PRODUCTS

NATROSOL 250 HHX

CAS: 9004-62-0
Molecular Formula: C36H70O19
IUPAC Name: 1-[[3,4,5-tris(2-hydroxypropoxy)-6-[4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol
Molecular Weight: 806.9

Natrosol 250 HHX is a fine powder, water soluble hydroxyethylcellulose.
Natrosol 250 HHX offers compatibility with other materials such as emulsion polymers, natural and synthetic gums, emulsifiers and defoamers.
Natrosol 250 HHX is used as non-ionic thickener, water retention aid and rheology modifier.
Natrosol 250 HHX imparts very good flow properties.
Natrosol 250 HHX is used in water-based tile adhesives, wallpaper, latex and plywood adhesives.

Natrosol 250 HHX is a hydroxyethyl cellulose.
Natrosol 250 HHX is derived from vegetable cellulose and is used as a highly efficient non-ionic thickener.
Natrosol 250 HX is a fine sized white powder.
Natrosol 250 HHX ensures a completely clear, transparent and stable gel.
Dissolved in cold or hot water.
Natrosol 250 HHX can be used to produce clear, smooth and uniform solutions of varying viscosities.
Natrosol 250 HHX is well suited for making gels, shampoos and conditioners in liquid form and for stabilizing O/W emulsions.

Natrosol HEC is easily dissolved in cold or hot water to give crystal clear solutions of varying viscosities.
Solutions of Natrosol HEC are pseudoplastic or shear-thinning.
As a result, personal care products formulated with Natrosol HEC dispense rich and thick from the container, but spread easily on hair and skin.

Natrosol 250 Pharm hydroxyethylcellulose (HEC) is a nonionic, water-soluble polymer widely used in pharmaceutical formulations.
Like Aqualon and Blanose sodium carboxymethylcellulose (CMC), it is a cellulose ether, but it differs in that it is nonionic and its solutions are unaffected by cations and, thus, less affected by pH changes and more tolerant of the presence of anions and organic co-solvents.
Natrosol 250 Pharm hydroxyethylcellulose (HEC) also differs from other cellulose ethers, such as Klucel hydroxypropylcellulose (HPC) and Benecel hydroxypropylmethylcellulose (HPMC), in that it is soluble in both cold and hot water and does not precipitate from aqueous solutions at elevated temperatures.

The Natrosol 250 Pharm HEC polymer is a partially substituted poly(hydroxyethyl) ether of cellulose.
The base of the HEC molecule is formed by the polysaccharide cellulose and its β (1→4)–linked D-glucose units.
The structure of the cellulose molecule can be visualized as a polymer chain composed of repeating cellobiose units.
These, in turn, are composed of two anhydroglucose units (β-glucopyranose residues).
Each anhydroglucose unit contains three hydroxyls capable of reaction.

acidity/alkalinity: pH 6.0 – 8.5 for a 1% w/v aqueous solution

density (bulk): 0.4 – 0.6 g/cm³

density (tap): 0.6 – 0.7 g/cm³

moisture content: ≤ 5% (w/w) of water

particle size: distribution standard grind, retained on #40 mesh (420 µm; max 10%)
X-grind, retained on #60 mesh (250 µm; max 0.5%)
type HHW, retained on #80 mesh (177 µm; max 0.5%)

Natrosol 250 Pharm HEC dissolves quickly in cold or hot water to form clear and smooth solutions; furthermore, it does not gel or precipitate even when heated to the boiling point of water.
Natrosol 250 Pharm HEC is essentially insoluble in organic solvents.
Natrosol 250 Pharm HEC is, however, partly soluble in some solvents, usually those that are miscible with water (e.g., ethanol: water mixtures), or that contain polar groups (e.g., glycerin and propylene glycol at temperatures around 55 °C to 60 °C).

Natrosol 250 Pharm HEC can absorb moisture from the atmosphere, as do other hygroscopic or finely divided materials.
The amount of moisture absorbed depends on the initial moisture content of Natrosol 250 Pharm HEC and on the relative humidity of the surrounding air.
Opened bags not totally used may experience moisture uptake.
During prolonged storage, the moisture content of Natrosol 250 Pharm HEC reaches an equilibrium level that varies with temperature and the humidity of the surrounding atmosphere, particularly after the bag is opened.

To maintain its original moisture content, Natrosol 250 Pharm HEC should be stored in tightly closed containers in a dry atmosphere.
If stored in open containers, the moisture content will change to an equilibrium value determined by the relative humidity of the environment.
The effects of relative humidity on equilibrium moisture contents of different grades of Natrosol 250 Pharm HEC at 25 °C (left) and 40 °C.

Natrosol 250 Pharm HEC is readily soluble in either hot or cold water.
However, as with most water-soluble thickeners, the particles tend to agglomerate, or lump, when first wetted with water.
Thus, the time required to achieve complete solution of Natrosol 250 Pharm HEC is usually governed by the degree of lumping that can develop during the solution process.
In general, the low-viscosity grades are more easily dissolved than the high-viscosity grades. Employing these methods will facilitate the quick preparation of solutions of Natrosol 250 Pharm HEC:

method 1: stirring

Natrosol 250 Pharm HEC is sifted slowly into the vortex of vigorously agitated water.
The rate of addition should be slow enough for the particles to separate without lump formation, but not so slow that the solution thickens appreciably before all the solids are added.
Agitation should be continued until all the swollen or gelatinized particles are dissolved to yield a smooth solution.

method 2: use of water miscible organic solvent

Excellent solution rates can be obtained by prewetting Natrosol 250 Pharm HEC with a water-miscible organic liquid before the powder is added to water.
Anhydrous ethyl alcohol is suitable for this use, as are other organic liquids such as propylene glycol and glycerin.

method 3: blending with other water insoluble materials

Improved solution rates can be obtained by dryblending Natrosol 250 Pharm HEC with other dry components (preferably water insoluble) contained in the formulation prior to dispersing in water.
This technique effectively separates particles of Natrosol 250 Pharm HEC so that no lumping is experienced when the dry mix is added to water.

All polymer solutions and many pharmaceutical formulations such as syrups, dispersions, emulsions, gels and creams are examples of non-Newtonian fluids.
This means that their viscosities are not fixed, but rather are dependent upon the degree of shear to which they are exposed.
By far the most common form of nonNewtonian behavior is shear-thinning or pseudoplastic flow, where the viscosity decreases with increasing shear rate.
Solutions of Natrosol 250 Pharm HEC are examples of shear-thinning materials.
Thus, if a solution of high-viscosity Natrosol 250 Pharm HEC appears to be a viscous liquid as it is poured from a bottle, it can behave as a runny liquid when applied as a lotion to the skin, and yet when high stress is removed, it will quickly revert to its original high viscosity.
Because of this behavior, Natrosol 250 Pharm HEC is extensively used to modify the viscosity of solutions, dispersions, and emulsions.
Depending on the selected grade and the concentration used, a wide variety of viscosities can be achieved with Natrosol 250 Pharm HEC.
Thus, solution viscosity is dependent on several factors.

Features & Benefits:

-Excellent salt tolerance

-Imparts slip and lubricity

-Ability to create clear formulations

-Stabilizes emulsion systems

-Surface-treated to aid incorporation into water

-Vegan suitable

Related Applications:
-Personal Care

-Antiperspirant, Deodorant

-Baby Care

-Hair Care

-Oral Care

-Skin Care

-Sun Care

Related Benefits:

-Personal Care

-Cold-processable

-Nature-derived

-Vegan Suitable

Related Functions:

-Personal Care

-Rheology Control

-Rheology Modifiers

Hydroxyethyl cellulose is a gelling and thickening agent derived from cellulose.
It is widely used in cosmetics, cleaning solutions, and other household products.
Hydroxyethyl cellulose and methyl cellulose are frequently used with hydrophobic drugs in capsule formulations, to improve the drugs' dissolution in the gastrointestinal fluids.
This process is known as hydrophilization.

Hydroxyethyl cellulose is also used extensively in the oil & gas industry as a drilling mud additive under the name HEC as well in industrial applications, paint & coatings, ceramics, adhesives, emulsion polymerization, inks, construction, welding rods, pencils and joint fillers.

Hydroxyethyl cellulose can be one of the main ingredients in water-based personal lubricants.
It is also a key ingredient in the formation of big bubbles as it possesses the ability to dissolve in water but also provide structural strength to the soap bubble.
Among other similar chemicals, it is often used as slime.

Hydroxyethyl cellulose is a polysaccharide derivative with gel thickening, emulsifying, bubble-forming, water-retaining and stabilizing properties.
It is used as a key ingredient in many household cleaning products, lubricants and cosmetics due to its non-ionic and water-soluble nature.
It is often used as an ingredient in ophthalmic pharmaceutical preparations such as artificial tear solutions and adjunct agent in topical drug formulations to facilitate the delivery of drugs with hydrophobic character.

SYNONYMS:

aldiamed

hydroxyethylcellulose

hydroxyethylcellulose, sodium salt

hydroxyl ethyl cellulose

Lacrigel

Minims Artificial Tears

Natrosol 250

Cellulose hydroxyethylate

HYDROXYETHYLCELLULOSE

Cellulose hydroxyethyl ether

2-Hydroxyethyl cellulose ether

DB11602