N-Dimethylacetamide also secures changes of refractive infex due to moisture, peroxides, nonvolatile matters, and impurities, as well as UV absorption, making it most suitable for preparation of eluents for GPC.
The filtration through a 0.45 μm membrane filter in the final process allows obtaining data with high reproducibility and prolongs the column life.
DESCRIPTION
N,N-Dimethylacetamide (DMAc) is widely used to compose the solvent mixtures for cellulose.
Static and dynamic light scattering studies of the cellulose dissolved in varying concentrations of N,N-Dimethylacetamide mixtures have been reported.
Dimethylacetamide (DMAc or DMA) is the organic compound with the formula CH3C(O)N(CH3)2.
This colorless, water-miscible, high-boiling liquid is commonly used as a polar solvent in organic synthesis.
N,N-Dimethylacetamide is miscible with most other solvents, although it is poorly soluble in aliphatic hydrocarbons.
N,N-Dimethylacetamide is prepared commercially by the reaction of dimethylamine with acetic anhydride or acetic acid. Dehydration of the salt of N,N-Dimethylacetamide and acetic acid also furnishes this compound.
CH3CO2H·HN(CH3)2 → H2O + CH3CON(CH3)2
N,N-Dimethylacetamide can also be produced by the reaction of dimethylamine with methyl acetate.
Furthermore, N,N-Dimethylacetamide (DMAc) is a colorless to yellow liquid with a faint, specific amine-like odor.
N,N-Dimethylacetamide is miscible with water and other organic substances.
N,N-Dimethylacetamide is a versatile intermediate with a variety of applications for example as solvent.
Moreover, N,N-Dimethylacetamide is an excellent solvent with high solving power for high molecular-weight polymers and synthetic resins.
N,N-Dimethylacetamide is used as a reaction solvent for the manufacture of acryl and polyamide fibres.
N,N-Dimethylacetamide is also used for the manufacture of agro chemicals, dyes and pharmaceuticals.
In addition, N,N-Dimethylacetamideis a synthetic organic compound that is produced from a reaction of dimethylamine and acetic acid or acetic anhydride.
N,N-Dimethylacetamide is a colorless to yellow liquid with a faint odor resembling ammonia.
N,N-Dimethylacetamide has similar density to water and is miscible with water and organic substances.
Additionally, N,N-Dimethylacetamide is an organic compound which is commonly associated with many industrial uses, either as a starting material or an intermediate.
N,N-Dimethylacetamide is a good solvent that is used in polymer dissolution, especially in the fiber industry.
Historically, N,N-Dimethylacetamide was also tested as a possible antineoplastic agent in a phase 1 study involving 17 patients.
However, liver and central nervous system (CNS) toxicity associated with N,N-Dimethylacetamide was observed and these patients had altered mental states, resulting in no further drug development.
N,N-dimethylacetamide(DMAC) is colorless and transparent liquid with the formula CH3CON(CH3)2.
This low-toxic, flammable and high thermal stability liquid is commonly miscible with most organic solvents, such as water, alcohols, ethers, esters, benzene, chloroform and aromatic compounds and so on.
A variety of resin could be well dissolved in N,N-Dimethylacetamide, especially polyurethane and polyimide resin.
Usually N,N-Dimethylacetamide is employed as reaction medium in the preparation process of heat resistance synthetic fiber, plastic film, coating, medicine and polyacrylonitrile fiber，and mainly used as solvents in the organic synthesis and pharmaceuticals industry.
PROPERTIES
Autoignition Temperature: Not auto-flammable
Boiling Point/Range: 164-166 °C (1.013 hPa)
Color: Colorless to Yellowish
Density: 0.94 g/cm3 (20 °C)
Flashpoint: 11.5 %(V) (99 °C)
Form: Liquid
Grade: Headspace Solvents
Incompatible Materials: Strong oxidizing agents
Lower Explosion Limit: 1.2 %(V) (51 °C)
Melting Point/Range: -20 °C
Partition Coefficient: -0.77 (25 °C)
Solubility: Soluble in most organic solvents
Solubility in Water: Completely miscible
Upper Explosion Limit: 11.5 %(V) (99 °C)
Vapor Pressure: 2 hPa (20 °C)
Viscosity: 1.02 mPa.s (20 °C)
pH-Value: 4 at 200 g/l (20 °C)
Storage Temperature: Ambient
FIRST AID
EYES: First check the victim for contact lenses and remove N,N-Dimethylacetamide if present.
Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center.
Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.
SKIN: IMMEDIATELY flood affected skin with water while removing and isolating all contaminated clothing.
Gently wash all affected skin areas thoroughly with soap and water.
If symptoms such as redness or irritation develop, IMMEDIATELY call a physician and be prepared to transport the victim to a hospital for treatment.
INHALATION: IMMEDIATELY leave the contaminated area; take deep breaths of fresh air.
If symptoms (such as wheezing, coughing, shortness of breath, or burning in the mouth, throat, or chest) develop, call a physician and be prepared to transport the victim to a hospital.
Provide proper respiratory protection to rescuers entering an unknown atmosphere.
Whenever possible, Self-Contained Breathing Apparatus (SCBA) should be used; if not available, use a level of protection greater than or equal to that advised under Protective Clothing.
INGESTION: DO NOT INDUCE VOMITING.
If the victim is conscious and not convulsing, give 1 or 2 glasses of water to dilute the N,N-Dimethylacetamide and IMMEDIATELY call a hospital or poison control center.
Be prepared to transport the victim to a hospital if advised by a physician.
If the victim is convulsing or unconscious, do not give anything by mouth, ensure that the victim's airway is open and lay the victim on his/her side with the head lower than the body.
DO NOT INDUCE VOMITING. IMMEDIATELY transport the victim to a hospital.
SYNONYMS
N,N-DIMETHYLACETAMIDE
127-19-5
Dimethylacetamide
Acetamide, N,N-dimethyl-
DMAc
Acetdimethylamide
Dimethyl acetamide
N,N-Dimethyl acetamide
Dimethylamide acetate
N,N-Dimethylethanamide
Dimethylacetone amide
Acetic acid, dimethylamide
NSC 3138
N.N-Dimethylacetamide
Hallucinogen
CBC 510337
SK 7176
UNII-JCV5VDB3HY
