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Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment.
Octinoxate is used in cosmetics and personal care products as a UV absorber to protect the skin from UV rays and as a stabilizer to prevent deterioration of product quality due to UV exposure.
Octinoxate is used in sunscreens, skin care products, makeup products, hair care products, and so on.
CAS Number: 5466-77-3
EC Number: 226-775-7
MDL Number: MFCD00072582
Chem/IUPAC Name: 2-ethylhexyl 3-(4-methoxyphenyl)prop-2-enoate
Molecular Formula : C18H26O3
Molecular Weight: 290.40 g/mol
SYNONYMS:
Octinoxate, 5466-77-3, 83834-59-7, 2-Ethylhexyl 4-methoxycinnamate, Parsol MCX, Parsol MOX, Parsol, 2-Ethylhexyl-p-methoxycinnamate, 4-Methoxycinnamic Acid 2-Ethylhexyl Ester, Octyl methoxycinnamate, Escalol 557, 2-Ethylhexyl trans-4-methoxycinnamate, (E)-2-Ethylhexyl 3-(4-methoxyphenyl)acrylate, Uvinul MC80, Ethylhexyl p-methoxycinnamate, Heliopan New, 2-Ethylhexyl p-methoxycinnamate, 2-Ethylhexyl 3-(4-methoxyphenyl)acrylate, (E)-Octinoxate, Ethylhexyl methoxycinnamate, Uvinul MC 80, 2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate, Ocinoxate, Eusolex 2292, Jeescreen omc, Solarom omc, Neo heliopan AV, UNII-4Y5P7MUD51, Escalol 557nb, Uvinul mc 80n, Escalol 557t, Uvinul mc 90, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, 4Y5P7MUD51, Octyl p-Methoxycinnamate, NSC-26466, Octyl 4-methoxycinnamic acid, DTXCID905302, DTXSID1025302, DTXSID9047205, EC 629-661-9, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, (2E)-, 2-Ethylhexyl methoxycinnamate, octylmethoxycinnamate, 2-Ethylhexyl |trans|-4-methoxycinnamate, NCGC00160623-01, SHADE UVAGUARD COMPONENT OCTINOXATE, OCTINOXATE (MART.), OCTINOXATE [MART.], octinoxato, OCTINOXATE (USP-RS), OCTINOXATE [USP-RS], Octinoxate [USAN], Parsol mcx-sa, OCTINOXATE (USP MONOGRAPH), OCTINOXATE [USP MONOGRAPH], CAS-5466-77-3, octyl-methoxycinnamate, (E)-Octyl methoxycinnamate, octinoxatum, octinoxate powder, Octinoxate 6%, Octinoxate 6.0%, MFCD00072582, 2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate, UvinulT MC 80 N, 2-ethylhexyl 3-(4-methoxyphenyl)-2-propenoate, Neo heliopan, type AV, UV Shield SPF 42, Octinoxate (USP/INN), ethylhexl methoxycinnamate, OCTINOXATE [HSDB], UV MILD SUN BLOCK, OCTINOXATE [VANDF], OCTINOXATE [WHO-DD], SCHEMBL15609, MLS004773966, DTXCID0028119, Ethylhexyl Methoxycinnamate cream, OCTINOXATE [ORANGE BOOK], CHEBI:88667, HY-B1234A, HY-B1234R, 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethylhexyl ester, D02BA02, MSK3409, OCTYL METHOXYCINNAMATE [MI], STUDIO MOISTURE TINTSPF 15, HY-B1234, NSC26466, Tox21_111942, Tox21_201327, Tox21_302576, OCTYL METHOXYCINNAMATE [VANDF], AKOS015838519, Tox21_111942_1, 2-Ethylhexyl 4-methoxycinnamate, 98%, CCG-267384, CS-4732, DB09496, FO29526, 2-Ethylhexyl (trans)-4-methoxycinnamate, NCGC00160623-02, NCGC00160623-03, NCGC00160623-04, NCGC00181309-01, NCGC00256897-01, NCGC00258879-01, AS-11708, SMR001550370, TONYMOLY KISS KISS LIP ESSENCE BALM, CAS-83834-59-7, 2-Ethylhexyl trans-4-methoxycinnamate, 98%, 2-ETHYLHEXYL-TRANS-4-METHOXYCINNAMATE, CS-0031468, ETHYLHEXYL P-METHOXYCINNAMATE [VANDF], M1082, NS00013675, (E)-2-Ethylhexyl3-(4-methoxyphenyl)acrylate, D05225, Ethylhexyl methoxycinnamate, Octyl methoxycinnamate, 2-Ethylhexyl p-methoxycinnamate, Parsol MCX, Uvinul MC80, Escalol 557, Neo Heliopan AV, (RS)-2-Ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate, 2-Ethylhexyl 4-methoxycinnamate, 4-Methoxycinnamic acid 2-ethylhexyl ester, OMC, Octyl methoxycinnamate, (RS)-2-Ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate, Ethylhexyl methoxycinnamate, Octinoxate, Uvinul MC80, (E)-3-(4-methoxyphenyl) prop-2-enoic acid 2-ethylhexyl ester, Octinoxate, OMC, OCTYL METHOXYCINNAMATE, 2-ETHYLHEXYL TRANS-4-METHOXYCINNAMATE, MC80, PARSOL MCX, Neo Heliopan AV, 2-ETHYLHEXYL P-METHOXYCINNAMATE, OCTYL P-METHOXYCINNAMATE, 2-ETHYLHEXYL 4-METHOXYCINNAMATE, Ethylhexyl methoxycinnamate, Octinoxate, OM-Cinnamate, OM Cinnamate, Octyl Methoxycinnamate, 2-Ethylhexyl 4-methoxycinnamate, Parsol MCX, OMCU, Uvinul MC80, ETHYLHEXYL METHOXYCINNAMATE, 2-ETHYLHEXYL P-METHOXYCINNAMATE, 2-ETHYLHEXYL 4-METHOXYCINNAMATE, 2-ETHYLHEXYL ESTER P-METHOXYCINNAMIC ACID, 2-ETHYLHEXYL METHOXYCINNAMATE, 2-ETHYLHEXYL P-METHOXYCINNAMATE, 2-ETHYLHEXYL-4-METHOXYCINNAMATE, AI3-05710, CCRIS 6200, EINECS 226-775-7, ESCALOL, NEO HELIOPAN, 2-Ethylhexyl-4-methoxycinnamate, 4-Methoxycinnamic Acid 2-Ethylhexyl Ester, EHMC, Octinoxat (INN), 4-Methoxycinnamic Acid 2-Ethylhexyl Ester, Octyl Methoxycinnamate, 2-Ethylhexyl-p-methoxycinnamate, Octinoxate, Ethylhexyl Methoxycinnamate
Octinoxate (also known as octyl methoxycinnamate [OMC], parsol, parsol MCX, parsol MOX, escalol, 2-ethylhexyl p-methoxycinnamate)
Octinoxate is created by combining methoxycinnamic acid (which can be extracted from the Aquilegia vulgaris plant) and 2-ethylhexanol.
Octinoxate, USP is a UV-stabilizer excipient.
Octinoxate is a popular ingredient in many sunscreen and skin care products because it is a UV filter.
Octinoxate is a cinnamate ester.
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
Octinoxate was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun.
Octinoxate is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption.
Octinoxate's use in pharmaceutical and cosmetic formulations is approved by FDA.
Octinoxate acts as a sunscreen agent.
Octinoxate absorbs UV-B rays from the sun and protects the skin from damage.
Octinoxate finds application in formulating sunscreens and lip balms.
Octinoxate is a substance that shields the skin from harmful UVB rays.
Octinoxate is an ingredient in some cosmetic products, such as sunscreen.
Another name for Octinoxate is octyl-methoxycinnamate.
Octinoxate is a type of chemical known as a cinnamate ester. Cinnamate esters are organic acids that occur naturally in certain foods, such as grapes.
Companies first began using octinoxate as a form of UV protection in the 1950s.
Octinoxate works by absorbing UVB rays from the sun.
This is the type of UV light most associated with sunburn and skin cancer.
Manufacturers typically combine the octinoxate with other substances that prevent the skin from absorbing it.
This minimizes the risk of octinoxate affecting someone’s health.
However, the skin may still absorb a small amount.
Octinoxate is the UVB filter in 90% of sunscreens in the United States.
The Food and Drug Administration (FDA) has approved Octinoxate for use in cosmetic and pharmaceutical products.
Octinoxate, also called Octyl methoxycinnamate or (OMC), is a UV filter.
Octinoxate can be absorbed rapidly through skin.
Octinoxate has been detected in human urine, blood and breast milk, which indicates that humans are systemically exposed to this compound.
Octinoxate is an endocrine disruptor that mimics estrogen and can disrupt thyroid function.
Octinoxate filters UV‐B rays from the sun. It does not protect against UV-A rays.
Octinoxate dissolves in oil, which makes it a fat-seeking substance in the body.
Octinoxate is formed by combining methoxycinnamic acid and 2-ethylhexanol- compounds which are not harmful on their own.
When mixed together, they form a clear liquid that does not dissolve in water.
Octinoxate is a chemical sunscreen that filters UVB rays.
Octinoxate is safe and effective when applied topically.
Octinoxate (Octyl methoxycinnamate) is a thyroid hormone receptor agonist, reducing the levels of triiodothyronine (T3) and thyroxine (T4) and transcription levels of genes related to type II deiodinase (deio2) in Japanese Medaka.
Octinoxate inhibits CYP1A1 and CYP1B1 to regulate hyaluronan (HA) (HY-B0633A) metabolism in a PI3K pathway-dependent manner in human keratinocytes.
Octinoxate also exhibits an anti-estrogenic and anti-androgenic effect in vitro and in vivo.
Octinoxate, also known as octyl methoxycinnamate, is a common organic compound utilized in sunscreens and personal care products to protect the skin from the harmful effects of ultraviolet (UV) radiation.
Octinoxate is an organic sun filter (from carbon).
Also known as octyl methoxycinnamate and ethylhexyl methoxycinnamate, octinoxate is the oldest and most common sunscreen active used in sunscreens around the world.
Technically considered broad spectrum on its own, octinoxate remains most effective within the UVB range, since its UVA-protecting abilities peak at 360 nanometers (the UVA light spectrum goes from 320–400 nanometers).
Interestingly, research has also shown that peak UV absorption of octinoxate is 310 nanometers, just shy of where the UVA spectrum begins.
But for certain, octinoxate is a reliable UVB filter.
Octinoxate has a solid record of safety backed by decades of research and mounds of studies.
No studies have demonstrated that octinoxate, as used in SPF products, is harmful to people.
In the studies where such claims are made, the conditions are simply do not apply to how octinoxate is used in sunscreens.
This sunscreen ingredient’s cinnamic acid component can be allergenic for some people; however, this is an individual response and simply means your skin cannot tolerate Octinoxate. Octinoxate is not considered irritating or photosensitizing to broad populations.
Octinoxate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
Octinoxate was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun.
Octinoxate is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption.
Octinoxate's use in pharmaceutical and cosmetic formulations is approved by FDA.
On the ingredient labels, it is listed as “Ethylhexyl methoxycinnamate” or “Octinoxate.”
Octinoxate is suspected to be a possible endocrine disruptor, and further safety assessment is ongoing in Europe.
On the other hand, the safety of octinoxate has been evaluated by scientific agencies affiliated with regulatory authorities in many countries and regions.
Based on the results of these evaluations, octinoxate has been approved for use in cosmetics, personal care products, and OTC drugs in various countries and regions around the world, provided that it is not used in the products beyond the upper concentration limits as specified in laws and regulations.
Octinoxate, also known as ethylhexyl methoxycinnamate, is a common organic compound used as a chemical UV filter in sunscreens and other personal care products.
Octinoxate functions by absorbing UVB radiation, and other UV filters are frequently combined with it to offer broad-spectrum defence against UVB and UVA rays.
Although octinoxate effectively shields the skin from UV damage, safety issues have been raised.
According to certain research, octinoxate may interfere with hormone production and perhaps cause endocrine disruption.
The FDA and the European Union have both approved the use of octinoxate in sunscreens up to a 7.5% concentration each.
Additionally, an independent expert panel known as the Cosmetic Ingredient Review (CIR) examined the safety of octinoxate and came to the conclusion that it is safe to use in cosmetics at concentrations up to 10%.
As a UV filter, octinoxate, sometimes called octyl methoxycinnamate, is a chemical substance frequently found in sunscreens and other personal care products.
UVB radiation, which can lead to sunburn and help develop skin cancer, is absorbed by it.
Octinoxate is a lipophilic substance, which means it may penetrate the skin and is oil-soluble.
This makes Octinoxate possible for it to offer efficient UVB radiation protection, but it also raises questions regarding its safety and the possibility of skin irritation.
According to certain research, octinoxate may have endocrine-disrupting effects, which means it may affect how the body produces hormones.
Octinoxate, also known as octyl methoxycinnamate, is a common chemical found in many sunscreens and skincare products.
Octinoxate's primary function is to absorb ultraviolet B (UVB) rays from the sun, thereby protecting the skin from sunburn and other forms of damage.
Octinoxate, or octyl methoxycinnamate, is a more recent sunscreen component.
Octinoxate is clear, colorless liquid.
Octinoxate is slightly soluble in water.
Octinoxate is well soluble in alcohols and oils, isopropanol.
Octinoxate is highly effective organic ultraviolet filter.
Octinoxate is offered as a special additive in moisturizers, lipsticks, nail polishes, shampoos, sunscreens.
Octinoxate is liquid UVB filter.
When exposed to UV radiation, Octinoxate can break down into components that cause irritation, this effect can be reduced if properly encapsulated.
Octinoxate works best in formulas when combined with zinc oxide.
Octinoxate has been shown to penetrate the skin, leading to systemic absorption.
Octinoxate, also known as octyl methoxycinnamate, is a chemical compound widely used as a UV filter in sunscreens and various cosmetic products.
Octinoxate primarily absorbs ultraviolet B (UVB) radiation, protecting the skin from harmful effects such as sunburn and DNA damage.
Octinoxate is a cinnamate ester formed by the reaction of methoxycinnamic acid and 2-ethylhexanol, resulting in a clear liquid that is oil-soluble and not water-soluble.
Octinoxate has been utilized since the 1950s and is found in approximately 90% of sunscreens in the United States
Octinoxate is the most commonly used UVB absorber in sunscreen today.
USES and APPLICATIONS of OCTINOXATE:
Octinoxate is a UV-B category 1 sunscreen used for OTC sun protection products such as sunscreens, personal care products, sun care, baby sun care, daily skin care, decorative cosmetic with sun protection and broad spectrum UV- B filter.
Octinoxate is found in hair color products and shampoos, sunscreen, lipstick, nail polish, and skin creams.
In products other than sunscreens, Octinoxate is used as a UV filter to protect the products from degrading when exposed to the sun.
Octinoxate is commonly used as a safe ultraviolet (UV) filter used in the aquatic environment.
Cosmetics and personal care products containing UV filters are used worldwide to protect skin from UV rays, which is one of the factors that cause skin cancer and skin aging, and to maintain skin health.
Octinoxate is used in cosmetics and personal care products as a UV absorber to protect the skin from UV rays and as a stabilizer to prevent deterioration of product quality due to UV exposure.
Octinoxate is used in sunscreens, skin care products, makeup products, hair care products, and so on.
USES AND BENEFITS OF OCTINOXATE:
Octinoxate is primarily used for its UV-absorbing properties:
*Sunscreen Agent:
Octinoxate absorbs UV-B rays, protecting the skin from sunburn and DNA damage.
*Cosmetic Product Stabilizer:
Octinoxate prevents degradation of products like shampoos, hair color products, and nail polish when exposed to sunlight.
CHARACTERISTICS OF OCTINOXATE:
*UV Absorption:
Octinoxate is effectively absorbs UV-B radiation, which is responsible for tanning and sunburn.
*Photostability:
Octinoxate may degrade upon exposure to sunlight, potentially reducing its effectiveness over time.
*Compatibility:
Octinoxate is easily incorporated into various oil-based formulations, enhancing the versatility of cosmetic products.
These properties make octinoxate a widely used ingredient in sunscreens and other personal care products, offering protection against the harmful effects of UV radiation.
WHAT PRODUCTS CAN CONTAIN OCTINOXATE?
Companies use octinoxate in products that require an SPF.
These can include:
*sunscreens
*lip balms
*hand or face moisturizers
*makeup products
*perfumes
*hair sprays
*aftershaves
People can find this ingredient on product labels under various names.
WHAT OCTINOXATE DOES:
Octinoxate filters UVB rays from the sun and is the most widely used chemical absorber in the skincare industry.
It’s also found in hair color products, shampoos, lipstick, nail polish, and more where Octinoxate functions as a UV filter to protect the products from degrading when exposed to sunlight.
WHAT PRODUCTS HAVE OCTINOXATE IN THEM?
*Octinoxate can be found in:
*Sunscreen
*Shampoos
*Lipsticks
*Other personal care products
WHAT DOES OCTINOXATE DO?
Octinoxate, also known as ethylhexyl methoxycinnamate, is a common ingredient in sunscreens, shampoos, lipsticks, and other products.
Octinoxate serves a number of different functions as an active ingredient in sunscreens.
Octinoxate scatters the sun’s UVB rays.
Since it’s inexpensive, Octinoxate also serves as a good ingredient to keep sunscreen costs down.
Octinoxate does its job as a UVB absorber and prevents burns.
Octinoxate poses a number of risks to coral reefs as well as humans.
HOW TO MAKE OCTINOXATE?
What Are Octinoxate and Avobenzone?
Are They Safe as Sunscreen?
Octinoxate appears in many so-called “natural” sunscreens, but it is not a natural sunscreen.
To make Octinoxate, it is mixed with methanol, a petroleum byproduct of sulfuric acid.
This mixture is then heated until it dissolves in water.
And that’s how Octinoxate is created.
MECHANISM OF ACTION OF OCTINOXATE:
Octinoxate works by absorbing UVB radiation (wavelengths of 280-320 nm) through ESIPT.
When a UVB photon hits the cinnamate moiety, an electron is excited to a higher energy level.
This triggers a rearrangement of protons within the molecule, dissipating the energy as heat instead of damaging the skin cells.
PHYSICAL AND CHEMICAL PROPERTIES OF OCTINOXATE:
Melting point: 61-64 °C
Boiling point: 198-200 °C
Solubility: Insoluble in water, soluble in oils
Stability: Degrades in sunlight
BENEFITS OF OCTINOXATE:
Octinoxate protects against sunburn, reduces the likelihood of developing skin cancer and minimizes sun damage.
*Skin Types
Octinoxate is recommended for everyone.
However, look for a sunscreen that combines this chemical ingredient with a UVA blocker to provide complete sun protection!
OCTINOXATE IS FOUND:
Found In
*Hair color products and shampoos
*Sunscreen
*Lipstick
*Nail polish
*Skin creams
OCTINOXATE AT A GLANCE:
* Globally approved UV filter used for 50+ years
* Provides excellent UVB protection
* Filters a portion of UVA rays
* Backed by numerous studies confirming its safety as used in sunscreens
* Its cinnamic acid component can be allergenic for some
* Also known as octyl methoxycinnamate and ethylhexyl methoxycinnamate
WHERE DOES OCTINOXATE COME FROM?
Octinoxate is a synthetic organic compound (based on carbon, oxygen and hydrogen) that absorbs UV rays.
Octinoxate is a derivative of cinnamic acid that can be found in cinnamon.
WHY IS OCTINOXATE USED?
Octinoxate protects the skin from the sun's harmful effects, which can lead to long-term skin cancer.
Octinoxate mostly absorbs UVB radiation.
Octinoxate has a positive impact on the texture and appearance of the cosmetic products in which it is used.
WHAT DOES OCTINOXATE DO?
Octinoxate, also known as ethylhexyl methoxycinnamate, is a common ingredient in sunscreens, shampoos, lipsticks and other products.
Octinoxate serves a number of different functions as an active ingredient in sunscreens.
First, Octinoxate disperses the sun’s UVB rays, which cause burns.
Since Octinoxate is inexpensive, it also serves as a good ingredient to keep the cost of sunscreen low.
WHAT IS THE MECHANISM OF OCTINOXATE?
Octinoxate, also known as octyl methoxycinnamate or OMC, is a widely used organic compound in sunscreen formulations.
Octinoxate's primary function is to absorb ultraviolet B (UVB) rays from the sun, which are responsible for causing skin burns, DNA damage, and contributing to skin cancer.
Understanding the mechanism of Octinoxate involves delving into its chemical structure, absorption properties, and its interaction with the skin.
Chemically, Octinoxate is an ester formed from methoxycinnamic acid and 2-ethylhexanol.
The molecule contains a conjugated double-bond system that allows it to absorb high-energy UVB light.
When Octinoxate absorbs UVB radiation, the energy from the light raises the molecule to an excited state.
This excitation promotes electrons within the molecule to higher energy orbitals.
As the molecule returns to its ground state, Octinoxate releases the absorbed energy as lower-energy, less harmful radiation, generally in the form of heat.
Octinoxate's ability to absorb UVB light is particularly important for protecting the skin from harmful effects.
Octinoxate covers the UVB range of 280-320 nanometers, effectively filtering out these rays before they penetrate the skin.
This absorption capability prevents the UVB radiation from reaching the deeper layers of the epidermis and dermis, thereby reducing the risk of sunburn and long-term skin damage.
When applied to the skin in sunscreen formulations, Octinoxate is often combined with other UV filters, such as avobenzone or titanium dioxide.
This combination helps to provide broad-spectrum protection, covering both UVB and UVA (320-400 nanometers) rays.
The formulation of these sunscreens is designed to ensure that Octinoxate remains stable upon exposure to sunlight, heat, and other environmental factors, maintaining its efficacy over time.
In addition to its UV-absorbing properties, Octinoxate is chosen for its aesthetic qualities.
Octinoxate is a liquid at room temperature and has a pleasant texture, making it easy to incorporate into various cosmetic formulations.
Octinoxate does not leave a white residue on the skin, which is often a drawback of inorganic UV filters like zinc oxide and titanium dioxide.
Despite its widespread use and effectiveness, Octinoxate has faced scrutiny regarding its potential environmental impact, especially on marine ecosystems.
Studies have shown that Octinoxate can contribute to coral bleaching when it washes off into the ocean.
This has led some regions to ban or restrict sunscreens containing Octinoxate to protect marine life.
In conclusion, Octinoxate operates primarily by absorbing UVB radiation and converting it into less harmful forms of energy, thereby protecting the skin from sunburn and potential long-term damage.
Its chemical structure allows it to effectively filter UVB rays, and its favorable properties make Octinoxate a popular ingredient in sunscreen formulations.
UNDERSTANDING OCTINOXATE AND OCTINOXATE'S ROLE IN SUNSCREENS:
Is octinoxate safe in sunscreen?
Octinoxate, also known as octyl methoxycinnamate, is a chemical UV filter commonly used in sunscreens to protect against UVB radiation.
Octinoxate functions by absorbing UVB rays, which can lead to sunburn and help promote skin cancer.
Octinoxate is a lipophilic substance, which means it may penetrate the skin and is oil-soluble.
This property enables Octinoxate to offer efficient UVB radiation protection, but it also raises questions regarding its safety and the possibility of skin irritation.
In addition to sunscreens, octinoxate is a UV-blocking ingredient used in many other personal care products, such as moisturisers, lip balms, and hair care items.
While octinoxate is efficient in blocking UVB rays, UVA radiation is less well-protected by the chemical.
Use a sunscreen that offers broad-spectrum protection against UVA and UVB radiation because UVA radiation can also cause skin damage and raise your risk of developing skin cancer.
It's crucial to take into account any potential safety issues when selecting an octinoxate-containing sunscreen, especially for people with sensitive skin or a history of allergic reactions.
Customers could prefer sunscreens that employ alternative UV filters since they are thought to be safer and offer broad-spectrum defence against both UVA and UVB radiation.
UVB PROTECTION AND OCTINOXATE MECHANISM:
UVB radiation is a form of ultraviolet light that can damage the skin, resulting in sunburns, and promoting the growth of skin cancer.
In order to defend against UVB radiation's damaging effects, octinoxate acts by absorbing it before it can reach the skin.
A chemical filter called octinoxate works by absorbing UVB rays and transforming them into less damaging energy.
This is accomplished by absorbing UVB light, which is subsequently released as heat.
This procedure aids in stopping UVB rays from damaging the skin by preventing penetration.
Because octinoxate is a lipophilic molecule, which means it is oil-soluble and may permeate the skin, it is good at blocking UVB light.
This quality enables it to offer durable protection against UVB rays, even when exposed to moisture or perspiration.
It's crucial to remember that UVA radiation, which can potentially cause skin damage and increase the risk of skin cancer, is not shielded by octinoxate.
This is why it's crucial to use a broad-spectrum sunscreen that shields the skin from UVA and UVB rays.
PHYSICAL and CHEMICAL PROPERTIES of OCTINOXATE:
Compound Is Canonicalized: Yes
CAS Number: 5466-77-3
EC Number: 226-775-7
Molecular Formula: C₁₈H₂₆O₃
Molecular Weight: 290.40 g/mol
Appearance: Colorless to pale yellow viscous liquid
XLogP3-AA: 5.3
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 10
Exact Mass: 290.18819469 Da
Monoisotopic Mass: 290.18819469 Da
Topological Polar Surface Area: 35.5 Ų
Heavy Atom Count: 21
Formal Charge: 0
Complexity: 304
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 1
Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
CAS Number: 5466-77-3
Product Name: Octinoxate
IUPAC Name: 2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate
Molecular Formula: C18H26O3
Molecular Weight: 290.4 g/mol
InChI: InChI=1S/C18H26O3/c1-4-6-7-15(5-2)14-21-18(19)13-10-16-8-11-17(20-3)12-9-16/h8-13,15H,4-7,14H2,1-3H3/b13-10+
InChI Key: YBGZDTIWKVFICR-JLHYYAGUSA-N
SMILES: CCCCC(CC)COC(=O)C=CC1=CC=C(C=C1)OC
Canonical SMILES: CCCCC(CC)COC(=O)C=CC1=CC=C(C=C1)OC
Isomeric SMILES: CCCCC(CC)COC(=O)/C=C/C1=CC=C(C=C1)OC
Melting Point: Approximately -25 °C
Boiling Point: 198–200 °C at 3 torr
Density: 1.01 g/cm³
Solubility: Insoluble in water; soluble in oil and organic solvents
Empirical Formula (Hill Notation): C18H26O3
Beilstein: 5946632
EC Number: 226-775-7
MDL number: MFCD00072582
UNSPSC Code: 41116107
PubChem Substance ID: 329823103
NACRES: NA.24
Physical State: Liquid
Color: No data available
Odor: No data available
Melting Point/Freezing Point: < -25 °C
Initial Boiling Point and Boiling Range: 140 - 150 °C at 0.1 hPa
Flammability (Solid, Gas): No data available
Upper/Lower Flammability or Explosive Limits: No data available
Flash Point: 193 °C - DIN 51758
Autoignition Temperature: No data available
Decomposition Temperature: No data available
pH: No data available
Viscosity:
Viscosity, Kinematic: No data available
Viscosity, Dynamic: No data available
Water Solubility: 0.0002 g/l at 20 °C
Partition Coefficient: n-octanol/water: log Pow: 6.1 -
Potential bioaccumulation (External MSDS)
Vapor Pressure: No data available
Density: 1.005 - 1.013 g/cm³ at 25 °C
Relative Density: No data available
Relative Vapor Density: No data available
Particle Characteristics: No data available
Explosive Properties: No data available
Oxidizing Properties: None
Other Safety Information: No data available
Boiling Point: 198-200°C
Melting Point: -25°C
Solubility: Insoluble in water, soluble in oil
Physical state: Viscous liquid
Color: Not available
Odor: Not available
Flammability (solid, gas): Not available
Upper/lower flammability or explosive limits: Not available
Flash Point: 193°C - DIN 51758
Autoignition temperature: Not available
Decomposition temperature: Not available
pH: Not available
Viscosity:
Kinematic viscosity: Not available
Dynamic viscosity: Not available
Water solubility: 0.0002 g/l at 20°C
Partition coefficient: n-octanol/water (log Pow): 6.1
- Indicates potential bioaccumulation
Vapor pressure: Not available
Density: 1.01 g/cm3
Relative density: Not available
Relative vapor density: Not available
Particle characteristics: Not available
Explosive properties: Not available
Oxidizing properties: None
Other safety information: Not available
Chemical Information:
Chemical formula: C18H26O3
Molar mass: 290.403 g·mol−1
Beilstein Number: 5946632
MDL: MFCD00072582
XlogP3-AA: 5.30 (estimated)
FIRST AID MEASURES of OCTINOXATE:
-Description of first-aid measures:
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Remove contact lenses.
*If swallowed:
After swallowing:
Make victim drink water (two glasses at most).
Consult doctor if feeling unwell.
-Indication of any immediate medical attention and special treatment needed:
No data available
ACCIDENTAL RELEASE MEASURES of OCTINOXATE:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up with liquid-absorbent material.
Dispose of properly.
Clean up affected area.
FIRE FIGHTING MEASURES of OCTINOXATE:
-Extinguishing media:
*Suitable extinguishing media:
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.
EXPOSURE CONTROLS/PERSONAL PROTECTION of OCTINOXATE:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Safety glasses
*Skin protection:
not required
*Respiratory protection:
Not required.
-Control of environmental exposure:
Do not let product enter drains.
HANDLING and STORAGE of OCTINOXATE:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed.
Light sensitive.
STABILITY and REACTIVITY of OCTINOXATE:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
-Incompatible materials:
No data available
