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OCTOCRYLENE

Octocrylene readily absorbs through the skin at levels about 14 times the FDA cutoff for systemic exposure. 
Octocrylene is an ester formed by the Knoevenagel condensation of 2-ethylhexyl cyanoacetate with benzophenone. 
Octocrylene has been linked to aquatic toxicity, potentially harming coral health. 

CAS Number: 6197-30-4
Molecular Formula: C24H27NO2
Molecular Weight: 361.48
EINECS Number: 228-250-8

Synonyms: Octocrylene, 6197-30-4, 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, Octocrylene, 2-ETHYLHEXYL-2-CYANO-3,3-DIPHENYLACRYLATE, 2-Propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester, 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate, 5A68WGF6WM, Octocrylene [INN], 2-Cyano-3,3-diphenylacrylic Acid 2-Ethylhexyl Ester, NSC-760433, MLS002454364, DTXSID9025299, Octocrylene (INN), Parsol 340, UV-3039, NCGC00091585-03, NCGC00091585-05, ANTHELIOS SX COMPONENT OCTOCRYLENE, SMR001371988, CAPITAL SOLEIL COMPONENT OCTOCRYLENE, OCTOCRYLENE (MART.), OCTOCRYLENE [MART.], 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate, 97%, OCTOCRYLENE (USP-RS), OCTOCRYLENE [USP-RS], DTXCID205299, Octocrylene [USAN], Octocrileno, Octocrilenum, OCTOCRYLENE (USP IMPURITY), OCTOCRYLENE [USP IMPURITY], OCTOCRYLENE (USP MONOGRAPH), OCTOCRYLENE [USP MONOGRAPH], Octocrilenum [INN-Latin], Octocrileno [INN-Spanish], UV Absorber-3, CAS-6197-30-4, CCRIS 4814, EINECS 228-250-8, Octocrylene [USAN ], UNII-5A68WGF6WM, Octocrilen, 2-Ethylhexyl 2-cyano-3,3-diphenyl-2-acrylate, 2-Ethylhexyl 2-cyano-3,3-diphenyl-2-propenoate, 2-Cyano-3,3-diphenyl-2-propenoic acid 2-ethylhexyl ester, 2-Ethylhexyl 2-cyano-3,3-diphenyl-prop-2-enoate, Octocrylene, 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate|Parsol 340, Octocrylene (USP), Neo heliopan 303, Uvinul N539, 2-ETHYLHEXYL 2-CYANO-3,3-DIPHENYL-PROP-2-ENOATE, Uvinul N-539, OCTOCRYLENE [MI], EC 228-250-8, SCHEMBL16483, Octocrylene [WHO-DD], 80135-31-5, cid_22571, Octocrylene, analytical standard, CHEMBL1201147, BDBM74416, OCTOCRYLENE [ORANGE BOOK], CHEBI:135526, GLXC-27412, HMS3039D04, AMY40810, BCP15293, HY-A0087, Octyl 2-Cyano-3,3-diphenylacrylate, Tox21_111153, Tox21_200236, 2-CYANO-3,3-DIPHENYL-2-PROPENOIC ACID, 2-ETHYLHEXYL ESTER, MFCD00059260, s1750, AKOS015900539, Tox21_111153_1, 1ST3418, AC-7027, CCG-268181, CS-4296, NSC 760433, NCGC00091585-01, NCGC00091585-04, NCGC00091585-06, NCGC00257790-01, AS-13821, 2-ethylhexyl alpha-cyano-beta-phenylcinnamate, 2-ethylhexyl-alpha-cyano-beta-phenylcinnamate, NS00010308, OCTOCRYLENE COMPONENT OF ANTHELIOS SX, OCTOCRYLENE COMPONENT OF CAPITAL SOLEIL, D05227, D70471, A833511, Q424805, SR-01000864577, Q-201499, SR-01000864577-2, 2-cyano-3,3-diphenyl-acrylic acid 2-ethylhexyl ester, 2-cyano-3,3-diphenyl-acrylic acid 2-ethyl-hexyl ester, Octocrylene, United States Pharmacopeia (USP) Reference Standard, Octocrylene, Pharmaceutical Secondary Standard, Certified Reference Material.

Octocrylene has been found in various environments, not least those of swimming pools, where it is evidently released by consumers to the point that it is now considered an emerging micropollutant similar to poly-fluoroalkyl substances (PFAS), blue-green algae, toxic fungal products, hormones, psychoactive drugs, pesticides, cosmetics, and industrial additives and drugs. 

Octocrylene is a viscous, clear, colorless oi introduced in commercial sunscreens and anti-ageing creams about 15 years ago. 
Octocrylene is the 2-ethylhexyl ester of 2-cyano-3,3-diphenylacrylic acid, with the extended conjugation of the acid portion that absorbs UVB and short-wave UVA (ultraviolet) rays, with wavelengths from 280 to 320 nm, which promote tanning but also contribute to the onset of sunburn and skin cancer. 

Octocrylene is used in various body care products, in concentrations up to 10%, to provide an adequate sun-protection factor or to protect the body care formulations themselves from UV radiation.
Octocrylene is a chemical compound commonly used in sunscreens and other cosmetic products as a UV filter. 
Its primary function is to absorb UVB and short-wave UVA rays, protecting the skin from sunburn and damage caused by ultraviolet radiation.

Octocrylene absorbs UVB rays (280–320 nm) and UVA rays (320–400 nm), which are known to cause skin aging, burns, and potentially skin cancer.
Octocrylene is valued for its photostability, meaning it does not break down easily when exposed to sunlight. 
This makes it effective in stabilizing other sunscreen ingredients, like Avobenzone, which can degrade in sunlight.

Besides its UV-filtering ability, it also has emollient properties, helping to moisturize the skin.
Apart from sunscreens, Octocrylene is found in anti-aging creams, lip balms, and hair care products.
Octocrylene can penetrate into the skin where it acts as a photosensitizer, resulting in an increased production of free radicals under illumination.

Octocrylene may also pass through the skin, into the blood stream, eventually being metabolized and excreted in urine in form of its metabolites.
Octocrylene can convert to benzophenone through a retro-aldol condensation.
The reaction occurs slowly over time, yielding significant concentration of benzophenone in all commercial cosmetics tested formulated with octocrylene.

In coral, octocrylene has been shown to accumulate in the form of fatty acid conjugates and trigger mitochondrial dysfunction.
Octocrylene is a (2-ethylhexyl)-2-cyano-3,3-diphenylacrylate. 
Acts as a liquid ultraviolet absorber (UVA). 

Particularly suitable for the stabilization of PVC-p and PVC plastisols. 
Applicable for the stabilization of PVC-p and PVC plastisols. 
Can also be used in PUR, Octocrylene and PMMA to improve the anti-aging performance of material when exposed to UV radiation.

Some individuals may experience allergic reactions, particularly those with sensitive skin or pre-existing skin conditions.
There are concerns about its effects on marine ecosystems, particularly coral reefs. 
As a result, some regions have restricted the use of certain UV filters, including Octocrylene, in sunscreens.

Octocrylene is a versatile organic compound widely used in sunscreens, cosmetics, and personal care products due to its ability to absorb ultraviolet (UV) radiation and stabilize other UV-absorbing agents. 
Octocrylene primarily absorbs UVB rays (280–320 nm) and a portion of UVA rays (320–400 nm). 
While it is effective against UVB rays, which cause sunburn, it is typically combined with other filters to provide broad-spectrum protection.

One of the unique properties of Octocrylene is its ability to stabilize other UV filters like avobenzone, which absorbs UVA rays but degrades rapidly in sunlight. 
Octocrylene helps prevent this degradation, enhancing the overall effectiveness and longevity of the sunscreen.
Octocrylene also has emollient properties, meaning it helps keep the skin hydrated by forming a barrier that reduces moisture loss. 

Additionally, Octocrylene is water-resistant, making it a common ingredient in sunscreens that are designed for prolonged outdoor activities or swimming.
In the United States, Octocrylene is approved by the Food and Drug Administration (FDA) as a safe and effective ingredient in over-the-counter (OTC) sunscreens at concentrations up to 10%. 
Similarly, it is approved by the European Union for use in sunscreens and other personal care products.

Though generally considered safe, Octocrylene can cause skin sensitivity or allergic reactions, particularly in individuals with pre-existing skin conditions like eczema or those prone to contact dermatitis. 
Studies suggest that when exposed to sunlight, Octocrylene may form reactive oxygen species (ROS), which could contribute to skin irritation.
The study suggests that octocrylene can break down to form a substance called benzophenone, which may lead to cancer. 

According to one study, benzophenone levels can increase in products over time. 
The European Commission recently concluded that although there was some evidence of octocrylene’s hormone-disrupting potential, current use concentrations of up to 10 percent were considered safe.
Octocrylene is an organic compound used as an ingredient in sunscreens and cosmetics. 

The extended conjugation of the acrylate portion of the molecule absorbs UVB and short-wave UVA (ultraviolet) rays with wavelengths from 280 to 320 nm, protecting the skin from direct DNA damage. 
The Octocrylene is a fatty alcohol, adding emollient and oil-like (water resistant) properties.
Octocrylene, unlike conventional and unconventional pollutants, are still largely unregulated by legislation and are not restricted by maximum permitted values. 

Furthermore, they are potentially dangerous for the environment and human health, even in an overall context of insufficient data linked to their dangerousness.
Octocrylene is a viscous, oily liquid that is clear and colorless.

Melting point: -10 °C (lit.)
Boiling point: 218 °C/1.5 mmHg (lit.)
Density: 1.051 g/mL at 25 °C (lit.)
vapor pressure: 0Pa at 25℃
refractive index: n20/D 1.567(lit.)
Flash point: >230 °F
storage temp.: 15-25°C
solubility: Chloroform (Slightly), Methanol (Sparingly)
form: Oil
color: Colourless to Light Yellow
Merck: 14,6756
InChIKey: FMJSMJQBSVNSBF-UHFFFAOYSA-N
LogP: 6.1 at 23℃

Octocrylene protects the skin from the harmful effects of the sun and premature skin aging. 
Octocrylene helps prevent the risk of skin cancer. 
This filter mainly absorbs UVB rays, and shorter UVA rays, which are responsible for aging but also for skin cancer.

Octocrylene is an ester derivative. Esters react with acids to liberate heat along with alcohols and acids. 
Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. 
Heat is also generated by the interaction of esters with caustic solutions. 

Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.
The IUPAC name of Octocrylene is 2-ethylhexyl 2-cyano-3,3-diphenylprop-2-enoate. 
With the CAS registry number 6197-30-4, it is also named as 2-Propenoic acid, 2-cyano-3,3-diphenyl-, 2-ethylhexyl ester.

Octocrylene's categories are cosmetic raw material; UV-Absorber; Stabilizers; Polymer Additives; Polymer Science. 
Octocrylene is clear and colorless viscous liquid which is probably combustible. 
Octocrylene is an ester formed by the condensation of a diphenyl cyanoacrylate with 2-ethylhexanol. 

When heated to decomposition it emits toxic vapors of NOx. 
Additionally, Octocrylene should be sealed in the container and stored in the cool and dry place.
Octocrylene (Octocrylene, 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate) is a highly effective oil-soluble sunscreen agent used to absorb and filter the UVA rays (320-400 nm) of the sun. 

Octocrylenes CAS number is 6197-30-4, and it is known by other names like Uvinul N539, Eusolex OCR, and Luvimer 100P. 
Octocrylene is an organic compound that is a colorless to pale yellow crystalline powder, and its molecular formula is C24H27NO2.
Octocrylene is typically soluble in organic solvents such as acetone, ethyl acetate, and ethanol. 

Octocrylene has a melting point of around 27°C to 32°C and has a density of 1.06 g/cm³. 
It is usually stable in acidic and neutral pH levels, but its stability decreases under alkaline conditions.
Octocrylene has some unique characteristics such as photostability, which describes its ability to maintain its effectiveness even when exposed to UV radiation. 

Octocrylene can also work synergistically with other UV filters like avobenzone, helping to enhance their UVA-absorbing abilities while adding to the overall SPF (Sun Protection Factor) of a sunscreen product.
Octocrylene finds wide application in cosmetics, especially in sun protection products. 
It has been used in the formulation of products that offer a broad-spectrum protection against both UVB and UVA rays, such as sunscreens, oils, lotions, and creams. 

Octocrylene is also found in some other personal care products, including facial and body moisturizers, hair sprays, and lip balms. 
Its use in personal care products is safe, and it is approved by regulation bodies such as the U.S. Food and Drug Administration and the European Union.
Octocrylene is usually packed in air-tight containers to maintain its stability and is often transported as a solid. 

Octocrylene is produced through chemical methods involving the reaction between 2-ethylhexanol and the acid chloride derivative of 3,3-diphenylacrylic acid. 
Manufacturers usually ensure that the production processes adhere to the strict standards set for the personal care industry.
Octocrylene is a highly effective chemical sunscreen agent used in a wide range of personal care products. 

Its unique properties make it an excellent candidate for sunscreens, offering broad-spectrum coverage, photostability, and synergy with other UV filters. 
Its safe use makes it a key ingredient in personal care products that help protect the skin from harmful sun rays. 
Octocrylene is manufactured under strict industry standards and transported in air-tight containers that maintain its stability.

Octocrylene is one of the key ingredients in sunscreen formulations due to its ability to absorb UV radiation and protect the skin from harmful effects like premature aging (photoaging) and skin cancer.
Octocrylene is also used in various cosmetic products, including moisturizers, anti-aging creams, foundations, and lip balms, where it provides UV protection and maintains skin hydration.
Octocrylene can be found in hair care products where it protects the hair from UV damage and helps prevent color fading.

Some people are concerned about the body’s ability to absorb octocrylene, which can present in the blood, urine, and breast milk. 
Octocrylene may promote the production of free radicals, which can damage DNA, potentially increasing the risk of melanoma. 
However, further research is necessary.

People with sensitive skin or skin conditions, such as eczema, may prefer to avoid products containing octocrylene. 
Alternatively, a person can perform a patch test before using a product containing octocrylene for the first time. 
The patch test should indicate if an individual is allergic or sensitive to an ingredient in the product.

The Food and Drug Administration (FDA) evaluated the safety of octocrylene for use in sunscreen products and found that concentrations of up to 10% are safe.
The European Scientific Committee on Consumer Safety (SCCS) also stated that octocrylene is safe in products containing concentrations of no more than 10%.
Octocrylene is a diarylmethane. 

Octocrylene is an ester formed by the condensation of a diphenylcyanoacrylate with 2-ethylhexanol, used in sunscreens and cosmetics.
Octocrylene is a uVB sunscreen with strong water-resistant properties and a rather broad-band absorption range. 

It exhibits good photostability, and is being evaluated by many companies as an effective SPF booster and waterproofing enhancer. 
This is an expensive ingredient with an  approved usage level of 7 to 10 percent in both the united States and the european union. 
Although gaining in popularity among formulators, its cost and usage level can limit use. 

In addition, some studies are indicating it may cause allergic reactions in skin with a history of photoallergy.
Octocrylene is a compound often used as an additive in sun screen, and is thought to have skin moisturizing effects because of its emollient properties. 
What makes this chemical such a popular additive to sun block, is its ability to neutralize UV radiation dissipated by sunlight, and to minimize skin damage from prolonged sun exposure. 

Uses:
Octocrylene is used as an ingredient in sunscreen and other cosmetics. 
Octocrylene can absorb UVA and UVB (absorption range 250-360nm, can block all UVB and part of UVA), which is a new generation of sunscreen agents.
It absorbs UVB rays (280–320 nm) and provides some UVA protection, preventing sunburn and reducing the risk of skin cancer.

Octocrylene is often included in sunscreens to stabilize other active ingredients, like avobenzone, which breaks down under sunlight. 
This ensures that the sunscreen remains effective for a longer time.
Octocrylene's water-resistant properties make it an important ingredient in sunscreens designed for swimming or outdoor activities.

Many daily moisturizers and anti-aging creams include Octocrylene to offer mild sun protection while keeping the skin hydrated.
As an emollient, Octocrylene helps keep the skin smooth and moisturized, making it a popular ingredient in various skincare products.
Octocrylene is used in lip balms and lipsticks to protect the delicate skin of the lips from UV damage while also helping to maintain moisture and prevent chapping.

It is included in some hair care products like shampoos and conditioners to shield the hair from UV radiation, which can cause color fading and hair damage. 
This is particularly useful in products for color-treated hair.
Some makeup products, especially foundations and primers, incorporate Octocrylene to provide additional sun protection, reducing the need for separate sunscreen.

In multi-functional beauty products like BB creams and CC creams, Octocrylene helps offer sun protection while moisturizing the skin.
Octocrylene can also be used in fragrances to stabilize the formulation and prevent the degradation of perfume compounds when exposed to sunlight.
Octocrylene is a core ingredient in broad-spectrum sunscreens, absorbing UVB and short-wave UVA rays to protect the skin from harmful sun exposure. 

It helps prevent sunburn, photoaging (skin aging caused by UV light), and the risk of skin cancer.
One of the most important functions of Octocrylene in sunscreens is its role as a photostabilizer. 
It is frequently used alongside avobenzone, a UVA filter that degrades quickly in sunlight. 

Octocrylene stabilizes avobenzone and prevents it from breaking down, ensuring that sunscreens remain effective for longer periods under sun exposure.
Octocrylene helps enhance the water resistance of sunscreen formulations, making it an essential component in products designed for water-based activities such as swimming or sports.
Many moisturizers designed for daily use include Octocrylene as part of their SPF (sun protection factor) ingredients. 

These products provide hydration and mild sun protection in a single application, ideal for everyday wear.
In addition to sun protection, Octocrylene’s emollient properties make it suitable for anti-aging creams, where it helps retain moisture and reduce the appearance of fine lines while preventing further UV-induced aging.
These multi-purpose beauty creams often incorporate Octocrylene to offer skin hydration, light coverage, and sun protection in a single product.

Octocrylene is used in lip balms, lip glosses, and lipsticks to protect the lips from UV damage. 
The lips are particularly sensitive to sun exposure, and without adequate protection, they are prone to dryness, burns, and aging.
Octocrylene's ability to retain moisture makes it ideal for lip care products, where it helps keep the lips smooth and hydrated, reducing chapping and dryness.

Hair is also susceptible to UV damage, which can cause color fading, dryness, and structural damage. 
Octocrylene is included in hair care products such as shampoos, conditioners, and leave-in treatments to provide UV protection and preserve hair health, especially for dyed or treated hair.
For individuals with color-treated hair, Octocrylene protects against the fading effects of the sun, allowing the color to last longer.

Octocrylene is a common ingredient in makeup products that provide sun protection, such as foundations, concealers, primers, and pressed powders. 
Octocrylenes often advertise an SPF rating and aim to give users UV protection without the need for an additional sunscreen layer.
These are tinted moisturizers that blend skincare and makeup in one product. 

Octocrylene contributes to the sun protection feature, allowing these creams to offer light coverage, hydration, and UV protection in a single formula.
Octocrylene is sometimes found in setting sprays or finishing powders that claim to have sun protection, offering users a lightweight option to shield their skin after makeup application.
Octocrylene is used in some fragrance formulations to prevent the breakdown of volatile compounds when exposed to sunlight. 

It helps preserve the fragrance's integrity, preventing discoloration or degradation of the perfume.
Octocrylene can be included in self-tanning lotions and sprays to provide some level of UV protection while enhancing the longevity and appearance of the sunless tan.
After-sun products, such as lotions or creams designed to soothe and hydrate the skin after sun exposure, may contain Octocrylene to provide ongoing protection from UV radiation while moisturizing the skin.

In dermatology, Octocrylene is incorporated into specialized creams or treatments that require sun protection. 
Octocrylene is often found in products used to treat conditions like melasma, where sun protection is critical for managing hyperpigmentation.
Some medical dressings or bandages designed for sensitive areas of the skin include Octocrylene to prevent sun exposure and protect healing skin from UV damage.

Beyond personal care products, Octocrylene can be used in the manufacturing of plastics and coatings as a UV stabilizer. 
Octocrylene helps prevent the degradation of polymers when exposed to sunlight, prolonging the lifespan and appearance of products made from materials like plastics, rubber, or synthetic fibers.
Offers solid protection against UVB and short-wave UVA radiation.

Enhances the photostability of other UV filters, particularly avobenzone, ensuring the longevity and efficacy of sunscreens and cosmetics.
Its emollient properties help maintain skin hydration, making it a beneficial ingredient in products for dry or sensitive skin.
Contributes to the water resistance of sunscreens and skincare products, ensuring they remain effective during activities like swimming or sweating.

Some individuals with sensitive skin may experience allergic reactions, such as redness or irritation, particularly if exposed to high concentrations.
Like other chemical UV filters, Octocrylene has been scrutinized for its impact on marine life, particularly coral reefs. 
This has led to regulatory actions in places like Hawaii, where it is banned in certain sunscreens.

There is ongoing research into the potential for Octocrylene to act as an endocrine disruptor, which means it might interfere with the body’s hormonal systems. 
Octocrylene is an ingredient used in sunscreens for its ability to absorb UV rays, protecting the skin from sun damage. 
Octocrylene is chemically related to cinnamates. It can be used to boost SPF and improve water resistance in a given formulation. 

Octocrylene is photostable and can improve the photostability of other sunscreens. 
It is expensive and can present difficulties in formulation.
Octocrylene is used as ultraviolet absorber in plastics, paints and dyes. 

And Octocrylene is also used as an ingredient in sunscreens and cosmetics that is protecting the skin from direct DNA damage. 
Octocrylene can penetrate into the skin where it acts as a photosensitizer.
People can use the following data to convert to the molecule structure. 

Safety Profile:
Some studies suggest that Octocrylene may act as an endocrine disruptor, meaning it could interfere with the body's hormonal systems. 
Endocrine disruptors are chemicals that mimic or block hormones and disrupt the body’s normal functions.
Some individuals, especially those with sensitive skin or pre-existing skin conditions like eczema, may experience allergic reactions to Octocrylene. 

Symptoms can include redness, itching, swelling, and rash at the site of application.
When exposed to sunlight, Octocrylene can react with the skin and cause photodermatitis, a condition where the skin becomes inflamed due to a reaction between UV light and the chemical on the skin.


 

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