ORTHO-PHTHALIC ALDEHYDE

Ortho-Phthalic Aldehyde is an aromatic dialdehyde compound widely used as a chemical reagent, analytical indicator, and intermediate in disinfectant and specialty chemical applications.
Ortho-Phthalic Aldehyde reacts readily with primary amines to produce fluorescent isoindole derivatives, making it highly valuable in chromatographic and biochemical quantification.
Ortho-Phthalic Aldehyde is appreciated for its high reactivity, pronounced chromophoric behavior, and suitability for analytical detection and industrial processing.

CAS Number: 643-79-8
EC Number: 211-402-2
Molecular Formula: C₈H₆O₂
Molecular Weight: 134.13 g/mol

Synonyms: Ortho-Phthalic Aldehyde, o-Phthalaldehyde, Phthaldialdehyde, OPA, 1,2-Benzenedicarboxaldehyde, Ortho-Phthalic Aldehyde, Ortho-Phthaldehyde, o-Phthaldehyde, OPA, o-Phthalaldehyde, o-Phthalic Dialdehyde, Ortho-Phthalic Dialdehyde, Phthalic Dialdehyde, Phthaldialdehyde, 1,2-Phthalic Dialdehyde, 1,2-Benzenedicarboxaldehyde, 1,2-Diformylbenzene, Benzene-1,2-dicarbaldehyde, Benzene-1,2-dicarboxaldehyde, Benzene-1,2-dialdehyde, o-Benzene Dialdehyde, Orthobenzenedial, Benzene-o-dialdehyde, Aromatic Dialdehyde, Aromatic Dialdehyde OPA, Aromatic Instrument Disinfectant OPA, OPA High-Level Disinfectant, OPA Medical Disinfectant, OPA Clinical Disinfectant, OPA Hospital Disinfectant, OPA Instrument Reprocessing Disinfectant, OPA Endoscope Disinfectant, OPA Sterilization Agent, OPA Cold Sterilant, OPA Sterilant, OPA Biocidal Agent, OPA Microbicidal Solution, OPA Antimicrobial Solution, OPA Healthcare Disinfectant, OPA Medical Grade Disinfectant, OPA High-Efficacy Disinfectant, OPA High-Level Instrument Disinfectant, Dialdehyde Disinfectant, Dialdehyde Sterilant, Aromatic Dialdehyde Sterilant, Ortho-Phthalic Aldehyde Reagent Grade, Ortho-Phthalic Aldehyde Analytical Grade, Ortho-Phthalic Aldehyde Laboratory Grade, Ortho-Phthalic Aldehyde Industrial Grade, Ortho-Phthalic Aldehyde Fine Chemical, Ortho-Phthalic Aldehyde Specialty Chemical, Ortho-Phthalic Aldehyde Raw Material, Ortho-Phthalic Aldehyde Organic Intermediate, Ortho-Phthalic Aldehyde Industrial Intermediate, Ortho-Phthalic Aldehyde Process Intermediate, Ortho-Phthalic Aldehyde Production Intermediate, OPA Chemical Intermediate, OPA Organic Intermediate, OPA Chromogenic Reagent, OPA Fluorescent Reagent, OPA Derivatization Reagent, OPA Amino Acid Derivatization Reagent, OPA HPLC Reagent, OPA Chromatography Reagent, OPA Analytical Reagent, Orthophthaldehyde Research Reagent, Orthophthaldehyde Fluorescence Reagent, Orthophthaldehyde Specialty Reagent, Ortho-Phthalaldehyde Medical Processing Chemical, Ortho-Phthalaldehyde Instrument Processing Chemical

APPLICATIONS

Ortho-Phthalic Aldehyde is used in analytical chemistry.
Ortho-Phthalic Aldehyde forms fluorescent derivatives with primary amines.
Ortho-Phthalic Aldehyde is applied in HPLC and fluorimetric detection.

Ortho-Phthalic Aldehyde is used in biochemical research.
Ortho-Phthalic Aldehyde allows quantification of amino acids and proteins.
Ortho-Phthalic Aldehyde supports ultra-sensitive laboratory assays.

Ortho-Phthalic Aldehyde is employed in disinfectant formulations.
Ortho-Phthalic Aldehyde serves as a component in high-level medical disinfectants.
Ortho-Phthalic Aldehyde assists in sterilization of medical instruments.

Ortho-Phthalic Aldehyde is used in organic synthesis.
Ortho-Phthalic Aldehyde functions as a versatile aromatic intermediate.
Ortho-Phthalic Aldehyde participates in condensation and reduction chemistry.

Ortho-Phthalic Aldehyde is applied in specialty polymer and resin production.
Ortho-Phthalic Aldehyde contributes to crosslinking reactions.
Ortho-Phthalic Aldehyde enhances thermal and mechanical characteristics of materials.

Ortho-Phthalic Aldehyde is used as a high-level disinfectant for medical instruments.
Ortho-Phthalic Aldehyde enables sterilization of heat-sensitive endoscopic devices.

Ortho-Phthalic Aldehyde is used in centralized sterilization units.
Ortho-Phthalic Aldehyde reduces cross-contamination risks in medical environments.
Ortho-Phthalic Aldehyde is used in automated reprocessing machines.

Ortho-Phthalic Aldehyde shortens turnaround times for clinical instruments.
Ortho-Phthalic Aldehyde is used in surgical clinics.
Ortho-Phthalic Aldehyde maintains disinfection standards during high patient throughput.

Ortho-Phthalic Aldehyde is used in dental offices.
Ortho-Phthalic Aldehyde disinfects mirrors, probes, and rotary equipment.

Ortho-Phthalic Aldehyde is used in ophthalmic instrument preparation.
Ortho-Phthalic Aldehyde supports disinfection of delicate optical tools.
Ortho-Phthalic Aldehyde is used in gastrointestinal endoscopy clinics.

Ortho-Phthalic Aldehyde replaces glutaraldehyde in long-term reprocessing systems.
Ortho-Phthalic Aldehyde is used in outpatient surgical suites.
Ortho-Phthalic Aldehyde reduces infection control burden during same-day procedures.

Ortho-Phthalic Aldehyde is used in ambulatory care centers.
Ortho-Phthalic Aldehyde supports compliance with sterile processing guidelines.

Ortho-Phthalic Aldehyde is used in emergency department equipment reprocessing.
Ortho-Phthalic Aldehyde helps maintain instrument readiness.

Ortho-Phthalic Aldehyde is used in laboratory equipment disinfection.
Ortho-Phthalic Aldehyde disinfects reusable pipettes and analytical tools.

Ortho-Phthalic Aldehyde is used in production of fluorescent derivatization reagents.
Ortho-Phthalic Aldehyde derivatizes primary amines for analytical detection.
Ortho-Phthalic Aldehyde is used in HPLC methodology development.

Ortho-Phthalic Aldehyde enhances detection of amino acids and peptides.
Ortho-Phthalic Aldehyde is used in LC-MS sample preparation workflows.
Ortho-Phthalic Aldehyde increases signal sensitivity for trace amine analysis.

Ortho-Phthalic Aldehyde is used in forensic laboratories.
Ortho-Phthalic Aldehyde supports detection of biological amines in forensic samples.

Ortho-Phthalic Aldehyde is used in environmental analysis.
Ortho-Phthalic Aldehyde assists in quantification of amines in water samples.

Ortho-Phthalic Aldehyde is used in occupational exposure testing.
Ortho-Phthalic Aldehyde helps detect airborne amines in industrial workplaces.

Ortho-Phthalic Aldehyde is used in biochemical protein assays.
Ortho-Phthalic Aldehyde forms fluorescent adducts enabling quantification.
Ortho-Phthalic Aldehyde is widely used as a disinfectant and analytical reagent.

Ortho-Phthalic Aldehyde enables high-level disinfection of heat-sensitive medical instruments.
Ortho-Phthalic Aldehyde offers advantages in odor and exposure profile compared to glutaraldehyde.

DESCRIPTION

Ortho-Phthalic Aldehyde appears as a pale yellow to off-white crystalline solid.
Ortho-Phthalic Aldehyde has a mild aromatic odor.
Ortho-Phthalic Aldehyde is sensitive to oxidation and may darken over time.

Ortho-Phthalic Aldehyde exhibits limited solubility in water.
Ortho-Phthalic Aldehyde is soluble in alcohols, acetone, and other polar organic solvents.
Ortho-Phthalic Aldehyde reacts strongly with nucleophilic functional groups.

Ortho-Phthalic Aldehyde contains two aldehyde groups positioned ortho on a benzene ring.
Ortho-Phthalic Aldehyde forms fluorescent isoindole derivatives upon reacting with amines.
Ortho-Phthalic Aldehyde is widely used as a chromogenic reagent in laboratory settings.

Ortho-Phthalic Aldehyde is stable under dry, cool, and light-protected conditions.
Ortho-Phthalic Aldehyde may polymerize or oxidize under improper storage.
Ortho-Phthalic Aldehyde should be kept tightly sealed to maintain purity.

Ortho-Phthalic Aldehyde is an aromatic dialdehyde consisting of a benzene ring substituted with two aldehyde groups in the ortho position.
Ortho-Phthalic Aldehyde is also known as o-Phthalaldehyde or OPA.
Ortho-Phthalic Aldehyde is typically obtained as a white to pale yellow crystalline solid.

Ortho-Phthalic Aldehyde dissolves in organic solvents and forms reactive aqueous solutions.
Ortho-Phthalic Aldehyde exhibits strong reactivity toward primary aliphatic amines.
Ortho-Phthalic Aldehyde generates fluorescent isoindole derivatives in derivatization reactions.

Ortho-Phthalic Aldehyde is sensitive to oxidation and polymerization reactions.
Ortho-Phthalic Aldehyde must be protected from light and air during storage.
Ortho-Phthalic Aldehyde requires proper ventilation during use in healthcare environments.

Ortho-Phthalic Aldehyde is regulated due to occupational exposure considerations.
Ortho-Phthalic Aldehyde should be stored in sealed containers under controlled temperature.
Ortho-Phthalic Aldehyde is valued for its analytical selectivity and disinfection efficiency.

PROPERTIES

Chemical Formula: C₈H₆O₂
Molecular Weight: 134.13 g/mol
Appearance: Pale yellow to off-white crystalline solid
Odor: Mild aromatic odor
Density: ~1.26 g/cm³ (solid)
Melting Point: ~54–56 °C
Boiling Point: ~315–320 °C (decomposes)
Solubility in Water: Slight (~1–2 g/L at ambient)
Solubility in Alcohols: Freely soluble
Solubility in Acetone: Soluble
Vapor Pressure: Low at ambient temperature
Flash Point: >160 °C (closed cup)
Thermal Stability: Decomposes at elevated temperatures
Chemical Reactivity: Highly reactive with amines and nucleophiles
Fluorescence Behavior: Produces fluorescent isoindole complexes
Oxidation Sensitivity: High; prone to color change during storage
Storage Stability: Good when stored cool and protected from light

FIRST AID

Inhalation:
Move to fresh air.
Seek medical attention if respiratory irritation occurs.

Skin Contact:
Wash thoroughly with soap and water.
Seek medical advice if irritation develops.

Eye Contact:
Rinse with plenty of water for at least 15 minutes.
Seek immediate medical attention.

Ingestion:
Rinse mouth with water.
Do not induce vomiting.
Seek immediate medical attention.

Note to Physicians:
Treat symptomatically; monitor for irritant or sensitization responses.

HANDLING AND STORAGE

Handling:
Use gloves, goggles, and appropriate PPE.
Ensure sufficient ventilation during handling.

Avoidance:
Avoid heat, strong bases, and oxidizing agents.
Avoid skin and eye contact.

Spill Procedures:
Avoid dust generation.
Collect mechanically and clean with compatible solvents.
Dispose according to regulations.

Storage:
Store in tightly sealed containers.
Keep in a cool, dry, light-protected environment.
Minimize air exposure to preserve stability.