PRODUCTS

O-PHTHALALDEHYDE (OPA)

O-Phthalaldehyde (OPA) is a compound that reacts with primary amines to produce a product that emits a highly fluorescent blue colour.
O-Phthalaldehyde (OPA) is a pale yellow crystalline solid.
O-Phthalaldehyde (OPA), also known as OPDA or 1,2-benzenedicarboxaldehyde, is an organic compound with the chemical formula C₈H₆O₂.

CAS Number: 643-79-8
Molecular Formula: C8H6O2
Molecular Weight: 134.13
EINECS Number: 211-402-2

Synonyms: Aldehyde, ortho-Phthalic, o Phthalaldehyde, o Phthaldialdehyde, O-Phthalaldehyde (OPA), o-Phthaldialdehyde, ortho Phthalaldehyde, ortho Phthalic Aldehyde, orthO-Phthalaldehyde (OPA), ortho-Phthalic Aldehyde, Orthophthaldialdehyde, Phtalaldehydes [French], Phthalaldehyde; Phthalic aldehyde, Phthalic dialdehyde, Phthalyldicarboxaldehyde, o-Phthaldialdehyde, 1,2-Benzenedicarboxaldehyde, [ChemIDplus] Cidex OPA, [Merck Index] OPA, 1,2-Benzenedialdehyde, 1,2-Diformylbenzene, 1,2-Phthalaldehyde, 2-Formylbenzaldehyde;, o-Benzenedicarbaldehyde, Benzenedicarboxaldehyde, OP 100S; OP 100SF, o-Phthalic aldehyde, Phthalic dicarboxaldehyde, Phtharal, [NTP] UN2923.

O-Phthalaldehyde (OPA) or orthO-Phthalaldehyde (OPA) is the chemical compound with the formula C6H4(CHO)2.
Often abbreviated OPA, the molecule is a dialdehyde, consisting of two formyl (CHO) groups attached to adjacent carbon centres on a benzene ring.
O-Phthalaldehyde (OPA) is a dialdehyde consisting of two formyl groups attached to adjacent carbon centres on a benzene ring.

O-Phthalaldehyde (OPA) is a white to pale yellow solid that is soluble in water, alcohols, and some organic solvents.
O-Phthalaldehyde (OPA) is primarily used as a disinfectant and sterilizing agent.

O-Phthalaldehyde (OPA) is a highly effective antimicrobial compound, particularly against bacteria, fungi, and viruses.
O-Phthalaldehyde (OPA) has a broad spectrum of activity and is often used in medical and laboratory settings for disinfection of medical instruments, endoscopes, and other equipment.
O-Phthalaldehyde (OPA) is also used in the pharmaceutical industry as a disinfectant for drug manufacturing facilities and in water treatment applications.

One of the notable features of O-Phthalaldehyde (OPA) is its rapid action and effectiveness even at low concentrations.
O-Phthalaldehyde (OPA) has been widely used as an alternative to glutaraldehyde, another commonly used disinfectant, due to its superior performance and reduced toxicity.
O-Phthalaldehyde (OPA) has been found to be less irritating to the skin and respiratory system compared to glutaraldehyde.

O-Phthalaldehyde (OPA) is a cyclic compound with a structure consisting of a central benzene ring with two aldehyde functional groups (-CHO) attached to adjacent carbon atoms.
O-Phthalaldehyde (OPA)s chemical formula is C₈H₆O₂, and its molecular weight is 134.13 grams per mole.
O-Phthalaldehyde (OPA) has a melting point of around 64-66 °C (147-151 °F) and a boiling point of approximately 258-260 °C (496-500 °F).

O-Phthalaldehyde (OPA) is sparingly soluble in nonpolar solvents but dissolves readily in polar solvents such as water, alcohols, and ethers.
There are some researches show, pH7.5 contains the sterilizing agent of O-Phthalaldehyde (OPA) 0.5%, and its sterilizing power, sterilization speed, stability and toxicity all are better than glutaraldehyde, can kill mycobacterium in the 5min, the bacterium number reduces by 5 logarithmic value, and O-Phthalaldehyde (OPA) is very stable, tasteless in pH3～9 scopes, non-stimulated to human nose, eye mucosa, and need not activate before using, various materials are had good consistency, have tangible microbiocidal activity.

O-Phthalaldehyde (OPA) is the chemical compound with the formula C6H4(CHO)2.
O-Phthalaldehyde (OPA) is one of three isomers of benzene dicarbaldehyde, related to phthalic acid.
This pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids.

O-Phthalaldehyde (OPA) dissolves in water solution at pH < 11.5.
O-Phthalaldehyde (OPA)s solutions degrade upon UV illumination and exposure to air.
O-Phthalaldehyde (OPA) was first described in 1887 when it was prepared from α,α,α’,α’-tetrachloro-o-xylene.

A more modern synthesis is similar: the hydrolysis of the related O-Phthalaldehyde (OPA) using potassium oxalate, followed by purification by steam distillation.
O-Phthalaldehyde (OPA), also known as OPA, belongs to the class of organic compounds known as benzoyl derivatives.
These are O-Phthalaldehyde (OPA)s containing an acyl moiety of benzoic acid with the formula (C6H5CO-).

O-Phthalaldehyde (OPA) has been identified in human blood as reported by (PMID: 31557052 ).
O-Phthalaldehyde (OPA) is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives.
Technically O-Phthalaldehyde (OPA) is part of the human exposome.

O-Phthalaldehyde (OPA) can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health.
An individual's O-Phthalaldehyde (OPA) begins before birth and includes insults from environmental and occupational sources.

O-Phthalaldehyde (OPA), reacts with all primary amine-containing analytes to yield fluorescent isoindole derivatives.
O-Phthalaldehyde (OPA), provides an accurate measure of both composition and absolute protein-peptide content.
O-Phthalaldehyde (OPA), ıdeal for work with recombinant proteins and synthetic peptides.

O-Phthalaldehyde (OPA), can be used for fluorescent protein or peptide assay
O-Phthalaldehyde (OPA), pre-column derivatization mixtures can be injected into LC without any processing
Fluoraldehyde Reagent Solution contains OPA (O-Phthalaldehyde (OPA)), which reacts with primary amines of amino acids, peptide and proteins to enable fluorescent detection and quantitation.

O-Phthalaldehyde (OPA) that can be used as a protein or peptide assay reagent or as a pre- or post-column detection reagent for amino acid analysis (HPLC).
Reaction of O-Phthalaldehyde (OPA) with proteins and peptides yields linear results over a wide range of concentrations.
The O-Phthalaldehyde (OPA) is supplied ready to use and enables fast quantitation of proteins or peptides in solution.

The reactivity of O-Phthalaldehyde (OPA) is complicated by the fact that in water it forms both a mono- and dihydrate, C6H4(CHO)(CH(OH)2) and C6H4(CH(OH))2O, respectively.
O-Phthalaldehyde (OPA)s reactions with nucleophiles often involves the reaction of both carbonyl groups.
O-Phthalaldehyde (OPA)(OPA)-amine reaction and OPA-amine-thiol reaction have been developed to effectively modify native peptides and proteins under the physiological conditions.

O-Phthalaldehyde (OPA), pale pale yellow solid is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids.
O-Phthalaldehyde (OPA) is a building block in the synthesis of heterocyclic compounds and a reagent in the analysis of amino acids.

Melting point: 55-58 °C(lit.)
Boiling point: 83-84 °C (0.7501 mmHg)
Density: 1.13
vapor pressure: 0.56Pa at 25℃
refractive index: 1.4500 (estimate)
Flash point: >230 °F
storage temp.: 2-8°C
solubility: The solubility of O-Phthalaldehyde (OPA) is 3g/100 mL diisopropyl ether, 5g/100mL deionized water, 20g/100mL chloroform, or 20g/100mL acetone at 20°C.
form: powder
color: yellow
PH: 7 (53g/l, H2O, 20℃)
Water Solubility: soluble
Sensitive: Air Sensitive
Merck: 14,7368
BRN: 878317
Exposure limits ACGIH: SL .025 mg/100 cm2; Ceiling 0.1 ppb (Skin)
Stability: Stable. Air sensitive. Incompatible with strong oxidizing agents, strong bases.
LogP: 0.99 at 30℃

O-Phthalaldehyde (OPA) is relatively stable under normal storage conditions.
O-Phthalaldehyde (OPA) should be stored in a cool, dry place away from direct sunlight.
O-Phthalaldehyde (OPA) is important to keep O-Phthalaldehyde (OPA) containers tightly sealed to prevent exposure to air, moisture, and contaminants.

Over time, O-Phthalaldehyde (OPA) may undergo gradual oxidation, leading to a yellow discoloration.
However, this does not significantly affect its disinfection properties.
O-Phthalaldehyde (OPA) exerts its antimicrobial activity by interacting with cellular components of microorganisms, primarily proteins and enzymes.

O-Phthalaldehyde (OPA) disrupts the integrity of microbial cell walls and membranes, inhibits enzymatic activity, and interferes with essential cellular processes, ultimately leading to microbial death.
O-Phthalaldehyde (OPA) is compatible with various materials commonly used in medical and laboratory settings, such as stainless steel, glass, rubber, and plastics like polyethylene and polypropylene.

However, O-Phthalaldehyde (OPA) may cause discoloration or damage to certain materials, such as polycarbonate, acrylics, and some types of elastomers.
O-Phthalaldehyde (OPA) is recommended to perform compatibility testing on sensitive materials before prolonged exposure to O-Phthalaldehyde (OPA).
O-Phthalaldehyde (OPA) is widely used in analytical chemistry as a reagent for the determination and quantification of various compounds.

O-Phthalaldehyde (OPA) is commonly employed as a derivatizing agent for amino acids and proteins in high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) analyses.
O-Phthalaldehyde (OPA) reacts with primary amines to form highly fluorescent derivatives, allowing for sensitive detection and quantification of amino acids and other amine-containing compounds.

O-Phthalaldehyde (OPA) has a strong odor, often described as pungent or unpleasant.
Proper ventilation is recommended when working with O-Phthalaldehyde (OPA).
O-Phthalaldehyde (OPA) is sensitive to light and may undergo photochemical degradation.

Therefore, it is advisable to store O-Phthalaldehyde (OPA) in amber-colored containers and protect it from direct light exposure.
The pH of the solution can affect the stability and reactivity of O-Phthalaldehyde (OPA).
Generally, a slightly acidic pH (around 4-5) is optimal for its derivatization reactions.

O-Phthalaldehyde (OPA) exhibits rapid and potent antimicrobial activity, making it highly effective against a wide range of microorganisms, including bacteria, fungi, and viruses.
O-Phthalaldehyde (OPA) is known for its ability to kill bacterial spores, which are highly resistant to many disinfectants.
Compared to other disinfectants like glutaraldehyde, O-Phthalaldehyde (OPA) is generally less toxic, less irritating to the skin and respiratory system, and less likely to cause allergic reactions.

O-Phthalaldehyde (OPA) has a shorter contact time requirement for effective disinfection, which can improve workflow efficiency in healthcare and laboratory settings.
O-Phthalaldehyde (OPA) is a dialdehyde in which two formyl groups are attached to adjacent carbon centres on a benzene ring.
O-Phthalaldehyde (OPA), in the presence of 2-mercaptoethanol, reacts with primary amines to form highly fluorescent products.

Phthalaldehyde , primary amine and a sulfhydryl.
O-Phthalaldehyde (OPA) can be manufactured by oxidation of phthalan by nitrogen monoxide in acetonitrile with N-hydroxyphthalimide as the catalyst to yield 80% to 90%.

O-Phthalaldehyde (OPA) disinfectant is composed of the following raw materials by weight percent: 0.5-1% of O-Phthalaldehyde (OPA), 0.5-5% of ASK solution (which is obtained by adding alkylene aliphatic sulfonic anhydride in an alkaline solution to react), 5-20% of short chain alcohol, 0.1-1% of complexing agent, 0.2-2% of pH buffer agent, and the balance of deionized water. By adopting the compound form of the O-Phthalaldehyde (OPA) disinfectant and the alkylene aliphatic sulfonic anhydride, good synergic sterilization effect and no foam are realized, and the spraying and immersion disinfection can be satisfied.

Uses Of O-Phthalaldehyde (OPA):
O-Phthalaldehyde (OPA) is used in the following products: biocides (e.g. disinfectants, pest control products).
O-Phthalaldehyde (OPA) is used in the following areas: health services.

Other release to the environment of O-Phthalaldehyde (OPA) is likely to occur from: indoor use as processing aid and indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters).
O-Phthalaldehyde (OPA) used as a disinfectant and in the fluorometric determination of primary amines and thiols; [Merck Index] Used to sterilize medical and dental equipment, as an enzyme inhibitor, indicator, chemical intermediate, diagnostic agent, tanning agent for leather, in water treatment, pulp and paper manufacturing, oil field water flooding, hair colorings, wood treatment, and antifouling paints.

O-Phthalaldehyde (OPA) has been used; in the preparation of O-phthaldialdehyde reagent for analysing gentamycin content, in the preparation of reagent for determining the degree of hydrolysis of milk proteins, in the measurement of free amino acids of milk samples by o-phthaldialdehyde/N-acetyl-L-cysteine (OPA/NAC) assay, in the derivatization of putrescine samples.

O-Phthalaldehyde (OPA) is mainly used as a high-level disinfectant (a low-temperature chemical method) for heat-sensitive medical and dental equipment such as endoscopes and thermometers; in recent years, O-Phthalaldehyde (OPA) has gained popularity as a safe and better alternative to glutaraldehyde.
O-Phthalaldehyde (OPA) is widely used as a disinfectant and sterilizing agent due to its potent antimicrobial properties.

O-Phthalaldehyde (OPA) is effective against a broad spectrum of microorganisms, including bacteria, fungi, and viruses.
O-Phthalaldehyde (OPA) is commonly employed in healthcare settings for disinfection of medical instruments, such as endoscopes, surgical equipment, and dialysis equipment.
O-Phthalaldehyde (OPA) is also utilized in pharmaceutical manufacturing facilities to disinfect equipment and surfaces involved in drug production.

O-Phthalaldehyde (OPA) is used in water treatment applications to control microbial growth and eliminate bacteria and other microorganisms in water systems.
O-Phthalaldehyde (OPA) can be employed in various settings, including municipal water treatment plants, swimming pools, spas, and water storage tanks.
O-Phthalaldehyde (OPA) is utilized in analytical chemistry as a derivatizing agent for the quantification and detection of amino acids, peptides, and other amine-containing compounds.

O-Phthalaldehyde (OPA) reacts with primary amines to form highly fluorescent derivatives, enabling sensitive detection and analysis in techniques such as high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS).
O-Phthalaldehyde (OPA) is an active area of research and development.

Research efforts focus on areas such as wastewater treatment, development of new disinfection strategies, and enhancement of its stability and antimicrobial capabilities.
O-Phthalaldehyde (OPA) is sometimes used in dental care as a disinfectant.
It can be utilized for disinfection of dental instruments and equipment to help prevent cross-contamination and maintain proper infection control.

O-Phthalaldehyde (OPA) finds applications in veterinary and animal care settings.
O-Phthalaldehyde (OPA) can be used to disinfect medical instruments and equipment used in veterinary clinics, animal hospitals, and research facilities.

O-Phthalaldehyde (OPA) has been explored for its potential use in food processing and preservation.
O-Phthalaldehyde (OPA) may have applications in disinfecting equipment used in food production, such as food processing machinery and utensils, to ensure food safety and prevent microbial contamination.

O-Phthalaldehyde (OPA) is used in pharmaceutical research and development for its antimicrobial properties.
O-Phthalaldehyde (OPA) may be incorporated into formulations or studied for its potential as an active ingredient in antimicrobial drugs or disinfectant solutions.

O-Phthalaldehyde (OPA) has been investigated for its effectiveness in controlling microbial growth and preventing disease outbreaks in aquaculture settings.
O-Phthalaldehyde (OPA) may be utilized in fish farms and aquaculture facilities to disinfect equipment, tanks, and water systems.

O-Phthalaldehyde (OPA) is commonly used in research laboratories for disinfection purposes.
It can be employed to sterilize laboratory equipment, glassware, and surfaces to maintain a sterile and contamination-free environment.
O-Phthalaldehyde (OPA) is used in hemodialysis units for the disinfection of dialyzers, which are essential components of the hemodialysis process.

O-Phthalaldehyde (OPA) helps in preventing cross-contamination and maintaining a sterile environment during dialysis treatments.
O-Phthalaldehyde (OPA) is employed in the biotechnology and biopharmaceutical industries.
O-Phthalaldehyde (OPA) can be used for the disinfection of equipment and surfaces in bioprocessing facilities, laboratories, and cleanrooms to ensure the integrity and safety of biopharmaceutical products.

O-Phthalaldehyde (OPA) is sometimes utilized in environmental monitoring and testing.
It can be employed to disinfect sampling equipment used in environmental studies, water quality testing, and microbial analysis to prevent contamination and maintain the accuracy of results.
O-Phthalaldehyde (OPA) can be used in heating, ventilation, and air conditioning (HVAC) systems for the disinfection of cooling coils, condensate pans, and air handling units.

O-Phthalaldehyde (OPA) helps in controlling microbial growth and preventing the spread of contaminants through the air.
O-Phthalaldehyde (OPA) is used in sterile processing departments of hospitals and healthcare facilities.
O-Phthalaldehyde (OPA) can be applied for the disinfection and sterilization of medical devices, surgical instruments, and other equipment used in surgical procedures and patient care.

O-Phthalaldehyde (OPA) continues to be explored in research and development for new applications and improvements in existing uses.
Scientists are investigating its potential in various fields, such as antimicrobial coatings, antimicrobial textiles, and innovative disinfection methods.
O-Phthalaldehyde (OPA) can be used in the preservation of biological samples in laboratories and research facilities.

O-Phthalaldehyde (OPA) helps to inhibit microbial growth and maintain the integrity of the samples for extended periods.
O-Phthalaldehyde (OPA) can be widely used for precolumn derivatization of amino acids in O-Phthalaldehyde (OPA) separation or Capillary electrophoresis.
For flow cytometric measurements of protein thiol groups.
Precolumn derivatization reagent for primary amines and amino acids.

The fluorescent derivative can be detected by reverse-phase O-Phthalaldehyde (OPA).
The reaction requires O-Phthalaldehyde (OPA), primary amine and a sulfhydryl.
O-Phthalaldehyde (OPA) is primarily used as a disinfectant and sterilizing agent in various industries, including healthcare, pharmaceuticals, and water treatment.

O-Phthalaldehyde (OPA) is commonly employed for disinfecting medical equipment, such as endoscopes, surgical instruments, and dialysis equipment.
O-Phthalaldehyde (OPA) is also utilized in the manufacturing of pharmaceutical products as a disinfectant for facilities and equipment involved in drug production.
In water treatment, O-Phthalaldehyde (OPA) can be used to control microbial growth and eliminate bacteria and other microorganisms in water systems.

O-Phthalaldehyde (OPA) is a high-level chemical disinfectant that is commonly used for disinfection of dental and medical
instruments as an alternative to glutaraldehyde, which is a known skin and respiratory sensitizer.
O-Phthalaldehyde (OPA) is used as a disinfectant and as a tanning agent in leather industry.

O-Phthalaldehyde (OPA) is useful for the sterilization of endoscopic instruments, thermometers, rubber and plastic equipment which cannot be sterilized by heating system.
O-Phthalaldehyde (OPA) is also used as an intermediate in synthesis of pharmaceuticals, medicines, and other organic compounds.
O-Phthalaldehyde (OPA)(OPA) is used for precolumn derivatization of amino acids for HPLC separation and for flow cytometric measurements of protein thiol groups.

O-Phthalaldehyde (OPA) used for fluorometric determination of histamine, histidine and other amino acids.
Also O-Phthalaldehyde (OPA) used for cholesterol assay in the picomole range.
O-Phthalaldehyde (OPA) has been used in the preparation of O-phthaldialdehyde reagent for analysing gentamycin content.

O-Phthalaldehyde (OPA) in the preparation of reagent for determining the degree of hydrolysis of milk proteins.
O-Phthalaldehyde (OPA) in the measurement of free amino acids of milk samples by O-phthaldialdehyde/N-acetyl-L-cysteine (OPA/NAC) assay.
O-Phthalaldehyde (OPA) is used for the quick visualization of histamine, characterized by the appearance of a yellow stain.

Safety Profile:
O-Phthalaldehyde (OPA) can be a respiratory and skin irritant, and prolonged or repeated exposure may cause sensitization.
It is recommended to handle O-Phthalaldehyde (OPA) in a well-ventilated area and use appropriate personal protective equipment (PPE), such as gloves, goggles, and a lab coat, to minimize exposure.
Adhering to recommended usage concentrations and following safety guidelines provided by manufacturers or regulatory bodies is essential to ensure safe handling and minimize potential risks.

O-Phthalaldehyde (OPA) is considered to have a relatively low environmental impact compared to some other disinfectants.
It is biodegradable and does not persist in the environment for extended periods.
However, like any chemical, O-Phthalaldehyde (OPA) should be handled and disposed of responsibly to minimize any potential environmental impact.

The primary routes of human exposure to O-Phthalaldehyde (OPA) are by inhalation and through the skin, which may occur through accidental or occupational exposures.
Along with its increasing popularity as a chemical sterilizer, O-Phthalaldehyde (OPA) has many applications in analytical methods and in diagnostic kits.

O-Phthalaldehyde (OPA) is also used as an intermediate in the synthesis of pharmaceuticals and as a reagent in the tanning industry, hair colorings, wood treatment, and antifouling paints.
O-Phthalaldehyde (OPA) was approved for use as an indoor antimicrobial pesticide in 1997; however, it is no longer registered with the United States Environmental Protection Agency (USEPA) for this use.