NICOTINYL ALCOHOL

Nicotinyl Alcohol is a pyridine-containing alcohol commonly identified as 3-pyridinemethanol, and Nicotinyl Alcohol is used as a chemical intermediate for pharmaceuticals, agrochemicals, and specialty pyridine derivatives.
Nicotinyl Alcohol is valued because the pyridine ring provides basicity and coordination behavior, while the hydroxymethyl group enables straightforward conversion into esters, ethers, aldehydes, and other functional intermediates.
Nicotinyl Alcohol must be handled with good industrial hygiene because Nicotinyl Alcohol can irritate eyes and skin and pyridine-like materials can have noticeable odor and inhalation concerns, so appropriate PPE and ventilation are recommended.

CAS Number: 100-55-0
EC Number: 202-857-9
Molecular Formula: C6H7NO
Molecular Weight: 109.13 g/mol

Synonyms: Nicotinyl Alcohol, 3-Pyridinemethanol, Pyridin-3-ylmethanol, 3-Hydroxymethylpyridine, 3-Pyridylmethanol, Nicotinyl Alcohol Intermediate, 3-Pyridine Methanol, Pyridine-3-methanol, Nicotinyl Methanol, 100-55-0, Nicotinyl Alcohol Reagent, Nicotinyl Alcohol Technical Grade, Nicotinyl Alcohol, NICOTINYL ALCOHOL, Nicotinyl alcohol, 3-Pyridinemethanol, 3-pyridinemethanol, Pyridin-3-ylmethanol, pyridin-3-ylmethanol, 3-(Hydroxymethyl)pyridine, 3-(hydroxymethyl)pyridine, 3-Hydroxymethylpyridine, 3-hydroxymethylpyridine, 3-Pyridylmethanol, 3-pyridylmethanol, Pyridine-3-methanol, pyridine-3-methanol, 3-Pyridine methanol (spacing variant), 3-Pyridinemethanol (Nicotinyl Alcohol), Nicotinyl Alcohol (3-pyridinemethanol), Nicotyl Alcohol (common variant), 3-Pyridinecarbinol (common variant), 3-Pyridyl Carbinol (variant), 3-Pyridyl carbinol, 3-Pyridinemethanol (pyridinyl methanol), Nicotinyl Alcohol (pyridinyl methanol), 3-(Hydroxymethyl)pyridine (nicotinyl alcohol), Nicotinyl Alcohol (CAS 100-55-0), CAS 100-55-0, 3-Pyridinemethanol (CAS 100-55-0), Nicotinyl Alcohol (C6H7NO), C6H7NO, 3-Pyridinemethanol (C6H7NO), Nicotinyl Alcohol (EC 202-874-8) (common listing), EC 202-874-8, Nicotinyl Alcohol (EINECS 202-874-8), Nicotinyl Alcohol Reagent, Nicotinyl Alcohol Analytical Grade, Nicotinyl Alcohol Laboratory Grade, Nicotinyl Alcohol Technical Grade, Nicotinyl Alcohol Industrial Grade, Nicotinyl Alcohol High Purity, Nicotinyl Alcohol 98%, Nicotinyl Alcohol 99%, Nicotinyl Alcohol Intermediate

APPLICATIONS

Nicotinyl Alcohol is used as an intermediate in pharmaceutical synthesis to build pyridine-containing active ingredients and intermediates.
Nicotinyl Alcohol is incorporated into multi-step routes where the hydroxymethyl group enables formation of esters and ethers for further transformations.
Nicotinyl Alcohol is used in medicinal chemistry to prepare libraries of substituted pyridine derivatives for screening.

Nicotinyl Alcohol is used in agrochemical synthesis as a building block for pyridine-based herbicide and pesticide intermediates.
Nicotinyl Alcohol is incorporated into specialty crop protection intermediate routes where pyridine rings are required for activity.
Nicotinyl Alcohol is used in chemical R&D to develop new pyridine-containing compounds with tuned properties.

Nicotinyl Alcohol is used in specialty chemical synthesis to produce nicotinyl esters and nicotinyl ethers used in fragrance, solvent, or additive development in compatible contexts.
Nicotinyl Alcohol is incorporated into esterification processes to create more lipophilic pyridine derivatives.
Nicotinyl Alcohol is used in quaternization and salt formation routes where pyridine basicity enables ionic derivatives.

Nicotinyl Alcohol is used in coordination chemistry as a ligand or ligand precursor due to pyridine nitrogen coordination capability.
Nicotinyl Alcohol is incorporated into metal-complex synthesis where pyridyl alcohol functionality supports binding and reactivity.
Nicotinyl Alcohol is used in materials chemistry research where pyridine-containing ligands influence polymer and surface interactions.

Nicotinyl Alcohol is used in laboratory synthesis as a starting material for oxidation to pyridinecarboxaldehydes in controlled oxidation routes.
Nicotinyl Alcohol is incorporated into oxidation reactions to generate pyridine aldehyde intermediates for condensation chemistry.
Nicotinyl Alcohol is used in route development where selective conversion of alcohol to aldehyde is required.

Nicotinyl Alcohol is used in polymer and resin functionalization research where pyridine groups are introduced to adjust polarity and adhesion.
Nicotinyl Alcohol is incorporated into functional monomer and side-chain synthesis to provide basic sites for interaction with acids or metals.
Nicotinyl Alcohol is used in coatings and adhesive research where pyridine functionality can improve substrate interaction in compatible designs.

Nicotinyl Alcohol is used in analytical chemistry as a reference compound for pyridine alcohol identification and quantification.
Nicotinyl Alcohol is incorporated into calibration solutions for chromatographic method development.
Nicotinyl Alcohol is used in environmental and process monitoring where pyridine derivatives are tracked.

Nicotinyl Alcohol is used in education and research to demonstrate pyridine chemistry, basicity, and functional group interconversion under supervised laboratory conditions.
Nicotinyl Alcohol is incorporated into teaching laboratories as a reagent for esterification or oxidation demonstrations with proper safety controls.
Nicotinyl Alcohol is valued because Nicotinyl Alcohol provides a versatile pyridine-functional building block for many synthesis pathways and specialty derivative development.

Nicotinyl Alcohol is used as an intermediate in pharmaceutical synthesis involving pyridine derivatives.
Nicotinyl Alcohol supports building of nicotinic-acid-related side chains in medicinal chemistry routes.
Nicotinyl Alcohol helps introduce a hydroxymethyl functionality on a pyridine ring for further derivatization.

Nicotinyl Alcohol is used in production of esters and ethers of pyridine alcohols for fine chemical applications.
Nicotinyl Alcohol supports synthesis of nicotinyl esters used as specialty intermediates.
Nicotinyl Alcohol helps enable controlled functional group transformations on pyridine scaffolds.

Nicotinyl Alcohol is used in synthesis of prodrug-like intermediates where pyridine rings are part of the structure.
Nicotinyl Alcohol supports formation of carbonate, ester, and ether linkages in drug design chemistry.
Nicotinyl Alcohol helps tune polarity and reactivity in designed intermediates.

Nicotinyl Alcohol is used in production of nicotinyl alcohol esters for cosmetic and dermatological ingredient research.
Nicotinyl Alcohol supports development of pyridine-containing skin-care actives in exploratory work.
Nicotinyl Alcohol helps enable structure–activity screening of nicotinic derivatives.

Nicotinyl Alcohol is used in topical formulation research as a nicotinate-related ingredient candidate.
Nicotinyl Alcohol supports evaluation of skin-feel and warming or flushing-related effects in controlled studies.
Nicotinyl Alcohol helps build ingredient blends positioned for microcirculation-themed cosmetics where permitted.

Nicotinyl Alcohol is used in manufacture of vasodilatory research compounds derived from nicotinic chemistry.
Nicotinyl Alcohol supports synthesis of derivatives that may influence peripheral blood flow in pharmacology research.
Nicotinyl Alcohol helps create candidates for screening in controlled experimental models.

Nicotinyl Alcohol is used in preparation of nicotinyl halides and activated intermediates through conversion of the alcohol group.
Nicotinyl Alcohol supports formation of chlorides, bromides, or sulfonates for substitution reactions.
Nicotinyl Alcohol helps enable coupling reactions that attach pyridine rings to larger molecules.

Nicotinyl Alcohol is used in synthesis of quaternized pyridinium compounds in some routes.
Nicotinyl Alcohol supports preparation of pyridinium salts used in catalysis or antimicrobial research.
Nicotinyl Alcohol helps provide a handle for introducing additional substituents on the pyridine nitrogen.

Nicotinyl Alcohol is used in agrochemical research as an intermediate for pyridine-containing actives.
Nicotinyl Alcohol supports building blocks used in herbicide and insecticide candidate synthesis.
Nicotinyl Alcohol helps expand pyridine chemistry libraries for bioactivity screening.

Nicotinyl Alcohol is used in dye and pigment research as a pyridine-containing intermediate in certain syntheses.
Nicotinyl Alcohol supports preparation of heteroaromatic dyes and optical brightener candidates.
Nicotinyl Alcohol helps tune dye polarity and binding behavior through pyridine functionality.

Nicotinyl Alcohol is used in fragrance research as a precursor for pyridine-containing odorants in niche programs.
Nicotinyl Alcohol supports synthesis of specialty aroma chemicals where heteroaromatics are explored.
Nicotinyl Alcohol helps provide unique odor profile tuning through pyridine chemistry.

Nicotinyl Alcohol is used in polymer chemistry research to introduce pyridine functionality into monomers and additives.
Nicotinyl Alcohol supports synthesis of pyridyl-functional acrylates, methacrylates, or urethanes in some routes.
Nicotinyl Alcohol helps create functional polymers with metal-binding or pH-responsive behavior.

Nicotinyl Alcohol is used in corrosion inhibitor research as a pyridine-based adsorption candidate.
Nicotinyl Alcohol supports screening of nitrogen heterocycles for metal surface interaction.
Nicotinyl Alcohol helps evaluate protective film formation on steel or copper in controlled tests.

Nicotinyl Alcohol is used in coordination chemistry as a ligand precursor for pyridyl alcohol-based complexes.
Nicotinyl Alcohol supports synthesis of metal complexes used in catalysis and materials research.
Nicotinyl Alcohol helps provide oxygen and nitrogen donor sites for bidentate coordination designs.

Nicotinyl Alcohol is used in catalyst development to prepare pyridine-containing ligands and catalyst modifiers.
Nicotinyl Alcohol supports tuning of catalyst acidity and adsorption behavior.
Nicotinyl Alcohol helps study ligand effects on selectivity in metal-catalyzed reactions.

Nicotinyl Alcohol is used in analytical chemistry as a reference compound for pyridine alcohol quantification.
Nicotinyl Alcohol supports calibration of GC, HPLC, and LC-MS methods in QC labs.
Nicotinyl Alcohol helps validate identity and purity tests for pyridine intermediates.

Nicotinyl Alcohol is used in sample preparation to spike and recover pyridine alcohols in method validation.
Nicotinyl Alcohol supports matrix-effect studies in analytical development.
Nicotinyl Alcohol helps establish detection limits and recovery rates in complex samples.

Nicotinyl Alcohol is used in environmental chemistry research as a model pyridine derivative for fate studies.
Nicotinyl Alcohol supports biodegradation and adsorption experiments under controlled conditions.
Nicotinyl Alcohol helps evaluate transformation pathways of nitrogen heterocycles.

Nicotinyl Alcohol is used in materials science research to create pyridine-functional surface modifiers.
Nicotinyl Alcohol supports attachment to surfaces via subsequent functionalization chemistry.
Nicotinyl Alcohol helps create metal-binding or pH-responsive surface layers in experimental work.

Nicotinyl Alcohol is used in UV-absorber and stabilizer research as a heteroaromatic intermediate in some designs.
Nicotinyl Alcohol supports synthesis of pyridine-containing stabilizer candidates.
Nicotinyl Alcohol helps tune polarity and compatibility of stabilizers with polymer matrices.

Nicotinyl Alcohol is used in battery and electrochemical research as a building block for pyridine-containing binders in niche studies.
Nicotinyl Alcohol supports synthesis of functional polymers for electrode interfaces.
Nicotinyl Alcohol helps introduce nitrogen sites that can interact with metal ions in experimental systems.

Nicotinyl Alcohol is used in laboratory education to demonstrate heteroaromatic functional group interconversions.
Nicotinyl Alcohol supports teaching of oxidation to aldehydes and acids on a pyridine ring.
Nicotinyl Alcohol helps illustrate substitution chemistry on activated pyridine derivatives.

Nicotinyl Alcohol is used in R&D to prepare nicotinyl aldehyde by controlled oxidation of the alcohol group.
Nicotinyl Alcohol supports production of aldehyde intermediates for condensation reactions.
Nicotinyl Alcohol helps enable synthesis of Schiff bases and heterocycle derivatives.

Nicotinyl Alcohol is used in R&D to prepare nicotinic acid derivatives through oxidation and further transformations.
Nicotinyl Alcohol supports routes that interconvert alcohol, aldehyde, and carboxylic acid forms.
Nicotinyl Alcohol helps build pyridine carboxylate chemistry in controlled studies.

Nicotinyl Alcohol is used in manufacturing scale-up studies for pyridine alcohol handling and purification.
Nicotinyl Alcohol supports distillation and crystallization route development in fine chemical plants.
Nicotinyl Alcohol helps optimize impurity control for downstream synthesis performance.

Nicotinyl Alcohol is used in quality control to check assay, water content, and pyridine-related impurities.
Nicotinyl Alcohol supports specification setting for pharmaceutical and industrial grades.
Nicotinyl Alcohol helps ensure reproducible reactivity in downstream synthesis.

Nicotinyl Alcohol is used in supply chains as a niche intermediate for heteroaromatic chemical production.
Nicotinyl Alcohol supports diversified manufacturing of pyridine-based actives and materials.
Nicotinyl Alcohol helps provide a versatile functional handle for multiple chemical transformations.

Nicotinyl Alcohol is used in medicinal chemistry libraries where pyridine alcohol motifs are explored for solubility and binding.
Nicotinyl Alcohol supports fragment-based design and scaffold hopping studies.
Nicotinyl Alcohol helps provide polar heteroaromatic fragments for screening campaigns.

Nicotinyl Alcohol is used in formulation R&D to evaluate odor, stability, and compatibility of pyridine-containing ingredients.
Nicotinyl Alcohol supports compatibility screening with fragrances, preservatives, and solvents.
Nicotinyl Alcohol helps map stability under light, heat, and pH stress.

Nicotinyl Alcohol is used in pilot reactions as a safer, measurable pyridine intermediate compared with more reactive derivatives.
Nicotinyl Alcohol supports stepwise conversion into activated leaving groups when needed.
Nicotinyl Alcohol helps enable controlled chemistry planning and safer reagent handling.

Nicotinyl Alcohol is used in research on pyridine-based bioactive compounds where alcohol functionalization is required.
Nicotinyl Alcohol supports rapid synthesis of ester libraries for activity screening.
Nicotinyl Alcohol helps produce analog series by varying ester chain length and substituents.

Nicotinyl Alcohol is used in chemical catalogs and reference collections as a standard pyridine alcohol building block.
Nicotinyl Alcohol supports reproducible procurement for R&D teams.
Nicotinyl Alcohol helps accelerate synthesis by providing an off-the-shelf heteroaromatic intermediate.

DESCRIPTION

Nicotinyl Alcohol is a pyridine-containing alcohol commonly described as hydroxymethyl pyridine and is related to nicotinic acid chemistry.
Nicotinyl Alcohol is typically supplied as a colorless to pale yellow liquid or low-melting solid depending on isomer and purity.
Nicotinyl Alcohol has a characteristic pyridine-like odor typical of nitrogen heteroaromatic compounds.

Nicotinyl Alcohol contains a pyridine ring that provides basicity and nitrogen coordination behavior.
Nicotinyl Alcohol contains a primary alcohol group that is reactive toward oxidation, esterification, and substitution.
Nicotinyl Alcohol therefore serves as a versatile intermediate for making esters, ethers, halides, and aldehydes.

Nicotinyl Alcohol is moderately polar and shows limited to moderate solubility in water depending on structure and pH.
Nicotinyl Alcohol is generally more soluble in alcohols and polar organic solvents than in hydrocarbons.
Nicotinyl Alcohol can form salts under acidic conditions due to pyridine nitrogen protonation.

Nicotinyl Alcohol stability depends on storage conditions and exposure to air and light.
Nicotinyl Alcohol can undergo oxidation or discoloration over time if not properly stored.
Nicotinyl Alcohol should be stored in tightly closed containers away from strong oxidizers and strong acids.

Nicotinyl Alcohol can irritate skin, eyes, and respiratory tract with improper exposure.
Nicotinyl Alcohol handling typically requires gloves, goggles, and good ventilation in industrial or laboratory settings.
Nicotinyl Alcohol quality control commonly includes assay, water content, and impurity profiling suitable to intended use.

Nicotinyl Alcohol is valued because it combines a reactive alcohol handle with a widely used pyridine heteroaromatic scaffold.
Nicotinyl Alcohol is selected when pyridine functionality and a functionalizable side chain are needed in synthesis.
Nicotinyl Alcohol use and regulatory considerations depend on end use and region, so compliant handling and disposal are important.

Nicotinyl Alcohol is a pyridyl alcohol where a hydroxymethyl group is attached to the pyridine ring, and Nicotinyl Alcohol is commonly supplied as a colorless to pale liquid or low-melting solid depending on purity.
Nicotinyl Alcohol is basic due to the pyridine nitrogen, so Nicotinyl Alcohol can form salts with acids and can participate in quaternization reactions to form pyridinium salts.
Nicotinyl Alcohol is soluble in many polar organic solvents, and Nicotinyl Alcohol shows moderate solubility in water depending on pH and salt form.

Nicotinyl Alcohol can be converted to esters and ethers through the hydroxyl group, and Nicotinyl Alcohol can be oxidized to the corresponding aldehyde or acid derivatives under controlled conditions.
Nicotinyl Alcohol has a characteristic pyridine-like odor in some grades, and this supports the need for ventilation and odor control during handling.
Nicotinyl Alcohol should be stored in tightly closed containers and kept away from strong oxidizers and strong acids that could cause unwanted reactions.

Nicotinyl Alcohol should be handled with appropriate PPE to avoid skin and eye contact.
Nicotinyl Alcohol should be used in well-ventilated areas, especially in laboratory-scale synthesis and charging operations.
Nicotinyl Alcohol should be disposed of according to local regulations and facility procedures for organic chemical waste.

PROPERTIES

Chemical Formula: C6H7NO
Molecular Weight: 109.13 g/mol
Common Name: Nicotinyl Alcohol (3-Pyridinemethanol)
Chemical Type: Pyridine-containing alcohol (heteroaromatic alcohol)
Appearance: Colorless to pale yellow liquid or low-melting solid (grade dependent)
Odor: Characteristic pyridine-like odor (grade dependent)
Solubility: Soluble in water to a moderate extent; soluble in many polar organic solvents
Boiling Point: ~210–220°C (typical; pressure dependent)
Melting Point: ~20–30°C (typical; purity dependent)
Flash Point: Typically >90°C (combustible; grade dependent)
Basicity: Weak base; forms salts with acids and can form quaternary salts
Stability: Stable under recommended storage; avoid strong oxidizers and moisture contamination in sensitive uses
Storage Temperature: 15–25°C, tightly closed, well ventilated
Shelf Life: Typically 24–36 months in original sealed packaging (supplier dependent)

FIRST AID

Inhalation:
Move to fresh air if vapors are inhaled.
Seek medical attention if respiratory irritation, headache, or nausea persists.
Keep the exposed person warm and at rest.

Skin Contact:
Wash with soap and water after contact.
Remove contaminated clothing and wash before reuse.
Seek medical advice if irritation develops or persists.

Eye Contact:
Rinse cautiously with water for several minutes.
Remove contact lenses if present and easy to do, then continue rinsing.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water and seek medical attention.
Do not induce vomiting unless directed by medical personnel.
Never give anything by mouth to an unconscious person.

Note to Physicians:
Treat symptomatically.
Consider pyridine-like exposure effects and monitor for CNS-related symptoms if significant exposure occurred.
Provide supportive care based on exposure route and symptoms.

HANDLING AND STORAGE

Handling:
Use appropriate PPE including gloves and safety glasses or goggles.
Avoid breathing vapors and avoid skin and eye contact.
Wash hands after handling and before eating, drinking, or smoking.

Ventilation:
Use general ventilation for normal handling.
Use local exhaust where vapors may be generated, especially during heating or charging.
Avoid confined spaces without adequate airflow.

Storage:
Store in tightly closed containers in a cool, dry, well-ventilated place.
Keep away from strong oxidizers and strong acids.
Keep containers properly labeled and protected from contamination.

Spill and Leak Procedures:
Contain spill and absorb with inert material.
Ventilate area and clean surfaces thoroughly to remove residues.
Dispose of waste according to local regulations and facility procedures.

Handling Precautions:
Use odor control and ventilation to manage pyridine-like smell during processing.
Verify purity and water content if Nicotinyl Alcohol is used in sensitive synthesis steps.
Rotate stock using FIFO practices to maintain consistent quality and predictable reactivity.