NEOPENTYLGLYCOL

NEOPENTYLGLYCOL = NPG

CAS Number: 126-30-7
EC Number: 204-781-0
Molecular Formula: C5H12O2
Molar Mass: 104.148 g/mol

Neopentylglycol (NPG) is a polyalcohol offering superior performance advantages in many end-use applications due to Neopentylglycol high chemical and thermal stability.

Neopentylglycol can be used as an intermediate for both plasticizers and for synthetic lubricants. 
In most polyester resin formulations, Neopentylglycol is used as the sole glycol component. 
Neopentylglycol offers excellent thermal stability, weathering, and stain resistance.

Neopentylglycol is an industrially important and versatile diol, mainly employed as a building block for polyesters and polyurethanes.
Neopentylene glycol imparts desirable properties to Neopentylglycol derivatives, including low color, good weathering and chemical resistance, and high thermal and hydrolytic stability. 

Neopentylglycol is a crystalline solid at room temperature that is highly reactive and colorless to white in color. 
Neopentylglycol has good solubility in water, alcohols, ethers, ketones and toluene. 
As a typical glycol, Neopentylene glycol  can undergo reactions such as esterification, etherification, condensation and oxidation

Neopentylglycol is the industry standard glycol component in high-quality polyester resins for industrial coatings and fiberglass-reinforced plastics applications. 
Most polyester resin formulations contain Neopentylglycol as the sole glycol component, or Neopentylglycol is used in conjunction with a modifying glycol to achieve desired properties.

Neopentylglycol and Purified Terephthalic Acid are the primary components for polyester powder coating resins. 
Neopentylglycol delivers the overall toughness, stain and detergent resistance, and outdoor weathering performance required of coil coatings for appliances and products for exterior applications. 
Gel coats containing unsaturated polyesters made from Neopentylglycol and Purified Isophthalic Acid provide excellent weatherability and water and stain resistance.

Neopentylglycol is also used in polyester polyols for polyurethane coatings for the automotive, industrial maintenance, transportation, and aerospace markets.

In the United States, Neopentylglycol may be lawfully used as a reactant for coatings and other products intended for use in contact with foods under specific federal food additive regulations.
Neopentylglycol is a unique polyalcohol that has proven itself in many applications, especially in the production of polyester and alkyd resins for various coatings and plastics due to Neopentylglycol high chemical and thermal stability.

Neopentylglycol, also known as Dimethylolpropan, is a hydroscopic crystalline organic chemical compound, colorless-to-white in color. 
Neopentylglycol is industrially synthesized by the aldol reaction of formaldehyde and isobutyraldehyde, which results in formation of intermediate hydroxypivaldehyde. 
This can be converted to Neopentylglycol through catalytic hydrogenation of aldehyde group to an alcohol group.

The major driver for global Neopentylglycol market is the increasing use of Neopentylglycol as a base resin for coatings, hydraulic fuels, greases, and aircraft engine lubricant. 
Resistance to oxidation, non-polar chemical nature, and enhanced stability towards heat, light, and water are some of the superior properties Neopentylglycol possess.

Neopentylglycol is soluble in water, benzene, chloroform, ethanol, and diethyl ether. 
Furthermore, Neopentylglycol demand is increasing due to Neopentylglycol growing use as a chemical intermediate for the synthesis of resins, polyester, alkyd resins, paints, synthetic lubricants, adhesives, and others. 
Neopentylglycol is also used as a base product for plasticizers, pharmaceuticals, pesticides, fragrances, fabric softeners, vibration dampers, and others.

The global Neopentylglycol market is expected to witness a substantial growth due to the increasing penetration of nepentyl glycol in paints and coatings, which is complementary to various end-use industries such as automotive, aerospace, ship building, construction, among others. 
Heavy investments in infrastructure projects in emerging countries and the new product development in pharmaceuticals and personal care products are likely to offer substantial opportunities to Neopentylglycol

Neopentylglycol (IUPAC name: 2,2-dimethylpropane-1,3-diol) is an organic chemical compound. 
Neopentylglycol is used in the synthesis of polyesters, paints, lubricants, and plasticizers. 

When used in the manufacture of polyesters, Neopentylglycol enhances the stability of the product towards heat, light, and water. 
By esterification reaction with fatty or carboxylic acids, synthetic lubricating esters with reduced potential for oxidation or hydrolysis, compared to natural esters, can be produced.

NPG can be used as an intermediate for both plasticizers and for synthetic lubricants. 
In most polyester resin formulations, NPG is used as the sole glycol component. 
NPG offers excellent thermal stability, weathering, and stain resistance. 

Global paints & coatings industry is accelerating at a fast pace owing to the escalating demand from automotive, transportation, and building & construction sectors. 
Housing subsidies along with socio-economic development by the regional governments will also positively impact Neopentylglycol demand. 
Increasing necessity for advanced adhesives & sealants with easy usability and low VOC content will further promulgate the overall Neopentylglycol market development.

Shifting trends in the preparation of chemicals using organic compounds along with the adoption of advanced industrial synthesis, such as green catalytic process, are among the major factors stimulating the raw material supply dynamics. 
Stringent government regulations concerning VOC emissions will also support the Neopentylglycol business operations. 
The organic nature of the product will further help in the production of organic chemicals used in agrochemicals, skincare, and pharmaceutical application industries.

Neopentylglycol is available in three forms:
Platelets in bags that exhibit excellent caking stability on storage.
Bulk molten shipped in tank trucks that require a heated tank for storage.
Neopentylglycol, a liquid at or above 38°C containing 90 parts NPG and 10 parts water, is delivered in bulk and can be stored at a much lower temperature than molten NPG.

Research of Neopentylglycol:
Neopentylglycol has been reported that plastic crystals of Neopentylglycol exhibit a colossal barocaloric effect (CBCEs), which is a cooling effect caused by pressure-induced phase transitions. 
The obtained entropy changes are about 389 joules per kilogram per kelvin near room temperature. 
This CBCE phenomenon is likely to be very useful in future solid-state refrigeration technologies.

Neopentylglycol Market, By Type:
Neopentylglycol sales from flakes generated over USD 900 million in 2018 and expected to  hold a significant industry share. 
Key benefits including ease of handling during storage, enhanced usability, and low maintenance in terms of transportation and application have enhanced the demand Neopentylglycol flake demand across the resins & coatings industry. 
Increasing product adoption rate in saturated polyesters for coil coatings, powder coatings & stoving enamels fueling Neopentylglycol market growth.
 
Neopentylglycol slurry market is set to witness over 6.5% CAGR up to 2025. 
The market will witness a substantial growth due to Neopentylglycol’s unique structure and high thermal stability, making Neopentylglycol an attractive option for a wide variety of applications including fibreglass reinforced resins, alkyd coating resins, polyester polyols plasticizer, powder coating resins, etc. 
High crystalline and weatherability assistance of the product are among the key factors supporting the market demand.

Automotive parts/insulation hold over 18% of the market share in the Neopentylglycol market in 2018. 
Neopentylglycol is widely used in insulation and coatings application owing to Neopentylglycol high chemical and thermal stability. 

Growing necessity for insulation in automotive to reduce the heat-related issues with the engine will boost the Neopentylglycol application in automotive sector. 
Applicability of Neopentylglycol enables high performance standards including greater thermal stability, fire safety and mechanical stability of the end-use product.

Applications of Neopentylglycol:

Industries Applications of Neopentylglycol:
Coatings
Lubricants 
Polyurethanes
Adhesives

Main Applications of Neopentylglycol: 
Alkyd resin paint,
Polyester resin, 
Powdered paint.

Application Percentages of Neopentylglycol:
Coatings - 42.0
Automotive parts/insulation - 10.5
Construction insulation - 9.5
Furniture/footwear - 6.3
Plasticisers - 5.3
Electronic products - 5.2
Automotive/construction/adhesives - 4.2    
Lubricants - 3.2
Fibres - 2.1
Pharmaceuticals - 2.1

Uses of Neopentylglycol:
Neopentylglycol is used primarily in base resins for coatings. 
Important uses of Neopentylglycol are also found in hydraulic fluids, synthetic lubricant oils, greases, metal-working fluids and aircraft engine lubricants. 
Other applications of Neopentylglycol include textiles, pharmaceuticals, pesticides, plasticisers and petroleum

Neopentylglycol (NPG, IUPAC name 2,2-dimethyl-1,3-propanediol) is an important industrial intermediate used in the synthesis of polyesters, especially resins for airplane or boat manufacturing. 
The Neopentylglycol structure provides excellent resistance to light, heat, and hydrolysis. 
NPG is also being used in a variety of formulations in varnish coatings, synthetic lubricants, and plasticizers.

Neopentylglycol is an organic chemical compound. 
Neopentylglycol is used in the synthesis of polyesters, paints, lubricants, and plasticizers. 

When used in the manufacture of polyesters, Neopentylglycol enhances the stability of the product towards heat, light, and water. 
By esterification reaction with fatty or carboxylic acids, synthetic lubricating esters with reduced potential for oxidation or hydrolysis, compared to natural esters, can be produced.

Other Uses of Neopentylglycol:
Adhesives/sealants-B&C
Architectural coatings
Auto OEM
Auto refinish
Automotive
Building materials
Coil coatings
Construction chemicals
Equipment & machinery
Inks
 
Intermediates:
Lubricants
Paints & coatings
Polycarbonate
Polymer modification
Process additives
Protective coatings
Textile
Wind energy
Key attributes
Excellent thermal stability for low resin color
Excellent weathering
Good chemical and stain resistance
Good chemical, stain, and humidity resistance
Good hardness/flexibility balance
Ideal glass transition temperature range
Outstanding powder flow and fluidization characteristics
Outstanding weathering
Rapid reactivity during esterification and cure

Adhesives and Sealants:
Neopentylglycol is used as a building block for the production of polyurethane adhesive resins (polyester polyol and polycarbonate diol) providing flexibility and adhesion.

Coatings:
Neopentylglycol (NPG), or 2, 2-dimethyl-1,3-propanediol, is mainly used as a building block for coating resins such as saturated polyesters (major application in powder coatings), alkyds (e.g. coating metal furniture and fixtures),  unsaturated polyesters (e.g. artificial marble and gelcoat for boats), and finally for the production of polyurethane resins (polyester polyol and polycarbonate diol).
Neopentylglycol provides high hydrolytic stability, high UV stability (UVA/UVB), weatherability, adhesion and a good balance between hardness and flexibility.

Others:
Neopentylglycol is utilised in the production of polyester lubricants and plasticizers

Lubricants:
Neopentylglycol Ester is a fatty ester, which exhibits low viscosity and high thermal stability.

Functions: 
Neopentylglycol Ester

Product Applications: 
Grinding oils, Semi-synthetics, Soluble oils, Synthetics

Product Classes: 
Lubricants, Metalworking & Grease, Lubricity Additive

Technology of Neopentylglycol:
There are two main routes to Neopentylglycol using isobutyraldehyde and formaldehyde. 
In one, the raw materials react with a strongly alkaline catalyst to form Neopentylglycol. 
But, large amounts of formate salts are formed as byproduct and the process is only economically viable when a profitable use is found for the formate.

In a second and more common process, the aldolisation reaction is carried out in the presence of an amine catalyst. 
This is further hydrogenated in the presence of a catalyst and the molten Neopentylglycol is solidified by means of a flaking roll, or a crystallising or cooling belt.

Reactions of Neopentylglycol:
Neopentylglycol is synthesized industrially by the aldol reaction of formaldehyde and isobutyraldehyde. 
This creates the intermediate hydroxypivaldehyde, which can be converted to Neopentylglycol with either excess formaldehyde or by palladium on carbon hydrogenation. 

Neopentylglycol has two primary hydroxyl groups. Neopentylglycol is a white material in flakes. 
Neopentylglycol is used in saturated polyesters for powder coatings, coil coatings and other stoving enamels, unsaturated polyesters for gel coats and reinforced plastics and in esters for synthetic lubricants.

Neopentylglycol is a propane-1,3-diol carrying two methyl groups at position 2.
Neopentylglycol is used as a protecting group for ketones, for example in gestodene synthesis.

A condensation reaction of Neopentylglycol with 2,6-di-tert-butylphenol gives CGP-7930.
Organoboronic acid esters of Neopentylglycol are useful in the Suzuki reaction.

Storage and Transport of Neopentylglycol:
Neopentylglycol is packed in 25-kg polyethylene bags. 
Other packaging types and sizes can also be used which will ensure the quality of the product to be preserved and the handling safety thereof.

Neopentylglycol should be stored in covered and dry places, in tightly sealed bags.
Neopentylglycol is not considered a hazardous material according to RID/ADR.

Health and Safety of Neopentylglycol:
Neopentylglycol is a white, crystalline solid with a mint-like odour. 
Finely dispersed particles form explosive mixtures in air and Neopentylglycol reacts violently with oxidants.

Properties of Neopentylglycol:
Chemical formula: C5H12O2
Molar mass: 104.148 g/mol
Melting point: 129.13 °C (264.43 °F; 402.28 K)
Boiling point: 208 °C (406 °F; 481 K)
Solubility in water: good
Solubility: soluble in benzene, chloroform, very soluble in ethanol, diethyl ether
Flash point: 129 °C (264 °F; 402 K)

Formula: C5H12O2 / (CH3)2C(CH2OH)2
Density: 1.1 g/cm³
Solubility in water, g/100ml at 20°C: 83
Vapour pressure, Pa at 20°C: 30
Relative vapour density (air = 1): 3.6
Relative density of the vapour/air-mixture at 20°C (air = 1): 1.0
Flash point: 107°C
Auto-ignition temperature: 388°C
Explosive limits, vol% in air: 1.1-11.4
Octanol/water partition coefficient as log Pow: -0.84  

Thermochemistry of Neopentylglycol:
Std enthalpy of formation (ΔfH⦵298): -551.2 kJ•mol−1

Names of Neopentylglycol:

Regulatory process names of Neopentylglycol:
1,3-Propanediol, 2,2-dimethyl-
2,2-Dimethyl-1,3-propanediol
2,2-dimethyl-1,3-propanediol
2,2-dimethylpropane-1,3-diol
2,2-dimethylpropane-1,3-diol
2,2-Dimethyltrimethylene glycol
Dimethylolpropane
Dimethyltrimethylene glycol
Hydroxypivalyl alcohol
Neol
Neopentanediol
Neopentylglycol
Neopentylene glycol
NPG

CAS name of Neopentylglycol:
1,3-Propanediol, 2,2-dimethyl-

IUPAC names of Neopentylglycol:
1,3-Propanediol, 2,2-dimethyl-
2,2-Dimethyl-1,3-propanediol
2,2-dimethyl-1,3-Propanediol
2,2-dimethyl-1,3-propanediol
2,2-dimethylpropan-1,3-diol
2,2-Dimethylpropane-1,3-diol
2,2-dimethylpropane-1,3-diol
2,2-dimethylpropane-1,3-diol
2,2-dimethylpropane-1,3-diol (Neopentylglycol)

Trade names of Neopentylglycol:
1,3-Dihydroxy-2,2-dimethylpropane
1,3-Propanediol, 2,2-dimethyl- (6CI, 7CI, 8CI, 9CI)
2,2-Dimethyl-1,3-dihydroxypropane
2,2-Dimethyl-1,3-propanediol
2,2-Dimethyltrimethylene glycol
Dimethylolpropane
Fomrez Series
Hydroxypivalyl alcohol
Neo Pentyl glycol
Neopentanediol
Neopentil Glicole
Neopentylglycol
Neopentylene glycol
Neopentylglykol
NPG
VIBRATHANE Series
Witcobond Series
neopentylglycol

Synonyms of Neopentylglycol:
Neopentylglycol
2,2-Dimethylpropane-1,3-diol
126-30-7
2,2-DIMETHYL-1,3-PROPANEDIOL
Dimethylolpropane
1,3-Propanediol, 2,2-dimethyl-
Neopentanediol
Neopentylglycol
Neopentylene glycol
Neol
Hydroxypivalyl alcohol
Dimethyltrimethylene glycol
NPG Glycol
2,2-Dimethyltrimethylene glycol
UNII-QI80HXD6S5
NSC 55836
MFCD00004685
QI80HXD6S5
2,3 propanediol
1,3-Dihydroxy-2,2-dimethylpropane
2,2-Dimethyl-1,3-propanediol, 99%
DSSTox_CID_7036
DSSTox_RID_78285
DSSTox_GSID_27036
WLN: Q1X1 & 1 & 1Q
CAS-126-30-7
CCRIS 3273
2,2-Dimethyl-1,3 propanediol
EINECS 204-781-0
Propanediol, 2,2-dimethyl-, 1,3-
BRN 0605291
2,2-Bis(hydroxymethyl)propane
AI3-05739
2,2-dimethylolpropane
ACMC-1C2GC
EC 204-781-0
SCHEMBL19621
CBDivE_004836
4-01-00-02551 (Beilstein Handbook Reference)
2,2-dimethyl-1,3-propandiol
2,2-dimethylpropan-1,3-diol
2,2-dimethyl 1,3-propanediol
2.2-dimethyl-1,3-propanediol
2,3-Dimethyl-1,3-propanediol
CHEMBL3184801
DTXSID8027036
HSDB 8424
2,2-dimethyl -1,3-propanediol
2,2-dimethyl-1,3-propane diol
2,2-dimethyl-propane-1,3-diol
NSC6366
CHEBI:143768
ZINC388175
AMY25552
NSC-6366
NSC55836
2,2-Dihydroxy-2,2-dimethylpropane
2,2-Dimethyl-1,3-dihydroxypropane