PRODUCTS

OCTOPIROX (ANTIDANDRUFF)

Octopirox (antidandruff) is used anti-dandruff/anti-itch: Shampoo, conditioner, scalp tonic, cream rinse
Octopirox (antidandruff) is used deodorants: Roll-on, spray, foot deodorant cream, stick
Octopirox (antidandruff) is used anti-acne products: Gel, lotion, cleanser

CAS Number: 68890-66-4
EC Number: 272-574-2
Chem/IUPAC Name: 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
Empirical Formula (Hill Notation): C14H23NO2 · C2H7NO
Molecular Formula: C16H30N2O3
Molar mass: ~ 298.43 g/mol

SYNONYMS:
Piroctone Olamine, Octopirox, Piroctone ethanolamine salt, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone monoethanolamine, Piroctone oleamine, Pyridine-amino ethanol, Octopiroxolamine, Piroctone Olamine, 68890-66-4, Octopirox, Kopirox, Piroctone Ethanolamine, Octopyrox, Piroctoneolamine, Piroctone Ethanolamine Salt, Piroctone Olamine [USAN], UNII-A4V5C6R9FB, EINECS 272-574-2, A4V5C6R9FB, 2-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one, NSC-759894, Piroctone Ethanolamine Salt (1:1), EC 272-574-2, NSC 759894, Piroctone Olamine (USAN), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)pyridinone, 2-aminoethanol salt, PIROCTONE OLAMINE (MART.), PIROCTONE OLAMINE [MART.], PIROCTONE OLAMINE (USP-RS), PIROCTONE OLAMINE [USP-RS], 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)-2-PYRIDONE MONOETHANOLAMINE, (+/-)-, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt, DTXCID2026735, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethan-1-ol (1:1), Allermyl, Keratolux, Octopirox (TN), SCHEMBL2843, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one compound with 2-aminoethanol (1:1), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1), 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compound with 2-aminoethanol (1:1), CHEMBL2107154, BTSZTGGZJQFALU-UHFFFAOYSA-N, AMY40819, BCP29912, HY-B1345, MFCD01690792, s5213, Piroctone Olamine, Analytical Standard, AKOS025149526, CCG-267454, CS-7659, PIROCTONE ETHANOLAMINE [WHO-DD], AS-15254, P2178, D05505, Piroctone Ethanolamine Salt; Octopirox; Kopirox, PIROCTONE ETHANOLAMINE SALT (1:1) [MI], A836281, Q412572, W-104652, 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine, Piroctone Olamine, United States Pharmacopeia (USP) Reference Standard, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol, 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt, EcoGard, POOctopirox, Piroctone Olamine, Ethanol, 2-amino-, compd. with 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1) (9CI), 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-pyridone monoethanolamine salt, Octopirox, Octopyrox, Piroctone Ethanolamine Salt, Piroctone Olamine, piroctone olamine, 1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one-2-aminoethanol (1:1), 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1), 2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1), 4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon, octopiroxolamine, 1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt, Octopirox, Pyridine-amino ethanol

Octopirox (antidandruff) is an effective, practically nontoxic antidandruff active ingredient.
Octopirox (antidandruff) is particularly suitable for the manufacture of antidandruff shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.

Octopirox (antidandruff) is one of the most efficient anti-dandruff actives available on the market today.
Octopirox (antidandruff) is a highly effective anti-dandruff and antimicrobial agent.
Octopirox (antidandruff) has low aquatic toxicity and broad-spectrum preservation.

Octopirox (antidandruff) is sensitive towards UV light and might be decomposed depending on the amount of irradiation.
Octopirox (antidandruff) gives clear, transparent, pH- and temperature stable formulation.
Octopirox (antidandruff) has a shelf life of 5 years.

Octopirox (antidandruff) (INCI: Piroctone Olamine) is a nontoxic antidandruff active ingredient which is particularly suitable for the manufacture of hair care products such as shampoos and hair care products such as hair tonics and cream rinses with an antidandruff action.
Octopirox (antidandruff) is extremely easy to formulate, enabling stable formulations with no effort.

Octopirox (antidandruff) controls the growth of microorganisms effectively and is directly targeting the cause of dandruff.
Octopirox (antidandruff), whose chemical name is zinc pyrithione, is an active ingredient found in certain dermatological and cosmetic products, especially in shampoos and creams designed to treat scalp and hair issues.

Octopirox (antidandruff) is a well-known Piroctone Olamine, which has a high antibacterial and antimicrobial activity, but shows a low level of toxicity and environmental pollution compared to the same Zinc pyrithione.
In cosmetics Octopirox (antidandruff) acts as a highly effective antiperspirant and anti-acne active additive, is used for the treatment and prevention of acne, has a wide range of activity not only against fungi and yeasts, but also against bacteria.

USES and APPLICATIONS of OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff) is widely used in anti‐dandruff shampoos and other scalp‐care products: e.g., marketed under the brand name Octopirox (antidandruff) as a potent anti‐dandruff/antimicrobial active in shampoos, conditioners, scalp tonics.
Octopirox (antidandruff) is also used for hair care products (cream rinses), scalp treatment, and in some cases as a preservative in cosmetic products (broad‐spectrum preservation) according to technical data.

Designed specifically to treat seborrheic dermatitis and dry scalp, piroctone olamine offers additional benefits: Octopirox (antidandruff) is environmentally friendly, multifunctional (doubles as preserving agent), and can be used in various cosmetic formats.
Applications of Octopirox (antidandruff): Shampoo, Hair Conditioner, hair Styling, Antiperspirant & Deodorant.

Octopirox (antidandruff) is an environmental friendly and multifunctional (doubles as a preserving agent).
Octopirox (antidandruff) can be used together with most cationic surfactants and active ingredients.
Octopirox (antidandruff) is present as free acid in neutral solutions and is chemically stable over a wide pH range.

Octopirox (antidandruff) is compatible with most surfactants, additives and active ingredients.
Octopirox (antidandruff) is gentle on the scalp and causes no flake and itching.
Octopirox (antidandruff) is suitable for shampoo, conditioner, scalp tonic, cream rinse and hair styling products.

Octopirox (antidandruff) is recommended for roll-on, spray, foot deodorant cream and stick.
Octopirox (antidandruff) can also be used in anti-acne products such as gel, lotion and cleanser.

Its effects include: Antifungal effects: Octopirox (antidandruff) can suppress the growth and multiplication of yeasts and fungi on the scalp, which can improve the condition of people suffering from dandruff and seborrheic dermatitis, conditions often associated with excessive yeast production.

Antibacterial effects: Zinc pyrithione also possesses antibacterial properties that can help reduce the proliferation of bacteria on the scalp.
This is particularly useful for individuals experiencing itching and inflammation associated with bacterial infections.
Dandruff reduction: Octopirox (antidandruff) helps limit dandruff formation on the scalp by regulating excessive sebum production and preventing flaking.

Relief from itching: Octopirox (antidandruff) can also assist in alleviating itching associated with skin conditions and scalp issues.
Octopirox (antidandruff) is considered a safe ingredient and is commonly used in a range of hair care and scalp products when used following recommended procedures and dosages.

Betula pendula leaf extract is an extract from the leaves of the silver birch tree that has several mechanisms of action on the skin in cosmetic and dermatological products: Anti-inflammatory effects: This extract can help alleviate inflammatory conditions on the skin and reduce irritation.

Antioxidant effects: Octopirox (antidandruff) contains substances with antioxidant properties that protect the skin from free radicals and help maintain its youthful appearance.
Skin moisturization: Silver birch leaf extract can contribute to skin hydration, improving its texture and elasticity.

Octopirox (antidandruff) is frequently used in cosmetic products aimed at rejuvenating and enhancing the skin and may be part of skincare and body care products.
Peculiarities of application of Octopirox (antidandruff): the component is stable at pH of the finished product from 3.0 to 9.0 and at temperatures up to 80 °C.

Octopirox (antidandruff) solubility depends significantly on pH.
In aqueous formulations, its solubility is greater in neutral and slightly alkaline environments than in acidic ones.
The pH value has a significant effect on the solubility of Octopirox (antidandruff) in surfactants.
The solubility in most surfactants increases in the pH range from 5 to 8.

ANTIBACTERIAL ACTIVITY of OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff) is a highly effective fungicide and antiperspirant active ingredient that has been used in the cosmetic industry for over 30 years.
It has a high level of antimicrobial activity, expressed as the minimum inhibitory concentration (MIC) of Octopirox (antidandruff) for most known Gram-positive and Gram-negative bacteria.

Pyroctonolamine or trade name Octopirox (antidandruff) is one of the most effective and non-toxic anti-dandruff agents on the market today.
Specifically formulated to treat dandruff, seborrheic dermatitis and dry scalp, Octopirox (antidandruff) has many benefits:
environmentally friendly
multifunctional (also acts as a co-preservative)

Octopirox (antidandruff) can be used in various cosmetics (including antibacterial soaps or cosmetics for problem skin).
Octopirox (antidandruff) helps to get rid of dandruff and scales on the scalp, eliminates itching, but it acts gently and does not irritate the skin.
Octopirox (antidandruff) is widely used in anti-dandruff shampoos as well as in hair care products such as toners and conditioners.

CHARACTERISTICS & BENEFITS of OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff) has strong antifungal and antimicrobial properties (especially against Malassezia spp., key in dandruff).

One summary:
“Octopirox (antidandruff) is one of the most efficient anti‐dandruff actives available on the market today.”
Octopirox (antidandruff) is described as gentle on the scalp, helping reduce flakes, itching, and maintaining scalp health.

Additional benefit:
Octopirox (antidandruff) has low aquatic toxicity (per manufacturer data) and compatibility with clear/transparent formulations, stability over wide pH and temperatures, ability to function with cationic surfactants, etc.

WHAT IS OCTOPIROX (ANTIDANDRUFF) USED FOR?
Octopirox (antidandruff) is quite beneficial in maintaining cosmetic and personal care products.
Octopirox (antidandruff) can commonly be found in products like shampoos, cleansers, and hair masks.

*Skin care:
Octopirox (antidandruff) can be used to eliminate the bad odor from the surface of the skin.
Octopirox (antidandruff) is a great preservative that helps in keeping skin care products free from bacterial growth

*Hair care:
Octopirox (antidandruff) is one of the most common 'anti-dandruff' ingredients that is added to hair care products.
Octopirox (antidandruff) is also good for preventing hair loss and split ends

*Cosmetic products:
In cosmetic products, Octopirox (antidandruff) makes use of its antifungal properties to keep the products free from unwanted bacterial growth for a longer time.
The addition of Octopirox (antidandruff) improves the quality of the products and makes them last longer

ORIGIN OF OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff) is basically an ethanolamine salt that is derived from Piroctone - which is a derivative of hydroxamic acid.
Octopirox (antidandruff) appears as a crystalline white powder with a faint distinctive odor.

WHAT DOES OCTOPIROX (ANTIDANDRUFF) DO IN A FORMULATION?
*Antimicrobial
*Preservative

SAFETY PROFILE of OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff) is safe for use when added under the recommended percentage usage - 0.1% for rinse-off products and 0.5% for leave-on products.
Octopirox (antidandruff) suits all skin and hair types, however, a patch test should be performed before full application.
Lastly, Octopirox (antidandruff) is not used in organic products because it is a chemical preservative.

ALTERNATIVES of OCTOPIROX (ANTIDANDRUFF):
*ZINC PYRITHIONE

SOLUBILITY of OCTOPIROX (ANTIDANDRUFF):
in water, alcohol, aqueous solutions of surfactants
is well soluble in alcohol (10%),
soluble in aqueous solutions of surfactants
is soluble in mixtures of water/alcohol (1-10%)
is slightly soluble in water (about 0,05%)
and oils (0,05 - 0,1%).

PERFORMANCE CLAIMS of OCTOPIROX (ANTIDANDRUFF):
*Anti-dandruff
*Scalp Care
*Enables clear formulations
*Broad Spectrum Preservation

BENEFITS of OCTOPIROX (ANTIDANDRUFF):
*Scalp Care Benefits
*Dandruff- and flake-free
*Itch-free
*Gentle on scalp
*Low aquatic toxicity (no labeling required)
*Broad-spectrum preservation

FORMULATION FEATURES of OCTOPIROX (ANTIDANDRUFF):
*Transparent formulation
*Easy to formulate
*pH- and temperature stable

PREPARE of OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff)/water mixture, disperse and add to the surfactant mixture, then heat up
Octopirox (antidandruff)/water mixture and heat to about 80°C with stirring, then cool and add to surfactant mixture.

DISSOLVE of OCTOPIROX (ANTIDANDRUFF):
Octopirox (antidandruff) in alcohol (propylene glycol) and add to the surfactant mixture.
when preparing an emulsion, add Octopirox (antidandruff) to the oil phase together with the emulsifier.
It is not recommended to add Octopirox (antidandruff) to surfactants without prior dissolution, this may lead to clumping and slower dissolution.

STORAGE of OCTOPIROX (ANTIDANDRUFF):
in a tightly closed container in a dry dark place at a temperature not exceeding 25˚C.
Keep Octopirox (antidandruff) out of direct sunlight.

PHYSICAL and CHEMICAL PROPERTIES of OCTOPIROX (ANTIDANDRUFF):
Appearance: White to faintly yellowish white crystalline powder.
Odour: Faint characteristic odour.
Melting point: ~ 130-135 °C.
Density: ~ 1.1 g/cm³ at 20 °C (approx value) in one
Solubility: Practically insoluble in water, soluble in alcohol/organic solvents.
Other physico‐chemical data: Log P approx 1.05-3.86 at 20-25 °C according to one source.
Melting point 134-138 °C; flash point ~161.9 °C.
Stability / Behaviour: Designed for use in surfactant systems, stable in shampoos etc;
sensitive toward UV light per one data sheet
CAS Number: 68890-66-4
EC Number: 272-574-2
INCI Name (for cosmetics): Piroctone Olamine (active ingredient name)

Molecular formula: C₁₆H₃₀N₂O₃ (salt form)
Molar mass: ~ 298.43 g/mol
Water Solubility: 0.351 mg/mL
logP: 3.77
logS: -2.8
pKa (Strongest Acidic): 6.87
pKa (Strongest Basic): -6.4
Physiological Charge: -1
Hydrogen Acceptor Count: 2
Hydrogen Donor Count: 1
Polar Surface Area: 40.54 Å²

Rotatable Bond Count: 5
Refractivity: 71.81 m³·mol⁻¹
Polarizability: 27.69 Å³
Number of Rings: 1
Bioavailability: 1
Rule of Five: Yes
Ghose Filter: Yes
Veber's Rule: No
MDDR-like Rule: No

Physical State: Solid
Storage: Store at 4°C
Melting Point: 130-136°C
MDL Number: MFCD01690792
Molecular Weight: 298.4267 g/mol
Chemical Formula: C16H30N2O3
Assay: 95.00 to 100.00%
Food Chemicals Codex Listed: No
Boiling Point: 344.10°C at 760.00 mm Hg (estimated)

Vapor Pressure: 0.000004 mmHg at 25.00°C (estimated)
Flash Point: 323.00°F TCC (161.90°C) (estimated)
logP (o/w): 3.696 (estimated)
Soluble in: water, 18.75 mg/L at 25°C (estimated)
Boiling Point: 344.1°C
Melting Point: 130-135°C
pH: 8.5-10.0
Solubility: Slightly soluble in water
Molecular Weight: 298.42 g/mol
Hydrogen Bond Donor Count: 3

Hydrogen Bond Acceptor Count: 4
Rotatable Bond Count: 5
Topological Polar Surface Area: 86.8Å²
Physical State: Powder
Color: White
Odor: Weak
Melting Point/Freezing Point: 132°C at 1.013 hPa
Initial Boiling Point and Boiling Range: 130-135°C (ECHA)
Flash Point: 161.9°C Pensky-Martens closed cup

Autoignition Temperature: >430°C at 1.013 hPa
pH: 8.5 at 25°C (saturated solution)
Water Solubility: Approximately 0.0298 g/l at 20°C - slightly soluble
Partition Coefficient (n-Octanol/Water): Log Pow: 3.86 at 20.5°C
Vapor Pressure: <0.1 hPa at 20°C
Density: 1.1 g/cm³ at 21.5°C
Relative Density: 1.1 at 21.5°C
Chemical Name: Piroctone ethanolamine
CAS No.: 68890-66-4

EINECS No.: 272-574-2
Molecular Formula: C14H23NO2·C2H7NO
Molecular Weight: 298.4 g/mol
Appearance: White or slightly yellow crystalline powder
Purity (HPLC): ≥99.0%
PH Value (1% aqueous suspension, 20°C): 9.0-10.0
Melting Point (ºC): 133-136°C
Weight Average: 298.427
Monoisotopic: 298.225642834
Chemical Formula: C16H30N2O3

InChI Key: BTSZTGGZJQFALU-UHFFFAOYSA-N
InChI: InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
IUPAC Name: 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-1,2-dihydropyridin-2-one; 2-aminoethan-1-ol
SMILES: NCCO.CC(CC1=CC(C)=CC(=O)N1O)CC(C)(C)C
CAS No.: 68890-66-4
EINECS No.: 272-574-2
Molecular Weight: 298.421
Molecular Formula:C16H30N2O3
Boiling Point(℃):344.1°C at 760 mmHg
Flash Point(℃):161.9°C

FIRST AID MEASURES of OCTOPIROX (ANTIDANDRUFF):
-Description of first-aid measures:
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation:
Fresh air.
*In case of skin contact:
Take off immediately all contaminated clothing.
Rinse skin with water/ shower.
*In case of eye contact:
After eye contact:
Rinse out with plenty of water.
Immediately call in ophthalmologist.
Remove contact lenses.
*If swallowed:
After swallowing:
Immediately make victim drink water (two glasses at most).
Consult a physician.
-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of OCTOPIROX (ANTIDANDRUFF):
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains.
Collect, bind, and pump off spills.
Observe possible material restrictions.
Take up dry.
Dispose of properly.
Clean up affected area.

FIRE FIGHTING MEASURES of OCTOPIROX (ANTIDANDRUFF):
-Extinguishing media:
*Suitable extinguishing media:
Water
Foam
Carbon dioxide (CO2)
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Suppress (knock down) gases/vapors/mists with a water spray jet.
Prevent fire extinguishing water from contaminating surface water or the ground water system

EXPOSURE CONTROLS/PERSONAL PROTECTION of OCTOPIROX (ANTIDANDRUFF):
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection.
Tightly fitting safety goggles
*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter type P2
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of OCTOPIROX (ANTIDANDRUFF):
-Conditions for safe storage, including any incompatibilities:
*Storage conditions.
Tightly closed.
Dry.

STABILITY and REACTIVITY of OCTOPIROX (ANTIDANDRUFF):
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature).