PRODUCTS

NIPACIDE FC

1,2-ethandiylbis(oxy) bismethanol. Low toxicity biocide. Effective against bacteria, fungi and yeast. Specifically developed for the complete microbiological protection of water based products against bacterial and fungal spoilage in the wet state.

CAS No. : 3586-55-8
EC No. : 222-720-6

Synonyms:
EMMD; nipasit fc; nipacid fc; nipasid fc; nipasid fc; nıpacıd fc; nıpacıde fc; nıpasıt fc; Formaldehyde releaser; 1,2-ethandiylbis(oxy) bismethanol; Methanol, 1, 1’-[1, 2-ethanediylbis (oxy)]bis-; Methanol, (ethylenedioxy) di-(7CI, 8CI); Methanol, [1,2-ethanediylbis(oxy)]bis-(9CI); (Ethylenedioxy)dimethanol; 1, 6-Dihydroxy-2,5-dioxahexane; Dascocide 9; Ethyleneglycol bis (hydroxymethyl ether); Ethylene glycol bis(semiformal); Nipacide FC; eddm; (Ethylendioxy)dimethanol; (ethylenedıoxy)dımethanol; Dascocide 9; Glycerol Impurity 5; (ethylenedioxy)dimethanol; Nipacide FC; 2-methyloloxyethoxymethanol; 1,6-Dihydroxy-2,5-dioxyhexane; 1,6-Dihydroxy-2,5-dioxahexane; Ethylene glycol bis(seMiforMal); 1,2-ETHANDIYLBIS(OXY)BISMETHANOL; 2-(hydroxymethoxy)ethoxymethanol; ethylene glycol dimethanol ether; (1,2-Ethanediylbis(oxy))bismethanol; (ethylenedioxy)dimethanol; [1,2-Ethandiylbis(oxy)]dimethanol [German] [ACD/IUPAC Name]; NIPACIDE FC; [1,2-Ethanediylbis(oxy)]dimethanol [ACD/IUPAC Name]; [1,2-Éthanediylbis(oxy)]diméthanol [French] [ACD/IUPAC Name]; 1,6-Dihydroxy-2,5-dioxyhexane; 222-720-6 [EINECS]; 3586-55-8 [RN]; Dimethylol glycol; Ethylene glycol bis(semiformal); Methanol, (1,2-ethanediylbis(oxy))bis-; Nipacide FC; Methanol, 1,1'-[1,2-ethanediylbis(oxy)]bis- [ACD/Index Name]; [2-(HYDROXYMETHOXY)ETHOXY]METHANOL; 1,2-Bi; [hydroxymethoxy]ethane; 1,6-dihydroxy-2,5-dioxahexane; 2-(hydroxymethoxy)ethoxymethanol; 2-methyloloxyethoxymethanol; Ethyleneglycolbis(semiformal); (ethylenedioxy)dimethanol; 1,6-Dihydroxy-2,5-dioxyhexane; Methanol, 1,2-ethanediylbis(oxy)bis-; 1,2-ETHANDIYLBIS(OXY)BISMETHANOL; [1,2-ethanediylbis(oxy)]bis-Methanol; ethylene glycol dimethanol ether; 2-(hydroxymethoxy)ethoxymethanol; 2-methyloloxyethoxymethan; 1,2-Bis[hydroxymethoxy]ethane; Ethylene glycol bis(semiformal); 1,2-Bis(hydroxymethoxy)ethane; 1,6-dihydroxy-2,5-dioxahexane; 1,6-dihydroxy-2,5-dioxyhexane

Nipacide FC

Nipacide FC is an in-can biocide based on EMMD.

Benefits of Nipacide FC
APEO free
Provides head-space protection
Solvent free
Bactericide
Fungicide

Technical Data of Nipacide FC
Product class   Formaldehyde releaser
Physical Form   Solution
Active content (ca.)    99%
pH stability   3 - 10
Temperature stability    40°C
Recommended Use Level     0.05 - 0.2%

Applications of Nipacide FC
Nipacide FC is recommended for preservation of a wide range of applications including:
water-based adhesives
polymer emulsions
water based decorative paints
metal working fluids
construction chemicals

Nipacide FC is a highly concentrated, formaldehyde donor biocide for the complete in-can and head space microbiological protection of industrial water based products against bacterial and fungal spoilage in the wet state. Nipacide FC demonstrates a broad spectrum of activity with fast action against microbial contamination in various applications.

Identification & Functionality of Nipacide FC

CASE Ingredients Functions of Nipacide FC
Anti-Fouling Agents
Antimicrobial Agents
Bactericides
Biocides
Fungicides
Technologies

Technical Details & Test Data of Nipacide FC
Incorporation
Nipacide FC is easy to incorporate into water based systems. It is recommended to add a small dosage of Nipacide FC at the start of the process to combat any microbial contamination of the raw materials and process waters and to ensure process hygiene. If elevated temperatures or highly alkaline pH values are likely to occur during processing, it is recommended that Nipacide FC be added after these production steps. Nipacide FC should be blended efficiently into the formulation to ensure optimum dispersion and performance.

Product Families of Nipacide FC
CASE Ingredients — Additives
Microbial Control & Preservation

Benefits of Nipacide FC
APEO free
Provides head-space protection
Solvent free
Bactericide
Fungicide

Nipacide FC is Soluble in Water

Compatibilty of Nipacide FC
Nipacide FC is compatible with most raw materials used in the manufacture of industrial water based products. However it is recommended that the compatibility of Nipacide FC with the application should always be checked and evaluated before use.

Applications & Uses of Nipacide FC

Markets of Nipacide FC
Building & Construction
Paints & Coatings

Applications of Nipacide FC
Paints & Coatings — Building & Construction
Decorative Paints
Building & Construction — Building Materials
Decorative Paints & Coatings

Coating Type of Nipacide FC: Waterborne
Use Level of Nipacide FC: 0.05-0.2% 0.05 - 0.2

Applications of Nipacide FC
Nipacide FC is recommended for preservation of a wide range of applications including:
Water-based adhesives
Polymer emulsions
Water based decorative paints
Metal working fluids
Construction chemicals

Shelf Life of Nipacide FC: 12 Months

Storage and Shelf Life
Nipacide FC must be stored in the original container, tightly closed in a well ventilated place, away from heat and direct sunlight. The shelf life is 365 days under recommended storage conditions in sealed original containers.

Blend of 1,2-ethandiylbis(oxy) bismethanol, bromo-nitropropanediol, chlorinated and non-chlorinated isothiazolinones. Low toxicity biocide. Effective against bacteria, fungi and yeast. Specifically developed for the complete microbiological protection of water based products against bacterial and fungal spoilage in the wet state.

About Nipacide FC
Nipacide FC is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 1 000 to < 10 000 per annum.

Nipacide FC is used in formulation or re-packing and in manufacturing.

Biocidal Uses of Nipacide FC
Nipacide FC is being reviewed for use as a biocide in the EEA and/or Switzerland, for: product preservation, preservation for liquid systems, controlling slimes, preservation for working / cutting fluids.

Consumer Uses of Nipacide FC
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the routes by which Nipacide FC is most likely to be released to the environment.

Article service life of Nipacide FC
ECHA has no public registered data on the routes by which Nipacide FC is most likely to be released to the environment. ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

Widespread uses by professional workers of Nipacide FC
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using Nipacide FC. ECHA has no public registered data on the routes by which Nipacide FC is most likely to be released to the environment.

Formulation or re-packing of Nipacide FC
Nipacide FC is used in the following products: oil and gas exploration or production products.
Release to the environment of Nipacide FC can occur from industrial use: formulation of mixtures.

Uses at industrial sites of Nipacide FC
ECHA has no public registered data indicating whether or in which chemical products the substance might be used. ECHA has no public registered data on the types of manufacture using Nipacide FC. ECHA has no public registered data on the routes by which Nipacide FC is most likely to be released to the environment.

Manufacture of Nipacide FC
Release to the environment of Nipacide FC can occur from industrial use: manufacturing of the substance.

Nipacide FC is not expected to move into air from wet soils or water surfaces. Nipacide FC is expected to be broken down by microorganisms but this depends on the amount of the chemical. It may not build up in tissues of aquatic organisms. RISK: Skin irritation has been reported in humans following direct skin contact with industrial or consumer products containing Nipacide FC. Allergic skin reactions have been reported in some individuals that use powder-free polyvinyl gloves containing Nipacide FC. No other information about potential health effects in humans exposed to Nipacide FC was located. Severe eye irritation was observed in laboratory animals with direct eye exposure. Decreased body weight, vomiting, damage to the lining of the stomach, and changes in blood chemistry were observed in laboratory animals exposed to a moderate oral doses of Nipacide FC over time. No evidence of infertility, abortions or birth defects was observed in laboratory animals orally exposed to Nipacide FC or during pregnancy. Slight delays in bone development were observed in offspring, but only at high doses that caused toxic effects in the pregnant animals (decreased body weight gain, labored breathing, stomach effects). The potential for Nipacide FC to cause cancer has not been examined in laboratory animals. The potential for Nipacide FC to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 13th Report on Carcinogens.

Nipacide FC should be evaluated in finished products at levels between 0.1% and 0.25%. Please note that Nipacide FC above 0.25% requires R43 (causes sensitization by skin contact) hazard labeling.

Nipacide FC is a low toxicity biocide specifically developed for the complete microbiological protection of water based products against bacterial and fungal spoilage in the wet state. Nipacide FC is a glycol based solution product.

Nipacide FC is recommended for a wide range of applications including adhesives, polymer emulsions, fountain solutions, MWF and paint where protection against fungi and bacteria is required in the wet state.

Nipacide FC is an antimicrobial and preservative chemical used in a wide variety of applications, such as cleaning and building products. It may be in the form of a white to yellow powder or liquid. While many uses of the chemical are approved by the federal government, it can cause allergic reactions in some individuals and is considered an ingredient of concern by many healthy products sources.

In addition to cleaning products, Nipacide FC has a wide range of other applications. It can be found in flea and tick treatments, paints, stains, car care products, textile solutions, metalworking fluids, oil recovery fluids, leather processing chemicals, pesticides, and paper mill systems. It is also used in building products, such as adhesives, caulks, sealants, grouts, spackle, and wallboard. In addition, Nipacide FC is commonly used in personal care products, like sunscreen and liquid hand soap, and as an inert ingredient on crops, such as blueberries, strawberries, tomatoes, spinach, lettuce, and more.

In concentrate and use-dilution metalworking fluids, the compatibility of Nipacide FC Biocide is concentration-dependent and varies from formulation to formulation. It is compatible with most metalworking fluid additives, including surfactants and amines. Compatibility with amines may vary by the type, concentration and pH. Strong reducing agents, such as sulfides, mercaptans, bisulfites and metabisulfites, or strong oxidizing agents, such as hypochlorites, may affect the efficacy of Nipacide FC. Laboratory or small-scale tests are recommended in order to evaluate Nipacide FC compatibility in use-dilution or concentrate metalworking fluids prior to commercialization.

Nipacide FC Biocide utilizes a two-step mechanism involving rapid growth inhibition leading to a loss of cell viability. Growth inhibition is the result of rapid disruption of the central metabolic pathways of the cell by inhibition of several specific enzymes, including dehydrogenases. The critical enzymes which are affected are associated with the Krebs cycle, nutrient metabolism and energy generation. The key physiological activities that are rapidly inhibited in microbial cells are respiration (oxygen consumption), energy generation (ATP synthesis), and growth (assimilation). Many of these key enzymes are present in both aerobic and anaerobic microorganisms, which explains why Nipacide FC is such a broad spectrum biocide.

Inhibition of cellular activity and growth is rapid (within minutes), whereas cell death (cidal activity) is observed after several hours’ contact. In general, the higher the concentration of biocide, the shorter the contact time required for more complete kill. Cell death results from the progressive loss of protein thiols in the cell from one of multiple pathways. As cell metabolism is disrupted, free radicals are produced which also results in cell death. This unique mechanism results in the broad spectrum of activity of Nipacide FC Biocide, low use levels for microbial control, and difficulty in attaining resistance by mutation. See technical bulletin (CS-632) for more detailed information.

Initial determinations of the efficacy of any biocidal product are made via minimum inhibitory concentration (MIC) measurements. The MIC test yields valuable information about the product’s inherent antimicrobial efficacy and spectrum of activity. The MIC for any product is the lowest level at which the active ingredient inhibits the growth of various microorganisms. This method is a useful tool for screening antimicrobial agents under standardized laboratory conditions, in nutrient-rich growth conditions. In interpreting the data, remember that low values correspond to high activity. Table 2 indicates that Nipacide FC Biocide possesses outstanding antimicrobial activity against a broad range of fungi (both yeasts and molds). Nipacide FC has very low MIC values for most of the fungi tested and there is no gap in the spectrum of activity among the organisms tested.

Nipacide FC Biocide was evaluated as a tankside fungicide in a wide variety of metalworking fluids, including synthetics, semi-synthetics, and soluble-oil fluids. In a oneweek eradication study described below, a total of 16 fluids from various manufacturers in the United States, Europe, and Japan were tested.

General population exposure can occur via dermal, inhalational, or oral routes from residential use and by ingesting treated food or food that was in contact with treated surfaces or equipment. Nipacide FC was detected in 40 of 60 different canned beers at concentrations in the low parts per billion. Estimated human intakes have been below recommended intake limits. Workers who manufacture, formulate, or apply these chemicals may be more highly exposed than the general population. Nipacide FC is efficiently absorbed from the gastrointestinal tract and through the skin, and is eliminated rapidly from the body as Nipacide FC glucuronide and sulfate conjugates (Bartels et al., 1998; Cnubben et al. 2002; Timchalk et al., 1998). Available evidence suggests that Nipacide FC does not accumulate in the body; however, small amounts of Nipacide FC have been measured in human adipose tissue.

In its chemical structure, a molecule of Nipacide FC has a methyl group substituted onto the ring of phenol. There are three forms (isomers) of Nipacide FC, these forms occur separately or as a mixture, which can also be called Nipacide FC or more specifically, triNipacide FC. About half of the world's supply of Nipacide FC are extracted from coal tar. The rest is produced by hydrolysis of chlorotoluenes or the related sulfonates. Another method entails methylation of phenol with methanol over a solid acid catalyst, often comprising magnesium oxide or alumina. Temperatures above 300 °C are typical. Anisole converts to Nipacide FC under these conditions.

Nipacide FC's production and use as an antibacterial, germicide, antiseptic and in mildew prevention may result in its release to the environment through various waste streams. If released to air, a vapor pressure of 0.1 mm Hg at 20 °C indicates Nipacide FC will exist solely as a vapor in the atmosphere. Vapor-phase Nipacide FC will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 5.8 hours. Nipacide FC does not absorb at wavelengths >290 nm and has been reported to be stable to sunlight for up to 24 hours. If released to soil, Nipacide FC is expected to have low mobility based upon an estimated Koc of 1,400. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 5.1X10-7 atm-cu m/mole. Nipacide FC is not expected to volatilize from dry soil surfaces based upon its vapor pressure. Volatilization from water surfaces is expected to be an important fate process based upon this compound's estimated Henry's Law constant. Estimated volatilization half-lives for a model river and model lake are 10 hours and 9 days, respectively. Degradation of Nipacide FC appears to be slower than other phenol derivatives. Studies in sewage showed 80-95% of the original compound remaining after 2 days and 60-70% remaining after 7 days. This is consistent with other studies that showed less than 40% degradation in activated sludge over 7 days. If released into water, Nipacide FC is not expected to adsorb to suspended solids and sediment based upon the estimated Koc. An estimated BCF of 66 suggests the potential for bioconcentration in aquatic organisms is moderate. Hydrolysis is not expected to be an important environmental fate process since this compound lacks functional groups that hydrolyze under environmental conditions. Occupational exposure to Nipacide FC may occur through inhalation and dermal contact with this compound at workplaces where Nipacide FC is produced or used. The most likely route of exposure to the general population is through dermal contact when using soaps or cleaning products that contain Nipacide FC as an antibacterial. A smaller population may be exposed to Nipacide FC when taking medications that contain Nipacide FC as an active ingredient.