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o-Phthalaldehyde (OPA) is an aromatic dialdehyde widely used as a high-level disinfectant, chemical reagent, and derivatizing agent in laboratory and medical applications.
o-Phthalaldehyde (OPA) offers rapid antimicrobial activity against bacteria, mycobacteria, and viruses, making it suitable for sterilization systems.
o-Phthalaldehyde (OPA) reacts strongly with amino groups and is used extensively in analytical chemistry for fluorometric and chromatographic detection of amines.
o-Phthalaldehyde (OPA) is valued for its high reactivity, efficiency, and broad compatibility in disinfection and biochemical assays.
CAS Number: 643-79-8
EC Number: 211-402-2
Molecular Formula: C8H6O2
Molecular Weight: 134.13 g/mol
Synonyms: Ortho-phthaldehyde, OPA reagent, Phthalic dialdehyde, Benzene-1,2-dicarboxaldehyde, Chemical sterilant OPA, Aromatic dialdehyde reagent, Fluorometric derivatization agent, Analytical OPA reagent, High-level disinfectant OPA, Biocidal aldehyde compound, o-Phthalaldehyde (OPA), OPA, ortho-Phthalaldehyde, 1,2-Benzenedicarboxaldehyde, 1,2-Phthalaldehyde, o-Phthalic Dialdehyde, Ortho-Phthalic Aldehyde, Phthalic Dialdehyde, o-Phthalaldehyde Reagent, OPA Sterilant, OPA Disinfectant, OPA High-Level Disinfectant, OPA Chemical, OPA Compound, OPA Substance, OPA Material, OPA Solution, OPA Concentrate, OPA Technical Grade, OPA Industrial Grade, OPA Pharmaceutical Grade, OPA Medical Grade, OPA Laboratory Grade, OPA Research Grade, OPA Analytical Grade, OPA Reagent Grade, OPA Pure, OPA Extra Pure, OPA High Purity, OPA Stabilized Grade, Certified OPA, OPA Certified Standard, OPA Analytical Standard, OPA Laboratory Standard, OPA Certified Reagent, OPA Testing Reagent, OPA Chromogenic Reagent, Ninhydrin Alternative Reagent, OPA Protein Detection Reagent, OPA Amino Acid Reagent, OPA Fluorescent Reagent, OPA Cell Disinfection Agent, OPA Instrument Sterilant, OPA Endoscope Disinfectant, OPA Healthcare Disinfectant, OPA Medical Equipment Disinfectant, Ortho-Dialdehyde Compound, Aromatic Dialdehyde, Aromatic Aldehyde Sterilant, Bactericidal Dialdehyde, Hospital-Grade OPA, High-Level Medical Disinfectant, Medical Chemical Disinfectant, Cold Sterilant OPA, High-Level Sterilizing Agent, Rapid Sterilizing Agent, Low-Odor Sterilant, Non-Glutaraldehyde Sterilant, Glutaraldehyde-Free Disinfectant
APPLICATIONS
o-Phthalaldehyde (OPA) is used as a high-level disinfectant for medical devices.
o-Phthalaldehyde (OPA) sterilizes endoscopes and surgical instruments.
o-Phthalaldehyde (OPA) delivers broad-spectrum antimicrobial action in healthcare sterilization systems.
o-Phthalaldehyde (OPA) is used in biochemical assays for amino acid detection.
o-Phthalaldehyde (OPA) forms fluorescent complexes with primary amines.
o-Phthalaldehyde (OPA) supports protein and peptide analysis in laboratory workflows.
o-Phthalaldehyde (OPA) is used in HPLC derivatization applications.
o-Phthalaldehyde (OPA) enhances detection sensitivity of amines and thiols.
o-Phthalaldehyde (OPA) improves chromatographic selectivity and precision.
o-Phthalaldehyde (OPA) is used in pharmaceutical quality control.
o-Phthalaldehyde (OPA) enables trace-level determination of amino compounds.
o-Phthalaldehyde (OPA) improves detection efficiency in drug research.
o-Phthalaldehyde (OPA) is used in environmental testing laboratories.
o-Phthalaldehyde (OPA) detects nitrogen-containing pollutants in water samples.
o-Phthalaldehyde (OPA) supports wastewater and drinking water monitoring.
o-Phthalaldehyde (OPA) is used in neuroscience research.
o-Phthalaldehyde (OPA) labels neurotransmitters and amine-containing compounds.
o-Phthalaldehyde (OPA) aids in fluorescence microscopy and biochemical tracking.
o-Phthalaldehyde (OPA) is used in industrial disinfection systems.
o-Phthalaldehyde (OPA) supports cold sterilization processes.
o-Phthalaldehyde (OPA) disinfects heat-sensitive instruments.
o-Phthalaldehyde (OPA) is used in food and beverage testing.
o-Phthalaldehyde (OPA) detects free amino nitrogen in fermentation processes.
o-Phthalaldehyde (OPA) supports brewing and beverage quality analysis.
o-Phthalaldehyde (OPA) is used in biotechnology manufacturing.
o-Phthalaldehyde (OPA) analyzes amino acids and protein hydrolysates.
o-Phthalaldehyde (OPA) assists in monitoring fermentation and bioprocessing.
DESCRIPTION
o-Phthalaldehyde (OPA) is a white to pale yellow crystalline solid.
o-Phthalaldehyde (OPA) has a characteristic pungent odor.
o-Phthalaldehyde (OPA) is highly reactive due to its dialdehyde functionality.
o-Phthalaldehyde (OPA) dissolves in alcohols and organic solvents.
o-Phthalaldehyde (OPA) forms fluorescent derivatives with primary amines.
o-Phthalaldehyde (OPA) is used in nanomolar detection chemistry.
o-Phthalaldehyde (OPA) has strong bactericidal and virucidal activity.
o-Phthalaldehyde (OPA) offers fast disinfection at controlled pH.
o-Phthalaldehyde (OPA) is used as a safer alternative to glutaraldehyde in many applications.
o-Phthalaldehyde (OPA) must be handled with caution due to sensitization potential.
o-Phthalaldehyde (OPA) is stable when stored away from light and moisture.
PROPERTIES
Appearance: White to pale yellow crystalline solid
Odor: Pungent aldehyde odor
Solubility: Soluble in alcohols, ethers, and organic solvents
Melting Point: ~55–57°C
Boiling Point: Decomposes before boiling
Flash Point: Combustible material
Density: ~1.2 g/cm³
Stability: Sensitive to light and air; store tightly closed
Reactivity: Reactive toward amines and nucleophiles
Storage Temperature: Store at 5–25°C in sealed, dark container
FIRST AID
Inhalation:
Move to fresh air immediately.
Seek medical attention if breathing discomfort occurs.
Skin Contact:
Wash thoroughly with soap and water.
Seek medical attention if irritation or sensitization develops.
Eye Contact:
Flush with water for 15 minutes.
Seek medical attention immediately.
Ingestion:
Rinse mouth and drink water.
Seek medical advice if symptoms develop.
Note to Physicians:
Treat symptomatically and monitor for respiratory or skin sensitization.
HANDLING AND STORAGE
Handling:
Wear gloves, goggles, and protective clothing.
Avoid inhalation and direct contact with skin or eyes.
Ventilation:
Use appropriate ventilation in handling and preparation areas.
Avoidance:
Avoid strong oxidizers and uncontrolled moisture exposure.
Spill and Leak Procedures:
Absorb with inert material and collect for disposal.
Ventilate area and wash surfaces thoroughly.
Storage:
Store tightly sealed in a cool, dry, dark environment.
Protect from light, heat, and moisture.
Handling Cautions:
Use chemical fume hood for laboratory preparation.
Dispose according to chemical waste regulations.
