OCTYL METHOXYCINNAMATE

Octyl methoxycinnamate is a cinnamate ester.
Octyl methoxycinnamate is an ester formed from methoxycinnamic acid and 2-ethylhexanol. 
Octyl methoxycinnamate is a liquid that is insoluble in water.

CAS Number: 5466-77-3
Molecular Formula: C18H26O3
Molecular Weight: 290.4
EINECS Number: 226-775-7

Synonyms: Octinoxate, 5466-77-3, 83834-59-7, 2-Ethylhexyl 4-methoxycinnamate, Parsol MCX, Parsol MOX, Parsol, 2-Ethylhexyl-p-methoxycinnamate, 4-Methoxycinnamic Acid 2-Ethylhexyl Ester, 2-Ethylhexyl p-methoxycinnamate, Octyl methoxycinnamate, 2-Ethylhexyl trans-4-methoxycinnamate, Escalol 557, (E)-2-Ethylhexyl 3-(4-methoxyphenyl)acrylate, Uvinul MC80, Ethylhexyl p-methoxycinnamate, Heliopan New, 2-Ethylhexyl 3-(4-methoxyphenyl)acrylate, (E)-Octinoxate, Ethylhexyl methoxycinnamate, Uvinul MC 80, Ocinoxate, Eusolex 2292, Jeescreen omc, Solarom omc, Neo heliopan AV, 2-ethylhexyl (E)-3-(4-methoxyphenyl)prop-2-enoate, UNII-4Y5P7MUD51, Escalol 557nb, Uvinul mc 80n, Escalol 557t, Uvinul mc 90, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, 4Y5P7MUD51, Sunscreen AV, Eusolex uv-pearls omc, Sun caps 664, Octyl p-Methoxycinnamate, NSC-26466, Octyl 4-methoxycinnamic acid, DTXCID905302, DTXSID1025302, DTXSID9047205, CHEBI:88667, EC 629-661-9, 2-Propenoic acid, 3-(4-methoxyphenyl)-, 2-ethylhexyl ester, (2E)-, 2-Ethylhexyl methoxycinnamate, octylmethoxycinnamate, 2-Ethylhexyl |trans|-4-methoxycinnamate, NCGC00160623-01, SHADE UVAGUARD COMPONENT OCTINOXATE, NSC 26466, OCTINOXATE (MART.), OCTINOXATE [MART.], OCTINOXATE (USP-RS), OCTINOXATE [USP-RS], Octinoxate [USAN], Parsol mcx-sa, OCTINOXATE (USP MONOGRAPH), OCTINOXATE [USP MONOGRAPH], CAS-5466-77-3, octyl-methoxycinnamate, (E)-Octyl methoxycinnamate, octinoxato, octinoxatum, Foundation, CalciumRepair, ExpressionMarine, Healthy Makeup, RetinC, sunscreen sprays, Anti AgingStar, VitaK, Alix Avien, octinoxate powder, RegemarineExtreme, HydromarineExtreme, Silky FinishFluid, La Creme Plus, Octinoxate 6%, SeborrheicPurifying, Beyond ColorLipcolor, Octinoxate 6.0%, Surf Bay Lip Balm, ultra color absolute, LBelSupremacie Teint, Parsol (TN), Beautiful Eyes Cream, Bebak Sun Protection, Hyaluronic FillerSerum, Premium Age Protector, The Healthy Foundation, UvinulT MC 80 N, 2-ethylhexyl 3-(4-methoxyphenyl)-2-propenoate, PERFECT BUSTBODY, Long Last Makeup 00, Long Last Makeup 01, Long Last Makeup 03, Long Last Makeup 05, Neo heliopan, type AV, UV Shield SPF 42, Garnier Skin Active BB, Octinoxate (USP/INN), ethylhexl methoxycinnamate, DR. IASO, Flormar BB BB01 Fair, OCTINOXATE [INN], Optimal Tinted Complexion, Flormar BB BB03 Light, OCTINOXATE [HSDB], UV MILD SUN BLOCK, Alix AvienVegan CC Cream, Camouflage Concealer Cream, Intervene Makeup SPF 15, OCTINOXATE [VANDF], Detoxifying Day Cream Rich, Beyond ColorLip Conditioner, Satin SatisfactionLip Color, Ultra Color RichCool Bliss, 2-Power Fabric SPF 25, All Hours Primer SPF 18, Cover Cream. Sun protection, CRYSTAL MIRACLE MULTI, OCTINOXATE [WHO-DD], SCHEMBL15609, Beyond ColorPlumping Lipcolor, Healthy MakeupLip Conditioner, Skin Recovery Face SPF 15, Detoxifying Day Cream Regular, Flormar CC 02 Anti Redness, Flormar CC 04 Anti Fatigue, MLS004773966, Flormar BB BB02 Fair Light, Kroger Dark Tanning OilSPF 4, MACSELECT TINT SPF 15, 2-ethylhexyl (2E)-3-(4-methoxyphenyl)prop-2-enoate, Flormar Mattifying BB 01 Fair, SELECTSPF 15 FOUNDATION, CHEMBL1200608, DTXCID0028119, Ethylhexyl Methoxycinnamate cream, OCTINOXATE [ORANGE BOOK], TREATMENT LIPSHINESPF 15, Alix AvienVegan Matte Foundation, Flormar Mattifying BB 03 Light, HY-B1234A, Rimmel BB Cream Beauty BalmDark, Tanning Sunscreen SPF 4Daylogic, Top Secrets BB Primer SPF 25, 3-(4-Methoxyphenyl)-2-propenoic acid 2-ethylhexyl ester, D02BA02, Balm with Natural Butters SPF15, Rimmel BB Cream Beauty BalmLight, Flormar CC 03 Anti Dark Circles, Pretty by Flormar BB 001 Light, Rimmel BB Cream Beauty BalmMedium, Ultra Color RichMoisture Seduction, 4-Methoxycinnamic Acid Octyl Ester, Bain de SoleilOrange Gelee SPF 4, FIRMING AND MOISTURIZINGBODY, Maquillaje Liquido Maxima Cobertura, MINERALIZE FOUNDATIONSPF 15, OCTYL METHOXYCINNAMATE [MI], STUDIO MOISTURE TINTSPF 15, HY-B1234, NSC26466, TRACELESSSKIN RESPONSIVE TINT, Beyond ColorPlumping Lip Conditioner, Intervene Makeup SPF 15 Soft Sand, p-Methoxyzimtsaure-2-ethylhexylester, Tox21_111942, Tox21_201327, Tox21_302576, Intervene Makeup SPF 15 Soft Beige, Intervene Makeup SPF 15 Soft Cocoa, Intervene Makeup SPF 15 Soft Honey, Intervene Makeup SPF 15 Soft Shell, Intervene Makeup SPF 15 Soft Toast, Intervene Makeup SPF 15 Soft Wheat, Mattifying Facial SPF 15 Oily Skin, MFCD00072582, s5320, Flormar Mattifying BB 02 Fair Light, OCTYL METHOXYCINNAMATE [VANDF], AKOS015838519, Intervene Makeup SPF 15 Soft Bisque, Intervene Makeup SPF 15 Soft Bronze, Intervene Makeup SPF 15 Soft Toffee, MOISTURE RICH FOUNDATIONSPF 15, Tox21_111942_1, 1ST3409, 2-Ethylhexyl 4-methoxycinnamate, 98%, CCG-267384, CS-4732, DB09496, Rimmel BB Cream Beauty BalmVery Light, ETHYLHEXYL METHOXYCI NNAMATE Cream, Intervene Makeup SPF 15 Soft Sunbeige, Long Last Make UP 02 (Neo Heliopan), MACHYPER REAL SPF 15 FOUNDATION, 2-Ethylhexyl (trans)-4-methoxycinnamate, FACE IT AQUA TINTED32800420, FACE IT AQUA TINTED32800421, Flormar Smooth Touch Foundation 10 Sand, Intervene Makeup SPF 15 Soft Porcelain, NARS AFTERGLOW LIP BALM CLEAN CUT, NCGC00160623-02, NCGC00160623-03, NCGC00160623-04, NCGC00181309-01, NCGC00256897-01, NCGC00258879-01, AS-11708, Flormar Smooth Touch Foundation 04 Ivory, Flormar Smooth Touch Foundation 06 Beige, Flormar Smooth Touch Foundation 11 Honey, Flormar Smooth Touch Foundation 12 Amber, Garnier Skin Renew Miracle Skin Perfector, GR LONGSTAY Matte Face Powder SPF 15, High Protection Sun Air Spray SPF50 PA, Hydrating Facial Cream SPF 15 Dry Skin, Hydrating Facial SPF 15 Mix Normal Skin, Pretty by Flormar BB 005 Natural Beige, SHISEIDO PROTECTIVE LIP CONDITIONER, SMR001550370, TONYMOLY KISS KISS LIP ESSENCE BALM, CAS-83834-59-7, Flormar Smooth Touch Foundation 13 Caramel, FUTURIST AGE RESISTING MAKEUPSPF 15, MICRO RETOUCHINGBLUR COMPACT SPF 50, TOM FORD TRACELESS FOUNDATIONSPF 15, 2-Ethylhexyl trans-4-methoxycinnamate, 98%, 2BENEFIANCE PROTECTIVE HAND REVITALIZER, CS-0031468, ETHYLHEXYL P-METHOXYCINNAMATE [VANDF], M1082, NS00013675, OCTINOXATE COMPONENT OF SHADE UVAGUARD, True Color Flawless Liquid Foundation SPF15, (E)-2-Ethylhexyl3-(4-methoxyphenyl)acrylate, Ceramide Time Complex Moisture Cream SPF 15, DOUBLE MATTEOIL CONTROL MAKEUP SPF 15, Dr. C. Tuna Sun 6 SPF Tan and Care Carrot, ESIKAHydrated Face Makeup Foundation SPF 15, Flormar Smooth Touch Foundation 01 Porcelain, Skin Caviar Foundation Sunscreen SPF 15-Buff, True Color Ideal Nude Matte Foundation SPF20, D05225, D95744, Flormar Perfect Coverage Foundation 115 Toffee, Flormar Smooth Touch Foundation 03 Light Ivory, Flormar Smooth Touch Foundation 05 Soft Beige, Skin Caviar Foundation Sunscreen SPF 15-Mocha, Skin Caviar Foundation Sunscreen SPF 15-Peche, Skin Caviar Foundation Sunscreen SPF 15-Petal, VIRTUAL SKINSUPER NATURAL FINISH SPF 10, Flormar Smooth Touch Foundation 09 Golden Beige, Flormar Smooth Touch Foundation 14 Dark Caramel, P-METHOXYCINNAMIC ACID 2-ETHYLHEXYL ESTER, Pretty by Flormar Cover up Foundation 004 Ivory, Pretty by Flormar Cover up Foundation 006 Beige, Pretty by Flormar Cover up Foundation 010 Sand, Pretty by Flormar Cover up Foundation 011 Honey, Pretty by Flormar Cover up Foundation 012 Amber, A840663, CLE DE PEAU BEAUTE RADIANT FOUNDATIONBEIGE, CLE DE PEAU BEAUTE RADIANT FOUNDATIONIVORY, CLE DE PEAU BEAUTE RADIANT FOUNDATIONMOCHA, CLE DE PEAU BEAUTE RADIANT FOUNDATIONOCHER, EN300-22794950, Flawless Finish Bare Perfection Makeup SPF 8 Buff, Flawless Finish Bare Perfection Makeup SPF 8 Fawn, Flormar Smooth Touch Foundation 02 Pink Porcelain, Flormar Smooth Touch Foundation 07 Golden Neutral, MICRO RETOUCHINGN203 NATURAL BEIGE SPF50, Pretty by Flormar Mattifying Foundation 004 Ivory, Pretty by Flormar Mattifying Foundation 006 Beige, Pretty by Flormar Mattifying Foundation 010 Sand, Pretty by Flormar Mattifying Foundation 011 Honey, Pretty by Flormar Mattifying Foundation 012 Amber, Pretty by Flormar Weigthless Foundation 004 Ivory, Pretty by Flormar Weigthless Foundation 006 Beige, Pretty by Flormar Weigthless Foundation 010 Sand, Pretty by Flormar Weigthless Foundation 011 Honey, Pretty by Flormar Weigthless Foundation 012 Amber, Q739648, SHISEIDO REVITALESSENCE SKIN GLOW FOUNDATION, SR-01000883955, SUGAR SPICE LIP TREATMENT SUNSCREEN SPF 15, 2-Ethylhexyl 4-methoxycinnamate, analytical standard, Flawless Finish Bare Perfection Makeup SPF 8 Beige, Flawless Finish Bare Perfection Makeup SPF 8 Bisque, Flawless Finish Bare Perfection Makeup SPF 8 Cameo, Flawless Finish Bare Perfection Makeup SPF 8 Cream, Flawless Finish Bare Perfection Makeup SPF 8 Honey, Flawless Finish Bare Perfection Makeup SPF 8 Ivory, Flawless Finish Bare Perfection Makeup SPF 8 Mocha, Flormar Perfect Coverage Foundation 118 Dark Brown, Fresh Mint Moisturizing Sunscreen Lip Balm SPF 15, MINERALIZESATIN FOUNDATION SPF 15 FOUNDATION, Pretty by Flormar Cover up Foundation 007 Neutral, Pretty by Flormar Cover up Foundation 013 Caramel, Pretty by Flormar Mattifying Foundation 007 Neutral, Pretty by Flormar Mattifying Foundation 013 Caramel, Pretty by Flormar Weigthless Foundation 007 Neutral, Pretty by Flormar Weigthless Foundation 013 Caramel, Protective Makeup SPF 15 with Edelwess Stem Cells, RAIN AND SHINE LIPTINTWITH SPF 10 SUNSCREEN, Skin Caviar Foundation Sunscreen SPF 15-Pure Ivory, Skin Caviar Foundation Sunscreen SPF 15-Soft Ivory, Skin Caviar Foundation Sunscreen SPF 15-Warm Beige, Skin Caviar Foundation Sunscreen SPF 15-Warm Ivory, Skin Caviar Foundation Sunscreen SPF 15-Warm Linen, SR-01000883955-1, Sweet Berry Moisturizing Sunscreen Lip Balm SPF 15, Flawless Finish Bare Perfection Makeup SPF 8 Camellia, Flormar Perfect Coverage Foundation 117 Dark Caramel, Pretty by Flormar Cover up Foundation 001 Porcelain, Pretty by Flormar Cover up Foundation 005 Soft Beige, Pretty by Flormar Mattifying Foundation.

Octyl methoxycinnamate is primarily used in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage. 
Octyl methoxycinnamate is also used to reduce the appearance of scars.
Octyl methoxycinnamate or ethylhexyl methoxycinnamate (INCI) or octinoxate (USAN), trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms. 

A clear, oil-soluble, "cosmetically-elegant" liquid that is the most commonly used chemical sunscreen. 
It absorbs UVB radiation (at wavelengths: 280-320 nm) with a peak protection at 310nm. 
It only protects against UVB and not UVA rays (the 320-400 nm range) – so always choose products that contain other sunscreens too. 

Octyl methoxycinnamate is not very stable either, when exposed to sunlight, it kind of breaks down and loses its effectiveness (not instantly, but over time - it loses 10% of its SPF protection ability within 35 mins). 
To make it more stable it can be - and should be - combined with other sunscreen agents to give stable and broad-spectrum protection (the new generation sunscreen agent, Tinosorb S is a particularly good one for that).
Octyl methoxycinnamate has been detected in human urine, blood and breast milk, which indicates that humans are systemically exposed to this compound. 

Octyl methoxycinnamate is an endocrine disruptor that mimics estrogen and can disrupt thyroid function.
Octyl methoxycinnamate filters UV‐B rays from the sun. 
Octyl methoxycinnamate does not protect against UV-A rays. 

Octyl methoxycinnamate dissolves in oil, which makes it a fat-seeking substance in the body. 
It is formed by combining methoxycinnamic acid and 2-ethylhexanol- compounds which are not harmful on their own. 
When mixed together, they form a clear liquid that does not dissolve in water. 

Octyl methoxycinnamate is found in hair color products and shampoos, sunscreen, lipstick, nail polish, and skin creams. 
In products other than sunscreens, it is used as a UV filter to protect the products from degrading when exposed to the sun.
Octyl methoxycinnamate is an ultraviolet (UV) protection agent commonly used in sunscreens, face foundations, and lip care products. 

Octyl methoxycinnamate acts as a UV filter and blocks the Sun’s UV-B rays which have been associated with sunburn and skin cancer, thus protecting the skin.
Octyl methoxycinnamate is primarily used as a sun-protection agent that works on UV-B rays of the Sun and prevents skin damage. 
It is also used in cosmetics and personal care products to keep the other ingredients fresh and effective. 

Octyl methoxycinnamate is used in sunscreens and other products like foundations, lip balms, and makeup to block the harmful UV-B rays from the Sun and protect the skin against sunburn and skin cancer. 
Octyl methoxycinnamate also may help the skin to absorb other ingredients. 
The maximum concentration in ready-for-use products is 7.5% in the United States (U.S.) and 10% in the European Union (E.U.).

Octyl methoxycinnamate is a cinnamate ester and common ingredient in sunscreen and other skin care products to minimize DNA photodamage.
Octyl methoxycinnamate was originally developed in 1950's as an organic UV-B filter that absorbs UV-B rays from sun.
Octyl methoxycinnamate is often combined with nanoparticles or other water-resistant liposomes in formulations to increase the localization at the epidermis and decrease the risk of percutaneous absorption.

Octyl methoxycinnamate's use in pharmaceutical and cosmetic formulations is approved by FDA.
A clear, oil-soluble, "cosmetically-elegant" liquid that is the most commonly used chemical sunscreen.
Octyl methoxycinnamate absorbs UVB radiation (at wavelengths: 280-320 nm) with a peak protection at 310nm.

Octyl methoxycinnamate only protects against UVB and not UVA rays (the 320-400 nm range) – so always choose products that contain other sunscreens too.
Octyl methoxycinnamate is not very stable either, when exposed to sunlight, it kind of breaks down and loses its effectiveness (not instantly, but over time - it loses 10% of its SPF protection ability within 35 mins).
To make it more stable it can be - and should be - combined with other sunscreen agents to give stable and broad-spectrum protection (the new generation sunscreen agent, Tinosorb S is a particularly good one for that).

Regarding safety, there are also some concerns around Octinoxate.
In vitro (made in the lab not on real people) and animal studies have shown that it may produce hormonal (estrogen-like) effects.
Do not panic, the studies were not conducted under real life conditions on real human people, so it is probably over-cautious to avoid Octinoxate altogether.

However, if are pregnant or a small child (under 2 yrs. old), choose a physical (zinc oxide/titanium dioxide) or new-generation Tinosorb based sunscreen, just to be on the super-safe side.
Overall, Ethylhexyl Methoxycinnamate is an old-school chemical sunscreen agent.
There are plenty of better options for sun protection today, but it is considered "safe as used" (and sunscreens are pretty well regulated) and it is available worldwide (can be used up to 10% in the EU and up to 7.5% in the US).

Octyl Methoxycinnamate is a UV-B category 1 sunscreen used for OTC sun protection products such as sunscreens, personal care products, sun care, baby sun care, daily skin care, decorative cosmetic with sun protection and broad spectrum UV- B filter.
Octyl methoxycinnamate, also called Octinoxate or (OMC), is a UV filter. 
Octyl methoxycinnamate can be absorbed rapidly through skin.

Octyl methoxycinnamate has been detected in human urine, blood and breast milk, which indicates that humans are systemically exposed to this compound.
Octyl methoxycinnamate is an endocrine disruptor that mimics estrogen and can disrupt thyroid function.
Found in: Hair color products and shampoos, sunscreen, lipstick, nail polish, skin creams.

What to look for on the label: Octinoxate,o methoxycinnamate (OMC), parsol, parsol MCX, parsol MOX, escalol, 2-ethylhexyl pmethoxycinnamate.
Octyl methoxycinnamate’s important to know that the presence of this or other sunscreen actives in the body does not mean health is at risk.
Octyl methoxycinnamate is anticipated that the additional testing being done will reaffirm the safety of these ingredients; however, those who remain concerned can choose sunscreens with mineral actives (titanium dioxide and zinc oxide) which are not included in the FDA’s new call for additional testing.

Octyl Methoxycinnamate has a solid record of safety backed by decades of research and mounds of studies.
No studies have demonstrated that octinoxate, as used in SPF products, is harmful to people.
In the studies where such claims are made, the conditions are simply do not apply to how Octyl Methoxycinnamate is used in sunscreens.

This sunscreen ingredient’s cinnamic acid component can be allergenic for some people; however, this is an individual response and simply means skin cannot tolerate this ingredient.
Octyl Methoxycinnamate is not considered irritating or photosensitizing to broad populations.
The risk of an allergic response can be minimized by formulating Octyl Methoxycinnamate in the oil phase (not the water phase) of a sunscreen.

This along with other formulary steps such as encapsulation and special emulsification approaches also stabilize Octyl Methoxycinnamate.
When such steps are not taken, upwards of 60% of Octyl Methoxycinnamate’s protective ability in a sunscreen is lost when exposed to UV light.
But since this issue is well known among sunscreen chemists, it’s not a concern for today’s sunscreens with oOctyl Methoxycinnamate.

Octyl Methoxycinnamate is sometimes accused of being a hormone disruptor.
This effect has primarily been demonstrated via oral intake of large amounts of this ingredient or examining its effect on isolated cells.
In cases where a hormonal change was measured via topical application, the difference was one million-fold less than what was measured from normal hormonal activity in the body.

Studies involving people have shown that Octyl Methoxycinnamate does not have a biologically significant effect on hormones.
There simply isn’t any research backing the claim that Octyl Methoxycinnamate has any link to health risks when used in sunscreen formulas.
In fact, the European Union’s (EU) permitted usage level for Octyl Methoxycinnamate in sunscreens is higher than the maximum amount permitted in the United States (7.5% in the United States, 10% in the EU).

China, Australia, Brazil, Argentina, India and Thailand are among the other countries permitting Octyl Methoxycinnamate levels up to 10%.
Octyl Methoxycinnamate is often accused of being a threat to coral reefs and has been banned from use in sunscreen in some parts of the world; however, numerous data gaps exist on this issue.
Such gaps include the lack of information on many other UV filters whose effects on coral reefs have yet to be studied.

More important, research is clear that several other factors, from changing climate to coastal development and invasive species have a much stronger link to coral reef damage and demise than sunscreen use by people.
This sunscreen active is one of several currently undergoing further safety testing under the purview of the United States Food and Drug Administration (FDA).
This testing is to gain a better understanding of the systemic absorption, metabolism, and elimination of these sunscreen actives when small amounts enter the body via topical use.

As referenced above, the presence of this or other sunscreen actives in the body does not mean your health is at risk.
Octyl methoxycinnamate is anticipated that the additional testing being done will reaffirm the safety of these ingredients; however, those who remain concerned can choose sunscreens with mineral actives (titanium dioxide and zinc oxide) which are not included in the FDA’s new call for additional testing.
Octyl Methoxycinnamate or ethylhexyl methoxycinnamate, trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms.

Octyl methoxycinnamate is an ester formed from methoxycinnamic acid and 2-ethylhexanol.
Octyl methoxycinnamate is a liquid that is insoluble in water.
Octyl methoxycinnamate is primarily used in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage.

Octyl methoxycinnamate is also used to reduce the appearance of scars.
Octyl Methoxycinnamate is an organic compound that is an ingredient in some sunscreens and lip balms. Octyl methoxycinnamate is an ester formed from methoxycinnamic acid and (RS)-2-ethylhexanol.
Octyl Methoxycinnamate is a clear liquid that is insoluble in water.

Octyl methoxycinnamate's primary use is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage.
Octyl methoxycinnamate is also used to reduce the appearance of scars.

Octyl methoxycinnamate or Octinoxate is also known as ethylhexyl methoxycinnamate is an organic compound, an ester formed from methoxycinnamic acid and ethylhexanol. 
Octyl methoxycinnamate is primarily used in sunscreens as a UV-B rays’ absorber. For further information refer to Ethylhexyl methoxycinnamate

Melting point: <-25℃
Boiling point: 198-200°C
Density: 1.009
refractive index: 1.543-1.547
Flash point: 193°C
storage temp.: 2-8°C
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Liquid
color:Clear colorless to yellow
Water Solubility: <0.1 g/100 mL at 27 ºC
BRN: 5946632
Stability: Stable. Incompatible with strong oxidizing agents.
InChIKey: YBGZDTIWKVFICR-JLHYYAGUSA-N
LogP: 5.921 (est)
CAS DataBase Reference: 5466-77-3(CAS DataBase Reference)
EWG's Food Scores: 6

Octyl methoxycinnamate dissolves in oil, which makes it a fat-seeking substance in the body.
Octyl methoxycinnamate is formed by combining methoxycinnamic acid and 2-ethylhexanol- compounds which are not harmful on their own.
When mixed together, they form a clear liquid that does not dissolve in water.

Octyl methoxycinnamate is found in hair color products and shampoos, sunscreen, lipstick, nail polish, and skin creams.
In products other than sunscreens, it is used as a UV filter to protect the products from degrading when exposed to the sun. 
Endocrine disruption, reproductive and developmental toxicity, organ system toxicity.

Octyl methoxycinnamate increases cell proliferation in cells that grow in response to estrogen exposure.
Lifetime estrogen exposure is an established risk factor in the development and progression of breast cancer.
Octyl methoxycinnamate affects other hormone systems as well.

For instance, Octyl methoxycinnamate reduces thyroid hormones in blood serum.
Thyroid hormones are critical for metabolic functions in the body including mammary gland development.
Octyl methoxycinnamate exposure has also been found to alter the reproductive systems of female offspring, with significantly lowered hormone (estradiol and progesterone) levels, which is associated with infertility and miscarriages.

In males there is a reduction of sperm count at all dose levels.
Reproductive organs and development toxicity: Numerous studies have reported that octinoxate exhibits antiandrogenic activity, which is linked to harmful effects on reproductive organ development in male and female fetuses exposed in utero.
These effects can be further passed onto their offspring.

Moreover, octinoxate alters weight and structure of reproductive organs in male and female rats.
Octyl methoxycinnamate is approved for use in cosmetics worldwide; the maximum concentration in ready-for-use preparations varies according to local legislation.
According to the U.S. FDA the recommended use levels is up to 7.5 percent. 

Despite the numerous studies and concerns about octinoxate toxicity and the effect on human body systems, Octyl methoxycinnamate is approved worldwide. 
In the United States, it is required to be listed on labels as an active ingredient. 
To avoid the product in sunscreen, read the list of active ingredients and skip products that rely on Octyl methoxycinnamate. 

Check labels on hair care products, lipsticks nail polish and skin creams, and choose products that do not contain octinoxate or octyl methoxycinnamate (OMC).
Octyl Methoxycinnamate is an organic ester used in sunscreens (and lip balms) formed from methoxycinnamic acid and 2-ethylhexanol (Source).
Octyl methoxycinnamate is a sun blocking agent that absorbs UVB rays, but not UVA rays.

However, when Octyl methoxycinnamate is exposed to sunlight, it is rendered less effective, although this reaction can be prevented by the addition of other ingredients (as seen in the formula of Tinsorb).
Octyl methoxycinnamate is also used to reduce to appearance of scars.
According to the Cosmetics Database, which rates Octyl methoxycinnamate as 70% safe, there are many concerns regarding its use, including: biochemical changes that cause mutation and cell death upon exposure to sunlight (which is likely when used as a sunscreen ingredient); immunotoxicity and photoallergic effects; reproductive toxicity that leads to estrogenic effects; organ system toxicity, especially in the liver; and enhanced skin absorption. 

Octyl methoxycinnamate should be used with caution by pregnant women and children.
One study performed in 2000 raised safety concerns about Octyl Methoxycinnamate's toxicity, but was performed on mouse cells at concentrations lower than typical levels in sunscreens.
"However, a more recent study concluded that Octyl Methoxycinnamate does not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes.

Estrogenic effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users".
Olefin metathesis has been widely studied. One of the synthesis pathways for Octyl methoxycinnamate includes cross metathesis. 
The high efficiency of the nitro-Grela catalyst has been used in the cross metathesis of trans-anethole with Octyl methoxycinnamate to produce octyl methoxycinnamate (86% yield).

Octyl methoxycinnamate is a clear liquid that is insoluble in water.
Octyl methoxycinnamate's primary use is in sunscreens and other cosmetics to absorb UV-B rays from the sun, protecting the skin from damage. 
Octyl methoxycinnamate is also used to reduce the appearance of scars.

Octyl methoxycinnamate can be found in hair color products and shampoos, sunscreen, lipstick, nail polish, skin creams.
A recent study concluded that octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes.
Estrogenic effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users and were also shown in test tube experiments.

A study published in 2011 explored the effects of pre- and post-natal exposure to high doses of Octyl methoxycinnamate in rats and showed, for example, that the testes weight and testosterone levels were significantly reduced in male rats.
This common sunscreen ingredient is shown to have hormone-mimicking effects on laboratory animals. This chemical is found in humans, including mothers' milk samples.
Octyl methoxycinnamate is one of the most frequently used chemical UV filters worldwide and has been reported to cause photosensitisation and photoallergic effects.

Octyl methoxycinnamate easily penetrates the upper layer of the skin and, when exposed to UV radiation, generates free radicals in skin cells.
Octyl methoxycinnamate is a clear liquid that is insoluble in water.
Octyl methoxycinnamate is used in the formulation of many types of beauty products, including sunscreens and makeup products that marketed to contain ingredients that protect the skin from the sun.

Octyl methoxycinnamate is often listed as Octinoxate on sunscreen products.
When you see on the ingredient listed for shampoos and other hair care products is it being used to protect these personal care products from deterioration caused by UV rays.
UV light has a wavelength shorter than visible light.

Prolonged exposure to UV light may result in health effects in the skin, eye and immune system.
UV light damages collagen and contributes to aging of skin.
Octyl methoxycinnamate can help protect against sunburn and other skin damage caused by UV light by absorbing UV radiation.

The Food and Drug Administration (FDA) conducted an OTC (over the counter) drug review of Octyl methoxycinnamate and did approve it for use in sunscreens up to a concentration of 7.5%.
There are some studies that this ingredient may produce excess reactive oxygen species that can interfere with cellular signaling, cause mutations, and lead to cell death.
This reaction may also be implicated in cardiovascular disease.

However, another study concluded that octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity.
Once again, we as consumers need to balance the benefits of the ingredients against the harmful side effects.
Octyl methoxycinnamate is a chemical sun blocking agent that absorbs ultraviolet radiation in UVB range.

Octyl methoxycinnamate is a chemical ingredient found in some brands of sunscreen and lip balm that blocks UV-B rays from the sun to protect the skin against harmful radiation.
Octyl methoxycinnamate is the most commonly used chemical for blocking UV-B rays.
Octyl methoxycinnamate is an organic compound formed from methoxycinnamic acid and 2-ethylhexanol. When mixed together, they form a clear liquid that does not dissolve in water.

Octyl methoxycinnamate can absorb UV-B rays from the sun but does not protect against UV-A rays.
Octyl methoxycinnamate is the nomenclature termed by the International Nomenclature of Cosmetic Ingredients (INCI), which provides names for certain chemicals and other ingredients used in soaps, cosmetics and related ingredients.
Octyl methoxycinnamate is referred to as octinoxate according to the United States Adopted Names (USAN), which provides individual names for pharmaceutical products sold in the United States.

Concern about effects on coral reefs resulted in a bill in the state legislature of Hawaii to limit use of sunscreens containing Octyl methoxycinnamate and oxybenzone.
For the same reasons, the government of Palau signed a law in 2018 (becoming effective in 2020) that restricted the sale and use of sunscreen and skincare products that contain a list of ten different chemicals, including the UV filters octyl methoxycinnamate, oxybenzone and octocrylene, with fines of US$1,000 for retailers who violate the law and the power to confiscate such products from non-commercial users.
One study performed in 2000 raised safety concerns about Octyl methoxycinnamate by demonstrating toxicity to mouse cells at concentrations lower than typical levels in sunscreens.

However, another study concluded that Octyl methoxycinnamate and other sun screening agents do not penetrate the outer skin in sufficient concentration to cause any significant toxicity to the underlying human keratinocytes.
Estrogenic and neurological effects were noted in laboratory animals at concentrations close to those experienced by sunscreen users and were also shown in vitro.
Octyl methoxycinnamate has been shown to be light sensitive with a decrease in UV absorption efficiency upon light exposure.

This degradation causes formation of the Z-octyl-p-methoxycinnamate from the E-octyl-p-methoxycinnamate. 
In contrast, the OMC does not show degradation when kept in darkness for extended periods of time.
A study carried out in 2017 by the Research Centre for Toxic Compounds in the Environment at Masaryk University, Czech Republic, indicates that octyl methoxycinnamate (EHMC) may damage human cell DNA. 

When exposed to sun rays, the spatial arrangement of its molecules changes and isomerisation takes place. While until now only unchanged EHMC has been researched, Massaryk University researchers focused on its isomers and found out that it has a significant genotoxic effect under lab conditions. 
Octyl methoxycinnamate means that it may potentially damage human DNA and cause genome mutations which may lead to serious health risks.
In swimming pools with hypochlorite in aqueous solution, octyl methoxycinnamate has been shown to produce chlorine-substituted intermediates. 

The chlorination intermediates of octyl methoxycinnamate demonstrated weak mutagenic effects on the Salmonella typhimurium TA 100 strain. 
The reactions depended on the pH, compound structures, and chlorine dose.
Octyl methoxycinnamate is a substance that shields the skin from harmful UVB rays. 

Octyl methoxycinnamate is an ingredient in some cosmetic products, such as sunscreen. 
Another name for it is Octyl methoxycinnamate.
Octyl methoxycinnamate or ethylhexyl methoxycinnamate or octinoxate, trade names Eusolex 2292 and Uvinul MC80, is an organic compound that is an ingredient in some sunscreens and lip balms. 

It is an ester formed from methoxycinnamic acid and 2-ethylhexanol. 
Octyl methoxycinnamate is a liquid that is insoluble in water.
Octyl methoxycinnamate is an ester of 4-methoxycinnamic acid and 2-ethyl hexanol, a strong UVB absorber and is one of the most widely used UV-B filters with excellent protection potential. 

It is an oil-soluble (insoluble in water), colorless to pale yellow (yellowing when exposed to light), practically odorless, oily liquid that can be easily incorporated into the sunscreen formulation. 
Octyl methoxycinnamate has a refractive index (at 20 °C) of 1.542–1.548 and boosts the SPF when combined with other UV filters.
Octyl methoxycinnamate is ideal for water-resistant sunscreens, lipsticks, protective hair care,  and daycare products for everyday protection against UV-B rays. 

In addition, it is compatible with most cosmetic ingredients and an excellent solubilizer for many solid UV filters such as Ethylhexyl Triazone, Diethylhexyl Butamido Triazone, Diethylamino Hydroxybenzoyl Hexyl Benzoate, and Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine.

Due to Octyl Octyl methoxycinnamate is a derivative of cinnamate acid (unsaturated fatty acid), an antioxidant should be added to the cosmetic composition, to guarantee the oxidative stability of the product. 
Octyl methoxycinnamate is approved worldwide in various concentrations.

Uses:
Octyl methoxycinnamate is an UV induced cyclobutane pyrimidine dimer (CDP) formation inhibitior.
Octyl methoxycinnamate is the drug name for the sunscreen chemical generally known as octyl methoxycinnamate and ethylhexyl methoxycinnamate.
Octyl methoxycinnamate is used as UV-B-absorbing agent in sunscreens and cosmetic creams, lotions, lipsticks, sun oils, etc.

Octyl methoxycinnamate is the most common active ingredient in sunscreens for protection against UV-B rays.
It may be combined with oxybenzone and titanium oxide.
Studies have evaluated the efficacy of octyl methoxycinnamate in preventing postoperative peritoneal adhesions and determined that octyl methoxycinnamate covering peritoneal surfaces decreases adhesion formation. 

This effect is more notable when Octyl methoxycinnamate is applied before the induction of trauma.
Chromophore groups, such as C=C, C=O, and O-N=O, have loosely held electrons that are excited by radiation. 
Hence, Octyl methoxycinnamate is able to absorb radiation when the electron energy level is increased to an excited state.

Octyl methoxycinnamate is used in the following products: laboratory chemicals, perfumes and fragrances, pharmaceuticals, photochemicals, polishes and waxes, washing & cleaning products and cosmetics and personal care products.
Other release to the environment of Octyl methoxycinnamate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use as processing aid.

Octyl methoxycinnamate is used in the following products: cosmetics and personal care products, laboratory chemicals, perfumes and fragrances, pharmaceuticals and photo-chemicals.
Release to the environment of Octyl methoxycinnamate can occur from industrial use: formulation of mixtures and formulation in materials.
Octyl methoxycinnamate is used in the following products: cosmetics and personal care products, laboratory chemicals, perfumes and fragrances, pharmaceuticals, photo-chemicals and washing & cleaning products.
Octyl methoxycinnamate is used for the manufacture of: chemicals.

Release to the environment of Octyl methoxycinnamate can occur from industrial use: in processing aids at industrial sites, as an intermediate step in further manufacturing of another substance (use of intermediates), in the production of articles, as processing aid, for thermoplastic manufacture and as processing aid.
Octyl methoxycinnamate is a key ingredient in many sunscreens, where it helps protect the skin from harmful UVB rays, reducing the risk of sunburn and long-term skin damage.

Octyl methoxycinnamate is often included in daily moisturizers and body lotions to provide additional sun protection.
Many lip balms contain Octyl methoxycinnamate to shield the lips from UV damage, preventing chapping and sunburn.
Cosmetic products such as foundations, BB creams, and tinted moisturizers may include Octyl methoxycinnamate to offer sun protection alongside their primary functions.

Some shampoos, conditioners, and hair sprays use Octyl methoxycinnamate to protect hair from UV damage, which can cause color fading and brittleness.
Octyl methoxycinnamate is included in anti-aging skincare products to help prevent photoaging, which is the premature aging of the skin caused by repeated exposure to ultraviolet radiation.
Some facial powders include Octyl methoxycinnamate to provide a matte finish with sun protection, combining cosmetic and protective benefits.

Octyl methoxycinnamate can be found in aftershaves and fragrances to protect the skin from UV damage, especially since these products are often used on exposed skin areas.
These multi-purpose creams combine skincare, makeup, and sun protection, with Octyl methoxycinnamate often included to help shield the skin from UV rays.
Certain baby lotions and sunscreens contain Octyl methoxycinnamate to provide gentle UV protection for sensitive baby skin.

Octyl methoxycinnamate is frequently used in sport and water-resistant sunscreen formulations due to its effectiveness and stability.
Some self-tanning products incorporate Octyl methoxycinnamate to offer sun protection along with the cosmetic benefits of a tanned appearance.
Many daily wear cosmetics, such as tinted moisturizers and light foundations, include Octyl methoxycinnamate to ensure users receive sun protection as part of their everyday routine.

Products designed to treat specific skin conditions, like rosacea or hyperpigmentation, might use Octyl methoxycinnamate to prevent further UV-induced skin damage.
Octyl methoxycinnamate is often combined with other UV filters, like avobenzone or zinc oxide, to provide broad-spectrum sun protection, covering both UVA and UVB rays.
Octyl methoxycinnamate can degrade in sunlight. 

To counteract this, it is often used with stabilizing agents to prolong its efficacy in sun-exposed products.
The concentration of Octyl methoxycinnamate in products is regulated, typically up to 7.5% in the US and 10% in the EU, to ensure safety and effectiveness.
Concerns about the environmental impact of Octyl methoxycinnamate, particularly its potential harm to coral reefs, have led to restrictions or bans in some regions, such as Hawaii and Palau.

Safety profile:
Octyl methoxycinnamate is considered safe for use in cosmetics in the E.U. and the U.S. if used in the recommended concentrations. 
It may however have some effects on the endocrine system of the body which makes hormones.

Health Concerns:
Octyl methoxycinnamate increases cell proliferation in cells that grow in response to estrogen exposure.
Lifetime estrogen exposure is an established risk factor in the development and progression of breast cancer. 
Octyl methoxycinnamate affects other hormone systems as well. 

For instance, it reduces thyroid hormones in blood serum.
Thyroid hormones are critical for metabolic functions in the body including mammary gland development.
Octyl methoxycinnamate has also been found to alter the reproductive systems of female offspring, with significantly lowered hormone (estradiol and progesterone) levels, which is associated with infertility and miscarriages. 

In males, there is a reduction in sperm count at all dose levels. 
Numerous studies have reported that Octyl methoxycinnamate exhibits antiandrogenic activity, which is linked to harmful effects on reproductive organ development in male and female fetuses exposed in utero. 

These effects can be further passed onto their offspring. 
Moreover, Octyl methoxycinnamate alters the weight and structure of reproductive organs in male and female rats.