OCTENIDINE DIHYDROCHLORIDE

CAS NO: 70775-75-6

SYNONYM:

OCTENIDINE HYDROCHLORIDE; UNII-U84956NU4B; U84956NU4B; 1-Octanamine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2); Win 41464-2; N-octyl-1-[10-(4-octyliminopyridin-1-yl)decyl]pyridin-4-imine dihydrochloride; Octenidine hydrochloride (USAN); Octenidine hydrochloride; Octenidine HCl; CHEMBL36342; SCHEMBL126065; HY-B2170A; DTXSID90221025; Win-414642; BCP22785; EINECS 274-861-8; LAS189962; MFCD01938808; s5012; CCG-270262; CS-6224; LAS-189962; KS-000002K2; WIN-41464-2; O0388; D05222; Q1409243; N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis(1-octanamine) dihydrochloride; N,N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylammonium) dichloride; Octenidine hydrochloride; OCTENIDINE DIHYDROCHLORIDE; N,N'-(1,10-Decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-1-octanaMine Hydrochloride; N'-(decane-1,10-diyldi-1(4H)-pyridyl-4-ylidene)bis(octylaMMoniuM) dichloride; 1-OctanaMine,N,N'-(1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene)bis-, hydrochloride (1:2); ocenidine dihydrochloride

Octenidine hydrochloride is a cationic surfactant with antimicrobial activity against Gram-positive and Gram-negative bacteria. Octenidine hydrochloride, approved in various European countries as a medicinal substance and used for skin antisepsis in combination with aliphatic alcohols, e.g. with detergents such as propan-1-ol and propan-2-ol or antiseptic soap. Octenidine hydrochloride is also used for antisepsis on wounds and mucous membranes as a single agent as an approved combination of Octenidine hydrochloride and phenoxyethanol. Since octenidine hydrochloride is only approved and used topically and is almost not absorbed, no systemic effect is to be expected.

Therefore, no further pharmacokinetic studies or studies on metabolism have been performed. Octenidine hydrochloride is chemically stable, non-flammable, easy to use and safe, without resistance development and low toxicity to human and environment. Octenidine hydrochloride's popularity among therapists and wound care professionals is based on good clinical results, easy and painless application, and local tolerance. Semi-liquid preparations and dressings are described, as well as combinations readily obtainable with phenoxyethanol, mouthwashes and vaginal applications.

Octenidine hydrochloride is not absorbed either through the skin or through mucous membranes or wounds and does not cross the placental barrier. However, cation-active compounds cause local irritation and are extremely toxic when administered parenterally. Octenidine hydrochloride (octenidine) was used 20 years ago for skin, mucous membrane and wound antisepsis. Octenidine dihydrochloride in all types of mammalian food production It is an antiseptic agent used for skin and mucosal disinfection and short-term supportive antiseptic wound.

Octenidine hydrochloride CAS no.70775-75-6 API, active pharmaceutical additive to the pharmaceutical industry Octenidine hydrochloride is an effective antiseptic compound for skin mucous membranes and wounds. Octenidine hydrochloride is a cationic surfactant and bis- (dihydropyridinyl) -decan derivative used in concentrations of 0.1-2.0 % for skin, mucous membrane and wound antisepsis. Octenidine hydrochloride is similar in action to the quaternary ammonium compounds in Octenidine hydrochloride action, but has a wider spectrum of action. Octenidine currently replaces quats or chlorhexidine in water- or alcohol-based skin, mucous and wound antiseptics in continental Europe.

In aqueous formulations Octenidine hydrochloride is generally fortified by the addition of 2-phenoxyethanol. Octenidine dihydrochloride is intended for use in short-term supportive antiseptic wound treatment in all mammalian food producing species for skin and mucosal disinfection and as a 0.1% aqueous solution for cutaneous use. Octenidine dihydrochloride for skin and mucosal disinfection in whole mammal Use for short term supportive antiseptic wound treatment in food producing species and as a 0.1% aqueous solution for cutaneous use. Octenidine hydrochloride shows antiseptic activity against a wide range of bacteria and some fungi in vitro. The lowest MIC value (1 ppm) for Octenidine hydrochloride was observed for Staphylococcus aurerus. Octenidine hydrochloride showed a lower MIC for MRSA strains than other studied antiseptics.

Octenidine hydrochloride is an antiseptic (topical). Octenidine hydrochloride is a cationic surfactant and derivative of bis (dihydropyridinyl)  decan. Octenidine hydrochloride is used as a modern antiseptic for skin, mucous membranes and wounds, medicines. Octenidine hydrochloride has biological roles as pharmacological role. Octenidine hydrochloride, Brønsted acid have chemical roles as surfactants. Octenidine hydrochloride has chemical entities as pyridines, secondary amines. Octenidine dihydrochloride (octenidine) was used 20 years ago for skin, mucous membrane and wound antisepsis. Octenidine dihydrochloride (N, N '- (1,1-0-Decandiild-1 (4-H) -pyridinyl-4ylidene) bis 1-octanamine) -dihydrochloride - CAS No 70775-75-6), in all types of mammalian food production It is an antiseptic agent of the short-term supportive antiseptic wound used for skin and mucosal disinfection. Octenidine dihydrochloride did not show any genotoxic potential against gene mutations in bacteria.

Octenidine dihydrochloride did not induce chromosomal aberrations in cultured Chinese hamster ovary cells or human lymphocytes, with or without S9 activation. The genotoxicity of octenidine dihydrochloride was investigated in vitro in the Mouse Lymphoma TK locus assay in L5178Y cells. Octenidine dihydrochloride EMA / CVMP / 7000219/2009 Page 4/11 results for the European public MRL assessment report (EPMAR) were negative. To summarize, there is no evidence of the genotoxic potential of octenidine dihydrochloride in in vitro mammalian cell tests.

Octenidine hydrochloride shows antiseptic activity against a wide range of bacteria and some fungi in vitro. The lowest MIC value (1 ppm) for Octenidine hydrochloride was observed for Staphylococcus aurerus. Octenidine hydrochloride showed a lower MIC for MRSA strains than for other antiseptics. Skin application of Octenidine hydrochloride to the hands and feet of the cynomolgus monkey dropped the resident microflora on the skin. This reduction was due to the concentration and number of applications. No studies on secondary pharmacodynamics or pharmacodynamic drug interactions have been presented.

Despite the fact that cationic substances such as octenidine hydrochloride react with anionic substances, thus spoiling the antiseptic effect. However, the lack of secondary pharmacodynamic and drug interaction studies was justified as there was no information in the literature on pharmacodynamic effects other than germicidal effects, and pharmacokinetic studies with Octenidine hydrochloride indicated a low systemic exposure after cutaneous administration.

Octenidine dihydrochloride is active against Gram-positive and Gram-negative bacteria. Since 1987, octenidine has been used in Europe as an antiseptic, in concentrations of 0.1 to 2.0%. It is a substitute for chlorhexidine, with respect to its slow action and concerns about the carcinogenic impurity 4-chloroaniline. Octenidine preparations are less expensive than chlorhexidine and no resistance had been observed as of 2007. They may contain the antiseptic phenoxyethanol. 

Octenidine dihydrochloride is active against Gram-positive and Gram-negative bacteria. In vitro suspension tests with 5 minute exposure time have shown that octenidine requires lower effective concentrations than chlorhexidine to kill common bacteria like Staphylococcus aureus, Escherichia coli, Proteus mirabilis and the yeast Candida albicans. Octenidine is absorbed neither through the skin, nor through mucous membranes, nor via wounds and does not pass the placental barrier. However, cation-active compounds cause local irritation and are extremely poisonous when administered parenterally.

In a 2016 in vitro study of mouth rinses on gingival fibroblasts and epithelial cells octenidine showed a less cytotoxic effect, especially on epithelial cells, compared to chlorhexidine after 15 min. Wound irrigation with octenidine has caused severe complications in dogs, aseptic necrosis and chronic inflammation in penetrating hand wounds. Octenidine dihydrochloride was tested in single dose (non GLP) toxicity studies, at doses up to 3160 mg/kg orally in rat and up to 800 mg/kg orally in rabbit. Mortality was observed at 794 and 800 mg/kg respectively. Effects consisted mainly of dyspnoea, ataxia, inactivity, reduced motor activity, nasal discharge, stool changes, anorexia, hyperaemia of duodenum and hyperaemia and ulceration of the stomach and irritation of the gastrointestinal tract.

Octenidine dihydrochloride is a cationic surfactant, with antimicrobial activity against Gram-positive and Gram-negative bacteria. Octenidine approved as a medicinal substance in several European countries and used for skin antisepsis in combination with aliphatic alcohols, e.g. propan-1-ol and propan-2-ol, or with detergents such as antiseptic soap. Octenidine is also used for antisepsis on wounds and mucosa either as a single substance, as an approved combination of Octenidine and phenoxyethanol. Octenidine is virtually not absorbed via the skin or mucous membranes. Because Octenidine is only approved and used topically and is virtually not absorbed, no systemic effects are to be expected. Therefore, no further pharmacokinetic studies or studies on behalf of metabolism have been conducted. Octenidine is easy and safe to handle, chemically stable, not inflammable, without resistance development and low toxicity to man and the environment alike. Its popularity among therapists and wound care specialists is based on good clinical results, easy and pain-free application and local tolerance.

Beside readily available combinations with phenoxyethanol, mouth rinses, and vaginal applications, semi-fluid preparations and dressings are described. Octenidine dihydrochloride (octenidine) was introduced for skin, mucous membrane and wound antisepsis more than 20 years ago. Until now, a wealth of knowledge has been gained, including in vitro and animal studies on efficacy, tolerance, safety and clinical experience both from case reports and prospective controlled trials. Nowadays, octenidine is an established antiseptic in a large field of applications and represents an alternative to older substances such as chlorhexidine, polyvidone-iodine or triclosan. The review is based on the current literature and unpublished original data as well. Octenidine dihydrochloride belongs to the group of bispyridines. The active substance has non-specific antimicrobial, antifungal and antiviral properties. Octenidine dihydrochloride is used for the treatment of wound infections and for disinfecting the skin and mucous membrane. Octenidine dihydrochloride is an antiseptic.

Octenidine dihydrochloride works by preventing the growth of bacteria and other microorganisms on the skin and helps in preventing skin infections.  is only for external use. You are recommended to avoid the use of Octenidine dihydrochloride on eyes, eyelids, mouth or nose. If  Octenidine dihydrochloride  comes in contact with these areas accidentally, rinse with plenty of water immediately. Octenidine dihydrochloride is a cationic antiseptic belonging to the bispyridine class of chemicals and being effective against gram-positive and gram-negative bacteria. It is an antiseptic agentintended for use in oral hygiene, preventing plaque and gingivitis, as a whole body wash for methicillin-resistant S. aureus (MRSA) decolonization, for skin disinfection of premature newborn infant, and short-term supportive antiseptic wound treatment as a 0.1% aqueous solution for cutaneous use.

Octenidine dihydrochloride is a cationic surfactant and bis-(dihydropyridinyl)-decane derivative used in concentrations of 0.1-2.0% for skin, mucous membrane and wound antisepsis. Octenidine dihydrochloride is similar in its action to quaternary ammonium compounds, but is of somewhat broader spectrum of activity. Octenidine is currently increasingly used in continental Europe as a substitute for quats or chlorhexidine in water- or alcohol-based skin, mucosa and wound antiseptics. In aqueous formulations, it is often potentiated with addition of 2-phenoxyethanol. Octenidine dihydrochloride is already effective at an application concentration of 0.1% in aqueous solution and can be used in the pharmaceutical, biopharmaceutical and cosmetics industries.