OCTYLISOTHIAZOLINONE (OIT)

OCTYLISOTHIAZOLINONE (OIT)

CAS NO: 26530-20-1

SYNONYM :2-Octyl-3(2H)-isothiazolone, Octhilinone; Isothiazolin-3-one; 3(2H)-Isothiazolone; isothiazolin; 1,2-Thiazol-3-one; Isothiazolinone;; Octhilinone; 26530-20-1; 2-n-Octyl-4-isothiazolin-3-one; 2-Octyl-4-isothiazolin-3-one; 2-octylisothiazol-3(2H)-one; 2-Octyl-3-isothiazolone; Pancil; 2-Octyl-2H-isothiazol-3-one; 3(2H)-Isothiazolone, 2-octyl-; 2-Octyl-3(2H)-isothiazolone; Kathon 893; Skane 8; Kathon 893F; Micro-chek skane; Kathon LM; Microbicide M-8; Micro-chek 11; Micro-chek 11D; Kathon SP 70; Kathon LP preservative; Kathon 4200; Pancil-T; Skane M8; 2-octyl-1,2-thiazol-3-one; 4-Isothiazolin-3-one, 2-octyl-; Vinylzene IT 3000DIDP; Octyl-3(2H)-isothiazolone; RH 893; Octhilinone [ANSI:BSI:ISO]; CCRIS 6082; EINECS 247-761-7; 2-Octyl-3-isothioazolone; 2-Octyl-3-isothiazolinone; Octyl-4-isothiazol-3-one; EPA Pesticide Chemical Code 099901; 2-n-Octyl-3-isothiazolone; BRN 1211137; CHEBI:81936; SMR001370885; DSSTox_CID_5805; Kathon; CAS-26530-20-1; C11H19NOS; Pancil T; 2-octyl-1,2-thiazol-3(2H)-one; Skane M 8; ACMC-1CDE4; Vinyzene IT 3000DIDP; KSC163A4D; SCHEMBL396433; CHEMBL1562104; DTXSID1025805; BDBM66023; HSDB 6713; KS-00000ZYZ; 2-Octyl-4-Isothiazolin-3-Ketone; Octhilinone 10 microg/mL in Acetonitrile; 2-Octyl-4-isothiazolin-3-one, PESTANAL(R), analytical standard; 2-Octyl-2H-isothiazol-3-on; Octhilinon; OIT; OI

Octylisothiazolinone belongs to the isothiazolinone class of compounds and is a widely used biocide .
Chemical properties 
Octylisothiazolinone can degrade in the environment through hydrolysis , photolysis , microbial degradation, or exposure to nucleophilic particles.
Usage 
Due to its fungicidal effect, octylisothiazolinone is used as a film preservative to protect a coating film, as a wood preservative (until 2006 [1] ) and in cooling lubricants , roofing paints, printing inks and textiles. Trade names of formulations containing octylisothiazolinone are, for example, RH-893 , Kathon 893 or Skane M8 . 
Biological importance 
As sensitization is possible with skin contact, products with a concentration of 500 ppm or more must be labeled on the packaging.

Application field (Octylisothiazolinone (OIT) 45%)
Octylisothiazolinone (OIT) 45%: Mainly used in the synthetic leather, genuine leather, polymer, and paints industries to protect against mildews.
Performance characteristics
1. Serve as a broad-spectrum, long-lasting biocide to kill bacteria and fungi of all kinds Octylisothiazolinone.
2. Octylisothiazolinone can be uniformly dispersed in the slurries of acrylic resin and polyurethane resin.
3. Octylisothiazolinone excellent resistance to high temperature.
4. Applicable in the medium of the pH value in the range of 3 to 9 Octylisothiazolinone.
5. Octylisothiazolinone low toxicity; completely in line with the strictest EU standards.
Cautions
Octylisothiazolinone for use in the synthetic leather, genuine leather, and polymer industries, the concentration of using is recommended to be 0.3-1.0% (w/w); instructions for the concentration of using in the paint industry will be offered by the company’s technology division depending actual applications.
Application field (Octylisothiazolinone (OIT) 98%)
Octylisothiazolinone (OIT) 98%: Suitable for applications in the industrial oil, plastic, building materials, leather, paint, and textile printing and dyeing areas to protect against mildews
Performance characteristics
1. Demonstrate an excellent bactericidal effect; with broad-spectrum, long-lasting features.
2. Octylisothiazolinone Low toxicity; easy to operate; can be added at any production step.
3. Applicable in the medium of the pH value in a range of 5 to 9 Octylisothiazolinone.
4. Good uniformity of dispersion; contain no VOC; with thermal stability.
5. Octylisothiazolinone not combustible and easy to transport and use.
6. Stable in the intense ultraviolet or acid rain environment Octylisothiazolinone.
Usage and Cautions
1. Octylisothiazolinone is recommended to use the concentration of using in the range of 0.1 to 0.5%, depending on the actual applications. This product is also widely used for sterilization of interior and exterior latex paints to protect against mildews; suitable for use in the production of eco-friendly latex paints; it is recommended to adopt the adding concentration of 0.1 – 0.3% depending on the performance and service environment of paints.
2. If Octylisothiazolinone splashes onto the skin, rinse with water immediately to avoid irritation or cauma.
3. Octylisothiazolinone should be used in the medium of pH≤9.5.
4. Wear protective clothes, rubber gloves, goggles and masks; avoid any contact with the skin, eyes and mucous membranes Octylisothiazolinone.
Octylisothiazolinone Packaging and Shipping
Packaging: 1000 kg per IBC drum, 200 kg per drum.
Octylisothiazolinone Storage
Keep container tightly closed
Store in a cool dry well-ventilated place

Background: Octylisothiazolinone (OIT) is used as an antifungal agent by the leather industry.
Objectives: To show sensitization to Octylisothiazolinone (OIT) from leather, and to highlight the potential implications when cross-reactivity between Octylisothiazolinone (OIT) and methylisothiazolinone (MI) is studied.
Methods: Two patients with allergic contact dermatitis caused by a leather belt and shoes, respectively, were patch tested with methylchloroisothiazolinone (MCI)/MI, MI, MCI, Octylisothiazolinone (OIT), and benzisothiazolinone (BIT). High-performance liquid chromatography with ultraviolet detection (HPLC-UV) was used to detect isothiazolinone derivatives in leather goods. Additionally, files of Octylisothiazolinone (OIT)-sensitized patients, observed at the KU Leuven department during the period 1990-2015, were retrospectively analysed.
Results: Both patients had been primarily sensitized to Octylisothiazolinone (OIT), but the diagnosis in one of them could be achieved only when a higher patch test concentration of Octylisothiazolinone (OIT) (1000 ppm pet.) was used. HPLC-UV confirmed the presence of OIT in their leather goods. Non-relevant sensitization to MI was noted in both cases. Four additional cases of Octylisothiazolinone (OIT) sensitization from leather could be retrieved from the KU Leuven database.
Conclusions: Non-occupational sensitization to Octylisothiazolinone (OIT) from leather may occur. Patch test concentrations of >250 ppm pet. may be necessary for diagnosis, and to show cross-reactivity with MI. Safer use limits for OIT in the leather industry may be needed.
Keywords: CAS no. 26530-20-1; allergic contact dermatitis; biocide; cross-reaction; fungicide; high-performance liquid chromatography; leather; methylisothiazolinone; octylisothiazolinone; shoes.

Octylisothiazolinone is a biocide that has been reported as a moderate, but rare contact allergen. To investigate the occurrence of octylisothiazolinone contact allergy and allergic contact dermatitis diagnosed and registered in the Allergen Bank at Odense University Hospital during the past 20 years. Octylisothiazolinone has been used for targeted testing only. All octylisothiazolinone-patch test results registered in the Allergen Bank between January 1992 and February 2012 were analyzed. A total of 20 out of 648 patients patch tested with octylisothiazolinone had positive reactions. The majority of the patients (90%) with relevant sensitizations to octylisothiazolinone had been exposed in occupational settings and most patients were painters. Octylisothiazolinone is a relevant sensitizer.
octylisothiazolinone is an organic compound of the family of isothiazolinones . It is a biocide generally used for cleaning products for glass surfaces [ ref.  desired] .
Octylisothiazolinone can be degraded in the environment by hydrolysis , by photolysis , by microbial degradation or by a nucleophilic reaction and then decomposes into carbon monoxide and dioxide , CO and CO 2In oxides of nitrogen and sulfur oxides 
Recent animal tests have indicated cross-reactivity between methylisothiazolinone (MI), octylisothiazolinone (OIT), and benzisothiazolinone (BIT).To retrospectively analyse concomitant reactions to different isothiazolinones in patients in an occupational dermatology clinic during the ongoing MI contact allergy epidemic.We searched patch test files (January 2012 to February 2017) for patients with allergic reactions to Octylisothiazolinone (OIT), BIT, and MI, and analysed their patch test results, occupations, exposure, and diagnoses.We found 61 (9.4%) allergic reactions to MI, 19 (2.9%) reactions to Octylisothiazolinone (OIT) and 9 (1.4%) reactions to BIT in a total of 647 consecutively tested patients. Seventeen (89%) of the Octylisothiazolinone (OIT)-positive patients had concomitant reactions to MI, whereas only 3 (33%) BIT-positive patients had allergic reactions to MI. The MI reactions in Octylisothiazolinone (OIT)-positive patients were almost exclusively extreme reactions (+++). Exposure to Octylisothiazolinone (OIT) was identified in 26% of the Octylisothiazolinone (OIT)-positive patients, and 56% of the BIT-positive patients had been exposed to BIT.Allergic reactions to OIT were strongly associated with extreme reactions to MI, which suggests cross-sensitization. In contrast, BIT reactions were mostly independent.
Octylisothiazolinone is a light golden yellow clear liquid. It has a very faint but sharp odor. It is moderately soluble in water. USE: Octylisothiazolinone is used as a bactericide and fungicide in agriculture, cooling tower water, paints, and leather. Its use as a materials preservative include fabrics and textiles, sealants, adhesives and rubber and plastics. EXPOSURE: Workers who use Octylisothiazolinone may breathe in mists or have direct skin contact. The general population may have direct skin contact when using paint products containing Octylisothiazolinone. If Octylisothiazolinone is released to the environment, it will be broken down in air. Octylisothiazolinone released to air will also be in or on particles that eventually fall to the ground. It is not expected to be broken down by sunlight. It will not move into air from moist soil and water surfaces. It is expected to move slowly through soil. It will be broken down by microorganisms under certain conditions, and is not expected to build up in fish. RISK: Severe allergic reactions have been reported in some workers handling Octylisothiazolinone or products containing this chemical, characterized by severe itching and rash over arms, legs and upper back. Allergic skin reactions have also been reported in individuals following non-occupational contact with products containing Octylisothiazolinone. Additional data on the potential for Octylisothiazolinone to cause toxic effects in humans were not available. Octylisothiazolinone causes moderate to severe irritation to the eyes and skin of laboratory animals, and can cause severe skin damage with direct contact. It is considered moderately toxic to animals following exposure by any route. Data on the potential for Octylisothiazolinone to cause infertility in laboratory animals were not available. Increased abortion was observed in laboratory animals exposed to Octylisothiazolinone at moderate-to-high oral doses that cause mothers to be sick (decreased weight gain, decreased appetite). Some mothers died. No birth defects were observed in offspring. Data on the potential for Octylisothiazolinone to cause cancer in laboratory animals were not available. The potential for Octylisothiazolinone to cause cancer in humans has not been assessed by the U.S. EPA IRIS program, the International Agency for Research on Cancer, or the U.S. National Toxicology Program 14th Report on Carcinogens

Adhesive Octylisothiazolinone    General adhesives and binding agents for a variety of uses
Adhesive, water_based, consumer_use Octylisothiazolinone    Term applied when the only information the source indicates is 'consumer' or 'consumer product' ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) - see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with 'consumer_use
Antimicrobial Octylisothiazolinone    Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing
Antistatic Octylisothiazolinone    For prevention and removal of static
Beverage, powder Octylisothiazolinone    Modifier used when source indicates product is powder based
Building_construction Octylisothiazolinone    Related to the building or construction process for buildings or boats (includes activities such as plumbing and electrical work, bricklaying, etc)
Building_material, Octylisothiazolinone flooring    Flooring materials (carpets, wood, vinyl flooring), or related to flooring such as wax or polish for floors
Cleaning_washing Octylisothiazolinone    Related to all forms of cleaning/washing, including cleaning products used in the home, laundry detergents, soaps, de-greasers, spot removers, etc; modifiers included when specific information is known, such as drycleaning, laundry, soap, window/floor, etc
Colorant Octylisothiazolinone    Term used for colorants, dyes, or pigments; includes colorants for drugs, textiles, personal care products (cosmetics, tatoo inks, hair dye), food colorants, and inks for printing; modifiers included when application is known 
Consumer_use Octylisothiazolinone    Term applied when the only information the source indicates is 'consumer' or 'consumer product' ; also applied to terms that the source indicates are for consumer use, yet the descriptor term is ambivalent about usage (e.g., cleaning_washing products may be for industrial or consumer use, when the source indicates consumer use, the consumer_use term is also applied) - see appendix for full list of unambiguous consumer related terms plus ambiguous consumer related terms which if indicated are labeled with 'consumer_use' 
Detergent, fragrance Octylisothiazolinone    Fragrances or odor agents, can be used in home products (cleaners, laundry products, air fresheners) or similar industrial products; usage indicated when known; more specific modifiers included when known 
Flame_retardant     Octylisothiazolinone Fire prevention materials, or additives/coatings to prevent flammability in paints, textiles, plastics, etc
Impregnation Octylisothiazolinone    Impregnation materials and impregnation agents for various prodcts (wood, oils, grease, paper)
Lubricant Octylisothiazolinone    Generic lubricants, lubricants for engines, brake fluids, oils, etc (does not include personal care lubricants)
Manufacturing, chemical Octylisothiazolinone    General term used only when the only information known from the source is 'chemical,' typically related to manufacturing of chemicals, or laboratory chemicals 
Paint Octylisothiazolinone    Various types of paint for various uses, modifiers included when more information is known
Pesticide, antimicrobial Octylisothiazolinone    Type of pesticide used to destroy or inhibit the growth of disease-causing mechanisms, can be impregnated into clothing
Pesticide, bactericide Octylisothiazolinone Type of pesticide that kills bacteria
Pesticide, biocide, non_agricultural Octylisothiazolinone    Pesticide for non agricultural use
Pesticide, fungicide Octylisothiazolinone    Chemical used to kill or inhibit fungi growth
Preservatives Octylisothiazolinone    Includes preservatives used in cosmetics, film, wood preserving agents, foods, etc (note food preservatives are also indicated as food_additive)
Soap, fragrance Octylisothiazolinone    Fragrances or odor agents, can be used in home products (cleaners, laundry products, air fresheners) or similar industrial products; usage indicated when known; more specific modifiers included when known 
Stabilizer Octylisothiazolinone    General stabilizers, application unknown    

For Octylisothiazolinone (USEPA/OPP Pesticide Code: 099901) ACTIVE products with label matches. /SRP: Registered for use in the USA but approved pesticide uses may change periodically and so federal, state and local authorities must be consulted for currently approved uses.
Control of apple and pear canker and other fungal and bacterial diseases of top fruit and citrus fruit. Also promotes rapid wound callousing of treated wounds and pruning cuts.
Mildewcide, microbiocide, fungicide and bacteriocide
Octylisothiazolinone (OIT) is used to control sapstain and mold on wood via high pressure spray to logs that are processed to formulate plywood.
As a materials preservative, Octylisothiazolinone (OIT) is used in industrial premises. There are no residential use sites for Octylisothiazolinone as an active ingredient. However, Octylisothiazolinone is used as a materials preservative in various end-use products, some of which can be handled and used in residential settings.
Biocide in cooling-tower water, paints, cutting oils, cosmetics and shampoo; for leather preservation.
The National Pesticide Information Retrieval System (NPIRS) identifies 15 companies with active labels for products containing the chemical Octylisothiazolinone. To view the complete list of companies, product names and percent Octylisothiazolinone in formulated products click the following url and enter the CAS Registry number in the Active Ingredient field.
For more Formulations/Preparations (Complete) data for Octylisothiazolinone (28 total), please visit the HSDB record page.
Octylisothiazolinone can be prepared by reaction of dithio-N-n-dioctylpropionamide and sulfuryl chloride.