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Nonanedioic acid (Azelaic Acid), is a naturally occurring saturated dicarboxylic acid with the chemical formula C9H16O4.
Nonanedioic acid (Azelaic Acid)s structure consists of a nine-carbon chain with carboxylic acid groups (-COOH) at each end.
Nonanedioic acid (Azelaic Acid) is a topical antiacne agent which exerts its therapeutic action through a myriad of antimicrobial, antiproliferative and cytostatic effects.
CAS Number: 123-99-9
Molecular Formula: C9H16O4
Molecular Weight: 188.22
EINECS Number: 204-669-1
Synonyms: Azelaic acid, NONANEDIOIC ACID, 123-99-9, Finacea, Anchoic acid, Azelex, Lepargylic acid, 1,7-Heptanedicarboxylic acid, Skinoren, 1,9-Nonanedioic acid, Heptanedicarboxylic acid, n-Nonanedioic acid, Emerox 1110, Emerox 1144, azelate, acide azelaique, acidum azelaicum, Finevin, Acido azelaico, Azelainic acid, 1,7-Dicarboxyheptane, Azelaic acid, technical grade, Skinorem, ZK 62498, ZK-62498, Emery's L-110, Acidum azelaicum [Latin], NSC 19493, Azelainsaeure, Nonandisaeure, 26776-28-3, CHEBI:48131, UNII-F2VW3D43YT, EINECS 204-669-1, F2VW3D43YT, NSC-19493, BRN 1101094, DTXSID8021640, AI3-06299, HSDB 7659, NSC19493, MFCD00004432, MLS000069659, DTXCID501640, EC 204-669-1, 4-02-00-02055 (Beilstein Handbook Reference), NCGC00014993-07, SMR000059164, Acidum azelaicum (Latin), Azalaic Acid, Acide azelaique [French], Acido azelaico [Spanish], AZELAIC ACID (MART.), AZELAIC ACID [MART.], heptane-1,7-dicarboxylic acid, Azelaic acid [USAN:INN], Azelaic, CAS-123-99-9, Finacea (TN), Azelaic acid 99%, Azelex (TN), SR-01000075671, Azelaic acid (USAN/INN), Azelaicacidtech, Azelainsaure, Lepargylate, Nonandisaure, Anchoate, azelaic-acid, n-Nonanedioate, Acidum acelaicum, Finacea Foam, 1tuf, Azelaic Acid Gel, 1,9-Nonanedioate, SH-441, AGN-191861, Azelaic acid, 98%, Spectrum_000057, Water-solubleazelaicacid, Opera_ID_740, 1,7-Heptanedicarboxylate, Spectrum2_000995, Spectrum3_000278, Spectrum4_000401, Spectrum5_001304, Water-soluble azelaic acid, AZELAIC ACID [MI], Epitope ID:187039, A-9800, AZELAIC ACID [INN], Lopac-246379, SCHEMBL3887, AZELAIC ACID [HSDB], AZELAIC ACID [USAN], CHEMBL1238, Lopac0_000051, AZELAIC ACID [VANDF], BSPBio_001756, KBioGR_000662, KBioSS_000437, Nonanedioic acid Azelaic acid, MLS001148615, BIDD:GT0315, DivK1c_000532, SPECTRUM1500648, SPBio_001089, AZELAIC ACID [WHO-DD], GTPL7484, HMS501K14, KBio1_000532, KBio2_000437, KBio2_003005, KBio2_005573, KBio3_001256, Azelaic acid, analytical standard, D10AX03, NINDS_000532, HMS1921O11, HMS2092E22, HMS2234D10, HMS3260K03, HMS3372J07, Pharmakon1600-01500648, AZELAIC ACID [ORANGE BOOK], BCP18690, HY-B0704, Tox21_110063, Tox21_201989, Tox21_303011, Tox21_500051, Azelaic acid, technical grade, 80%, CCG-40081, LMFA01170054, NSC757406, s4550, STL059432, AKOS000120052, Tox21_110063_1, Azelaic acid, technical, ~85% (GC), Azelaic acid, Vetec(TM) reagent grade, DB00548, KS-5293, LP00051, NSC-757406, SDCCGMLS-0066619.P001, SDCCGMLS-0066619.P033, SDCCGSBI-0050040.P004, IDI1_000532, MLS-0066619, NCGC00014993-01, NCGC00014993-02, NCGC00014993-03, NCGC00014993-04, NCGC00014993-05, NCGC00014993-06, NCGC00014993-08, NCGC00014993-09, NCGC00014993-10, NCGC00014993-12, NCGC00014993-15, NCGC00093565-01, NCGC00093565-02, NCGC00093565-03, NCGC00093565-04, NCGC00093565-05, NCGC00093565-06, NCGC00093565-07, NCGC00256508-01, NCGC00259538-01, NCGC00260736-01, BP-27863, MLS-0066619.P021, SBI-0050040.P003, A0561, A1318, Dicarboxylic acid C9; Nonanedioic acid; AZA, EU-0100051, NS00011498, EN300-18040, C08261, D03034, D70171, AB00052140_12, Q413504, SR-01000075671-1, SR-01000075671-4, SR-01000075671-6, 0C50D8EC-0DB0-4F24-8EFC-2919E1F0D9BF, BRD-K08976401-001-18-5, Z57127532, F8889-5093, InChI 1/C9H16O4/c10-8(11)6-4-2-1-3-5-7-9(12)13/h1-7H2,(H,10,11)(H,12,13), azelaicacid,technicalgrade;Azelainic acid;Emerox 1110;Emerox 1144;emerox1110;emerox1144;Emery's L-110;ninandioic acid.
Nonanedioic acid (Azelaic Acid) hasbeen shown to inhibit DNA polymerases in several tumor cell lines.
Nonanedioic acid (Azelaic Acid) is an organic compound with the formula (CH2)7(CO2H)2.
This saturated dicarboxylic acid exists as a white powder.
Nonanedioic acid (Azelaic Acid) is found in wheat, rye, and barley.
Nonanedioic acid (Azelaic Acid) is a component of a number of hair and skin conditioners.
Nonanedioic acid (Azelaic Acid) is a naturally occurring saturated nine-carbon dicarboxylic acid (COOH (CH2)7-COOH).
It possesses a variety of biological actions both in vitro and in vivo.
Interest in the biological activity of AZA arose originally out of studies of skin surface lipids and the pathogenesis of hypochromia in pityriasis versicolor infection.
Later, Nonanedioic acid (Azelaic Acid) was shown that Pityrosporum can oxidize unsaturated fatty acids to C8-C12 dicarboxylic acids that are cornpetitive inhibitors of tyrosinase in vitro.
Nonanedioic acid (Azelaic Acid) was chosen for further investigation and development of a new topical drug for treating hyperpigmentary disorders for the following reasons: it possesses a middle-range of antityrosinase activity, is inexpensive, and more soluble to be incorporated into a base cream than other dicarboxylic acids.
Nonanedioic acid (Azelaic Acid) is another option for the topical treatment of mild to moderate inflammatory acne vulgaris.
It offers effectiveness similar to that of other agents without the systemic side effects of oral antibiotics or the allergic sensitization of topical benzoyl peroxide and with less irritation than tretinoin.
Nonanedioic acid (Azelaic Acid) is less expensive than certain other prescription acne preparations, but it is much more expensive than nonprescription benzoyl peroxide preparations.
Whether Nonanedioic acid (Azelaic Acid) is safe and effective when used in combination with other agents is not known.
Nonanedioic acid (Azelaic Acid) is the best known dicarboxylic acid.
Its name stems from the action of nitric acid (azote, nitrogen, or azotic, nitric) oxidation of oleic or elaidic acid.
Nonanedioic acid (Azelaic Acid) was detected among products of rancid fats.
Its origin explains for its presence in poorly preserved samples of linseed oil and in specimens of ointment removed from Egyptian tombs 5000 years old.
Nonanedioic acid (Azelaic Acid) was prepared by oxidation of oleic acid with potassium permanganate, but now by oxidative cleavage of oleic acid with chromic acid or by ozonolysis.
Nonanedioic acid (Azelaic Acid) is used, as simple esters or branched-chain esters) in the manufacture of plasticizers (for vinyl chloride resins, rubber), lubricants and greases.
Nonanedioic acid (Azelaic Acid) is now used in cosmetics (treatment of acne).
It displays bacteriostatic and bactericidal properties against a variety of aerobic and anaerobic micro-organisms present on acne-bearing skin.
Nonanedioic acid (Azelaic Acid) was identified as a molecule that accumulated at elevated levels in some parts of plants and was shown to be able to enhance the resistance of plants to infections.
Nonanedioic acid (Azelaic Acid) is a naturally occurring saturated, nonphenolic compound isolated from cultures Pityrosporum ovale.
Nonanedioic acid (Azelaic Acid) is a therapeutic agent with well-known antibacterial properties.
Nonanedioic acid (Azelaic Acid) is used in topical formulations to treat acne, rosacea, and hyperpigmentation.
Functions as an antimicrobial and anti-inflammatory agent.
Can reduce the production of keratin, which can block pores and lead to acne.
Nonanedioic acid (Azelaic Acid) as a precursor in the production of polymers, adhesives, and lubricants.
Used in the synthesis of plasticizers and fragrances.
Nonanedioic acid (Azelaic Acid) found in creams, gels, and foams for skin brightening and improving uneven skin tone.
Inhibiting the growth of acne-causing bacteria like Propionibacterium acnes.
Slowing down the production of melanin, addressing issues like melasma or post-inflammatory hyperpigmentation.
Nonanedioic acid (Azelaic Acid) is listed on the Australian Inventory of Industrial Chemicals (the Inventory).
Nonanedioic acid (Azelaic Acid) is often referred to by its common synonym of azelaic acid.
This evaluation will focus on determining whether the identified health hazards are appropriately risk-managed for the range of reported industrial uses of the chemical.
Nonanedioic acid (Azelaic Acid) should be noted that nonanedioic acid is used topically as a therapeutic good.
As this is an excluded use it is not considered in this evaluation.
Nonanedioic acid (Azelaic Acid) is a skincare ingredient used in cosmetics for its various beneficial properties.
Nonanedioic acid (Azelaic Acid) is a dicarboxylic acid derived from grains like wheat, barley, and rye.
Nonanedioic acid (Azelaic Acid) is known for its ability to exfoliate the skin, unclog pores, and reduce the production of keratin, making it effective in treating acne and improving skin texture.
Additionally, it possesses anti-inflammatory and antioxidant properties, helping to reduce redness and hyperpigmentation.
Nonanedioic acid (Azelaic Acid)s appearance is usually a white powder, and its chemical formula is C9H16O4.
Nonanedioic acid (Azelaic Acid) is commonly found in creams, serums, and spot treatments, catering to different skin concerns and promoting a clearer, more even complexion.
Nonanedioic acid (Azelaic Acid) is industrially produced by the ozonolysis of oleic acid.
It is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
The bacterial degradation of nonanoic acid gives azelaic acid.
Nonanedioic acid (Azelaic Acid) is an alpha,omega-dicarboxylic acid that is heptane substituted at positions 1 and 7 by carboxy groups.
Nonanedioic acid (Azelaic Acid) has a role as an antibacterial agent, an antineoplastic agent, a dermatologic drug and a plant metabolite.
It is a dicarboxylic fatty acid and an alpha,omega-dicarboxylic acid.
Nonanedioic acid (Azelaic Acid) is a conjugate acid of an azelaate(2-) and an azelaate.
Naturally occurring dicarboxylic acid that is bacteriostatic to Propionibacterium acnes.
It also decreases conversion of testosterone to 5{pi}ga-dihydrotestosterone (DHT) and alters keratinization of the microcomedone.
Nonanedioic acid (Azelaic Acid) may also be beneficial in the treatment of melasma.
The mechanism of action is not fully understood.
Nonanedioic acid (Azelaic Acid) synthesis is reduced, and mitochondrial cellular energy products are inhibited in melanocytes.
In plants, Nonanedioic acid (Azelaic Acid) serves as a "distress flare" involved in defense responses after infection.
It serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.
Nonanedioic acid (Azelaic Acid) is used for the treatment of mild to moderate acne, particularly in cases characterized by marked inflammation-associated hyperpigmentation.
Nonanedioic acid (Azelaic Acid) can reduce inammation, making it an eective treatment for symptoms of rosacea.
Clinical studies demonstrate that Nonanedioic acid (Azelaic Acid) gel can continually improve the appearance of swelling and visible blood vessels caused by rosacea.
It’s always important to wear sunscreen when go outside, but be especially mindful to wear SPF products when using Nonanedioic acid (Azelaic Acid).
Since it can thin skin, skin is more sensitive and prone to sun damage.
According to older research, Nonanedioic acid (Azelaic Acid) cream may be as eective as benzoyl peroxide and tretinoin (Retin-A) for the treatment of acne.
While azelaic acid results are similar to those of benzoyl peroxide, it’s also more expensive.
Nonanedioic acid (Azelaic Acid) also works more gently than alpha hydroxy acid, glycolic acid, and salicylic acid.
While these other acids are strong enough to be used on their own in chemical peels, azelaic acid isn’t.
This means that while Nonanedioic acid (Azelaic Acid) is less likely to irritate skin, it also has to be used consistently and given time to take eect.
Nonanedioic acid (Azelaic Acid) is a naturally occurring acid that’s milder than some more popular acids used to treat acne.
While the results of treatment with Nonanedioic acid (Azelaic Acid) might not be obvious right away, there is research that points to this ingredient as active.
Nonanedioic acid (Azelaic Acid), alternatively called nonanedioic acid and available through Acme-Hardesty under the name Matrilox LA001M, is a saturated dicarboxylic acid with a chemical structure of (CH2)7(CO2H)2.
Nonanedioic acid (Azelaic Acid), sold as a fine white powder, is derived primarily from wheat, rye and barley.
Acme-Hardesty is an authorized azelaic acid distributor, providing a product that is made from environmentally friendly, sustainable sources.
Nonanedioic acid (Azelaic Acid) is a naturally occurring compound produced by a yeast called Malassezia furfur.
For industrial applications, purified azelaic acid is made by the ozonolysis of oleic acid.
Acme-Hardesty’s product is fully European in origin and derived from oils obtained from sustainably produced vegetable crops.
As a result, it is fully vegetarian and both GMO- and BSE/TSE-free.
Nonanedioic acid (Azelaic Acid) is also free of common allergens such as tree nuts, peanuts, dairy and gluten.
Nonanedioic acid (Azelaic Acid), is a white crystalline solid with a melting point of 106.5 °C.
It occurs naturally in grains such as wheat, rye, and barley and is produced industrially by ozonolyzing oleic acid.
It is used topically to treat acne and rosacea.
Some plants release azelaic acid as a "distress flare" to signal cells to activate their defenses against attacking pathogens.
Nonanedioic acid (Azelaic Acid) is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
It is also produced by Malassezia furfur, also known as Pityrosporum ovale, which is a species of fungus that is normally found on human skin.
Nonanedioic acid (Azelaic Acid) is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Nonanedioic acid (Azelaic Acid) works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Nonanedioic acid (Azelaic Acid)'s antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Nonanedioic acid (Azelaic Acid) is a saturated dicarboxylic acid found naturally in wheat, rye, and barley.
It is a natural substance that is produced by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin.
Nonanedioic acid (Azelaic Acid) is effective against a number of skin conditions, such as mild to moderate acne, when applied topically in a cream formulation of 20%.
Nonanedioic acid (Azelaic Acid) works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear.
Nonanedioic acid (Azelaic Acid)'s antimicrobial action may be attributable to inhibition of microbial cellular protein synthesis.
Melting point: 98 °C
Boiling point: 286 °C100 mm Hg(lit.)
Density: 1,029 g/cm3
vapor density: 6.5 (vs air)
vapor pressure: <1 mm Hg ( 20 °C)
refractive index: 1.4303
Flash point: 215 °C
storage temp.: Store below +30°C.
solubility: 2.4g/l
form: Slightly Crystalline Powder or Flakes
pka: 4.53, 5.33(at 25℃)
color: White to slightly yellow
PH: 3.5 (1g/l, H2O)
Water Solubility: 2.4 g/L (20 ºC)
Merck: 14,905
BRN: 1101094
Stability: Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after: 28 days.
InChIKey: BDJRBEYXGGNYIS-UHFFFAOYSA-N
LogP: 1.57 at 25℃
Indirect Additives used in Food Contact Substances: AZELAIC ACID
FDA 21 CFR: 175.105; 175.300; 175.320
CAS DataBase Reference: 123-99-9(CAS DataBase Reference)
Nonanedioic acid (Azelaic Acid) finds versatile uses in skincare, haircare, and cosmetics due to its numerous beneficial properties.
It is primarily employed to treat acne and rosacea.
Nonanedioic acid (Azelaic Acid) helps exfoliate the skin, unclog pores, and reduce the proliferation of acne-causing bacteria.
Nonanedioic acid (Azelaic Acid) also has anti-inflammatory properties that calm redness and irritation associated with rosacea
It is used to address conditions like dandruff and scalp inflammation in hair care products.
Its anti-fungal and anti-inflammatory properties help combat dandruff-causing fungi and soothe irritated scalps.
By regulating sebum production, Nonanedioic acid (Azelaic Acid) also contributes to maintaining a healthier scalp environment, promoting overall hair health and reducing flakiness
In cosmetics, Nonanedioic acid (Azelaic Acid)'s ability to even out skin tone and reduce the appearance of hyperpigmentation makes it a popular ingredient in foundations, concealers, and BB creams.
Its exfoliating properties enhance the efficacy of chemical exfoliants in various skincare formulations, leading to smoother and more radiant skin
Nonanedioic acid (Azelaic Acid) is a naturally occurring dicarboxylic acid produced by the yeast Malassezia furfur.
Nonanedioic acid (Azelaic Acid) inhibits tyrosinase, a rate-limiting enzyme in the synthesis of the pigment melanin.
This may explain why diminution of melanin pigmentation occurs in the skin of some patients with pityriasis versicolor, a disease caused by M. furfur.
Nonanedioic acid (Azelaic Acid) is bacteriostatic against a number of species thought to participate in the pathogenesis of acne, including Propionibacterium acnes.
The drug may also reduce microcomedo formation by promoting normalization of epidermal keratinocytes.
Two step oxidation of tall oil fatty acid using peroxyformic acid and nitric acid/sodium metavanadate were used to produce azelaic acid.
Recrystallise it from H2O(charcoal) or thiophene-free benzene.
The acid can be dried by azeotropic distillation with toluene, the residual toluene solution is then cooled and filtered, and the precipitate is dried in a vacuum oven.
Nonanedioic acid (Azelaic Acid) has been purified by zone refining or by sublimation onto a cold finger at 10-3torr.
Nonanedioic acid (Azelaic Acid) distils above 360o with partial formation of the anhydride.
The dimethyl ester has m –3.9o and b 140o/8mm.
In plants, Nonanedioic acid (Azelaic Acid) serves as a "distress are" involved in defense responses after infection.
Nonanedioic acid (Azelaic Acid) serves as a signal that induces the accumulation of salicylic acid, an important component of a plant's defensive response.
Esters of this dicarboxylic acid and applications in lubrication and plasticizers.
In lubricant industries Nonanedioic acid (Azelaic Acid) is used as a thickening agent in lithium complex grease.
With hexamethylenediamine, Nonanedioic acid (Azelaic Acid) forms Nylon-6,9, which nds specialized uses as a plastic.
Nonanedioic acid (Azelaic Acid) is used to treat mild to moderate acne, both comedonal acne and inammatory acne.
It belongs to a class of medication called dicarboxylic acids.
Nonanedioic acid (Azelaic Acid) works by killing acne bacteria that infect skin pores.
It also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria.
Nonanedioic acid (Azelaic Acid) is also used as a topical gel treatment for rosacea, due to its ability to reduce inammation.
Nonanedioic acid (Azelaic Acid) clears the bumps and swelling caused by rosacea.
Nonanedioic acid (Azelaic Acid) has been used for treatment of skin pigmentation including melasma and postinammatory hyperpigmentation, particularly in those with darker skin types.
It has been recommended as an alternative to hydroquinone.
As a tyrosinase inhibitor, azelaic acid reduces synthesis of melanin.
According to one report of 1988 Nonanedioic acid (Azelaic Acid) (in combination with zinc sulfate) in vitro showed to be a potent (90% inhibition) 5α-Reductase inhibitor, similar to the hair loss drugs nasteride and dutasteride.
Middle 80s in vitro research evaluating acid's depigmenting (whitening) capability concluded it is eective (cytotoxic to melanocytes) only at high concentrations.
Nonanedioic acid (Azelaic Acid) is an organic compound with the formula HOOC(CH2)7COOH.
This saturated dicarboxylic acid exists as a white powder.
Nonanedioic acid (Azelaic Acid) is found in wheat, rye, and barley.
Nonanedioic acid (Azelaic Acid) is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners.
Nonanedioic acid (Azelaic Acid) inhibits tyrosinase.
The exact mechanism of action of azelaic acid is not known.
It is thought that azelaic acid manifests its antibacterial effects by inhibiting the synthesis of cellular protein in anaerobic and aerobic bacteria, especially Staphylococcus epidermidis and Propionibacterium acnes.
In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases. In anaerobic bacteria, azelaic acid impedes glycolysis.
Along with these actions, azelaic acid also improves acne vulgaris by normalizing the keratin process and decreasing microcomedo formation.
Nonanedioic acid (Azelaic Acid) may be effective against both inflamed and noninflamed lesions.
Specifically, azelaic acid reduces the thickness of the stratum corneum, shrinks keratohyalin granules by reducing the amount and distribution of filaggrin (a component of keratohyalin) in epidermal layers, and lowers the number of keratohyalin granules.
Nonanedioic acid (Azelaic Acid) is a dicarboxylic acid naturally occurring in wheat, rye and barley.
Nonanedioic acid (Azelaic Acid) finds applications in many different fields like constituent of renewable and/or compostable plastics, preparation of PVC plasticizers, ester-based synthetic lubricants, corrosion inhibitors and lithium complex grease.
Thanks to its high purity, Nonanedioic acid (Azelaic Acid) is particularly indicated as an active principle in skin care formulations.
Nonanedioic acid (Azelaic Acid) is produced through a chemical reaction called ozonolysis, which involves the reaction of oleic acid with ozone (O3) in the presence of a catalyst.
Nonanedioic acid (Azelaic Acid) is a monounsaturated fatty acid found in various vegetable oils like olive oil.
During the ozonolysis process, ozone molecules break the double bond in the oleic acid molecule, resulting in the formation of azelaic acid.
Uses Of Nonanedioic acid (Azelaic Acid):
Nonanedioic acid (Azelaic Acid) is used in lacquers, alkyd resins, plasticizers, adhesives, polyamides, urethane elastomers, and organic syntheses.
Nonanedioic acid (Azelaic Acid) is also used in treating of acne.
Nonanedioic acid (Azelaic Acid) is used to treat mild to moderate acne, both comedonal acne and inflammatory acne .
Nonanedioic acid (Azelaic Acid) belongs to a class of medication called dicarboxylic acids.
It works by killing acne bacteria that infect skin pores.
Nonanedioic acid (Azelaic Acid) also decreases the production of keratin, which is a natural substance that promotes the growth of acne bacteria Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation .
Nonanedioic acid (Azelaic Acid) clears the bumps and swelling caused by Rosacea.
Nonanedioic acid (Azelaic Acid) has been used for treatment of skin pigmentation including melasma and post inflammatory hyper pigmentation, particularly in those with darker skin types.
It has been recommended as an alternative to hydroquinone (HQ).
As a tyrosinase inhibitor, Nonanedioic acid (Azelaic Acid) reduces synthesis of melanin.
Nonanedioic acid (Azelaic Acid), also known as azalea acid, is a white to slightly yellow powder.
Nonanedioic acid (Azelaic Acid) is a medium-long chain dibasic acid.
In recent years, with the rapid development of the organic synthetic chemical industry, the demand for medium and long chain dibasic acids is increasing.
The medium and long chain dibasic acids and their derivatives have a wide range of industrial applications and a broad product market.
Nonanedioic acid (Azelaic Acid) is commonly used in dermatology for treating skin conditions due to its antibacterial, anti-inflammatory, and keratolytic properties.
Nonanedioic acid (Azelaic Acid) effective against mild to moderate acne.
Reduces the growth of acne-causing bacteria like Propionibacterium acnes.
Nonanedioic acid (Azelaic Acid) unclogs pores by regulating keratin production.
Nonanedioic acid (Azelaic Acid) reduces redness and swelling associated with rosacea.
Acts as an anti-inflammatory to calm sensitive skin.
Inhibits tyrosinase, an enzyme involved in melanin production, helping to lighten dark spots and improve skin tone.
Nonanedioic acid (Azelaic Acid) is used to treat post-inflammatory hyperpigmentation.
Nonanedioic acid (Azelaic Acid) has shown activity against a broad spectrum of bacteria, including Staphylococcus epidermidis, making it useful in managing bacterial skin infections.
Due to its skin benefits, azelaic acid is included in various cosmetic formulations.
Nonanedioic acid (Azelaic Acid) included in skin-brightening products to improve uneven skin tone.
Reduces the appearance of dark spots and freckles.
Promotes cellular turnover, which helps in reducing the appearance of fine lines and wrinkles.
Nonanedioic acid (Azelaic Acid) helps reduce oiliness in people with oily or acne-prone skin.
Nonanedioic acid (Azelaic Acid) safe for sensitive skin and doesn't clog pores, making it suitable for a wide audience.
Nonanedioic acid (Azelaic Acid) has applications beyond skincare and medicine:
Nonanedioic acid (Azelaic Acid) is used as a building block in the synthesis of polyamides and polyesters, which are materials for creating plastics and textiles.
Acts as a component in the formulation of biodegradable synthetic lubricants.
Added to improve the flexibility and durability of plastics.
Nonanedioic acid (Azelaic Acid) is used in specialty coatings, adhesives, and sealants due to its chemical stability and performance.
Nonanedioic acid (Azelaic Acid) derivatives are studied as potential bio-based chemicals for sustainable practices.
Used as a raw material for synthesizing drugs and active pharmaceutical ingredients.
Minimal side effects compared to other active ingredients like benzoyl peroxide or retinoids.
Works on multiple skin concerns (acne, pigmentation, rosacea) and is effective for various industrial processes.
Nonanedioic acid (Azelaic Acid) environmentally friendly and bio-derived from natural sources like grains.
Nonanedioic acid (Azelaic Acid) reduces inflammatory lesions by combating Propionibacterium acnes and Staphylococcus epidermidis bacteria.
Helps prevent the formation of blackheads and whiteheads by normalizing the shedding of dead skin cells.
Treats papules, pustules, and redness associated with mild to moderate rosacea.
Nonanedioic acid (Azelaic Acid) improves skin barrier function, reducing sensitivity to external triggers.
Treats uneven pigmentation due to overproduction of melanin.
Nonanedioic acid (Azelaic Acid) particularly effective for skin of color, where traditional treatments like hydroquinone may have side effects.
Nonanedioic acid (Azelaic Acid) softens and smooths skin affected by keratosis pilaris (rough bumps on the skin caused by excess keratin).
Useful as a mild anti-inflammatory and antimicrobial treatment for persistent rashes around the mouth.
Has demonstrated activity against fungal pathogens like Malassezia furfur, which can contribute to dandruff or seborrheic dermatitis.
Nonanedioic acid (Azelaic Acid) protects skin from oxidative stress, which contributes to premature aging and inflammatory skin diseases.
Nonanedioic acid (Azelaic Acid) offers a gentler alternative to hydroquinone for reducing dark spots and pigmentation.
Suitable for long-term use without the risk of side effects like ochronosis (skin darkening).
Nonanedioic acid (Azelaic Acid) provides mild exfoliation to promote skin renewal without the irritation caused by stronger acids like glycolic or salicylic acid.
Effective in fading the redness left behind by acne scars or irritation.
Well-tolerated by those with sensitive skin prone to irritation from harsher actives like retinoids or benzoyl peroxide.
Nonanedioic acid (Azelaic Acid) emerging as an ingredient in scalp treatments to address flakiness and oiliness due to its anti-fungal and keratolytic effects.
Nonanedioic acid (Azelaic Acid) investigated as a base or additive in topical formulations for inflammatory skin conditions beyond acne or rosacea.
Used in microencapsulation for controlled release of active pharmaceutical ingredients.
Nonanedioic acid (Azelaic Acid)s broad-spectrum antibacterial activity is leveraged for both over-the-counter and prescription topical applications.
Nonanedioic acid (Azelaic Acid) and its derivatives are being studied for treating other chronic conditions like psoriasis and atopic dermatitis.
Its long-chain structure makes it ideal for producing environmentally friendly, high-performance lubricants.
Offers excellent adhesion and flexibility, making it useful in applications requiring durable bonding.
Nonanedioic acid (Azelaic Acid) is used as a building block for bio-based plastics, reducing reliance on petroleum-derived materials.
Adds stability and durability to paints and specialty coatings, especially in high-performance applications.
Nonanedioic acid (Azelaic Acid) improves the flexibility and softness of plastic materials without compromising their strength.
Nonanedioic acid (Azelaic Acid) serves as a renewable chemical derived from oleic acid (from vegetable oils) for various applications.
Investigated as a potential precursor for synthesizing agrochemicals to enhance plant growth or defense mechanisms.
Nonanedioic acid (Azelaic Acid) flavor Enhancer Precursors: Used in the production of certain flavoring agents.
Food-Grade Lubricants: Found in food-safe lubricants due to its non-toxicity.
Nonanedioic acid (Azelaic Acid) studied for creating advanced materials like nanoparticles or biocompatible films.
Serves as a model compound for testing the efficacy of new drug delivery systems.
Nonanedioic acid (Azelaic Acid) works as an antibacterial, antifungal, anti-inflammatory, and exfoliating agent.
Nonanedioic acid (Azelaic Acid)non-toxic, non-comedogenic, and suitable for all skin types, including sensitive skin.
Renewable source (derived from natural oils) and biodegradable.
Safety Profile Of Nonanedioic acid (Azelaic Acid):
Nonanedioic acid (Azelaic Acid) is generally considered safe for topical use in skincare and cosmetics when used as directed and within recommended concentrations.
It is well-tolerated by most individuals, with minimal reports of adverse reactions. However, patch testing is advisable for individuals with sensitive skin to ensure compatibility and avoid potential irritations.
Low toxicity by ingestion.
Nonanedioic acid (Azelaic Acid) skinand eye irritant.
Closely related to glutaric acid and adipicacid.
Nonanedioic acid (Azelaic Acid) combustible when exposed to heat or flame; canreact with oxidizing materials.
