PRODUCTS

NIPAGIN A SODIUM

CAS Number: 35285-68-8
EC Number: 252-487-6
Molecular Formula: C9H9NaO3

Nipagin A Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals.
Nipagin A Sodium is suitable to preserve both rinse- off and leave- on formulations.
Nipagin A Sodium is effective against bacteria, molds and yeast.

Nipagin A Sodium is a Sodium salt of ethylparaben.
Nipagin A Sodium is a water-soluble antiseptic mainly used as a safe, high efficiency, broad-spectrum antibiotic for cosmetics.
Nipagin A Sodium is in the paraben family of preservatives used by the food, pharmaceutical, and personal care product industries.

Nipagin A Sodium is highly soluble in water and so easily incorporated into cosmetic formulations.
Nipagin A Sodium is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained.

Applications of Nipagin A Sodium:
Nipagin A Sodium is designed for preservation of a wide range of cosmetics and toiletries.
Nipagin A Sodium is suitable to preserve both rinse- off and leave- on formulations.
Formulations which are prone to bacteria contamination an additional antibacterial preservative, like Nipaguard DMDMH might be necessary to add as Nipagin A Sodium provides a higher efficacy against fungi than against bacteria.

Aqueous concentrates may be prepared up to 40% in strength.
The concentrate may then be added to the process, preferably slowly and with rapid mixing.

Due to the high pH of aqueous solutions of sodium parabens, the pH of the final product requires adjustment.
The aqueous solution should be used within a short time of preparation as prolonged storage will result in alkaline hydrolysis of the esters.

Nipagin A Sodium is important to note that, at the target pH of the formulation, the parabens will exist as the free esters and not as salts and, therefore, the solubility will also be that of the free esters.
Use of the sodium salts will facilitate introduction of the parabens.
Nipagin A Sodium will not allow higher concentrations to be used compared with the free esters.

Uses of Nipagin A Sodium:
Sodium ethyl p-hydroxybenzoate is widely used in food and pharmaceutical and textile industry for Nipagin A Sodium antiseptic property.
Nipagin A Sodium is also can be used in industries such as cosmetics, feed and so on.

Nipagin A Sodium is effective against bacteria, molds and yeast.
The recommended use level of Nipagin A Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.
The Paraben esters have many advantages as preservatives,like broad spectrum antimicrobial activity,effective at low use concentrations, compatible with a wide range of cosmetic ingredients, colourless, odourless, well documented toxicological and dermatological acceptability based on human experience (used in cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acid and a number of Nipagin A Sodium esters occur naturally in a variety of plants and animals, stable and effective over a wide pH- range, etc.

The Sodium Parabens, like Nipagin A Sodium have several additional advantages:
Nipagin A Sodium is highly soluble in cold water for ease of addition.
No heating stage required for incorporation, thus saving energy and plant occupancy.
Increased antimicrobial activity at alkaline pH.

Benefits of Nipagin A Sodium:
Nipagin A Sodium has high solubility in cold water,
Nipagin A Sodium performs broad spectrum of activity against bacteria and fungi,

Nipagin A Sodium shows effectiveness at low concentrations,
Nipagin A Sodium has stability over a broad pH-range.

Water-soluble of Nipagin A Sodium:
Biodegradability at environmental concentrations,
Global acceptance in personal care applications.

Microbial activity of Nipagin A Sodium:
Nipagin A Sodium has a broad spectrum of activity which includes the following common spoilage organisms.

Microorganisms MIC level (%)
Pseudomonas aeruginosa - 0.113
Escherichia coli - 0.056
Klebsiella pneumoniae - 0.056
Serratia marcescens - 0.056
Proteus vulgaris - 0.068
Salmonella enteritidis - 0.046
Staphylococcus aureus - 0.079
Streptococcus haemolyticus - 0.068
Bacillus cereus - 0.028

Yeasts
Candida albicans - 0.079
Saccharomyces cerevisiae - 0.056

Molds
Aspergillus niger - 0.045

pH stability of Nipagin A Sodium:
Nipagin A Sodium remains fully stable over a wide pH range from 3.0- 11.0.
Aqueous solutions of Nipagin A Sodium are not long- term stable at alkaline pH.

Temperature stability of Nipagin A Sodium:
The recommended maximum handling temperature is 80°C.

Storage instructions of Nipagin A Sodium:
Nipagin A Sodium is stable in sealed original containers.
Further information on handling, storage and dispatch is given in the EC safety data sheet.

Properties of Nipagin A Sodium:
Appearance: White powder
pH 9.5- 10.5
Water content: max. 5.0 %
Assay by non aqueous titration: 99 - 102 %

Names of Nipagin A Sodium:

CAS names of Nipagin A Sodium:
Benzoic acid, 4-hydroxy-, ethyl ester, sodium salt (1:1)

IUPAC names of Nipagin A Sodium:
Ethyl-4-hydroxybenzoat, Natriumsalz
Ethyl-4-hydroxybenzoat, sodium salt
p-Hydroxybenzoic acid ethyl ester sodium salt
sodium 4-(ethoxycarbonyl)benzen-1-olate
sodium 4-(ethoxycarbonyl)phenolate
Sodium 4-ethoxycarbonylphenoxide
Sodium ethylparaben
sodium;4-ethoxycarbonylphenolate
Sodium ethyl p-hydroxybenzoate

Synonyms of Nipagin A Sodium:
35285-68-8
Sodium ethylparaben
Sodium 4-(ethoxycarbonyl)phenolate
Sodium ethyl p-hydroxybenzoate
ethylparaben sodium
UNII-Z0D00IVA10
sodium;4-ethoxycarbonylphenolate
Benzoic acid, 4-hydroxy-, ethyl ester, sodium salt
Z0D00IVA10
Sodium Ethyl Parahydroxybenzoate
Sodium 4-ethoxycarbonylphenoxide
Ethylparaben, sodium salt
EINECS 252-487-6
Ethyl p-hydroxybenzoate, sodium salt
Ethylparaben Sodium Salt
C9H9NaO3
Ethylparaben sodium (NF)
4-Hydroxybenzoic acid, ethyl ester, sodium salt
SCHEMBL475793
DTXSID0042402
ACT02627
MFCD00016475
AKOS006229160
KS-0000108G
4-Hydroxybenzoic acid-ethyl ester sodium
O619
FT-0688110
D10929
M-2447
Q3963917
W-106682
UNII-F57SQP06GK component QYNMSPKSYXPZHG-UHFFFAOYSA-M
BENZOIC ACID, p-HYDROXY-, ETHYL ESTER, SODIUM DERIV.
4-Hydroxybenzoic acid, ethyl ester, sodium salt
Benzoic acid, 4-hydroxy-, ethyl ester, sodium salt
Benzoic acid, p-hydroxy-, ethyl ester, sodium deriv.
Ethyl p-hydroxybenzoate, sodium salt
Ethylparaben sodium
Ethylparaben, sodium salt
Sodium 4-ethoxycarbonylphenoxide
Sodium ethylparaben
252-487-6
35285-68-8
4-(Éthoxycarbonyl)phénolate de sodium
Benzoic acid, 4-hydroxy-, ethyl ester, sodium salt (1:1)
E215
ETHYLPARABEN SODIUM
Natrium-4-(ethoxycarbonyl)phenolat
p-hydroxybenzoic acid ethyl ester sodium salt
Sodium 4-(ethoxycarbonyl)phenolate
Sodium ethylparaben
Z0D00IVA10
[35285-68-8]
4-ethoxycarbonylphenolate
4-Hydroxybenzoic acid, ethyl ester, sodium salt
4-Hydroxybenzoic acid-ethyl ester sodium
5026-62-0
Benzoic acid, 4-hydroxy-, ethyl ester, sodium salt
Benzoic acid, 4-hydroxy-, methyl ester, sodium salt
BENZOIC ACID, p-HYDROXY-, ETHYL ESTER, SODIUM DERIV.
BENZOIC ACID, p-HYDROXY-, METHYL ESTER, SODIUM DERIV.
Bonomold OMNa
EINECS 225-714-1
EINECS 252-487-6
Ethyl p-hydroxybenzoate, sodium salt
ETHYL4-HYDROXYBENZOATESODIUMSALT
Ethylparaben sodium salt
Ethylparaben, sodium salt
Methyl 4-hydroxybenzoate sodium salt
METHYL P-HYDROXYBENZOATE, SODIUM SALT
Methylparaben sodium
methylparaben, sodium salt
MFCD00016475
NIPASEPT SODIUM
Preserval MS
Sodium
sodium 4-(ethoxycarbonyl)benzen-1-olate
SODIUM 4-(ETHOXYCARBONYL)BENZENOLATE
Sodium 4-(methoxycarbonyl)phenolate
sodium 4-carbethoxyphenolate
sodium 4-carbomethoxyphenolate
sodium 4-ethoxycarbonylphenolate
Sodium 4-ethoxycarbonylphenoxide
sodium 4-methoxycarbonylphenolate
sodium and 4-ethoxycarbonylphenolate
SODIUM ETHYL PARABEN
Sodium Ethyl Parahydroxybenzoate
Sodium ethyl p-hydroxybenzoate, tech.
Sodium methyl 4-hydroxybenzoate
Sodium methyl p-hydroxybenzoate
Sodium methylparaben
Sodium p-methoxycarbonylphenoxide
Sodium, (p-carboxyphenoxy)-, methyl ester (7CI)
sodium;4-ethoxycarbonylphenolate
Solparol
ST5405340
UNII:Z0D00IVA10
UNII-F57SQP06GK
UNII-Z0D00IVA10
benzoic acid, 4-hydroxy-, ethyl ester, sodium salt
benzoic acid, p-hydroxy-, ethyl ester, sodium deriv.
ethyl p-hydroxybenzoate, sodium salt
ethylparaben sodium
ethylparaben, sodium salt
4-hydroxybenzoic acid, ethyl ester, sodium salt
sodium 4-ethoxycarbonyl phenoxide
sodium 4-ethoxycarbonylphenoxide
sodium ethyl 4-hydroxybenzoate
sodium ethyl p-hydroxybenzoate
sodium ethyl paraben
sodium;4-ethoxycarbonylphenolate
Ethyl 4-hydroxybenzoate sodium salt,
p-Hydroxybenzoic acid ethyl ester sodium salt, Ethylparaben sodium salt