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CAS NUMBER: 139-13-9
EC NUMBER: 205-355-7
MOLECULAR FORMULA: C6H9NO6
MOLECULAR WEIGHT: C6H9NO6
Nitrilotriacetic acid is the aminopolycarboxylic acid with the formula N(CH2CO2H)3.
Nitrilotriacetic acid is a colourless solid that is used as a chelating agent, which forms coordination compounds with metal ions (chelates).
Nitrilotriacetic Acid is a white, crystalline solid compound.
Nitrilotriacetic acid is mainly used as a chelating and eluting agent and is found in laundry detergents.
Nitrilotriacetic acid is an odorless white solid.
Sinks in and mixes with water.
Nitrilotriacetic acid is a tricarboxylic acid and a NTA.
Nitrilotriacetic acid has a role as a nephrotoxic agent and a carcinogenic agent.
Nitrilotriacetic acid is a conjugate acid of a nitrilotriacetate(1-).
Nitrilotriacetic acid belongs to the class of organic compounds known as alpha amino acids.
These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
Nitrilotriacetic acid is an aminotricarboxylic acid with an empirical formula of C6H9NO6.
In the undissociated acid form, Nitrilotriacetic acid is composed of needles or prismatic crystals.
Nitrilotriacetic acid has a melting point of 241.5°C; its solubility in water at 22.5°C is 1.28 mg/mL.
The pH of the saturated solution is 2.3.
Nitrilotriacetic acid can sequester metal ions to form water-soluble complexes; it is an important chelating agent, with many industrial applications.
Because of its ability to chelate calcium and magnesium ions, the trisodium salt is used in laundry detergents as a "builder" to replace phosphates, the use of which has been restricted by legislation in some countries owing to their contribution to the eutrophication of lakes and ponds.
In 1977, the amount of Nitrilotriacetic acid used in detergents in Canada was 27 299 tonnes; more recent data on consumption were not identified.
Nitrilotriacetic acid is also used extensively in the treatment of boiler water to prevent accumulation of mineral scale.
Nitrilotriacetic acid is used to a lesser extent in photography, textile manufacturing, paper and cellulose production, metal plating and cleaning operations.
Nitrilotriacetic acid has been proposed as a therapeutic chelating agent for manganese poisoningFootnote2 and for the treatment of iron overloading, as it has a synergistic effect on the mobilization of iron by desferrioxamine.
Nitrilotriacetic acid and its sodium salts have been produced since the 1930s for use as metal chelating agents in household and industrial detergents, industrial water treatment, textile preparation and metal finishing.
Occupational exposure to nitrilotriacetic acid and its salts may occur during its production and use, but data on levels are limited.
Exposure to nitrilotriacetic acid, and presumably to its water-soluble metal complexes, occurs as a result of its presence in household detergents and in drinking-water.
Nitrilotriacetic acid has numerous commercial applications as a metal ion chelator, including pricipally its use in cleaning products, industril water treatment, textile preparation and metal finishing.
Nitrilotriacetic acid has also been used to a lesser extent in the pulp and paper industiy, in rubber processing, in photographic products, in the electrochemical industiy, in the tanning of leather, and in cosmeties.
The major use of Nitrilotriacetic acid, as the triium salt, has been in detergent systems as a chelating agent and as a laundiy detergent builder.
Nitrilotriacetic acid was originally proposed as a substitute for phosphates in detergents, when the eutrophic effect of phosphates on the aquatic envionment was recognized.
Nitrilotriacetic acid has been accepted for use as an ingredient in domestic detergent products in at least 16 countries and has actually been used in detergents in Canada and several European countries since the early 1970s.
Nitrilotriacetic acid is also used to reduce fabric yellowig by hyphlorite bleach and to increase the effectiveness in hard water of liquid detergent-sanitizer formulations based on quaternaiy ammonium germicides.
Nitrilotriacetic acid can chelate metal ions that commonly cause water 'hardness' (Ca2 + and Mg2 +) and is widely used to control precipitation and scling of salts of these ions, for example, in boiler feedwater.
Various salts of Nitrilotriacetic acid have been used to remove scle. Since the sodium-calcium NTA Nitrilotriacetic acid complex is relatively insoluble, it can form a coating on the scle andretard further scle formation.
lron oxide deposits such as mil scle are removed with Nitrilotriacetic acid,ammonium salts in the alkaline pH range, resulting in a degreased and cleaned surface.
Nitrilotriacetic acid is organic chelating agent used to control the concentration of metal ions in aqueous systems.
Nitrilotriacetic Acid is a white, crystalline solid compound. Nitrilotriacetic acid is mainly used as a chelating and eluting agent and is found in laundry detergents.
Nitrilotriacetic acid is a tricarboxylic acid and a NTA.
USES OF NITRILOTRIACETIC ACID:
Nitrilotriacetic acid mainly used in synthetic detergents, chemical plating, and non-cyanide electroplating, scale removers and scale inhibitors, printing and dyeing auxiliaries, plastic additives, industrial desulfurization, chemical analysis, photographic industry, crop production inhibition and printing inks, rare earth extraction, etc.
Nitrilotriacetic acid is commercially available as the free acid and as the sodium salt.
Nitrilotriacetic acid is produced from ammonia, formaldehyde, and sodium cyanide or hydrogen cyanide.
Worldwide capacity is estimated at 100 thousand tonnes per year.
Nitrilotriacetic acid is also cogenerated as an impurity in the synthesis of EDTA, arising from reactions of the ammonia coproduct.
Nitrilotriacetic acid is used as a chelating and sequestering agent, and as a builder in synthetic detergents.
Nitrilotriacetic acid is also used as an eluting agent in the purification of rare earth elements, as a boiler feed water additive, in water and textile treatment, in metal plating and cleaning and in pulp and paper processing.
Nitrilotriacetic acid is not used directly as cosmetic ingredient, but it is present as an additive in some ingredients.
Nitrilotriacetic acid is used in complexometric titrations.
A variant of Nitrilotriacetic acid is used for protein isolation and purification in the His-tag method.
The modified Nitrilotriacetic acid is used to immobilize nickel on a solid support.
This allows purification of proteins containing a tag consisting of six histidine residues at either terminus.
Nitrilotriacetic acid is mainly used as a chelating and eluting agent and is found in laundry detergents.
Nitrilotriacetic acid is a trisodium salt of nitrilotriacetic acid and has been used as a chelating (binding) agent for more than 50 years.
Nitrilotriacetate is used worldwide in a variety of market areas, with major emphasis in the detergent industry.
Nitrilotriacetic acid effectively controls a variety of metal ions in wash water thus allowing cleaning ingredients to work better.
Nitrilotriacetic acid is a chelating agent which forms coordination compounds with metal ions.
Nitrilotriacetic acid is used in complexometric titrations and as well as for protein isolation and purif ication in the His-tag method.
Nitrilotriacetic acid is used in sequestration of metals; chelometric analysis
Nitrilotriacetic acid is used as a chelating and sequestering agent, and as a builder in synthetic detergents.
Nitrilotriacetic acid is also used as an eluting agent in the purification of rare earth elements, as a boiler feed water additive, in water and textile treatment, in metal plating and cleaning and in pulp and paper processing.
-Industry Uses:
Nitrilotriacetic acid is used in the following products: pH regulators and water treatment products and laboratory chemicals.
Nitrilotriacetic acid is used in the following areas: formulation of mixtures and/or re-packaging, health services and scientific research and development.
Nitrilotriacetic acid is used for the manufacture of: chemicals.
Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites, in the production of articles, as processing aid and of substances in closed systems with minimal release.
Other release to the environment of this substance is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).
-Consumer Uses:
Nitrilotriacetic acid is used in the following products: washing & cleaning products, coating products, biocides (e.g. disinfectants, pest control products), fillers, putties, plasters, modelling clay, adhesives and sealants and polishes and waxes.
Other release to the environment of this substance is likely to occur from: outdoor use, indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters), outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids), outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products,
electrocequipment) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints).
APPLICATION OF NITRILOTRIACETIC ACID:
Nitrilotriacetic acid is a tripodal tetradentate trianionic ligand.
The uses of Nitrilotriacetic acid are similar to those of EDTA, both being chelating agents.
Nitrilotriacetic acid is used for water softening and as a replacement to sodium and potassium triphosphate in detergents, and cleansers.
In one application, Nitrilotriacetic acid as a chelating agent removes Cr, Cu, and As from wood that had been treated with chromated copper arsenate.
An excellent chelating agent.
-Laundry detergents
-Automatic dishwashing products
-Scale control in boiler water treatment
-Bottlewash formulations for removal of trace contaminating metal salts
-Carpet cleaning products
-Hard surface cleaners
-Metal cleaning and treatment
-Petroleum production and refining processes
-Thermochemical pulp processes
-Removal of hydrogen sulfide from natural gas (gas scrubbing)
-Polymer processing
-Textile scouring, bleaching and dyeing processes
-Vehicle washing products
-Natural gas fracking formulations (corrosion control)
PROPERTIES OF NITRILOTRIACETIC ACID:
-Quality Level: 200
-grade: Sigma Grade
-assay: ≥99%
-Melting point: 245 °C (dec.) (lit.)
-SMILES string: OC(=O)CN(CC(O)=O)CC(O)=O
-InChI: 1S/C6H9NO6/c8-4(9)1-7(2-5(10)11)3-6(12)13/h1-3H2,(H,8,9)(H,10,11)(H,12,13)
-InChI key: MGFYIUFZLHCRTH-UHFFFAOYSA-N
PHYSICAL AND CHEMICAL PROPERTIES OF NITRILOTRIACETIC ACID:
-Physical State: Solid
-Appearance: white
-Odor: none reported
-pH: 2.3 (saturated)
-Vapor Pressure: Negligible.
-Vapor Density: Not available.
-Evaporation Rate:Negligible
-Viscosity: Not available.
-Boiling Point: Not available.
-Freezing/Melting Point:241 deg C
-Decomposition Temperature:Not available.
-Solubility: Very slightly solutble in water
-Specific Gravity/Density:>1.000
-Molecular Formula:N(CH2COOH)3
-Molecular Weight:191.0661
PHYSICAL PROPERTIES OF NITRILOTRIACETIC ACID:
Nitrilotriacetic acid is available as a free flowing powder or 40% water solution.
Nitrilotriacetic acids obviously have different properties and handling characteristics.
Both products are classified as not regulated for transport, and can be shipped by any method.
Nitrilotriacetic acid’s properties have been well characterized:
Nitrilotriacetic acid powder is a monohydrate under most circumstances
Nitrilotriacetic acid powder is not flammable or combustible.
Nitrilotriacetic acid powder is not a dust explosion risk.
Nitrilotriacetic acid, if heated to decomposition, breaks down into carbon, carbon dioxide, nitrogen oxides, and water.
Nitrilotriacetic acid powder contains a distribution of particle sizes
Nitrilotriacetic acid powder is highly water soluble (457 grams Nitrilotriacetic acid NTA per liter of solution at 20°C)
Nitrilotriacetic acid powder, if spilled, can be slippery if it becomes damp.
Nitrilotriacetic acid solution is a low viscosity fluid
Nitrilotriacetic acid solution is non-flammable and not corrosive to metals in normal use and storage conditions.
CHEMICAL PROPERTIES OF NITRILOTRIACETIC ACID:
-White, crystalline powder.
-Insoluble in water and most organic solvents; forms mono-, di-, and tribasic salts that are water soluble.
-Combustible.
-70% biodegradable.
STORAGE OF NITRILOTRIACETIC ACID:
Store in a ventilated and dry place, away from moisture.
Keep away from fire and heat sources.
The packaging is required to be sealed.
Nitrilotriacetic acid should be stored separately from oxidants, alkalis, edible chemicals, etc., and avoid mixed storage.
SYNONYM:
139-13-9
2,2',2''-nitrilotriacetic acid
Triglycollamic acid
Nitrilotriacetate
Aminotriacetic acid
Complexon I
Trilon A
NTA
Glycine, N,N-bis(carboxymethyl)-
N,N-Bis(carboxymethyl)glycine
Komplexon I
Titriplex I
Versene NTA acid
2-[bis(carboxymethyl)amino]acetic acid
Nitrilotriessigsaeure
Hampshire NTA acid
Tri(carboxymethyl)amine
