Neo Heliopan 357 is a sunscreen agent that protects against the full spectrum of UV light.
Neo Heliopan 357 exposure to UV rays is a leading cause of skin cancer, and so use of an effective sunscreen, like avobenzone or avobenzone in combination with other agents, helps to lower risk of developing skin cancer.
Neo Heliopan 357 is susceptible to photodegredation, and therefore it is important that avobenzone be combined with photostabilizers in the final sunscreen product.
CAS Number: 70356-09-1
Molecular Formula: C20H22O3
Molecular Weight: 310.39
EINECS Number: 274-581-6
Synonyms: Avobenzone, 70356-09-1, Parsol 1789, Butyl methoxydibenzoylmethane, Escalol 517, Eusolex 9020, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propane-1,3-dione, NeoHeliopan 357, Avobenzona, Avobenzonum, 4-tert-Butyl-4'-methoxy-dibenzoylmethane, 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl)-1,3-propanedione, 1-(4-(tert-Butyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione, 4-TERT-BUTYL-4'-METHOXYDIBENZOYLMETHANE, HSDB 7423, UNII-G63QQF2NOX, Avobenzonum [INN-Latin], G63QQF2NOX, Avobenzona [INN-Spanish], EINECS 274-581-6, 1,3-Propanedione, 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-, NSC-758680, 1-(p-tert-Butylphenyl)-3-(p-methoxyphenyl)-1,3-propanedione, 1-(4-Methoxyphenyl)-3-(4-tert-butylphenyl)-1,3-propanedione, 4-methoxy-4'-tert-butyldibenzoylmethane, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione, Avobenzone [USAN:USP], DTXSID9044829, EC 274-581-6, NSC 758680, ANTHELIOS SX COMPONENT AVOBENZONE, NCGC00095112-01, CAPITAL SOLEIL COMPONENT AVOBENZONE, SHADE UVAGUARD COMPONENT AVOBENZONE, Avobenzonum (INN-Latin), Avobenzona (INN-Spanish), 1,3-Propanedione, 1-(4-(1,1-dimethylethyl)phenyl)-3-(4-methoxyphenyl)-, AVOBENZONE (MART.), AVOBENZONE [MART.], AVOBENZONE (USP-RS), AVOBENZONE [USP-RS], 23644-60-2, Avobenzone (USAN:USP
), DTXCID7024829, AVOBENZONE (USP IMPURITY), AVOBENZONE [USP IMPURITY], 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)propan-1,3-dione, AVOBENZONE (USP MONOGRAPH), AVOBENZONE [USP MONOGRAPH], 1-[4-(1,1-dimethylethyl)phenyl]-3-(4-methoxyphenyl)-1,3-propanedione, Parsol A, BMDBM cpd, SMR001562107, CAS-70356-09-1, butyl-methoxydibenzoylmethane, PONDSclarant b3, Ponds Clarant B3, Spectrum_001715, PONDSVAO-B3, AVOBENZONE [MI], SpecPlus_000764, Avobenzone (USP/INN), AVOBENZONE [INN], Spectrum2_001663, Spectrum3_000990, Spectrum4_001116, Spectrum5_001358, AVOBENZONE [HSDB], AVOBENZONE [USAN], Avobenzone(Parsol 1789), AVOBENZONE [WHO-DD], Anti-Dark Moisturizing Cream, Avobenzone (Parsol 1789), SCHEMBL15650, BSPBio_002659, KBioGR_001592, KBioSS_002195, MLS002695918, MLS006010050, BIDD
, DivK1c_006860, SPECTRUM1504190, SPBio_001845, Avobenzone, analytical standard, AVOBENZONE [ORANGE BOOK], CHEMBL1200522, KBio1_001804, KBio2_002195, KBio2_004763, KBio2_007331, KBio3_001879, CHEBI:134751, HMS1922F17, HMS2093C04, HMS3655C22, HMS3715F14, Pharmakon1600-01504190, HY-B0316, Tox21_111427, Tox21_202796, CCG-39080, LEADERS SUNBUDDY ALL OVER SUN, MFCD00210252, NSC758680, s1904, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedi- one, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)propane-1,3-dione, AKOS015838120, Tox21_111427_1, 1ST3417, AC-1682, DB09495, NCGC00095112-02, NCGC00095112-03, NCGC00095112-04, NCGC00095112-05, NCGC00260342-01, AS-12797, SBI-0052777.P002, AVOBENZONE COMPONENT OF ANTHELIOS SX, AVOBENZONE COMPONENT OF CAPITAL SOLEIL, AVOBENZONE COMPONENT OF SHADE UVAGUARD, B3382, NS00002639, SW219665-1, D03015, AB00053273_04, AB00053273_05, EN300-7406285, A836855, SR-05000001974, Q-200661, Q2775914, SR-05000001974-1, BRD-K14401183-001-10-7, BRD-K14401183-001-11-5, 1-(4-tert-butylphenyl)-3-(4-methoxyphenyl)-propane-1,3-dione, Avobenzone, United States Pharmacopeia (USP) Reference Standard, 1-(4-Methoxyphenyl)-3-(4-(tert)-butylphenyl)-1,3-propanedione, 1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedi-one, Avobenzone, Pharmaceutical Secondary Standard; Certified Reference Material
Neo Heliopan 357 is specifically the most effective sunscreen agent against UVA rays.
It's been considered a relatively safe chemical, but recent research suggests otherwise.
Of all sunscreen agents, Neo Heliopan 357 has one of the largest absorbance spectrums, absorbing light between 320 – 400 nm (peak absorption ~ 360 nm).
Neo Heliopan 357 degrades in the sun, resulting in the release of free radicals that may actually increase the risk for cancer.
Ultraviolet (UV) light is harmful for skin cells since it can damage genetic material.
The ozone layer absorbs radiation below 290 nm and thus cosmetic sunscreens need to filter radiation in UV-A (320–380 nm) and UV-B (290–320 nm) bands.
Although there are many available UV-B filters, proper UV-A filters are deficient. 1-(4-tert-Butylphenyl)-3-(4-methoxyphenyl) propane-1, 3-dione (trade name avobenzone (AB)) is the most widely used UV-A absorber in cosmetic sunscreens.
Despite its importance as a UV-A absorber, the photodynamics of AB are not completely understood.
This is due to a fact that photoexcited AB transforms into several transient tautomeric forms the lifetimes of which range from ps to ms.
These tautomerizations together with photodegradation are responsible for a complete loss of UV-A protection under irradiation.
Neo Heliopan 357 is a clear colorless to pale yellow liquid used as a photostabilizer and multi-functional emollient.
Neo Heliopan 357 confers photostability to the UVA-filter Butyl Methoxydibenzoylmethane and is an excellent solvent for oil soluble, solid UV-filters.
Neo Heliopan 357 adds gloss to finished formulations and is compatible with most commonly used cosmetic ingredients.
Neo Heliopan 357 is a commercial name for a specific UV filter used in sunscreens and other cosmetic products.
Neo Heliopan 357 is a type of avobenzone, also known by its chemical name butyl methoxydibenzoylmethane.
Neo Heliopan 357 belongs to a dibenzoyl methane derivative.
It is oil soluble ingredient. Since it is very sensitive to light, photostablizers are added in the sunscreen product to increase its stability and duration of action.
Neo Heliopan 357 has an absorption maximum of 357 nm. Sunscreens containing avobenzone is indicated for providing protection from the sun.
In addition to limiting the skin's exposure to the sun, using sunscreen agents may help reduce long-term sun damage such as premature aging of the skin and skin cancer.
Neo Heliopan 357 is capable of blocking UVA I, UVA II and UVB wavelengths, thereby limiting the impact of UV rays on skin.
Diminish the penetration of ultraviolet (UV) light through the epidermis by absorbing UV radiation within a specific wavelength range.
The amount and wavelength of UV radiation absorbed are affected by the molecular structure of the sunscreen agent.
Neo Heliopan 357 is an organic molecule and an oil-soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays.
Neo Heliopan 357 is primarily used as a broad-spectrum UV filter in sunscreens.
It effectively absorbs the full spectrum of UVA rays (320-400 nm), protecting the skin from harmful UV radiation and preventing photoaging and sunburn.
Neo Heliopan 357 is known for its stability in formulations, particularly in combination with other UV filters.
This helps maintain its effectiveness over time.
Neo Heliopan 357 is typically used in oil-based formulations due to its solubility in oils.
It is commonly found in various sunscreens and sun protection products.
Besides sunscreens, it may be used in other cosmetic products that offer sun protection benefits.
Neo Heliopan 357 is approved for use in cosmetics and sunscreens in many countries, including the EU, the USA, and others, with specific concentration limits established by regulatory agencies.
The concentration of Neo Heliopan 357 in formulations varies depending on the product and its intended sun protection factor (SPF).
Typically, Neo Heliopan 357 is used in concentrations ranging from 2% to 4% in sunscreen products.
Neo Heliopan 357 is a full-spectrum ultraviolet A (UVA) blocker.
It inhibits UVA-induced increases in melanin levels and tyrosinase activity in B16/F10 melanoma cells (IC30s = 21.94 and 24.25 μM, respectively).
Neo Heliopan 357 also inhibits UVA-induced production of reactive oxygen species (ROS) and 8-hydroxy-2''-deoxyguanosine (8-OH-dG; ), as well as inhibits UVA-induced depletion of glutathione (GSH; ), in B16/F10 cells.
Neo Heliopan 357 increases nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and upregulates the antioxidant response element (ARE) in UVA-irradiated B16/F10 cells when used at at a concentration of 30 μM.
Formulations containing avobenzone have been used as a sun protectant in sunscreen products.
Neo Heliopan 357 is an UVA filter.
It is used in sunscreen lotions and cosmetic formulations.
Neo Heliopan 357 has maximum absorption at ca 340–350 nm, decreasing under UV irradiation resulting in loss of the UVA protecting effect.
Its photostability is very sensitive as it is stable in polar protic solvent and is photolabile in nonpolar solvents.
Neo Heliopan 357 is a very effective UVA I absorber for a wide range of applications.
Neo Heliopan 357 is an oil soluble, crystalline powder.
Neo Heliopan 357 acts as an effective UVA absorber.
It should be used in association with effective UVB absorbers to achieve formulations with broad-spectrum UV protection.
Neo Heliopan 357 is used in sun care formulations.
Neo Heliopan 357 is a very effective UVA I absorber for a wide range of applications.
Neo Heliopan 357 is an oil soluble, crystalline powder.
This document provides safety information for Neo Heliopan 357.
It identifies the product and company details.
Neo Heliopan 357 is classified as a chronic aquatic toxicant.
It may cause long-lasting harmful effects in the aquatic environment.
The document provides guidance on handling, storage, exposure controls and personal protective equipment when working with the product.
Zinc Oxide has a long history of use as a skin protectant and has been used in a wide range of dermatological and cosmetic preparations.
In addition to its protecting, soothing, healing and antimicrobial properties, zinc oxide effectively scatters and absorbs UV radiation to provide broad band UV protection.
Neo Heliopan 357 is commonly used in combination with organic UV filters to obtain an optimum level of protection.
Neo Heliopan 357 is an organic molecule and an oil-soluble ingredient used in sunscreen products to absorb the full spectrum of UVA rays.
Neo Heliopan 357 was patented in 1973 and was approved in the EU in 1978.
It was approved by the FDA in 1988.
As of 2021, the FDA announced that they do not support avobenzone as being generally recognized as safe and effective (GRASE) citing the need for additional safety data.
Neo Heliopan 357 was banned in 2020 by the Palau government citing reef-toxicity concerns.
Pure Neo Heliopan 357 is a whitish to yellowish crystalline powder with a weak odor, dissolving in isopropanol, dimethyl sulfoxide, decyl oleate, capric acid/caprylic, triglycerides and other oils.
Neo Heliopan 357 is not soluble in water.
Neo Heliopan 357 is a dibenzoylmethane derivative. Avobenzone exists in the ground state as a mixture of the enol and keto forms, favoring the chelated enol.
This enol form is stabilized by intramolecular hydrogen-bonding within the β-diketone.
Its ability to absorb ultraviolet light over a wider range of wavelengths than many other sunscreen agents has led to its use in many commercial preparations marketed as "broad spectrum" sunscreens.
Neo Heliopan 357 has an absorption maximum of 357 nm.
Complexing Neo Heliopan 357 with cyclodextrins may also increase its photostability.
Formulations of avobenzone with hydroxypropyl-beta-cyclodextrin have shown significant reduction in photo-induced degradation, as well as decreased transdermal penetration of the UV absorber when used in high concentrations.
The photostability of Neo Heliopan 357 is further increased when sunscreens are formulated with antioxidant compounds.
Mangiferin, glutathione, ubiquinone, vitamin C, vitamin E, beta-carotene and trans-resveratrol have all demonstrated some ability to protect avobenzone from photodegradation.
The stability and efficacy of Neo Heliopan 357 seems to continue to increase as a greater amount of antioxidants are added to the sunscreen.
According to some studies, "the most effective sunscreens contain avobenzone and titanium dioxide.
Neo Heliopan 357 can degrade faster in light in combination with mineral UV absorbers like zinc oxide and titanium dioxide, though with the right coating of the mineral particles this reaction can be reduced.
A manganese doped titanium dioxide may be better than undoped titanium dioxide to improve avobenzone's stability.
Melting point: 81-84 °C
Boiling point: 463.6±35.0 °C(Predicted)
Density: 1.079
vapor pressure: 0Pa at 25℃
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)
form: Solid
pka: 9.74±0.13(Predicted)
color: White to Pale Yellow
Water Solubility: 27μg/L at 20℃
λmax: 356nm(EtOH)(lit.)
Merck: 14,888
InChIKey: GTIRDWBOUTYFQO-UHFFFAOYSA-N
LogP: 6.1 at 20℃
Neo Heliopan 357 is sensitive to the properties of the solvent, being relatively stable in polar protic solvents and unstable in nonpolar environments.
Also, when Neo Heliopan 357 is irradiated with UVA light, it generates a triplet excited state in the keto form which can either cause the avobenzone to degrade or it can transfer energy to biological targets and cause deleterious effects.
Neo Heliopan 357 has been shown to degrade significantly in light, resulting in less protection over time.
The UV-A light in a day of sunlight in a temperate climate is sufficient to break down most of the compound.
Data presented to the Food and Drug Administration by the Cosmetic, Toiletry and Fragrance Association indicates a −36% change in avobenzone's UV absorbance following one hour of exposure to sunlight.
For this reason, in sunscreen products, Neo Heliopan 357 is always formulated together with a photostabilizer, such as octocrylene.
The mixture is held for 8 h at reflux temperature with slight stirring.
The condenser is then replaced by a distillation column and the excess methyl alcohol is distilled off, towards the end under a slight vacuum but without the temperature exceeding 100°C.
The mixture is cooled and poured on to ice.
Neo Heliopan 357 the phases are left to separate, the organic phase is washed with ice-water, with a saturated sodium carbonate solution in the presence of ice and finally with ice until neutral.
The organic phase is dried over sodium sulfate and there is thus obtained a precipitate.
By distillation on a Widmer column (120 mm) there are obtained 345.0 g (90% yield) of the p-t-butylbenzoic acid methyl ester, boiling point 76°C/0.02 mmHg.
Neo Heliopan 357 to a round flask which has been well dried and flushed with nitrogen are added 85.0 g (1.1 mol) of sodium amide (50% suspension in toluene) and 180.0 g of isopropyl ether and there are now added dropwise thereto at a temperature of 50°-60°C 150.2 g (1 mol) of acetylanisole in 180.0 g of isopropyl ether.
Reaction sets in immediately and a white paste-like mass forms.
Neo Heliopan 357 after completion of the addition, the mixture is stirred for a further 0.5 h and then 192.3 g of p-t-butylbenzoic acid methyl ester are added rapidly at 25°-30°C.
The mixture is stirred for 0.5 h at room temperature, then for 3 h at 60°-70°C and left to stand for 12 h.
200.0 g of ice are then added and the mixture is acidified with 128.0 g (1.1 mol) of technical hydrochloric acid and 200 ml of ice-water.
The mixture is stirred until the sodium salt of the product has dissolved.
The phases are separated and the organic phase is washed with ice-water until neutral.
The organic phase is concentrated on a rotary evaporator and there are thus recovered 290.0 g of isopropyl ether.
The yield of 4-(1,1-dimethylethyl)-4'-methoxydibenzoylmethane, melting point 83.5°C is 199.8 g (64.5%) (recrystallisation from methanol).
As an enolate, Neo Heliopan 357 forms with heavy metal ions (such as Fe3+) colored complexes, and chelating agents can be added to suppress them.
Stearates, aluminum, magnesium and zinc salts can lead to poorly soluble precipitates.
Neo Heliopan 357 manufacturers also recommend to avoid the inclusion of iron and ferric salts, heavy metals, formaldehyde donors and PABA and PABA esters.
Neo Heliopan 357 in sunscreen may stain clothes yellow-orange and make them sticky if washed in iron-rich water, as it reacts with iron to produce rust.
The damage can be undone with a rust remover or stain remover.
The staining properties of sunblock made with avobenzone are particularly noticeable on fiberglass boats with white gelcoat.
Neo Heliopan 357 also reacts with boron trifluoride to form a stable crystalline complex that is highly fluorescent under UV irradiation.
The emission color of the crystals depends on the molecular packing of the boron Neo Heliopan 357 complex.
The photoluminescence may also be altered by mechanical force in the solid state, resulting in a phenomenon called "mechanochromic luminescence".
The altered emission color recovers itself slowly at room temperature or more swiftly at higher temperatures.
Neo Heliopan 357 is a diaryl ketone with two aromatic rings (one with a methoxy group and one with a tert-butyl group) connected through a carbonyl bridge.
This structure allows it to absorb a broad spectrum of UVA rays.
Typically a yellow to orange powder or a viscous liquid when formulated.
Generally has a mild odor, but this can be masked in formulations.
Neo Heliopan 357 is soluble in oils and fats but insoluble in water.
This makes it suitable for use in oil-based formulations, emulsions, and anhydrous products.
Neo Heliopan 357 can be less stable when exposed to sunlight and oxygen, which is why it is often combined with stabilizers or other UV filters to enhance its longevity in products.
Typically used at concentrations between 2% to 4%.
Neo Heliopan 357 is effective in providing broad-spectrum UVA protection, which complements UVB filters to offer comprehensive sun protection.
Included in various cosmetic products like foundations, moisturizers, and lip balms to provide added sun protection.
To improve stability, avobenzone is often combined with stabilizers like octocrylene or other UV filters.
Neo Heliopan 357 performs best in neutral to slightly acidic pH ranges, and extreme pH conditions can affect its efficacy.
Neo Heliopan 357 is approved for use in sunscreens as a broad-spectrum UV filter.
It is generally recognized as safe and effective when used within specified concentrations.
Approved for use in cosmetics and sunscreens with specific concentration limits.
The European Commission has set regulations to ensure its safe use in cosmetic products.
Similar regulations apply in various countries, where Neo Heliopan 357 is widely accepted and used in sun protection products.
Generally permits up to 5% in sunscreen products, though specific regulations may vary by country.
Generally considered safe for topical use in cosmetic and sunscreen products.
Rare cases of sensitivity or allergic reactions have been reported but are uncommon.
Low potential for irritation when used in recommended concentrations and formulations.
Neo Heliopan 357’s environmental impact is relatively low compared to some other chemicals.
However, its effects on aquatic life and ecosystems are still being studied.
Uses:
Neo Heliopan 357 is a sun-A screen chemical that offers broad-range protection against uVA rays.
It is associated with some photoinstability, which can be overcome in the overall sunscreen formulation.
Neo Heliopan 357 is approved for use up to 3 percent in the united States and 5 percent in the european union.
Neo Heliopan 357 is noted to rarely be photosensitizing.
Neo Heliopan 357 provides strong absorption through a large portion of the UVA spectrum including the majority of the UVA I range with peak absorption at 360 nm.
Photostability refers to the ability of a molecule to remain intact with irradiation.
It is potentially a problem with all UV filters, but particularly with the use of Neo Heliopan 357.
This effect may degrade other sunscreens in a formulation including octyl methoxycinnamate.
Octocrylene and some of the newer sunscreens including BEMT stabilized Neo Heliopan 357.
Non-UV filters such as diethylhexyl 2,6 naphthalate may also be used.
These molecules function as triplet–triplet quenchers.
Overall formulation with Neo Heliopan 357 is therefore particularly critical.
Neo Heliopan 357 is renowned for its ability to absorb a wide range of UVA rays (320-400 nm), making it a key ingredient in sunscreens to provide broad-spectrum protection.
Commonly included in both chemical and physical sunscreens to enhance their effectiveness against UVA-induced skin damage.
Often used in foundations and BB creams to offer added sun protection.
Incorporated into daily moisturizers to protect the skin from UVA rays, particularly those labeled with SPF.
Added to lip balms and glosses to prevent sun damage to the delicate skin on the lips.
Included in anti-aging formulations to help prevent UVA-induced skin aging and pigmentation.
Neo Heliopan 357 is used in eye creams to protect the sensitive skin around the eyes from sun damage.
Found in body lotions and after-sun products to provide ongoing sun protection and repair.
Occasionally included in hair care products to protect hair from UV damage.
Neo Heliopan 357 is used in water-resistant sunscreens to maintain protection during activities such as swimming or sweating.
Included in sports sunscreens for prolonged UV protection during physical activities.
Neo Heliopan 357 is often used in high SPF sunscreens to ensure that the product offers effective protection against both UVA and UVB rays.
Its inclusion helps maintain the integrity of the SPF rating over time.
Some modern skincare products include avobenzone as part of a broader anti-pollution or environmental defense strategy.
Neo Heliopan 357 helps protect the skin from the harmful effects of UV radiation and environmental pollutants.
In tinted sunscreens, Neo Heliopan 357 not only provides UV protection but also helps to even out skin tone and cover imperfections.
The added tint can also offer additional protection against visible light.
Neo Heliopan 357 is sometimes used in formulations designed for sensitive skin.
It is less likely to cause irritation compared to some other UV filters and is suitable for delicate skin areas.
Due to its sensitivity to light and oxygen, avobenzone is often combined with stabilizers like octocrylene to enhance its stability and extend its effectiveness in formulations.
In many formulations, avobenzone is used in combination with other UV filters, such as octocrylene, octinoxate, and zinc oxide, to provide a broad spectrum of protection and enhance overall sunscreen performance.
Neo Heliopan 357 can be effectively used in various types of formulations, including emulsions, gels, and sprays, to provide UV protection in a range of cosmetic and skincare products.
Numerous studies have confirmed the efficacy and safety of avobenzone in providing broad-spectrum UVA protection.
Its stability and effectiveness in formulations have been well-documented.
Neo Heliopan 357 is approved by regulatory bodies such as the FDA and the European Commission for use in sunscreens and cosmetics, within specified concentration limits.
This ensures its safety and effectiveness for consumers.
Neo Heliopan 357 is considered to have a relatively low environmental impact compared to some other UV filters, though ongoing research continues to assess its effects on aquatic environments.
Neo Heliopan 357 is used in post-procedure skincare products, such as those following laser treatments or chemical peels, to protect healing skin from UV damage and prevent pigmentation changes.
Some acne treatment formulations incorporate avobenzone to protect the skin from UV exposure, which can worsen acne or cause hyperpigmentation.
In addition to providing sun protection, avobenzone helps to improve the longevity and performance of foundation products, offering both coverage and UV protection in one step.
Neo Heliopan 357 is used in tinted formulations to blend with skin tones, providing a natural look while offering protection from UV damage.
Neo Heliopan 357 is included in lip balms, glosses, and lipsticks to prevent UV damage to the lips, which are prone to sunburn and aging.
Combines sun protection with moisturizing properties for comprehensive lip care.
In sunscreens designed for children, avobenzone is chosen for its effectiveness and relatively mild nature, though it is usually used in combination with other UV filters to ensure safety and effectiveness.
Included in water-resistant sunscreens to provide prolonged protection during activities such as swimming or sweating.
Neo Heliopan 357 remains effective even when exposed to water or moisture.
In advanced skincare formulations, avobenzone may be used in combination with other active ingredients such as antioxidants and peptides to provide enhanced protection and anti-aging benefits.
Neo Heliopan 357 is sensitive to light and oxygen, so it is often stabilized with antioxidants like vitamin E or UV stabilizers like octocrylene to maintain its effectiveness over time.
It is most stable in a neutral to slightly acidic pH, so formulation adjustments may be necessary to ensure its effectiveness in different products.
Neo Heliopan 357 is often combined with UVB filters (e.g., octocrylene, octinoxate) and physical blockers (e.g., zinc oxide, titanium dioxide) to offer comprehensive sun protection and improve overall sunscreen efficacy.
Neo Heliopan 357 can be included in various product forms such as creams, gels, sprays, powders, and emulsions, adapting to different consumer preferences and application needs.
Approved for use in sunscreens in the US at concentrations up to 3%.
Permitted in concentrations up to 5% in EU countries, with specific safety and efficacy standards.
Similar regulations apply in other regions, with Neo Heliopan 357 being recognized for its effectiveness and safety in sun protection.
Generally considered safe for topical use, with minimal risk of irritation or allergic reactions. Patch testing is recommended for individuals with sensitive skin.
Well-accepted by consumers for its efficacy and broad-spectrum protection, making it a popular choice in sunscreens and cosmetic products.
While Neo Heliopan 357 is considered to have a relatively low environmental impact compared to some other UV filters, research into its effects on marine ecosystems is ongoing.
Safety Profile:
Neo Heliopan 357, a petroleum-based sunscreen active ingredient, is not generally recognised as safe and effective (GRASE) by the FDA for lack of sufficient data to support this claim.
However, it is still the only FDA approved UVA filter (up to 3% concentration).
Neo Heliopan 357 is also approved in all other jurisdictions, such as EU (up to 5%), Australia, and Japan.
A 2017 study at Lomonosov Moscow State University found that chlorinated water and ultraviolet light can cause avobenzone to disintegrate into various other organic compounds, including; aromatic acids, aldehydes, phenols, and acetophenones which can cause adverse health effects.
Some individuals may experience allergic reactions or skin sensitivity to avobenzone.
This can manifest as redness, itching, or rash, particularly in those with sensitive skin or those using high concentrations.
Neo Heliopan 357’s advisable to perform a patch test before extensive use, especially for those with known sensitivities or allergies.
In rare cases, avobenzone can cause mild irritation.
This is usually more of a concern in high concentrations or in products designed for sensitive areas like the eyes.
Direct contact with the eyes can cause irritation.
Formulations intended for use near the eyes should be designed to minimize this risk.
Neo Heliopan 357 is known to degrade when exposed to sunlight and oxygen, potentially reducing its effectiveness over time.
This degradation can lead to reduced protection from UV rays if the product is not properly stabilized.