NIPAGIN M SODIUM

Nipagin M Sodium is highly soluble in water and so easily incorporated into cosmetic formulations.
Nipagin M Sodium is important to note that, whilst the aqueous solubility in alkaline solution is high, if the pH of the formulated product is acidic the sodium salt reverts to the ester and the low solubility is regained.

Nipagin M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries pharmaceuticals. 
Nipagin M Sodium is suitable to preserve both rinse- off and leave-on formulations.

Nipagin M Sodium is effective against bacteria, molds and yeast. 
The recommended use level of Nipagin M Sodium to preserve most product types is normally in the range of 0.1- 0.3 % based on the total weight of the finished product.

Nipagin M Sodium is a broad spectrum antimicrobial agent designed for preservation of a wide range of cosmetics, toiletries, and topical pharmaceuticals. 
Nipagin M Sodium is suitable to preserve both rinse-off and leave-on formulations. 
Nipagin M Sodium is highly soluble in cold water for ease of addition.

Nipagin M Sodium is designed for preservation of a wide range of cosmetics and toiletries. 
Nipagin M Sodium is suitable to preserve both rinse- off and leave- on formulations. 

Nipagin M Sodium is a broad spectrum antimicrobial agent designed forpreservation of a wide range of cosmetics, toiletries pharmaceuticals. 
Nipagin M Sodium is suitable to preserve both rinse- off and leave- onformulations.

Nipagin M Sodium is effective against bacteria, molds and yeast.
The recommended use level of Nipagin M Sodium to preserve most product types is normally in the range of 0.1 - 0.3 % based on the total weight of the finished product.

The Paraben esters have many advantages as preservatives, like broad spectrumantimicrobial activity, effective at low use concentrations, compatible with awide range of cosmetic ingredients, colourless, odourless, well documentedtoxicological and dermatological acceptability based on human experience (usedin cosmetics, food and pharmaceuticals since 1930ies), p-Hydroxybenzoic Acidand a number of Nipagin M Sodium esters occur naturally in a variety of plants and animals,stable and effective over a wide pH- range, etc.
The Sodium Parabens, like Nipagin M Sodium have several additional advantages:

Nipagin M sodium is highly soluble in cold water for ease of addition.
No heating stage required for incorporation, thus saving energy and plant occupancy.
Increased antimicrobial activity at alkaline pH.

Nipagin M Sodium is a highly water-soluble short-chain paraben in sodium salt form. 
The major benefit offered by the sodium salts is their high solubility in cold water, thereby enabling the introduction of parabens without heating or pre-dissolving in solvents.

Uses of Nipagin M Sodium:
Nipagin M Sodium is a water-soluble preservative. 
Nipagin M Sodium is a short-chain paraben in sodium salt form. 

Nipagin M Sodium offers a broad spectrum of activity against bacteria & fungi and stability over a broad pH-range. 
Nipagin M Sodium exhibits effectiveness at low concentrations. 

Nipagin M Sodium shows high solubility in cold water, low order of toxicity and good biodegradability at environmental concentrations. 
Nipagin M Sodium is used in all kinds of personal care products.

The Sodium Parabens, like Nipagin M Sodium have several additional advantages:
Nipagin M sodium is highly soluble in cold water for ease of addition.
No heating stage required for incorporation, thus saving energy and plant occupancy.
Increased antimicrobial activity at alkaline pH.

Applications of Nipagin M Sodium:
Nipagin M Sodium is designed for preservation of a wide range of cosmetics and toiletries. 
Nipagin M Sodium is suitable to preserve both rinse- off and leave- on formulations. 
Formulations which are prone to bacteria contamination an additional antibacterial preservative, like DMDMH might be necessary to add as Nipagin M Sodium provides a higher efficacy against fungi than against bacteria.

Benefits of Nipagin M Sodium:
High solubility in cold water,
Broad spectrum of activity against bacteria and fungi,
Low order of toxicity,
Effectiveness at low concentrations,
Stability over a broad pH-range.

Solubility of Nipagin M Sodium:
Water up to 33 %

pH stability of Nipagin M Sodium:
Nipagin M Sodium remains fully stable over a wide pH range from 3.0- 11.0.
Aqueous solutions of Nipagin M Sodium are not long- term stable at alkaline pH.

Temperature stability of Nipagin M Sodium:
The recommended maximum handling temperature is 80°C.

Microbial activity of Nipagin M Sodium:
Nipagin M Sodium has a broad spectrum of activity which includes the following common spoilage organisms.

Microorganisms MIC level (%)

Bacteria
Pseudomonas aeruginosa - 0.228
Staphylococcus aureus - 0.17

Microorganisms MIC level (%)

Yeasts
Candida albicans 0.114

Molds
Aspergillus niger 0.114

Storage instructions of Nipagin M Sodium:
Nipagin M Sodium is stable in sealed original containers.
Further information on handling, storage and dispatch is given in the EC safety data sheet.

Properties of Nipagin M Sodium:
Appearance: White powder
pH: 9.5- 10.5
Water content: max. 5.0 %
Assay by non aqueous titration: 99 - 102 %

Synonyms of Nipagin M Sodium:
5026-62-0
Methylparaben sodium
Sodium 4-(methoxycarbonyl)phenolate
Sodium methylparaben
Methyl 4-hydroxybenzoate, sodium salt
Preserval MS
Methyl 4-hydroxybenzoate sodium salt
Sodium 4-carbomethoxyphenolate
UNII-CR6K9C2NHK
sodium;4-methoxycarbonylphenolate
CR6K9C2NHK
Sodium methyl p-hydroxybenzoate
Sodium Methyl Parahydroxybenzoate
MFCD00016470
Solparol
Bonomold OMNa
Methyl 4-hydroxybenzoate, sodium salt, 99%
Sodium p-methoxycarbonylphenoxide
EINECS 225-714-1
Methyl p-hydroxybenzoate, sodium salt
Methylparaben, sodium salt
Sodium methyl 4-hydroxybenzoate
Methylparaben sodium 
Methylis parahydroxybenzoas natricum
sodium methyl paraben
Methylparaben sodium (NF)
EC 225-714-1
sodium 4carbomethoxyphenolate
SCHEMBL48756
Methyl p-hydroxybenzoate sodium
CHEMBL2106903
DTXSID1042156
Methyl 4-hydroxybenzoate,sodium salt
AKOS015961950
4-Hydroxybenzoic acid-methyl ester sodium
AC-15527
AK121814
AS-14805
M659
SC-27014
FT-0635516
ST50405340
KS-00000071
D02458
Sodium, (p-carboxyphenoxy)-, methyl ester (7CI)
Q-201383
Q3963920
UNII-F57SQP06GK component PESXGULMKCKJCC-UHFFFAOYSA-M
BENZOIC ACID, p-HYDROXY-, METHYL ESTER, SODIUM DERIV.
Methyl 4-hydroxybenzoate sodium salt, tested according to Ph.Eur.
4-hydroxybenzoic acid methyl ester sodium salt
methyl p-hydroxybenzoate sodium salt
METHYLPARABEN SODIUM
METHYLPARABEN, SODIUM SALT
METHYL 4-HYDROXYBENZOATE SODIUM
METHYL 4-HYDROXYBENZOATE SODIUM SALT
(p-carboxyphenoxy)-sodiumethylester
benzoicacid,4-hydroxy-,methylester,sodiumsalt
Benzoicacid,p-hydroxy-,methylester,sodiumderiv.
bonomoldomna
Sodium methyl neper gold
METHYL 4-HYDROXYBENZOATE SODIUM SALT, PH EUR
MethylParabenSodiumBp/Usp/Ep
Sodiummethylparabene
METHYLP-HYDROXYBENZOATESODIUM
METHYLPARABENSODIUM,NF
SODIUMMETHYLHYDROXYBENZOATE
Natrium-4-(methoxycarbonyl)phenolat
sodium 4-(methoxycarbonyl)phenolate
sodiummethylester4-hydroxybenzoate
preservalms
solparol
NIPAGIN SODIUM
P-HYDROXYBENZOIC ACID METHYL ESTER SODIUM SALT
SODIUM METHYL 4-HYDROXYBENZOATE
SODIUM METHYL PARABEN
SODIUM METHYL P-HYDROXYBENZOATE
sodium p-methoxycarbonylphenoxide
Sodium (p-carboxyphenoxy)-methyl ester
sodium 4-(methoxycarbonyl)phenoxide
Sodium 4-carbomethoxyphenolate
4-(Sodiooxy)benzoic acid methyl ester
4-Sodiooxybenzoic acid methyl ester
Methyl 4-hydroxybenzoate, sodium salt,99%
Methylis parahydroxybenzoas natricum, Sodium methyl 4-hydroxybenzoate
Methylparabens
Methyl 4-hydroxybenzoate, sodiuM salt, 99% 500GR
SodiuM Methl p-hydroxybenzoate
Benzoic acid,4-hydroxy-, Methyl ester, sodiuM salt (1:1)
Sodium Methyl-p-hydroxyl Benzoate
Methylis parahydroxybenzoas natricum
Sodium methyl acetate
Acetylsalicylic Acid Impurity 6 Sodium Salt (Sodium Methyl Parahydroxybenzoate)
4-hydroxybenzoate sodium saL
Methyl 4-hydroxybenzoate fandachem
5026-62-0
5026-26-0
C8H7NaO3
17413
API
Benzoic acid Series
Aromatic Esters