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N-Methylmorpholine (NMM) is a tertiary amine belonging to the morpholine family, widely used as a solvent, catalyst, and intermediate in chemical synthesis.
N-Methylmorpholine is valued for its high polarity, low volatility, and compatibility with a broad range of organic and inorganic compounds.
N-Methylmorpholine is extensively applied in pharmaceuticals, agrochemicals, polyurethane production, and specialty chemical industries.
CAS Number: 109-02-4
EC Number: 203-639-5
Molecular Formula: C5H11NO
Molecular Weight: 101.15 g/mol
Synonyms: N-Methylmorpholine, NMM, 4-Methylmorpholine, N-Methyl-tetrahydro-1,4-oxazine, Methylmorpholine, N-Methyl Morpholine, Industrial NMM solvent, Catalyst N-methylmorpholine, Pharmaceutical intermediate N-methylmorpholine, NMM base catalyst, Morpholine derivative N-methylmorpholine, Polyurethane catalyst NMM, Amine solvent N-methylmorpholine, Specialty chemical N-methylmorpholine, Organic base NMM
APPLICATIONS
N-Methylmorpholine is widely used as a catalyst in polyurethane foam production.
N-Methylmorpholine is employed in the manufacture of rigid, semi-rigid, and flexible polyurethane foams.
N-Methylmorpholine is applied in polyurethane elastomers and coatings as a reactive catalyst.
N-Methylmorpholine is utilized as a solvent in organic synthesis.
N-Methylmorpholine is used to dissolve a wide range of organic compounds.
N-Methylmorpholine is applied in reaction media requiring polar, aprotic solvents.
N-Methylmorpholine is incorporated into pharmaceutical synthesis as an intermediate.
N-Methylmorpholine is used in the preparation of active pharmaceutical ingredients (APIs).
N-Methylmorpholine is applied as a reagent in peptide synthesis.
N-Methylmorpholine is used in agrochemical production as a chemical intermediate.
N-Methylmorpholine is incorporated into herbicide and pesticide formulations.
N-Methylmorpholine is applied in the synthesis of plant protection agents.
N-Methylmorpholine is utilized in epoxy resin curing.
N-Methylmorpholine is used in adhesive and coating applications requiring amine-based hardeners.
N-Methylmorpholine is applied in specialty polymers as a curing accelerator.
N-Methylmorpholine is incorporated into textile processing as a finishing agent.
N-Methylmorpholine is used in leather treatment formulations.
N-Methylmorpholine is applied in industrial detergents and cleaners.
N-Methylmorpholine is employed in corrosion inhibitors for metal treatment.
N-Methylmorpholine is used in lubricant formulations for stability and performance.
N-Methylmorpholine is applied in fuel additive blends.
N-Methylmorpholine is utilized in laboratory synthesis as a base in organic reactions.
N-Methylmorpholine is used in acylation and esterification reactions.
N-Methylmorpholine is applied in halogenation and substitution reactions.
N-Methylmorpholine is incorporated into pigment and dye production.
N-Methylmorpholine is used in specialty coatings for enhanced adhesion.
N-Methylmorpholine is applied in ink formulations requiring stability.
N-Methylmorpholine is used in fine chemicals as a versatile building block.
N-Methylmorpholine is applied in process optimization for pharmaceutical scale-up.
N-Methylmorpholine is incorporated into biotechnological research for peptide coupling reactions.
DESCRIPTION
N-Methylmorpholine is a colorless liquid with a characteristic amine-like odor.
N-Methylmorpholine is miscible with water, alcohols, ketones, and hydrocarbons.
N-Methylmorpholine has high polarity, making it an effective solvent in synthesis.
N-Methylmorpholine is volatile and produces flammable vapors.
N-Methylmorpholine reacts with acids to form salts.
N-Methylmorpholine is corrosive to certain metals in the presence of moisture.
N-Methylmorpholine is stable under recommended storage conditions.
N-Methylmorpholine is biodegradable under environmental conditions.
N-Methylmorpholine exhibits low acute toxicity but requires careful handling.
N-Methylmorpholine is classified as hazardous due to flammability and irritant properties.
PROPERTIES
Chemical Formula: C5H11NO
Molecular Weight: 101.15 g/mol
Common Name: N-Methylmorpholine (NMM)
Appearance: Colorless liquid
Odor: Amine-like odor
Density: 0.92 g/cm³
Boiling Point: 115–117°C
Flash Point: 27°C (closed cup)
Solubility: Miscible with water and organic solvents
Reactivity: Reacts with strong oxidizing agents and acids
Chemical Stability: Stable under normal storage and handling conditions
Storage Temperature: Store at 5–25°C in tightly closed containers
FIRST AID
Inhalation:
If N-Methylmorpholine vapors are inhaled, move to fresh air immediately.
Seek medical attention if symptoms such as coughing, dizziness, or irritation occur.
Provide oxygen if breathing is difficult.
Skin Contact:
Wash affected area with plenty of soap and water.
Seek medical advice if irritation develops.
Remove contaminated clothing and wash before reuse.
Eye Contact:
Rinse eyes with water for at least 15 minutes, lifting eyelids frequently.
Seek immediate medical attention if irritation persists.
Remove contact lenses if present and easy to do.
Ingestion:
If N-Methylmorpholine is ingested, rinse mouth thoroughly with water.
Do not induce vomiting unless instructed by medical personnel.
Seek immediate medical attention.
Note to Physicians:
Treat symptomatically.
No specific antidote is available.
Provide supportive care and monitor respiratory and gastrointestinal function.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear gloves, protective goggles, and chemical-resistant clothing when handling N-Methylmorpholine.
Use appropriate respiratory protection in poorly ventilated areas.
Ventilation:
Ensure adequate ventilation to prevent vapor accumulation.
Use local exhaust ventilation if necessary.
Avoidance:
Avoid contact with skin, eyes, and clothing.
Do not eat, drink, or smoke while handling N-Methylmorpholine.
Wash hands thoroughly after handling.
Spill and Leak Procedures:
Absorb spills with inert materials such as sand or vermiculite.
Prevent entry into drains or watercourses.
Dispose of according to local regulations.
Storage:
Store N-Methylmorpholine in a cool, dry, and well-ventilated place.
Keep containers tightly closed and away from ignition sources.
Avoid exposure to sunlight and incompatible substances such as oxidizers.
Handling Cautions:
Ensure containers are properly labeled and sealed.
Ground and bond containers when transferring to prevent static discharge.
Follow all safety regulations for handling flammable liquids.
