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Neo Heliopan 303 is a viscous, clear, colorlesss oi introduced in commercial sunscreens and anti-ageing creams about 15 years ago.
Neo Heliopan 303 is the 2-ethylhexyl ester of 2-cyano-3,3-diphenylacrylic acid, with the extended conjugation of the acid portion that absorbs UVB and short-wave UVA (ultraviolet) rays, with wavelengths from 280 to 320 nm, which promote tanning but also contribute to the onset of sunburn and skin cancer.
Neo Heliopan 303 is used in various body care products, in concentrations up to 10%, to provide an adequate sun-protection factor or to protect the body care formulations themselves from UV radiation.
CAS Number: 6197-30-4
Molecular Formula: C24H27NO2
Molecular Weight: 361.48
EINECS Number: 228-250-8
Synonyms: Octocrylene, 6197-30-4, 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, Octocrilene, 2-ETHYLHEXYL-2-CYANO-3,3-DIPHENYLACRYLATE, 2-Propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester, 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate, 5A68WGF6WM, Octocrilene [INN], 2-Cyano-3,3-diphenylacrylic Acid 2-Ethylhexyl Ester, NSC-760433, MLS002454364, DTXSID9025299, Octocrilene (INN), Parsol 340, UV-3039, NCGC00091585-03, NCGC00091585-05, ANTHELIOS SX COMPONENT OCTOCRYLENE, SMR001371988, CAPITAL SOLEIL COMPONENT OCTOCRYLENE, OCTOCRYLENE (MART.), OCTOCRYLENE [MART.], 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, 97%, OCTOCRYLENE (USP-RS), OCTOCRYLENE [USP-RS], DTXCID205299, Octocrylene [USAN], Octocrileno, Octocrilenum, OCTOCRYLENE (USP IMPURITY), OCTOCRYLENE [USP IMPURITY], OCTOCRYLENE (USP MONOGRAPH), OCTOCRYLENE [USP MONOGRAPH], Octocrilenum [INN-Latin], Octocrileno [INN-Spanish], UV Absorber-3, CAS-6197-30-4, CCRIS 4814, EINECS 228-250-8, Octocrylene [USAN ], UNII-5A68WGF6WM, Octocrilen, 2-Ethylhexyl 2-cyano-3,3-diphenyl-2-acrylate, 2-Ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, 2-Cyano-3,3-diphenyl-2-propenoic acid 2-ethylhexyl ester; 2-Ethylhexyl 2-cyano-3,3-diphenyl-prop-2-enoate; Octocrylene; 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate|Parsol 340, Octocrylene (USP), Neo heliopan 303, Uvinul N539, 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-PROP-2-ENOATE, Uvinul N-539, OCTOCRYLENE [MI], EC 228-250-8, SCHEMBL16483, OCTOCRILENE [WHO-DD], 80135-31-5, cid_22571, Octocrylene, analytical standard, CHEMBL1201147, BDBM74416, OCTOCRYLENE [ORANGE BOOK], CHEBI:135526, GLXC-27412, HMS3039D04, AMY40810, BCP15293, HY-A0087, Octyl 2-Cyano-3,3-diphenylacrylate, Tox21_111153, Tox21_200236, 2-CYANO-3,3-DIPHENYL-2-PROPENOIC ACID, 2-ETHYLHEXYL ESTER, MFCD00059260, s1750, AKOS015900539, Tox21_111153_1, 1ST3418, AC-7027, CCG-268181, CS-4296, NSC 760433, NCGC00091585-01, NCGC00091585-04, NCGC00091585-06, NCGC00257790-01, AS-13821, 2-ethylhexyl alpha-cyano-beta-phenylcinnamate, 2-ethylhexyl-alpha-cyano-beta-phenylcinnamate, NS00010308, OCTOCRYLENE COMPONENT OF ANTHELIOS SX, OCTOCRYLENE COMPONENT OF CAPITAL SOLEIL, D05227, D70471, A833511, Q424805, SR-01000864577, Q-201499, SR-01000864577-2, 2-cyano-3,3-diphenyl-acrylic acid 2-ethylhexyl ester, 2-cyano-3,3-diphenyl-acrylic acid 2-ethyl-hexyl ester, Octocrylene, United States Pharmacopeia (USP) Reference Standard, Octocrylene, Pharmaceutical Secondary Standard; Certified Reference Material.
Neo Heliopan 303 clear yellow viscous liquid with mild characteristic odor, Miscible in methanol, n-butanol, ethyl acetate, mineral oil, hexane, toluene.
Neo Heliopan 303 is an effective oil soluble liquid UV‐B filter.
Neo Heliopan 303 has excellent dissolving properties for crystalline UV filters.
Neo Heliopan 303 is a trade name for Octocrylene, a chemical compound commonly used in sunscreens and other skincare products as a UV filter.
Neo Heliopan 303 absorbs UVB and some UVA rays, providing protection against the harmful effects of ultraviolet radiation.
It is often used in combination with other UV filters to enhance the effectiveness of sunscreens.
In addition to its UV-filtering properties, Neo Heliopan 303 also acts as a stabilizer for other sunscreen agents, particularly those that are prone to degradation under sunlight, like Avobenzone.
This makes it a valuable ingredient in formulations that require long-lasting sun protection.
Neo Heliopan 303 primarily serves as a UVB filter (280-320 nm) and offers some protection in the UVA range (320-400 nm).
Neo Heliopan 303 helps prevent sunburn and other damage caused by UV radiation, making it a key ingredient in sunscreens.
Neo Heliopan 303 stabilizes other UV filters in sunscreen formulations.
For instance, it prevents Avobenzone, a common UVA filter, from breaking down when exposed to sunlight, thereby extending the overall effectiveness of the sunscreen.
Neo Heliopan 303 also acts as an emollient, improving the texture and feel of skincare products.
It helps to keep the skin moisturized, leaving a smooth, non-greasy finish.
Neo Heliopan 303 is compatible with a wide range of other ingredients in cosmetic formulations, making it versatile for use in various products such as lotions, creams, and sprays.
Due to its oil-soluble nature, Neo Heliopan 303 contributes to the water-resistant properties of sunscreen formulations, ensuring protection even during swimming or sweating.
Neo Heliopan 303 acts as an effective oil-soluble and liquid UVB absorber.
It provides UV protection for a wide variety of cosmetic applications.
Neo Heliopan 303 offers additional absorption in the short-wave UVA spectrum.
Clear Yellow to pale yellow viscous liquid with mild characteristic odor.
Neo Heliopan 303 is an effective oil soluble and liquid UVB absorber offering additional absorption in the short-wave UVA spectrum.
Neo Heliopan 303 is an excellent solubilizer for crystalline UV absorbers.
Neo Heliopan 303 is an organic compound used as an ingredient in sunscreens and cosmetics.
It is an ester formed by the Knoevenagel condensation of 2-ethylhexyl cyanoacetate with benzophenone.
Neo Heliopan 303 is a viscous, oily liquid that is clear and colorless.
The extended conjugation of the acrylate portion of the molecule absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths from 280 to 320 nm, protecting the skin from direct DNA damage.
The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water resistant) properties.
Neo Heliopan 303 is a pale yellow liquid with a melting point of 96-98ºC.
An oil-miscible UV-B filter that is approved in the USA, Europe and in Japan for use in suncare preparations.
As it is miscible with many cosmetic oils, it can easily be incorporated in the oily phase of an emulsion.
Because it is Neo Heliopan 303 and oil-soluble, it is preferred for water-resistant and water-repellant formulations.
Also features excellent photostability, and its ability to stabilize Butyl Methoxydibenzoylmethane.
Neo Heliopan 303 is a globally approved sunscreen agent that primarily protects skin from the UVB range of sunlight while providing a small amount of UVA protection.
Neo Heliopan 303 also helps stabilize the UVA sunscreen ingredient avobenzone.
Therefore, the two are often found in the same sunscreen formulas.
This UV filter is highly stable in the presence of sunlight and can make it easier for chemists to incorporate other UV filters to achieve higher SPF ratings without worry that the filters will crystallize, which hinders their effectiveness.
Neo Heliopan 303 has been extensively reviewed and is considered safe as used in cosmetics and sunscreens.
It does not have endocrine-disrupting properties and is considered a “rare sensitizer”, as are many other synthetic UV filters.
An oil-soluble chemical sunscreen agent that protects skin in the UVB and somewhat in the UVA II range with a peak absorption of 304 nm.
Its protection is not strong enough on its own but it is quite photostable (loses 10% of SPF protection in 95 mins) and is often used to stabilize other photo-unstable UV-filters, for example, Neo Heliopan 303.
Neo Heliopan 303 is also often used to improve the water resistance of the products.
Neo Heliopan 303's safety profile is generally quite good, though a review study in Contact Dermatitis reports an "increasing number of patients with photo contact allergy to octocrylene."
Mainly adults with ketoprofen-sensitivity and children with sensitive skin are affected, so if have a small kid, it is probably better to use octocrylene-free sunscreens.
Neo Heliopan 303 can easily be incorporated into the oil phase of a formulation.
It is the most effective stabilizer for Avobenzone.
Neo Heliopan 303 is an excellent solubilizer for solid, crystalline UV absorbers.
In combination with other UV-filters high SPF can be achieved.
It is world wide approved.
Neo Heliopan 303 is a common ingredient in cosmetics and sunscreens.
Neo Heliopan 303 serves as an organic UV filter that helps protect the skin from harmful UVB radiation from the sun.
Neo Heliopan 303 is known for its ability to absorb and dissipate UV rays, preventing them from penetrating the skin and causing damage like sunburn and premature aging. Octocrylene’s inclusion in cosmetic products, especially sunscreens, enhances their effectiveness in providing broad-spectrum sun protection.
However, it is worth noting that some concerns have been raised about potential skin sensitivity and the need for careful formulation due to its potential to degrade in the presence of other UV filters or sunlight.
The chemical formula of Neo Heliopan 303 is C24H27NO2.
Neo Heliopan 303 is a versatile and widely used compound in skincare and cosmetics due to its sun-protective properties.
Neo Heliopan 303 serves as a key ingredient in products like sunscreens, where it acts as an organic UV filter. Octocrylene effectively absorbs and scatters harmful UVB rays, helping to shield the skin from sunburn and UV-induced damage.
Its ability to provide broad-spectrum protection makes it quite essential in this industry
Neo Heliopan 303 is often incorporated into products to offer an added layer of UV defense.
This UV-filtering property helps safeguard the skin from daily sun exposure, preventing the breakdown of collagen and elastin, which can lead to wrinkles and fine lines.
It is also lightweight in texture so it does not weigh down the skin
Neo Heliopan 303 is an organic compound used as an ingredient in sunscreens and cosmetics.
It is an ester formed by the reaction of 3,3- diphenylcyanoacrylate with 2-ethylhexanol.
It is a viscous, oily liquid that is clear and colourless.
The extended conjugation of the acrylate portion of the molecule absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths from 280 to 320 nm, protecting the skin from direct DNA damage.
The ethylhexanol portion is a fatty alcohol, adding emollient and oil-like (water-resistant) properties.
Neo Heliopan 303 is an organic sun filter.
This filter mainly absorbs UVB radiation, which is responsible for tanning but also for sunburn and skin cancer.
Neo Heliopan 303 protects the skin from the harmful effects of the sun and premature skin ageing.
It helps prevent the risk of skin cancer.
This filter mainly absorbs UVB rays, and shorter UVA rays, which are responsible for ageing but also for skin cancer.
Neo Heliopan 303 remains stable and therefore effective during exposure to the sun.
Neo Heliopan 303 stabilises avobenzone, a particularly effective filter against long UVA rays, enabling it to be used.
It enables sunscreen products to be water-resistant.
Neo Heliopan 303 is an ingredient used in sunscreens for its ability to absorb UV rays, protecting the skin from sun damage.
Neo Heliopan 303 is a thick colourless ingredient; it is very chemically stable and can be used as an additive to cosmetics to preserve any natural chemical degradation that can occur when skincare products are exposed to sunlight for prolonged periods.
Neo Heliopan 303 is classed as a chemical sunscreen due to this ability to protect the skin from UV damage.
Neo Heliopan 303 is different from your physical based sunscreens such as; zinc or titanium dioxide which work to protect the skin by creating a physical barrier.
Neo Heliopan 303 is also thought to have skin-moisturizing effects because of its emollient properties.
Emollients help to prevent moisture loss from the top layers of the skin.
However, it’s important to remember that the primary purpose of this ingredient is to neutralize UV radiation, and any emollient properties are just an added benefit.
Neo Heliopan 303 is often used in formulations for products such as; hair sprays, tanning oils, BB creams, conditioners, and CC creams.
Another useful chemical property of Neo Heliopan 303 is its ability to easily combine with other oils, which makes it helpful as an emulsifier – used to keep ingredients more thoroughly mixed to improve their effectiveness.
In-vitro studies have shown that sunscreen combinations containing octocrylene may increase UVA protection levels without causing instability or significantly harming the skin and boosting the sun protection factor (SPF).
Neo Heliopan 303 is an effective oil-soluble liquid UV‐B filter.
It has excellent dissolving properties for crystalline UV filters. Due to its outstanding photostability, it is used as a photostabilizer.
The conjugated acrylate portion absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths in the range of 280-320 nm which protects the skin from direct DNA damage.
The ethylhexanol portion is a fatty alcohol, which functions as an emollient due to its hydrophobicity.
Neo Heliopan 303 is a commercially used UVB filter, termed an environmental pollutant because of its stability, lipophilic nature, and resistance to sunlight degradation.
Neo Heliopan 303 is employed as an ingredient in water-resistant sunscreen products and high SPF formulations.
Sunscreen products are intended to be applied to the body every day, over the course of a lifetime.
The companies that make and sell sunscreen ingredients and products should test them thoroughly for potential short-term and long-term health effects.
This includes toxicity testing for irritation and skin allergies, as well as testing for skin absorption and the potential to cause cancer, disrupt the hormone system and impact reproduction and development.
Neo Heliopan 303 is used as an active ingredient in over-the-counter (OTC) sunscreens to protect skin against the damaging effects from ultraviolet (UV) light.
Neo Heliopan 303 is a liquid UVB sunscreen.
Clear, viscous yellow liquid, weak characteristic odor USP grade.
UVB filter and photostabilizer for other sunscreens (e.g. avobenzone). Excellent solvent for solid and/or water resistant sunscreens.
Neo Heliopan 303 is a versatile organic compound commonly utilized by formulators in the cosmetic and skincare industry.
Neo Heliopan 303 serves as a key active ingredient in sunscreens and various other skincare products designed to provide effective protection against the harmful effects of ultraviolet (UV) radiation from the sun.
As a formulator, understanding the properties and benefits of Octocrylene is crucial for creating high-quality sunscreens and skincare formulations.
Incorporating Neo Heliopan 303 into formulations requires careful consideration of its properties and compatibility with other ingredients.
Neo Heliopan 303 is typically used at concentrations ranging from 2% to 10% in sunscreen formulations.
The exact concentration should be determined based on the desired SPF (Sun Protection Factor) and the presence of other UV filters in the formula.
Neo Heliopan 303 is oil-soluble, which means it should be added to the oil phase of your formulation.
Ensure that Neo Heliopan 303 dissolves completely to maximize its UV-absorbing capabilities.
Neo Heliopan 303 can degrade when exposed to UV radiation. To enhance its stability, it is often combined with other UV filters like avobenzone and homosalate, which help prevent degradation.
Antioxidants like vitamin E can also be added to protect Neo Heliopan 303 from oxidation.
Neo Heliopan 303 is relatively stable across a broad pH range, making it suitable for a variety of formulations, including those containing acidic or alkaline ingredients.
Ensure Neo Heliopan 303 compatibility with other ingredients in your formulation, including emollients, thickeners, and emulsifiers.
Conduct compatibility tests to avoid potential issues such as phase separation or instability.
Be aware of regulatory guidelines, especially if you are formulating sunscreens.
The U.S. Food and Drug Administration (FDA) regulates the use of Neo Heliopan 303 in sunscreens, and compliance with their regulations is essential.
Neo Heliopan 303 offers numerous advantages to formulators in the creation of sunscreens and skincare products:
Neo Heliopan 303 is an effective UVB filter and provides valuable UV radiation protection, aiding in the prevention of sunburn.
When combined with other UV filters, Neo Heliopan 303 contributes to the overall stability of the sunscreen or skincare product, ensuring it maintains its efficacy over time.
When used alongside UVA-absorbing ingredients, Neo Heliopan 303 helps achieve broad-spectrum protection, safeguarding against both UVB and UVA rays, which are responsible for premature skin aging.
Neo Heliopan 303 can be easily incorporated into various formulation types, including lotions, creams, sprays, and sticks, making it adaptable to different product formats.
It enhances the water resistance of sunscreen formulations, making them suitable for outdoor activities and water-based sports.
Neo Heliopan 303 is generally well-tolerated by most skin types and is less likely to cause skin irritation or allergic reactions.
Melting point: -10 °C (lit.)
Boiling point: 218 °C/1.5 mmHg (lit.)
Density: 1.051 g/mL at 25 °C (lit.)
vapor pressure: 0Pa at 25℃
refractive index: n20/D 1.567(lit.)
Flash point: >230 °F
storage temp.: 15-25°C
solubility: Chloroform (Slightly), Methanol (Sparingly)
form: Oil
color: Colourless to Light Yellow
Merck: 14,6756
InChIKey: FMJSMJQBSVNSBF-UHFFFAOYSA-N
LogP: 6.1 at 23℃
Neo Heliopan 303 readily absorbs through the skin at levels about 14 times the FDA cutoff for systemic exposure.
Neo Heliopan 303 has been linked to aquatic toxicity, potentially harming coral health.
The study suggests that octocrylene can break down to form a substance called benzophenone, which may lead to cancer.
According to one study, benzophenone levels can increase in products over time.
The European Commission recently concluded that although there was some evidence of Neo Heliopan 303’s hormone-disrupting potential, current use concentrations of up to 10 percent were considered safe.
Neo Heliopan 303 is an organic ultraviolet (UV) filter that absorbs mainly UVB radiation and shorter UVA wavelengths.
Neo Heliopan 303 acts as a partial agonist of PPARγ, which alters the gene transcription profile of lipid metabolism enzymes.
In addition, Neo Heliopan 303 is cytotoxic and genotoxic to human skin fibroblasts and mediates the biosynthesis of estrogens such as estriol in zebrafish larvae, while affecting antioxidant pathways including glutathione transferase and peroxisomes.
Neo Heliopan 303 has been found in various environments, not least those of swimming pools, where it is evidently released by consumers to the point that it is now considered an emerging micropollutant similar to poly-fluoroalkyl substances (PFAS), blue-green algae, toxic fungal products, hormones, psychoactive drugs, pesticides, cosmetics, and industrial additives and drugs.
These substances, unlike conventional and unconventional pollutants, are still largely unregulated by legislation and are not restricted by maximum permitted values.
Furthermore, they are potentially dangerous for the environment and human health, even in an overall context of insufficient data linked to their dangerousness.
Neo Heliopan 303 is an ester derivative.
Neo Heliopan 303 esters react with acids to liberate heat along with alcohols and acids.
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products.
Heat is also generated by the interaction of esters with caustic solutions.
Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
Palau has banned the sale and use of three reef-toxic UV filters including Neo Heliopan 303 in its Responsible Tourism Education Act of 2018.
The United States Virgin Islands has also banned the use of sunscreens containing octocrylene, requiring that all visitors use "non-nano mineral sunscreen" containing zinc oxide and titanium dioxide.
Neo Heliopan 303 is a common ingredient in chemical sunscreens and anti-aging creams.
Neo Heliopan 303 protects the skin from UV rays, which can cause sunburns and skin cancer.
Some studies have questioned Neo Heliopan 303’s safety.
Manufacturers worldwide use Neo Heliopan 303 as an additive ingredient in skin care products and cosmetics.
It can help protect the skin against UV radiation and also has emollient properties.
However, the ingredient may cause side effects, such as allergic reactions.
Some research also shows that it can harm marine life, such as coral.
This article discusses Neo Heliopan 303 in further detail, including its benefits and potential side effects.
The article also explores the environmental impact of Neo Heliopan 303 and how to use octocrylene sunscreens.
Neo Heliopan 303 is synthesized through a chemical reaction known as the esterification process.
This involves combining a compound called 2-ethylhexanol with a chemical known as methacrylic acid.
The reaction results in the formation of Neo Heliopan 303, which can then be purified and used as a UV-filtering ingredient in cosmetics and sunscreen formulations.
Neo Heliopan 303 is also known under the names Octocrilene, 2-ethylhexyl 2-cyano-3 and 3-diphenylacrylate.
Neo Heliopan 303 is a compound often used as an additive in sunscreen and is thought to have skin moisturizing effects because of its emollient properties.
Neo Heliopan 303, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure.
Neo Heliopan 303 is also often combined with avobenzone, another common sunscreen ingredient often appearing on ingredient labels.
Because of its effectiveness, the chemical has been approved across the globe for use in cosmetics and skincare products, but the concentrations of this ingredient are usually limited to no more than 10 or 12 %.
However, the use of this chemical doesn’t just stop with sunscreen for the face and arms but can extend to a variety of other products, like hair spray, tannin oil, BB cream, conditioner, and CC cream, among others.
Neo Heliopan 303 may cause contact and photo contact allergy.
Rising demand for cosmetics and sunscreens due to increased incidences of skin cancer is expected to drive the octocrylene market.
Due to changing environment globally and increasing awareness about skin cancer, consumer groups are turning towards sunscreens.
Neo Heliopan 303 is an important and indispensable component due to its advantageous properties.
With the increase in the sunscreen and cosmetics industries worldwide, demand for octocrylene is anticipated to expand at a significant growth rate Neo Heliopan 303 is an organic compound and ester formed by the condensation of a diphenylcyanoacrylate with 2-ethylhexanol (a fatty alcohol, adding emollient and oil-like, water resistant properties).
Neo Heliopan 303 is primarily used as an active ingredient in sunscreens because of its ability to absorb UVB and short-wave UVA (ultraviolet) rays and protect the skin from direct DNA damage.
Neo Heliopan 303 is chemically related to cinnamates. It can be used to boost SPF and improve water resistance in a given formulation.
Octocrylene is photostable and can improve the photostability of other sunscreens. It is expensive and can present difficulties in the formulation.
Octocrylene is an ester of diphenylcyanoacrylate and 2-ethylhexanol formed by the condensation process.
The organic compound is a colourless, oily and viscous liquid.
Neo Heliopan 303 is primarily used in sunscreens owing to its skin moisturizing properties.
Neo Heliopan 303 can neutralize UV radiation emitted by the sun and minimizes skin damage caused by prolonged sun exposure.
The compound is approved by various regulatory organizations across the globe; however, its concentration is limited to 10-12% in any formulation.
It is not used to protect the face and arms.
It is widely used in the products such as BB cream, CC cream, hair spray, conditioner and tannin oil.
It is an ester formed by the Neo Heliopan 303 is an oil-miscible UV-B filter that is approved in the USA, Europe and in Japan for use in sun care preparations.
As Neo Heliopan 303 is miscible with many cosmetic oils, octocrylene can easily be incorporated in the oily phase of an emulsion.
Because Neo Heliopan 303 is hydrophobic and oil-soluble, Neo Heliopan 303 is preferred for water-resistant and water-repellant formulations octocrylene is also compatible with all common plasticizers.
On the basis of safety assessment, and considering the concerns related to potential endocrine-disrupting properties of Octocrylene, the SCCS is of the opinion that Neo Heliopan 303 is safe as a UV-filter at concentrations up to 10% in cosmetic products when used individually.
Neo Heliopan 303 is also considered safe for combined use of sunscreen cream/lotion, sunscreen pump spray, face cream, hand cream and lipstick at a concentration up to 10%.
However, the use of Neo Heliopan 303 at 10% or above in sunscreen propellant spray is not considered safe for the combined use.
Neo Heliopan 303 may sound otherworldly, but it's a skincare ingredient that may unknowingly be using daily—if you are applying sunscreen every day, which we highly recommend.
It's a chemical sunscreen ingredient, used not only for its own ability to protect skin from both UVA and UVB rays but also for its ability to increase further the stability and efficacy of other chemical sunscreen ingredients, hence its popularity and prevalence.
Ahead, dermatologists explain exactly how this ingredient works—and also weigh in on the controversy surrounding it.
Neo Heliopan 303 is approved for use in cosmetic products in many regions, including the United States, Europe, and Asia. Regulatory bodies like the FDA (U.S. Food and Drug Administration) and the European Commission have evaluated its safety and have set specific limits on its concentration in products.
Generally, Neo Heliopan 303 is considered safe when used as directed, with typical concentrations in sunscreens ranging from 7% to 10%.
Uses:
Neo Heliopan 303 is an ingredient used in sunscreens for its ability to absorb UV rays, protecting the skin from sun damage.
It is chemically related to cinnamates.
Neo Heliopan 303 can be used to boost SPF and improve water resistance in a given formulation.
Neo Heliopan 303 is photostable and can improve the photostability of other sunscreens.
It is expensive and can present difficulties in formulation.
Neo Heliopan 303 is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties.
Neo Heliopan 303 is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure.
Neo Heliopan 303 protects the skin from the harmful effects of the sun and premature skin aging.
It helps prevent the risk of skin cancer.
This filter mainly absorbs UVB rays, and shorter UVA rays, which are responsible for aging but also for skin cancer.
Neo Heliopan 303 is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Another release to the environment of Neo Heliopan 303 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as a processing aid.
Another release to the environment of Neo Heliopan 303 is likely to occur from, outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials) and indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment).
Neo Heliopan 303 can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones) and paper (e.g. tissues, feminine hygiene products, nappies, books, magazines, wallpaper).
Neo Heliopan 303 is used in the following products: cosmetics and personal care products, laboratory chemicals, perfumes and fragrances, pharmaceuticals and photo-chemicals.
Neo Heliopan 303 is used in the following areas: formulation of mixtures and/or re-packaging.
Another release to the environment of Neo Heliopan 303 is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as a processing aid.
Neo Heliopan 303 is used in the following products: cosmetics and personal care products and perfumes and fragrances.
Release to the environment of Neo Heliopan 303 can occur from industrial use: formulation of mixtures.
Neo Heliopan 303 is used in the following products: cosmetics and personal care products, laboratory chemicals, perfumes and fragrances, pharmaceuticals and photo-chemicals.
Neo Heliopan 303 is used in the following areas: formulation of mixtures and/or re-packaging.
Neo Heliopan 303 is used for the manufacture of plastic products.
Release to the environment of Neo Heliopan 303 can occur from industrial use: in the production of articles, in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), as a processing aid, for thermoplastic manufacture and as a processing aid.
When used as a sunscreen active ingredient, Neo Heliopan 303 protects the skin from the harmful effects of the sun’s UV rays.
Exposing unprotected skin to UV light can result in sunburn (primarily from UVB rays) and accelerate premature skin aging, as well as skin cancer (primarily from UVA rays).
Neo Heliopan 303 is used widely in sunscreens for its broad-spectrum UV absorbent properties.
The most common application of Neo Heliopan 303 is in sunscreens, where it provides UV protection and stabilizes other active ingredients.
Neo Heliopan 303 is included in moisturizers that offer sun protection, helping to maintain skin hydration while protecting against UV damage.
Used in lip care products with SPF, Neo Heliopan 303 helps protect the delicate skin of the lips from UV radiation.
By protecting the skin from UV damage, it helps prevent premature aging, such as wrinkles and fine lines, making it a common ingredient in anti-aging skincare products.
Neo Heliopan 303 is also found in makeup products like foundations and BB creams that offer sun protection, ensuring the skin is shielded from harmful UV rays while providing cosmetic coverage.
Neo Heliopan 303 is widely used in sunscreens to protect the skin from harmful UVB and some UVA rays.
Neo Heliopan 303 helps prevent sunburn and long-term skin damage like photoaging and skin cancer.
It stabilizes other sunscreen ingredients, particularly Avobenzone, which can degrade when exposed to sunlight.
This makes the sunscreen more effective and longer-lasting.
Added to moisturizers, Neo Heliopan 303 provides daily sun protection, making these products suitable for everyday use, particularly in anti-aging formulations.
It also contributes to the emollient properties of moisturizers, helping to keep the skin hydrated and smooth.
Neo Heliopan 303 is included in lip balms that offer sun protection, shielding the delicate skin of the lips from UV damage while also providing moisture.
Neo Heliopan 303 is used in makeup products that offer sun protection, ensuring that the skin is protected from UV rays while providing coverage and enhancing the complexion.
Neo Heliopan 303 helps protect the skin from UV-induced aging, such as wrinkles, fine lines, and hyperpigmentation, making it a common ingredient in anti-aging creams and serums.
Due to its oil-soluble nature, Neo Heliopan 303 contributes to the water-resistant properties of sunscreens, ensuring they remain effective during activities like swimming or sweating.
Neo Heliopan 303 is sometimes included in after-sun products to soothe the skin and provide continued protection from residual UV exposure after sun exposure.
Neo Heliopan 303 is used in hair care products, such as leave-in conditioners and sprays, to protect hair from UV damage, which can cause color fading and dryness.
In perfumes and fragrances, Neo Heliopan 303 helps to stabilize the formulation, preventing UV light from degrading the scent or causing discoloration.
It can be used in medicinal creams and ointments that require UV protection to protect sensitive skin during treatment.
Side effects:
Some people are concerned about the body’s ability to absorb Neo Heliopan 303, which can present in the blood, urine, and breast milk.
Neo Heliopan 303 may promote the production of free radicals, which can damage DNA, potentially increasing the risk of melanoma.
However, further research is necessary.
People with sensitive skin or skin conditions, such as eczema, may prefer to avoid products containing Neo Heliopan 303.
Alternatively, a person can perform a patch test before using a product containing octocrylene for the first time.
The patch test should indicate if an individual is allergic or sensitive to an ingredient in the Neo Heliopan 303.
The Food and Drug Administration (FDA) evaluated the safety of Neo Heliopan 303 for use in sunscreen products and found that concentrations of up to 10% are safe.
Safety Profile:
Low toxicity by ingestion.
Whenheated to decomposition it emits toxic vapors of NOx.
Neo Heliopan 303 can penetrate into the skin where it acts as a photosensitizer, resulting in an increased production of free radicals under illumination.
Neo Heliopan 303 may also pass through the skin, into the blood stream, eventually being metabolized and excreted in urine in form of its metabolites.
Neo Heliopan 303 can convert to benzophenone through a retro-aldol condensation.
The reaction occurs slowly over time, yielding significant concentration of benzophenone in all commercial cosmetics tested formulated with octocrylene.
In coral, Neo Heliopan 303 has been shown to accumulate in the form of fatty acid conjugates and trigger mitochondrial dysfunction.
