PRODUCTS

NEOTAME

Neotame can be used alone, but is often mixed with other sweeteners to increase their individual sweetness (i.e. synergistic effect) and decrease their off-flavors (e.g. saccharin).
Neotame is widely used in the food and beverage industry due to its high potency and stability.
Neotame is used in: Soft drinks and carbonated beverages, Dairy products such as yogurt and flavored milk, Baked goods and processed foods, Chewing gum and confectionery, Tabletop sweeteners, Nutritional and dietary products.

CAS Number: 165450-17-9
EC Number: 605-408-8
Molecular Formula: C₂₀H₃₀N₂O₅
Molecular Weight: 378.46 g/mol

SYNONYMS:
Neotame, N-[N-(3,3-dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester, E961, Newtame (common misspelling), NTM, (3S)-3-[(3,3-Dimethylbutyl)amino]-4-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino}-4-oxobutanoic acid, E961, N-(N-(3,3-Dimethylbutyl)-L-α-aspartyl)-L-phenylalanine 1-methyl ester, N-[N-(3,3- dimethyl butyl)-L-alpha-aspartyl]- L-phenyl alanine 1-methyl ester, N-[N-(3,3- dimethyl butyl)-laevo-alpha-aspartyl]- laevo-phenyl alanine 1-methyl ester, (3S)-3-(3,3- dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid, Neotame, 165450-17-9, N-(N-(3,3-dimethylbutyl)-L-alpha-aspartyl)-L-phenylalanine 1-methyl ester, VJ597D52EX, INS-961, INS NO.961, CHEBI:83503, DTXSID50167950, NC-00723, E 961, E-961, RefChem:165409, DTXCID2090441, 3-((3,3-dimethylbutyl)amino)-3-((1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl)propanoic acid, (S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoic acid, MFCD09039056, L-Phenylalanine, N-(3,3-dimethylbutyl)-L-alpha-aspartyl-, 2-methyl ester, methyl N-(3,3-dimethylbutyl)-L-alpha-aspartyl-L-phenylalaninate, Neutame., (3S)-3-(3,3-dimethylbutylamino)-4-[[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid, Neotame [NF], UNII-VJ597D52EX, NC 00723, HSDB 7965, Neotame (Standard), Neotame (Excipient), E961, NEOTAME [FHFI], NEOTAME [FCC], NEOTAME [II], NEOTAME [MI], NEOTAME [MART.], NEOTAME [USP-RS], MIRASEE 200, SCHEMBL4311, Neotame, analytical standard, (3S)-3-[(3,3-dimethylbutyl)amino]-3-{[(2S)-1-methoxy-1-oxo-3-phenylpropan-2-yl]carbamoyl}propanoic acid, CHEMBL3718532, N-[N-(3,3-Dimethylbutyl)-L-a-aspartyl]-L-phenylalanine 1-methyl ester, MSK5106, Neotame 1000 microg/mL in Water, HY-W011053A, HY-W011053R, s4442, AKOS016842430, CS-W011769, FN33351, GS-3213, HY-W011053, SY067109, N1112, F404989, Q415698, L-Phenylalanine, N-(3,3-dimethylbutyl)-L-|A-aspartyl-, 2-methyl ester, N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine methyl ester, L-PHENYLALANINE, N-(N-(3,3-DIMETHYLBUTYL)-L-.ALPHA.-ASPARTYL)-1-METHYL ESTER, N-(N-(3,3-DIMETHYLBUTYL)-L-.ALPHA.-ASPARTYL)-L-PHENYLALANINE 1-METHYL ESTER, (3S)-4-[[(1S)-1-benzyl-2-methoxy-2-oxo-ethyl]amino]-3-(3,3-dimethylbutylamino)-4-oxo-butanoic acid, (S)-3-((3,3-Dimethylbutyl)amino)-4-(((S)-1-methoxy-1-oxo-3-phenylpropan-2-yl)amino)-4-oxobutanoicacid, N-[N-(3,3-Dimethylbutyl)-L-α-aspartyl]-L-phenylalanine 1-methyl ester, 3-[(3,3-Dimethylbutyl)amino]-3-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)-C-hydroxycarbonimidoyl]propanoate

Neotame is a synthetic sweetener structurally similar to aspartame, yet significantly sweeter—approximately 7,000 to 13,000 times sweeter than sucrose.
This high-intensity sweetener, Neotame, features the addition of a 3,3-dimethylbutyl group to the dipeptide derived from aspartic acid and phenylalanine.
This modification not only enhances the sweetness of Neotame but also contributes to its thermal stability.

The molecular structure of Neotame allows it to efficiently activate sweet taste receptors, providing a sugar-like sweetness without the calories.
Neotame's attributes are particularly useful in studies focused on understanding sweetness perception mechanisms and developing alternatives to traditional sweeteners.
Neotame is produced by adding a 6-carbon (neohexyl) group to the amine nitrogen of aspartame.

Neotame is a sugar substitute that is 7,000 to 13,000 times sweeter than regular table sugar.
Like other artificial sweeteners, only a small amount of Neotame is needed to be an effective flavor enhancer.
In fact, this is what makes neotame of great interest to manufacturers of food products, since it is considerably less expensive to use as a sweetener than refined sugar or high fructose corn syrup.

In addition to use as a table sweetener, neotame has been approved for use in various processed foods, including pudding and gelatin mixes, canned fruits, fruit juices, jams, jellies, and syrup.
It may also be found in baked goods, frozen desserts, soft drinks and chewing gum.
Typically, many of these products are labeled as being sugar-less or sugar-free.

Neotame is a no-calorie sweetener, which is a derivative of the dipeptide composed of the amino acids, aspartic acid and phenylalanine.
The components of neotame are joined together to form a uniquely sweet ingredient.
Neotame is sweeter than other marketed no-calorie sweeteners and is approximately 30-40 times sweeter than aspartame; 7,000-13,000 times sweeter than sugar.

Neotame will deliver comparable sweetness to sucrose in various applications.
Neotame is quickly metabolized and fully eliminated by the body via normal biological processes.
Neotame has a clean, sweet taste like sucrose and unique flavor enhancement properties.

At projected trace levels of use, neotame will provide a full, sweet taste in foods and beverages.
Neotame (E961) is a high-intensity, non-caloric artificial sweetener and flavor enhancer that is 7,000 to 13,000 times sweeter than sucrose.
Neotame is an aspartame analog known for its heat stability,, clean sugar-like taste, and low cost, often used in baked goods, soft drinks, and dairy products.

Neotame is a high-intensity artificial sweetener derived from aspartame, designed to provide extremely strong sweetness with improved stability and safety characteristics.
Neotame is one of the most potent sweeteners available, being approximately 7,000–13,000 times sweeter than sucrose.
Structurally, neotame is a modified dipeptide similar to aspartame, but with an added 3,3-dimethylbutyl group, which enhances its sweetness and stability and reduces issues associated with phenylalanine metabolism.

Neotame, also known by the brand name Newtame, is a non-caloric artificial sweetener and aspartame analog.
By mass, Neotame is 7,000 to 13,000 times sweeter than sucrose.
Neotame has no notable off-flavors when compared to sucrose.

Neotame enhances original food flavors.
In 2002, FDA approved Neotame as a non-nutritive sweetener and flavor enhancer within the United States in foods generally, except meat and poultry.
In 2010, Neotame was approved for use in foods within the European Union with the E number E961.

Neotame has also been approved as an additive in many other countries outside US and EU.
Neotame's metabolism is fast and is not retained in the body.
Methanol forms in its metabolism.

Only trace amounts of neotame are added to foods, so the amount of methanol is insignificant for health.
Neotame is safe for type 2 diabetics and those with phenylketonuria.
French scientists Claude Nofre and Jean-Marie Tinti invented neotame.

In 1992, they filed a United States patent, which was granted in 1996
Neotame is a next-generation artificial sweetener developed to overcome some limitations of aspartame, such as instability and restrictions for people with phenylketonuria (PKU).
Neotame provides intense sweetness, improved shelf stability, and enhanced flavor performance, including the ability to mask bitter tastes.

Because of its potency, Neotame contributes virtually no calories to food products.
Neotameelongs to the class of organic compounds known as peptides.
Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.

USES and APPLICATIONS of NEOTAME:
Neotame has applicability in foods and beverages, including but not limited to, chewing gum, carbonated soft drinks, refrigerated and non-refrigerated ready-to-drink beverages, tabletop sweeteners, frozen desserts and novelties, puddings and fillings, yogurt-type products, baked goods and candies.
Neotame can also be used in both cooking and baking applications.

Neotame is a derivative of Aspartame (HY-B0361) and is a flavor enhancer and low-caloric, non-nutritive, high-intensity artificial sweetener that is 7000-13,000 times sweeter than sugar.
Neotame causes intestinal epithelial cell death at high concentrations.
Neotame induces Apoptosis of Caco-2 cells.

Neotame, an artificial sweetener available for use in food products.
Neotame (E 961) is the ‘perfect’ sweetener.
At least Neotame was meant to be when the search for a better version of aspartame began thirty years ago.

The result is an artificial sweetener with extreme sweetness, sugary taste and no off-flavours.
Due to its high sweetness potency, Neotame is used in very small quantities in food, beverages, and industrial applications.
Neotame can be used alone, but is often mixed with other sweeteners to increase their individual sweetness (i.e. synergistic effect) and decrease their off-flavors (e.g. saccharin).

Neotame is chemically somewhat more stable than aspartame.
Neotame's use can be cost effective in comparison to other sweeteners as smaller amounts of neotame are needed.
Neotame is suitable for use in carbonated soft drinks, yogurts, cakes, drink powders, and bubble gums among other foods.

Neotame can be used as a table top sweetener for hot drinks like coffee.
Neotame covers bitter tastes (e.g. caffeine).
Neotame is widely used in the food and beverage industry due to its high potency and stability.

Neotame is used in: Soft drinks and carbonated beverages, Dairy products such as yogurt and flavored milk, Baked goods and processed foods, Chewing gum and confectionery, Tabletop sweeteners, Nutritional and dietary products.
In addition to food applications, neotame is used in animal feed to improve palatability and intake.
Neotame is often combined with other sweeteners to enhance sweetness profiles and mask undesirable flavors.

-Common Uses:
Food Additive: Neotame is used as a non-nutritive sweetener and flavor enhancer.
Application of Neotame: Commonly found in chewing gum, soft drinks, desserts, yogurt, and baked goods.

USES AND APPLICATIONS, BENEFITS, CHARACTERISTICS of NEOTAME:
Neotame is a highly advanced artificial sweetener designed for modern food systems that require intense sweetness, stability, and low caloric contribution.
Its ability to function effectively under a wide range of processing conditions makes Neotame suitable for beverages, dairy products, baked goods, and dietary formulations.
Neotame is particularly valuable in low-calorie and sugar-free products, where it provides strong sweetness without impacting blood sugar levels.
Additionally, its flavor-enhancing properties allow Neotame to mask bitterness and improve overall sensory quality.
Due to its high potency, Neotame is economically efficient and contributes negligible metabolic byproducts, making it a versatile and widely accepted ingredient in both food and feed applications.

KEY CHARACTERISTICS of NEOTAME:
No Calories: Provides no energy (0 kcal).
No Effect on Blood Sugar: Suitable for diabetics.
No Caries: Does not contribute to tooth decay.
Cost-Effective: Low cost compared to other high-intensity sweeteners.

BENEFITS of NEOTAME:
Neotame is sweet.
7,000 to 13,000 times sweeter than sugar.
Neotame has no unwanted off-taste or aftertaste that many other sweeteners is burden with.
Neotame does not contribute energy (0 kcal), does not affect blood sugar levels (glycaemic index GI is 0) and does not cause caries.
Compared to aspartame, Neotame is cheaper and has several food technology advantages, which we will return to.

KEY ASPECTS OF NEOTAME:
*Sweetness Intensity:
Roughly 7,000–13,000 times sweeter than sugar; used in very small amounts.

*Stability:
Heat stable, allowing for use in cooking and baking, unlike aspartame.

*Approvals & Safety:
Approved by the FDA (2002), EFSA (2007), and in over 60 countries, including China, Australia, and Canada.
The JECFA established an ADI of 0–2 mg/kg bw.

*Composition:
A derivative of aspartame and 3,3-dimethylbutyraldehyde, it does not require a warning for phenylketonurics.

ALTERNATIVE PARENTS of NEOTAME:
*Phenylalanine and derivatives
*Aspartic acid and derivatives
*Alpha amino acid esters
*N-acyl-alpha amino acids and derivatives
*Alpha amino acid amides
*Amphetamines and derivatives
*Fatty acid esters
*N-acyl amines
*Dicarboxylic acids and derivatives
*Methyl esters
*Secondary carboxylic acid amides
*Amino acids
*Dialkylamines
*Carboxylic acids
*Hydrocarbon derivatives
*Carbonyl compounds
*Organic oxides
*Organopnictogen compounds

SUBSTITUENTS of NEOTAME:
*Alpha peptide
*Phenylalanine or derivatives
*Aspartic acid or derivatives
*Alpha-amino acid ester
*N-acyl-alpha amino acid or derivatives
*Alpha-amino acid amide
*N-substituted-alpha-amino acid
*Alpha-amino acid or derivatives
*Amphetamine or derivatives
*Fatty acid ester
*Monocyclic benzene moiety
*Dicarboxylic acid or derivatives
*Fatty amide
*N-acyl-amine
*Fatty acyl
*Benzenoid
*Methyl ester
*Secondary carboxylic acid amide
*Amino acid or derivatives
*Amino acid
*Carboxylic acid ester
*Carboxamide group
*Secondary amine
*Secondary aliphatic amine
*Carboxylic acid
*Amine
*Carbonyl group
*Organic nitrogen compound
*Organic oxygen compound
*Organonitrogen compound
*Organooxygen compound
*Hydrocarbon derivative
*Organopnictogen compound
*Organic oxide
*Aromatic homomonocyclic compound

SWEETNESS of NEOTAME:
Water solutions of neotame that are equivalent in sweetness to sucrose water solutions increase logarithmically in relative sweetness as the sucrose concentration of a comparably sweet sucrose solution increases until a plateau is reached.
Maximum sweetness is reached at neotame solution concentrations that are relatively as sweet as a water solution that is 15.1 percentage sucrose by weight, i.e., at 15.1 sucrose equivalence % (SE%).
For comparison, acesulfame K, cyclamate and saccharin reach their maximum sweetness at 11.6 SE%, 11.3 SE% and 9 SE%, respectively.
Neotame is a high-potency sweetener, and it is 7,000 to 13,000 times sweeter than table sugar.
Neotame contains flavor-enhancing properties, and compared to sucrose or aspartame, it has a relatively lower cost per sweetness factor.

CHEMISTRY of NEOTAME:
Structure
Neotame is formally a secondary amine of 3,3-dimethylbutanal and aspartame.
The latter is a dipeptide of phenylalanine and aspartic acid.
Neotame has 2 stereocenters and 4 stereoisomers.
Sweetness is due to the (2S),(3S)-stereoisomer.

Spectroscopy
Neotame NMR spectroscopy identifies its structure with a peak at 0.84 ppm indicating the three methyl groups on the carbon chain bonded to the nitrogen.

SYNTHESIS of NEOTAME:
Neotame is synthesized from aspartame through a reductive alkylation with 3,3-dimethylbutyraldehyde in a palladium catalyst with methanol.
The stereochemistry of aspartame is conserved during the synthesis and therefore, neotame and aspartame have the same stereochemistry.
(2S),(3S)-stereoisomer of aspartame is needed to synthesize the (2S),(3S)-stereoisomer of neotame.

PROPERTIES AND REACTIVITY of NEOTAME:
Neotame has similar stability as aspartame, but has greater stability especially in heated and dairy foods.
Increased temperature, moisture or pH increase losses, and are the main relevant properties of a food when considering the stability of neotame.

For example, about 90% of original neotame remains after 8 weeks of storage in pH 3.2 beverages.
Neotame is especially stable as a dry powder at room temperature and humidity even if mixed with glucose or maltodextrin, and is relatively inert in foods with reducing sugars like fructose.

Unlike aspartame, neotame doesn't form diketopiperazines via intra-molecular cyclization due to its N-alkyl substitution with 3,3-dimethylbutyl.
This increases Neotame's heat stability.
Over 1000 g of neotame dissolves in 1 kg of ethanol at 15 °C.

At 15 °C the solubility of neotame is 10.6 g/kg in water and 43.6 g/kg in ethyl acetate.
At 25 °C the solubilities are 12.6 g/kg and 77.0 g/kg, respectively.
At 40 °C the solubilities are 18.0 g/kg and 238 g/kg, respectively.
At 50 °C the solubilities are 25.2 g/kg and 872 g/kg, respectively.
Neotame is acidic and its 0.5 wt% solution has a pH of 5.80.

MANUFACTURE of NEOTAME:
Industrially neotame is made from 3,3-dimethylbutanal and aspartame via reductive amination.
They are dissolved in methanol, palladium on carbon catalyst is added, air is replaced with hydrogen and the reaction is carried out in room temperature under pressure for a few hours.
Catalyst is filtered out.

This can be aided with diatomaceous earth.
Methanol is distilled followed by addition of water.
The mixture is cooled for a few hours, neotame is isolated via centrifugation, washed with water and vacuum dried.

Neotame is milled to suitable size.
Neotame is a dipeptide composed of N-(3,3-dimethylbutyl)-L-aspartic acid and methyl L-phenylalanate units joined by a peptide linkage.
Neotame has a role as a xenobiotic, a sweetening agent and an environmental contaminant.

Neotame has a clean, sweet taste with no bitter or metallic notes, similar to aspartame and sugar across most attributes.
Potential high-intensity sweetener, sweetness variously stated to be 40 x sucrose and 7000-13000 x sucrose Neotame is an artificial sweetener made by NutraSweet that is between 7,000 and 13,000 times sweeter than sucrose (table sugar).

In the European Union Neotame is known by the E number E961.
Neotame is moderately heat stable and extremely potent.
Neotame is rapidly metabolized, completely eliminated, and does not accumulate in the body.

PHYSICAL PROPERTIES of NEOTAME:
Neotame is typically a white to off-white crystalline powder that is odorless or has a very faint odor.
Neotame has a clean, sweet taste with minimal aftertaste compared to some other artificial sweeteners.
Neotame has a melting point in the range of approximately 80–83 °C.

Neotame is moderately soluble in water and more soluble in organic solvents such as ethanol.
Neotame is relatively stable under dry storage conditions and shows improved stability over aspartame in both temperature and pH variations.
Neotame exhibits low hygroscopicity, meaning it does not readily absorb moisture from the environment, which is advantageous for storage and formulation.

CHEMICAL PROPERTIES of NEOTAME:
Neotame is a dipeptide methyl ester derivative, chemically related to aspartame but modified to enhance stability and sweetness.
It undergoes hydrolysis under certain conditions, breaking down into de-esterified neotame and minor metabolites, including methanol in very small quantities.
However, due to Neotame's extremely low usage levels, the contribution of these breakdown products is negligible.
Neotame is more stable than aspartame under heat and across a broader pH range, making it suitable for a wider range of food processing conditions.
Neotame is resistant to enzymatic breakdown compared to aspartame due to steric hindrance from its bulky side group.

CHARACTERISTICS of NEOTAME:
Neotame is characterized by:
Extremely high sweetness intensity (7,000–13,000× sucrose)
Clean sweetness profile with minimal bitterness
Very low caloric contribution due to minimal usage levels
Improved stability compared to aspartame
Effective flavor enhancer and bitterness masker
Suitable for a wide range of pH and temperature conditions

PHYSICAL AND CHEMICAL PROPERTIES of NEOTAME:
Neotame is a stable, high-intensity sweetener appearing as a white crystalline powder with moderate water solubility and good stability under a variety of environmental conditions.
Neotame has a melting point around 80–83 °C and exhibits low hygroscopicity.
Chemically, Neotame is a modified dipeptide ester with enhanced steric protection, which improves its resistance to hydrolysis and thermal degradation compared to aspartame.
Neotame remains stable across a wider pH range and under moderate heat, making it suitable for processed foods and beverages.
Its chemical structure allows Neotame to deliver intense sweetness while being used in extremely low concentrations.

BENEFITS of NEOTAME:
Neotame offers several advantages:
Extremely high sweetness efficiency (very small quantities required)
Virtually zero caloric contribution
Does not significantly affect blood glucose or insulin levels
Improved stability over earlier sweeteners like aspartame
Safe for individuals with PKU (phenylalanine contribution is negligible)
Neotame enhances flavor and masks bitterness

PHYSICAL and CHEMICAL PROPERTIES of NEOTAME:
CAS Number: 165450-17-9
EC Number: 605-408-8
Molecular Formula: C₂₀H₃₀N₂O₅
Molecular Weight: 378.46 g/mol
Chemical formula: C20H30N2O5
Molar mass: 378.469 g·mol−1
Appearance: white powder
Melting point: 80.9–83.4 °C (177.6–182.1 °F; 354.0–356.5 K)
Solubility in water: 12.6 g/kg at 25 °C
FDA UNII: VJ597D52EX
Nikkaji Web: J898.238D

Beilstein Number: 8352678
MDL: MFCD09039056
XlogP3: -0.10 (est)
Molecular Weight: 378.46910000
Formula: C20 H30 N2 O5
Appearance: white powder (est)
Assay: 97.00 to 100.00
Food Chemicals Codex Listed: No
Melting Point: 81.00 to 84.00 °C. @ 760.00 mm Hg
Boiling Point: 565.27 °C. @ 760.00 mm Hg (est)

Flash Point: 564.00 °F. TCC ( 295.70 °C. ) (est)
logP (o/w): 3.834 (est)
Soluble in: alcohol
water, 14.4 mg/L @ 25 °C (est)
Insoluble in: water
Molecular Weight: 378.5 g/mol
XLogP3: -0.1
Hydrogen Bond Donor Count: 3
Hydrogen Bond Acceptor Count: 6

Rotatable Bond Count: 12
Exact Mass: 378.21547206 Da
Monoisotopic Mass: 378.21547206 Da
Topological Polar Surface Area: 105 Å²
Heavy Atom Count: 27
Formal Charge: 0
Complexity: 495
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 2

Undefined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
Chemical Formula: C20H30N2O5
Average Molecular Weight: 378.4626
Monoisotopic Molecular Weight: 378.21547208

IUPAC Name: 3-[(3,3-dimethylbutyl)amino]-3-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl]propanoic acid
Traditional Name: 3-[(3,3-dimethylbutyl)amino]-3-[(1-methoxy-1-oxo-3-phenylpropan-2-yl)carbamoyl]propanoic acid
CAS Registry Number: 165450-17-9
SMILES: COC(=O)C(CC1=CC=CC=C1)NC(=O)C(CC(O)=O)NCCC(C)(C)C
InChI Identifier: InChI=1S/C20H30N2O5/c1-20(2,3)10-11-21-15(13-17(23)24)18(25)22-16(19(26)27-4)12-14-8-6-5-7-9-14/h5-9,15-16,21H,10-13H2,1-4H3,(H,22,25)(H,23,24)
InChI Key: HLIAVLHNDJUHFG-UHFFFAOYSA-N
Empirical Formula (Hill Notation): C20H30N2O5
CAS Number: 165450-17-9
Molecular Weight: 378.46

UNSPSC Code: 85151701
Beilstein/REAXYS Number: 8352678
MDL number: MFCD09039056
Physical state: powder
Color: white
Odor: No data available
Melting point/freezing point: 80 - 83 °C
Initial boiling point and boiling range: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available

Flash point: No data available
Autoignition temperature: No data available
Decomposition temperature: No data available
pH: No data available
Viscosity: Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Water solubility: No data available
Partition coefficient: n-octanol/water log Pow: 2,254

Vapor pressure: No data available
Density: No data available
Relative density: No data available
Relative vapour density: No data available
Particle characteristics: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information: No data available

FIRST AID MEASURES of NEOTAME:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of NEOTAME:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of NEOTAME:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2)
Foam
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of NEOTAME:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of NEOTAME:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Dry.

STABILITY and REACTIVITY of NEOTAME:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).
-Possibility of hazardous reactions:
No data available