OLETH-2

Oleth-2 finds application in a wide range of cosmetic and personal care products such as cleansers, shampoos, conditioners, body washes, and facial cleansers. 
Oleth-2 plays a crucial role in ensuring effective formulation and performance, providing consumers with clean, refreshed skin and hair.
Oleth-2 is used in skincare anti-aging, skincare anti-acne, skincare treatment, skincare moisturization, skincare protection, sun care, color cosmetics and hair care.

CAS Number: 9004-98-2
Chem/IUPAC Name: Poly(oxy-1,2-ethanediyl), .alpha.-9-(Z)-octadecenyl-.omega.-hydroxy (2 mol EO average molar ratio)
Molecular Formula: C22H44O3
Molecular Weight: 356.6 g/mol

SYNONYMS:
OLETH-2, Ethanol, 2-2-(9Z)-9-octadecenyloxyethoxy-, (Z)-3,6-dioxatetracos-15-en-1-ol, Ethanol, 2-[2-[(9Z)-9-octadecen-1-yloxy]ethoxy]-, 2-[2-[(9Z)-9-Octadecen-1-yloxy]ethoxy]ethanol, Oleth-2, 5274-65-7, Genapol 2, Oleth-2 [VANDF], Oleth-2 [II], BRIJ 93, Oleth-2 [INCI], Diethylene glycol monooleyl ether, 2-[2-[(Z)-octadec-9-enoxy]ethoxy]ethanol, UNII-7L6R1SQ6M0, 7L6R1SQ6M0, Ethanol, 2-(2-((9Z)-9-octadecenyloxy)ethoxy)-, Ethanol, 2-(2-(9-octadecenyloxy)ethoxy)-, (Z)-, Ethanol, 2-(2-((9Z)-9-octadecen-1-yloxy)ethoxy)-, 2-[2-[(9Z)-9-Octadecen-1-yloxy]ethoxy]ethanol, SCHEMBL2123908, DTXSID201021510, NS00022297, Q27268502, ameroxol OE-2, brij 92, brij O2, findet 1816/14, lipocol O-2, nikkol BO-2V, 2-[(Z)-octadec-9-enoxy]ethanol (peg-2), peg-2 oleyl ether, poe-2 oleyl ether, poly(oxy-1,2-ethanediyl), .alpha.-9-(Z)-octadecenyl-.omega.-hydroxy (2 mol EO average molar ratio), polyethylene glycol (2) oleyl ether, polyoxyethylene (2) oleyl ether

Oleth-2 is a 100% bio-based ethoxylated natural fatty alcohol, based on oleyl alcohol chemistry. 
This naturally derived surfactant, Oleth-2, offers a number of functional benefits, including detergency and wetting, for a variety of fabric care and HI&I applications.

Oleth-2 is a surfactant and emulsifying agent commonly used in cosmetic and personal care products. 
Oleth-2 belongs to the family of oleth ethers, which are produced by the ethoxylation of oleic acid or oleic alcohol. 

Oleth-2 is the polyethylene glycol ether of Oleyl Alcohol that conforms generally to the formula: CH3(CH2)7CH=CH(CH2)7CH2(OCH2CH2)nOH, where n has an average value of 2.
Oleth-2 is a member of the oleth surfactant family, which are ethoxylated fatty alcohols derived from oleic acid or oleic alcohol. 

Oleth-2 is produced through the ethoxylation process, resulting in a clear to slightly yellowish liquid. 
Oleth-2 is highly prized for its emulsifying and cleansing abilities in cosmetic formulations.

Oleth-2 is an ethoxylated (2 moles) oleyl alcohol, a pale, straw-colored liquid without odor. 
Oleth-2 is a water-in-oil emulsifier and solubilizer, especially for fragranced products designated as "fragrance grade" because of exceptionally low odor.

Oleth-2 is an exceptional nonionic W/O emulsifier and is used in a wide range of product types and applications. 
Oleth-2 is derived from a vegetable-derived alcohol.
Oleth-2 is an easy-to-use liquid form. 

Oleth-2's nonionic nature makes Oleth-2 an ideal ingredient for use in leave-on skin care products. 
Depending on product type, the use levels of Oleth-2 range from 0.5% to 10.0%.
Oleth-2 acts as a non-ionic co-emulsifier, emollient, solubilizer and stabilizing agent. 

USES and APPLICATIONS of OLETH-2:
Oleth-2 acts as a liquid, non-ionic co-emulsifier, emollient, solubilizer and stabilizing agent. 
Oleth-2 is used in skincare anti-aging, skincare anti-acne, skincare treatment, skincare moisturization.
Recommended use level of Oleth-2 is 1-5%. 

Oleth-2 is used for external use only.
Applications of Oleth-2: Emulsions for skin and hair care products
Oleth-2 finds widespread application in various cosmetic formulations due to its multifunctional properties.

Cleansing Agents: Oleth-2 is used in shampoos and body washes for effective dirt and oil removal.
Emulsifiers: Oleth-2 helps stabilize emulsions in creams and lotions by allowing oil and water components to mix.
Solubilizers: Oleth-2 aids in dissolving active ingredients that are not easily soluble in aqueous solutions.

Skin Conditioning Agents: Oleth-2 contributes to the texture and feel of cosmetic products, enhancing user experience
Oleth-2 is a chemical compound classified as a polyethylene glycol ether of oleyl alcohol, with the molecular formula C22H44O3. 
Oleth-2 consists of an average of two ethylene oxide units linked to oleyl alcohol, which contributes to its surfactant properties. 

Oleth-2 plays a crucial role in cosmetics and personal care products, functioning primarily as a surfactant for cleansing and emulsifying purposes. 
Its ability to reduce surface tension allows Oleth-2 to facilitate the mixing of oil and water, making it effective in various formulations such as shampoos, lotions, and creams.

In cosmetics, Oleth-2 primarily serves as an emulsifier and cleansing agent. 
Oleth-2 aids in blending oil and water-based ingredients, facilitating the formation of stable emulsions in various skincare and haircare products. 

Additionally, Oleth-2 contributes to the cleansing efficacy of formulations, helping to remove dirt, oil, and impurities from the skin and hair.
Oleth-2 finds application in a wide range of cosmetic and personal care products such as cleansers, shampoos, conditioners, body washes, and facial cleansers. 

Oleth-2 plays a crucial role in ensuring effective formulation and performance, providing consumers with clean, refreshed skin and hair.
Oleth-2 is used in skincare anti-aging, skincare anti-acne, skincare treatment, skincare moisturization, skincare protection, sun care, color cosmetics and hair care.

SCIENTIFIC RESEARCH APPLICATIONS OF OLETH-2:
-Surfactant Properties and Applications of Oleth-2:
Oleth-2, also known as polyethylene glycol (2) oleyl ether, is a non-ionic surfactant. 
This means Oleth-2 possesses both hydrophilic (water-loving) and hydrophobic (water-repelling) properties. 
This unique characteristic allows Oleth-2 to act as a solubilizer, emulsifier, and dispersant in various scientific research applications.

-Solubilization: 
Oleth-2 can improve the solubility of hydrophobic compounds in aqueous solutions. 
This is particularly useful for studying poorly soluble drugs, biological molecules, or environmental contaminants.

-Emulsification: 
Oleth-2 can help create and stabilize emulsions, which are mixtures of two immiscible liquids. 
This is valuable in research areas like drug delivery, where emulsions are used to encapsulate and deliver hydrophobic drugs.

-Dispersion: 
Oleth-2 can disperse solid particles in aqueous solutions, preventing them from settling or clumping together. 
This is beneficial in studies involving nanoparticles, proteins, or other insoluble materials.

WHAT DOES OLETH-2 DO IN A FORMULATION?
*Emulsifying
*Surfactant

CHEMICAL REACTIONS OF OLETH-2:
The synthesis of Oleth-2 involves the reaction of oleyl alcohol with ethylene oxide. 
This process results in the formation of ethers through alkoxylation, where the hydroxyl group of oleyl alcohol is converted into an ether linkage. 
The general reaction can be represented as follows:

Oleyl Alcohol+Ethylene Oxide→Oleth 2
Oleyl Alcohol+Ethylene Oxide→Oleth 2
This reaction can continue until all ethylene oxide is consumed, leading to different derivatives with varying numbers of ethylene oxide units.

SYNTHESIS METHODS OF OLETH-2:
The synthesis of Oleth-2 typically follows these steps:

*Starting Material: 
Oleyl alcohol is used as the primary starting material.

*Alkoxylation Reaction: 
The oleyl alcohol undergoes an alkoxylation reaction with ethylene oxide under controlled conditions (temperature and pressure) to form the polyethylene glycol ether.

*Purification: 
The resulting product is purified to remove unreacted starting materials and by-products.
This method can be adjusted to produce other Oleth compounds by varying the number of ethylene oxide units added during synthesis .

FUNCTIONS OF OLETH-2:
*Emulsifying agent: 
Oleth-2 promotes the formation of intimate mixtures between immiscible liquids by modifying the interfacial tension (water and oil)

*Surfactant: 
Oleth-2 reduces the surface tension of cosmetics and contributes to the uniform distribution of the product during use.

OLETH-2 IS PRESENT:
Oleth-2 is present in 0.01% of cosmetics.
Hair coloring (0.75%)

MAIN FUNCTIONS AND CHARACTERISTICS OF OLETH-2:
Here are its main functions and characteristics:

*Emulsifying Agent: 
Oleth-2 helps stabilize emulsions by reducing the surface tension between oil and water phases. This property is crucial in formulations like creams, lotions, and conditioners where oil and water need to be uniformly mixed to maintain product stability and texture.

*Surfactant: 
As a surfactant, Oleth-2 enhances the spreadability and solubility of cosmetic products. 
Oleth-2 enables oils and water-based ingredients to blend together smoothly, improving the application experience and ensuring even distribution on the skin or hair.

*Texture Enhancer: 
Oleth-2 contributes to the overall texture of formulations, providing a smooth and luxurious feel. 
This makes Oleth-2 valuable in products designed to moisturize and condition the skin or hair.

Farmoganic, as a supplier of cosmetic ingredients, ensures that Oleth-2 meets rigorous quality and safety standards. 
By incorporating Oleth-2 into their formulations, cosmetic manufacturers can create products that offer effective emulsification, improved texture, and enhanced performance for consumers.

INTERACTION STUDIES OF OLETH-2:
Interaction Studies
Research on Oleth-2 indicates that it may enhance the penetration of other active ingredients in formulations. 

SIMILAR COMPOUNDS OF OLETH-2:
Similar Compounds
Oleth-2 belongs to a broader category of Oleth compounds, each differing by the number of ethylene oxide units attached. 

UNIQUENESS OF OLETH-2:
What sets Oleth-2 apart from its counterparts is its specific balance between cleansing efficacy and mildness, making it suitable for sensitive skin formulations while still providing effective emulsification properties. 
Additionally, Oleth-2's moderate molecular weight allows for versatile applications without compromising product stability or performance

FUNCTIONS OF OLETH-2:
*Detergent, 
*Emulsifier, 
*Surfactant, 
*Surfactant (Nonionic), 
*Wetting Agent

CHEMICAL FAMILY OF OLETH-2:
Chemical Family: 
*Alcohol Ethoxylates, 
*Ethoxylated Fatty Alcohols, 
*Oleth

BIOLOGICAL PROPERTIES OF OLETH-2:
Recent research suggests that Oleth-2 might possess additional properties beyond its surfactant function:

*Antimicrobial activity: 
Studies have shown that Oleth-2 can exhibit antimicrobial activity against certain bacterial strains. 
This opens up potential applications in research related to disinfection, microbial control, and development of novel antimicrobial agents.

*Anti-inflammatory activity: 
In vitro studies suggest that Oleth-2 might have anti-inflammatory properties. 
However, further research is needed to understand the mechanisms and potential therapeutic implications.

*Limitations and Future Directions:
While Oleth-2 offers valuable properties for various scientific research applications, it's important to acknowledge some limitations:

LIMITED UNDERSTANDING OF BIOLOGICAL ACTIVITY OF OLETH-2:
The mechanisms and potential therapeutic applications of Oleth-2's antimicrobial and anti-inflammatory properties require further investigation.

*Potential environmental concerns: 
As with many surfactants, the environmental impact of Oleth-2 needs to be carefully assessed, particularly regarding biodegradability and potential ecotoxicity.

FUTURE RESEARCH ON OLETH-2 COULD FOCUS ON:
Exploring the potential of its biological activities: 
Delve deeper into the mechanisms and potential applications of Oleth-2's antimicrobial and anti-inflammatory properties.

Developing more sustainable alternatives: 
Investigate the development of environmentally friendly alternatives to Oleth-2 with similar functional properties.

PHYSICAL and CHEMICAL PROPERTIES of OLETH-2:
Molecular Weight: 356.6 g/mol
XLogP3: 7.3
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Rotatable Bond Count: 21
Exact Mass: 356.32904526 Da
Monoisotopic Mass: 356.32904526 Da
Topological Polar Surface Area: 38.7 Ų
Heavy Atom Count: 25
Formal Charge: 0
Complexity: 254
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 0

Defined Bond Stereocenter Count: 1
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes
CAS Number: 9004-98-2
Chem/IUPAC Name: Poly(oxy-1,2-ethanediyl), .alpha.-9-(Z)-octadecenyl-.omega.-hydroxy (2 mol EO average molar ratio)
COSING REF No: 77921
Other (deleted CASRN): 115453-13-9
ECHA ELINCS - REACH Pre-Reg: 500-016-2
FDA UNII: Search
XlogP3-AA: 7.30 (est)
Formula: (C2 H4 O)mult-C18 H36 O
NMR Predictor: Predict (works with Chrome, Edge, or Firefox)
Assay: 95.00 to 100.00

Food Chemicals Codex Listed: No
Boiling Point: 416.00 to 417.00 °C @ 760.00 mm Hg (est)
Flash Point: > 200.00 °F TCC (> 93.33 °C)
logP (o/w): 7.557 (est)
CAS Number: 5274-65-7
Product Name: Oleth-2
IUPAC Name: 2-[2-[(Z)-octadec-9-enoxy]ethoxy]ethanol
Molecular Formula: C22H44O3
Molecular Weight: 356.6 g/mol
InChI: InChI=1S/C22H44O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-19-24-21-22-25-20-18-23/h9-10,23H,2-8,11-22H2,1H3/b10-9-
InChI Key: MGYUQZIGNZFZJS-KTKRTIGZSA-N
SMILES: CCCCCCCCC=CCCCCCCCCOCCOCCO
Synonyms: OLETH-2; Ethanol, 2-2-(9Z)-9-octadecenyloxyethoxy-
Canonical SMILES: CCCCCCCCC=CCCCCCCCCOCCOCCO
Isomeric SMILES: CCCCCCCC/C=CCCCCCCCCOCCOCCO

FIRST AID MEASURES of OLETH-2:
-Description of first-aid measures
*General advice:
Show this material safety data sheet to the doctor in attendance.
*If inhaled:
After inhalation: 
Fresh air.
*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with
water/ shower.
*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Call in ophthalmologist. 
Remove contact lenses.
*If swallowed:
After swallowing: 
Immediately make victim drink water (two glasses at most). 
Consult a physician.
-Indication of any immediate medical attention and special treatment needed.
No data available

ACCIDENTAL RELEASE MEASURES of OLETH-2:
-Environmental precautions:
Do not let product enter drains.
-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills. 
Observe possible material restrictions. 
Take up dry. 
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of OLETH-2:
-Extinguishing media:
*Suitable extinguishing media:
Carbon dioxide (CO2) 
Foam 
Dry powder
*Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.
-Further information:
Prevent fire extinguishing water from contaminating surface water or the ground water system.

EXPOSURE CONTROLS/PERSONAL PROTECTION of OLETH-2:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:
*Eye/face protection:
Use equipment for eye protection. 
Safety glasses
*Body Protection:
protective clothing
*Respiratory protection:
Recommended Filter type: Filter A 
-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of OLETH-2:
-Conditions for safe storage, including any incompatibilities:
*Storage conditions:
Tightly closed. 
Dry.

STABILITY and REACTIVITY of OLETH-2:
-Reactivity:
No data available
-Chemical stability:
Stable under recommended storage conditions.
-Possibility of hazardous reactions:
No data available
-Conditions to avoid:
No data available