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Neo Heliopan AP is a highly effective and photostable UVA II absorber.
Neo Heliopan AP forms water soluble salts with the addition of a base.
Neo Heliopan AP is a retinoid that is used as a topical photoprotective agent.
CAS Number: 180898-37-7
Molecular Formula: C20H15N4NaO12S4
Molecular Weight: 654.59
EINECS Number: 429-750-0
Synonyms: Bisdisulizole disodium, Bisimidazylate, 180898-37-7, Disodium phenyldibenzimidazoletetrasulfonate, Neo heliopan AP, UNII-Z99XUY03BK, Bisdisulizole disodium [USAN], DISODIUM PHENYL DIBENZIMIDAZOLE TETRASULFONATE, Z99XUY03BK, disodium;6-sulfo-2-[4-(6-sulfo-4-sulfonato-1H-benzimidazol-2-yl)phenyl]-1H-benzimidazole-4-sulfonate, 1H-Benzimidazole-4,6-disulfonic acid, 2,2'-(1,4-phenylene)bis-, disodium salt, Disodium dihydrogen 2,2'-(1,4-phenylene)bis(1H-benzimidazole-4,6-disulfonate), CHEMBL2107318, SCHEMBL19878444, DTXSID001021219, 1ST3452, disodium;2-[4-(4,6-disulfobenzimidazol-3-id-2-yl)phenyl]benzimidazol-3-ide-4,6-disulfonic acid.
Neo Heliopan AP is water-soluble and can be absorbed through the skin.
Neo Heliopan AP also has antioxidant activity, which may help to protect against ultraviolet light-induced skin damage.
Neo Heliopan AP by Symrise acts as an effective UVA II absorber.
It is highly photostable, hygroscopic and compatible with ingredients and packaging.
In sun care formulations it shows synergistic effects with oil-soluble UVB filters.
In combination with the UVA I absorber Neo Heliopan AP very broad spectrum UVA protection products can be formulated.
It forms water soluble salts with the addition of a base.
It possesses an excellent safety profile including extremely low skin penetration.
Neo Heliopan AP provides UV protection and it is suitable for water-based transparent sunscreen products such as gels or clear sprays.
Bisdisulizole disodium (INN[1]/USAN, trade name Neo Heliopan AP, INCI disodium phenyl dibenzimidazole tetrasulfonate) is a water-soluble organic compound which is added to sunscreen products to absorb UVA rays.
Neo Heliopan AP is marketed by Symrise.
The use of bisdisulizole disodium has been approved in the European Union and other parts of the world up to 10% in sunscreen formulations, while it is not approved in the United States.
Neo Heliopan AP of this radiation, over half is received as infra-red (heat), nearly 40% as visible light and about 5% as invisible UV radiation.
UV radiation that reaches the earth surface is split into two categories, UVA and UVB.
All these forms of radiation can contribute to short-term and long-term skin damages.
While providing the best possible protection will always be the central goal for suncare offerings, also recognize that consumers are increasingly demanding more from the products they use.
By harnessing the power of Symrise’s cross-divisional capabilities are able to also offer the most appealing scents and the most enjoyable cosmetic textures.
Additionally, regional application laboratories support customers worldwide in the formulation of sun care products that meet the regional consumer needs.
Neo Heliopan AP Sodium Salt, also known as Disodium Phenyl Dibenzimidazole Tetrasulfonate , is a highly effective and photostable UVA II absorber .
Neo Heliopan AP forms water-soluble salts with the addition of a base.
Neo Heliopan AP is added to sunscreens to absorb UVA rays .
Neo Heliopan AP is a trade name for Bisdisulizole Disodium, a chemical compound used as a UV filter in sunscreens and other skincare products.
It provides protection against UVA radiation, which is responsible for skin aging and contributing to skin cancer.
It is specifically effective at absorbing UVA rays (320-400 nm), providing protection from long-wave ultraviolet light, which penetrates deeply into the skin and can cause significant damage over time.
Unlike many other UV filters that are oil-soluble, Neo Heliopan AP is water-soluble, which makes it suitable for formulations where a non-oily texture is desired, such as in gel-based or water-based sunscreens.
It is highly photostable, meaning it does not easily break down when exposed to sunlight.
This property ensures long-lasting protection and helps to stabilize other UV filters in the formulation.
Neo Heliopan AP can be combined with other UV filters to provide broad-spectrum protection (covering both UVA and UVB rays).
It is often used in conjunction with other UV filters to enhance the overall efficacy of sun protection products.
Neo Heliopan AP is a complex aromatic sulfonate, characterized by multiple benzimidazole rings and sulfonate groups.
This structure is designed to absorb high-energy UVA radiation effectively.
Unlike many organic UV filters that are lipophilic (fat-soluble), Neo Heliopan AP is hydrophilic (water-soluble).
This makes it particularly useful in formulations where a lightweight, non-greasy feel is desired, such as in water-based sunscreens and gels.
While Neo Heliopan AP mainly absorbs UVA rays, it can also contribute to some UVB protection when used in combination with other UV filters.
UVA rays are primarily responsible for photoaging, which includes wrinkles, sagging, and pigmentation issues, as well as an increased risk of skin cancers.
By filtering out UVA rays, Neo Heliopan AP helps prevent deeper skin damage that can lead to the breakdown of collagen and elastin fibers, essential for maintaining youthful skin.
One of the standout features of Neo Heliopan AP is its high photostability.
Unlike some other UV filters that degrade upon exposure to sunlight, Neo Heliopan AP remains stable, providing consistent protection over time.
This quality is crucial in maintaining the efficacy of sunscreens throughout prolonged sun exposure.
Neo Heliopan AP can also help stabilize other UV filters in the formulation, preventing them from breaking down and ensuring the product’s overall effectiveness.
Neo Heliopan AP's water solubility allows it to be used in light, non-oily formulations, which are increasingly popular in modern sunscreens and skincare products.
This makes it ideal for creating products with a pleasant, non-greasy feel on the skin.
Due to its mild profile, it is often included in products designed for sensitive skin, as it is less likely to cause irritation compared to some other UV filters.
The most common application of Neo Heliopan AP is in sunscreens, where it serves as a critical ingredient for providing broad-spectrum sun protection, particularly against UVA rays.
To achieve comprehensive sun protection, it is often used alongside other UV filters, such as Octocrylene, Homosalate, and Avobenzone, to ensure that both UVA and UVB rays are effectively blocked.
Neo Heliopan AP is included in moisturizers that offer sun protection, particularly those targeting anti-aging.
By protecting against UVA-induced photoaging, it helps maintain the skin’s youthful appearance.
Many day creams incorporate Neo Heliopan AP to provide daily sun protection while offering hydration and other skin benefits.
In makeup products, Neo Heliopan AP is used to offer sun protection without compromising the product’s texture or application.
Neo Heliopan AP allows for the creation of lightweight, non-oily foundations and BB creams that also protect the skin from UV damage.
Some lip balms and glosses include this ingredient to provide sun protection, particularly for the sensitive skin of the lips.
For people with sensitive or reactive skin, Neo Heliopan AP is a preferred UV filter due to its lower likelihood of causing irritation.
It is often found in products marketed for sensitive skin.
Neo Heliopan AP can be used in after-sun products to provide continued protection from residual UVA exposure, helping to soothe and protect the skin after sun exposure.
Neo Heliopan AP is approved for use in the European Union and is commonly found in sunscreens and skincare products across Europe.
It is also widely used in Asian markets, where high-performance sunscreens are in demand due to the regions' climatic conditions.
While Neo Heliopan AP is less commonly used in the U.S. due to stricter regulations on new UV filters, it is still valued in products that meet European or Asian standards.
Neo Heliopan AP is generally considered safe for use in personal care products.
It has been evaluated for its safety and efficacy, with specific concentration limits set by regulatory bodies to ensure consumer safety.
There is ongoing research into the environmental impact of UV filters, including Neo Heliopan AP, particularly concerning their effects on marine ecosystems.
However, its water solubility may influence its behavior in the environment differently compared to lipophilic UV filters.
Density : 1.82[at 20℃]
vapor pressure: 0Pa at 20℃
Water Solubility: 2g/L at 20℃
LogP: -2 at 23℃
Neo Heliopan AP is often combined with other UV filters to create formulations that offer comprehensive UVA and UVB protection.
For instance, while it excels at absorbing UVA radiation, it is typically paired with UVB filters like Octinoxate or Ethylhexyl Salicylate to cover the entire spectrum of UV radiation (290-400 nm).
When used with Avobenzone (a UVA filter), Neo Heliopan AP helps stabilize Avobenzone, preventing it from degrading quickly in sunlight.
This combination is particularly effective in creating long-lasting sunscreens.
Neo Heliopan AP is compatible with a wide range of cosmetic ingredients, including emollients, moisturizers, and antioxidants.
This allows formulators to develop multifunctional products that not only protect against UV damage but also provide additional skincare benefits, such as hydration and anti-aging.
Due to its water-soluble nature, Neo Heliopan AP enables the creation of lightweight, non-greasy sunscreens and skincare products.
This is particularly important in products designed for oily or acne-prone skin, where heavy, oil-based formulas can exacerbate skin issues.
Neo Heliopan AP is highly photostable, meaning it does not easily degrade when exposed to sunlight.
This ensures that the sunscreen remains effective for longer periods, providing consistent protection throughout sun exposure.
Its stability also contributes to a longer shelf-life for the final product, which is a critical factor for consumer satisfaction and product reliability.
Neo Heliopan AP is approved for use in the EU under the Cosmetics Regulation, which is known for its stringent safety standards.
Neo Heliopan AP is widely used in European sunscreens, particularly those marketed as high-performance or anti-aging products.
In countries like Japan, South Korea, and China, Neo Heliopan AP is popular due to the high demand for effective sun protection products.
These markets are known for their innovative skincare formulations, where UVA protection is often prioritized.
The U.S. FDA has a more restrictive process for approving new UV filters.
As of now, Neo Heliopan AP is not as commonly used in the U.S. market due to these regulatory constraints, though it is found in imported products that adhere to European or Asian standards.
Regulatory bodies set specific concentration limits for Neo Heliopan AP in cosmetic formulations to ensure safety.
Typically, these limits are in the range of 5-10% depending on the region and the specific application (e.g., leave-on vs. rinse-off products).
Neo Heliopan AP is generally well-tolerated by the skin. It is considered to have a low potential for causing skin irritation or sensitization, making it suitable for sensitive skin types.
Its water-soluble nature makes it less likely to clog pores compared to oil-based UV filters, which is an important consideration for individuals with acne-prone skin.
Studies on the percutaneous absorption of Neo Heliopan AP indicate that it has minimal systemic absorption when applied topically.
This minimizes the potential for systemic toxicity, making it a safe choice for regular use in sunscreens and daily moisturizers.
Extensive testing has not shown Neo Heliopan AP to be carcinogenic or mutagenic, further supporting its safety profile.
While the environmental impact of many UV filters is a growing concern, particularly with respect to coral reefs and aquatic life, Neo Heliopan AP's water solubility might influence its behavior differently in the environment compared to more persistent, oil-soluble filters.
However, ongoing research is necessary to fully understand its environmental footprint.
Neo Heliopan AP is a key ingredient in anti-aging skincare lines.
By filtering out UVA rays, it helps prevent the formation of free radicals that cause oxidative stress, leading to wrinkles, fine lines, and loss of skin elasticity.
UVA radiation is known to degrade collagen and elastin in the skin, leading to premature aging.
Neo Heliopan AP helps protect these structural proteins, maintaining the skin’s firmness and elasticity over time.
After dermatological procedures like laser treatments, chemical peels, or microneedling, the skin is particularly vulnerable to UV damage.
Neo Heliopan AP is used in post-procedure skincare products to offer gentle yet effective UVA protection, reducing the risk of hyperpigmentation and other complications.
Dermatologists often recommend products containing Neo Heliopan AP for patients with sensitive skin, rosacea, or other skin conditions that make them more susceptible to irritation from standard UV filters.
In some regions, Neo Heliopan AP may be included in prescription sunscreen formulations, particularly for patients at high risk of skin cancer or those with photosensitivity disorders.
There is a growing trend towards hybrid products that combine sun protection with other skincare benefits, such as antioxidants, anti-pollution ingredients, and hydrating agents.
Neo Heliopan AP’s versatility makes it an ideal candidate for such multifunctional formulations.
As consumer demand for “clean” beauty products grows, there is increasing interest in UV filters that are perceived as safe, non-toxic, and environmentally friendly.
Neo Heliopan AP’s profile as a water-soluble, mild, and effective UVA filter positions it well within this trend.
There is potential for Neo Heliopan AP to gain a foothold in the U.S. market, particularly if regulatory landscapes shift to allow more diverse UV filters.
As consumers become more educated about the importance of UVA protection, demand for products containing Neo Heliopan AP could increase.
The future of skincare is leaning towards personalized solutions.
Neo Heliopan AP’s flexibility could see it being incorporated into custom-made skincare products designed to cater to individual skin types and concerns, especially in regions with high UV exposure.
Uses:
Neo Heliopan AP is commonly used in sunscreens to protect the skin from the harmful effects of UVA radiation.
Included in moisturizers that offer sun protection, particularly those focused on anti-aging.
Neo Heliopan AP is used in foundations, BB creams, and other makeup products that include sun protection to ensure broad-spectrum coverage.
Helps in preventing photoaging caused by UVA exposure, making it a valuable ingredient in anti-aging formulations.
Due to its water-soluble nature and mild profile, it is often included in products designed for sensitive skin.
Neo Heliopan AP is widely used in sunscreens to provide broad-spectrum protection, particularly against UVA rays, which penetrate deeper into the skin and contribute to aging and skin cancer.
Its water solubility makes it ideal for lightweight, non-greasy sunscreen formulations, including gels and sprays.
Neo Heliopan AP is often included in high SPF sunscreens where robust UVA protection is needed.
Neo Heliopan AP is used in daily moisturizers that offer sun protection, particularly those marketed as anti-aging products.
Neo Heliopan AP helps protect the skin from UVA-induced photoaging.
Neo Heliopan AP is incorporated into tinted moisturizers, BB creams, and CC creams that provide light coverage with added sun protection.
In products designed for the delicate skin around the eyes, Neo Heliopan AP offers gentle UVA protection without irritating the skin.
Neo Heliopan AP Foundations and pressed powders containing Neo Heliopan AP provide sun protection while maintaining a smooth, non-oily finish.
Lip balms and glosses sometimes include this ingredient to protect the lips from UV damage, particularly UVA rays that can cause darkening and aging of the lips.
After-sun products that contain Neo Heliopan AP help soothe and protect the skin from residual UVA exposure, which can still cause damage after direct sun exposure has ended.
Due to its low potential for irritation, Neo Heliopan AP is often used in sunscreens and skincare products formulated for sensitive or reactive skin.
Neo Heliopan AP is included in products designed for use after dermatological procedures (such as laser treatments or chemical peels) to protect the skin while it heals.
Neo Heliopan AP is a key ingredient in anti-aging skincare products, where it helps prevent the breakdown of collagen and elastin caused by UVA rays, thereby reducing wrinkles and maintaining skin elasticity.
Many anti-aging day creams include this filter to provide daily protection against UVA-induced skin damage.
In some medical treatments involving light therapy, Neo Heliopan AP may be used to protect the skin from unwanted UVA exposure.
In certain regions, it is used in prescription sunscreens, particularly for patients with photosensitivity disorders or those at high risk of skin cancer.
Some hair care products, such as leave-in conditioners or sprays, may contain Neo Heliopan AP to protect hair and scalp from UV damage, which can lead to color fading and dryness.
Neo Heliopan AP is sometimes included in body lotions with SPF to protect the skin from UVA damage during daily activities.
Hand creams with sun protection often use Neo Heliopan AP to prevent aging of the hands due to sun exposure.
Sunscreens designed for protecting tattoos from fading and discoloration may include Neo Heliopan AP to shield the ink from UVA rays.
In products aimed at protecting the scalp, Neo Heliopan AP offers sun protection without leaving a greasy residue, which is important for comfort and appearance.
Neo Heliopan AP is used in hybrid formulations that combine sun protection with intense hydration.
These products are particularly popular in climates where both UV exposure and dry air are concerns.
The trend towards makeup products that offer skincare benefits, such as foundations with anti-aging ingredients and SPF, sees Neo Heliopan AP being used to ensure that the skin is protected throughout the day without the need for separate products.
Products designed for use in extreme conditions, such as high altitudes or in environments with intense UV exposure, often incorporate Neo Heliopan AP due to its reliable UVA protection.
These include specialized sunscreens for mountaineers, skiers, and outdoor workers.
In tropical regions, where high humidity can affect product stability and efficacy, Neo Heliopan AP is favored for its stability and non-greasy feel, making it ideal for sunscreens and daily moisturizers in these markets.
Neo Heliopan AP is included in sunscreens marketed to athletes and outdoor enthusiasts.
Neo Heliopan APs are designed to withstand sweat and water while providing long-lasting UVA protection, critical for preventing sunburn and long-term skin damage during prolonged outdoor activities.
Given its compatibility with water-resistant formulations, Neo Heliopan AP is used in sunscreens intended for swimming, surfing, and other water-based sports, where prolonged exposure to sunlight and water demands durable UV protection.
Sunscreens formulated for children often include Neo Heliopan AP because of its gentle nature and effectiveness in providing broad-spectrum protection without causing irritation.
These products are typically formulated to be hypoallergenic and easy to apply.
Products such as children’s daily moisturizers with added sun protection may also contain Neo Heliopan AP, ensuring that children’s skin is protected during regular outdoor activities.
As awareness grows regarding the impact of certain chemical sunscreens on coral reefs, Neo Heliopan AP is being explored as an alternative ingredient in reef-safe formulations, particularly due to its water solubility and lower persistence in marine environments.
Research is ongoing into the development of biodegradable sunscreens, where Neo Heliopan AP’s characteristics could contribute to formulations that are both effective and environmentally responsible.
As global regulations on sunscreen ingredients evolve, particularly in regions like the European Union and Australia, manufacturers are increasingly turning to Neo Heliopan AP to meet strict UVA protection requirements while maintaining product stability and safety.
With the rise of clean beauty, consumers are demanding more transparency about the ingredients in their skincare products.
Neo Heliopan AP’s reputation for being a safe and effective UVA filter makes it a preferred choice for brands that prioritize clean labeling and consumer trust.
Advances in cosmetic science have led to the development of micronized or nano-sized particles of Neo Heliopan AP, which enhance its effectiveness while maintaining a smooth, non-whitening application.
These formulations are particularly desirable in high-end cosmetics where aesthetic appeal is crucial.
Encapsulation techniques are being explored to improve the delivery and efficacy of Neo Heliopan AP in skincare products.
These systems allow for controlled release and enhanced stability of the UV filter, making it more effective over extended periods.
With the growing trend of personalized skincare, Neo Heliopan AP can be included in custom-made sunscreens and skincare products tailored to an individual’s specific skin type, UV exposure levels, and lifestyle needs.
As subscription-based skincare services grow in popularity, Neo Heliopan AP is used in a range of products that cater to ongoing sun protection needs, ensuring that users receive tailored solutions delivered regularly.
To protect the stability and effectiveness of Neo Heliopan AP, particularly in formulations sensitive to light and air, airless packaging technologies are increasingly used.
This ensures the product remains potent throughout its shelf life.
Neo Heliopan AP is found in portable formats such as sunscreen sticks, cushion compacts, and spray mists, catering to consumers who need convenient, re-applicable sun protection during the day.
With growing concerns about environmental pollution, Neo Heliopan AP is being researched for its potential role in anti-pollution skincare products that protect against both UV radiation and particulate matter.
Research into next-generation sunscreens is looking at combining Neo Heliopan AP with other advanced ingredients like DNA-repair enzymes, antioxidants, and infrared blockers, to create products that offer holistic skin protection beyond just UV rays.
Safety and Regulations:
Neo Heliopan AP is approved for use in various regions, including Europe and Asia, though it is less commonly found in products in the United States.
Neo Heliopan AP is considered safe for use in cosmetics and personal care products within the recommended concentration limits.
In rare cases, individuals with very sensitive skin or allergies may experience mild irritation or allergic reactions.
Symptoms could include redness, itching, or a rash.
It is usually well-tolerated, but individuals with known sensitivities should conduct a patch test before using products containing this ingredient.
As with many chemical ingredients, Neo Heliopan AP could cause irritation if it comes into direct contact with the eyes.
This is particularly relevant in products used around the eye area, such as certain sunscreens and eye creams.
Formulators must ensure that concentrations are appropriate and that products are tested for ocular safety.
While rare, some people may develop allergic reactions to Neo Heliopan AP.
This could manifest as skin redness, swelling, or hives.
If any adverse reaction occurs, discontinue use and consult a healthcare professional.
