OXYBISPROPANEDIOL (DIGLYCERIN)

Oxybispropanediol (diglycerin) is a high-purity polyol containing multiple hydroxyl groups, produced by the controlled condensation and purification of glycerin.
Oxybispropanediol (diglycerin) functions as an efficient humectant and solvent by strongly binding water molecules, enhancing hydration, formulation stability, and texture while reducing the stickiness typically associated with glycerin.
Because of its excellent tolerability, biodegradability, and wide formulation compatibility, Oxybispropanediol (diglycerin) is extensively used in skincare, oral care, pharmaceuticals, and food systems requiring sustained moisture retention.

CAS number: 59113-36-9
EC number: 261-652-8
Molecular formula: C6H14O5
Molecular weight: 166.17 g/mol

Synonyms: Diglycerol, Diglycerin, 3-(2,3-dihydroxypropoxy)propane-1,2-diol, 3-glyceryloxypropane-1,2-diol, 3YC120743U, Glycerol dimer, RESASSOL DN, DIGLYCERIN 801, GREAT OIL DI 1, RefChem:1083566, Beautyturess 80gTanning Cream, DTXSID10891325, Beautyturess 80g Shiny Tanning Cream, 261-605-5, 59113-36-9, 627-82-7, Diglycerine, alpha,alpha'-Diglycerol, 3,3'-Oxybis(propane-1,2-diol), 1,2-Propanediol, 3,3'-oxybis-, .alpha.,.alpha.'-Diglycerol, 4-Oxaheptane-1,2,6,7-tetrol, MFCD00049316, UC0A740LR3, 3,3'-Oxydi(propane-1,2-diol), NSC-8689, glyceryl ether, UNII-UC0A740LR3, diglyceryl ether, 3,3'-Oxydi(propylene glycol), 3,2-propanediol, NSC8689, 1,2-Propanediol, 3,3'-oxydi-, Oxydi(propanediol), 3,3'-Oxydi-1,2-propanediol; 4-Oxaheptane-1,2,6,7-tetrol; Bis(2,3-dihydroxypropyl) Ether; NSC 8689, EINECS 211-013-8, Tetrahydroxydipropyl Ether, 1, 3,3'-oxybis-, 1, 3,3'-oxydi-, Diglycerol (isomers mixture), SCHEMBL30754, 4-Oxaheptane-1,6,7-tetrol, 3,3'-oxydipropane-1,2-diol, 1,2,3-Propanetriol; Glycerin, 3,3'-Oxydi-1,2-propanediol, SCHEMBL11478187, UNII-3YC120743U, GPLRAVKSCUXZTP-UHFFFAOYSA-, DTXSID90872273, CHEBI:140430, DIGLYCERIN, ALPHA,ALPHA'-, bis-(2,3-dihydroxy-propyl)-ether, NSC 8689, EINECS 261-605-5, .ALPHA.,.ALPHA.'-DIGLYCERIN, AKOS015915864, Glycerol; Myo-Inositol EP Impurity B, FD39315, DIGLYCERIN, .ALPHA.,.ALPHA.'-, SY053494, DB-053322, CS-0197339, NS00009635, T0119, EC 261-605-5, F71162, .ALPHA.,.ALPHA.'-DIGLYCEROL, (+/-)-, EN300-7701666, F130200, Q27291013, InChI=1/C6H14O5/c7-1-5(9)3-11-4-6(10)2-8/h5-10H,1-4H2, 51493-70-0

Oxybispropanediol (diglycerin) is a colorless, odorless, water-soluble polyol produced by the condensation of two glycerin molecules.
Oxybispropanediol (diglycerin) is widely used as a humectant, moisturizer, solvent, and viscosity-modifying agent in cosmetic, personal care, pharmaceutical, and food applications.
Compared to glycerin, Oxybispropanediol (diglycerin) offers lower tackiness, improved skin feel, and longer-lasting moisture retention, making it especially suitable for high-performance skincare formulations.

Oxybispropanediol (diglycerin) has excellent hygroscopic properties, allowing it to attract and retain water, which helps maintain hydration and improve texture stability in formulations.
Oxybispropanediol (diglycerin) is non-toxic, non-irritating, and biodegradable, and shows good compatibility with a wide range of ingredients.
Due to its stability and mildness, Oxybispropanediol (diglycerin) is commonly used in creams, lotions, serums, oral care products, pharmaceuticals, and functional food products where gentle but effective moisturization is required.

Oxybispropanediol (diglycerin) is an excellent moisturizer and humectant that is highly valued in the cosmetic and personal care industry.
Oxybispropanediol (diglycerin) effectively attracts moisture, enhancing hydration in products like moisturizers, cleansers, and serums.

As a solvent and viscosity modifier, Oxybispropanediol (diglycerin) improves texture and stability in formulations.
In its raw form, Oxybispropanediol (diglycerin) appears as a colorless to pale yellow viscous liquid and has a mild, natural scent.

Oxybispropanediol (diglycerin) is generally recognized as safe for all skin types, being non-irritating and non-sensitizing.
Since Oxybispropanediol (diglycerin) is derived from natural sources, it is biodegradable and aligns with eco-friendly and sustainable cosmetics.
The chemical formula of Oxybispropanediol (diglycerin) is C12H24O6.

Oxybispropanediol (diglycerin) is a high-purity polyol with four hydroxyl groups, obtained by the reaction, distillation, and purification of glycerol.
Oxybispropanediol (diglycerin) is widely used in cosmetics as a moisturizer and as a raw material for fatty acid esters and other substances.
Oxybispropanediol (diglycerin) is a dimer of glycerol, therefore its molecular structure is larger.

Oxybispropanediol (diglycerin) has excellent moisturizing properties that reduce the stickiness of glycerin. 
Allows various textures from light to deep moist depending on the dosage.
In toiletry products, Oxybispropanediol (diglycerin) improves foam viscosity and elasticity.

Oxybispropanediol (diglycerin) is a polyol compound formed by linking two glycerol molecules via an ether bond, naturally present in some oils and also synthesized chemically.
In cosmetics, Oxybispropanediol (diglycerin) functions as a humectant, solvent, and texture modifier, offering high moisturizing power with mildness for various formulations.

Oxybispropanediol (diglycerin) is a highly pure polyol with four hydroxyl groups produced through glycerin reaction, distillation, and refinement.
Oxybispropanediol (diglycerin) is widely used as a moisturizer in cosmetics and as a raw material for fatty acid esters and other substances.

Oxybispropanediol (diglycerin) is a highly beneficial ingredient for individuals with dry or dehydrated skin, thanks to its humectant properties that enhance water retention within the skin.
Besides its moisturizing capabilities, Oxybispropanediol (diglycerin)erves as an effective solvent and can improve the viscosity of foam in personal care products.
You can find this versatile ingredient in various products such as cleansers, lotions, shaving creams, shampoos, and makeup items.

Created by bonding two glycerin molecules together, Oxybispropanediol (diglycerin)uppliers claim it provides longer-lasting hydration compared to glycerin, owing to its higher molecular weight, which slows down penetration and allows it to remain on the skin for an extended period.
Additionally, Oxybispropanediol (diglycerin) is less sticky than glycerin, contributing to a more aesthetically pleasing user experience.
That said, cosmetic chemists familiar with glycerin's aesthetic drawbacks know how to combine Oxybispropanediol (diglycerin) with other ingredients, such as dimethicone, for an improved sensory experience.

While the Cosmetic Ingredient Review (CIR) has not yet finalized their safety report on Oxybispropanediol (diglycerin), it is helpful to note that previous assessments for glycerin by the CIR concluded it as safe for cosmetic use.
As of 2022, the highest reported concentration of Oxybispropanediol (diglycerin) usage was 28% in skin cleansing products and up to 5% in non-spray face and neck products.

In its raw form, Oxybispropanediol (diglycerin) is a colorless to slightly yellow viscous liquid at room temperature.
Oxybispropanediol (diglycerin) may also be referred to as glycerol dimer or diglycerol.

As part of the glycerol ester family, Oxybispropanediol (diglycerin) is present in nearly 0.33% of skin and/or hair care formulas.
As a result, Oxybispropanediol (diglycerin) is listed in the ingredients of certain face masks, creams, shampoos, serums for sensitive skin, and some exfoliating wipes.

Oxybispropanediol (diglycerin) is used not only in the field of cosmetology, but also in the food industry.
Oxybispropanediol (diglycerin) appears as a food additive serving as an emulsifying agent, coating, gelling agent, or a carrier for colouring.

Uses of Oxybispropanediol (Diglycerin):
Oxybispropanediol (diglycerin) is widely used in cosmetics and personal care products due to its moisturizing and skin-conditioning properties.
As a potent humectant, Oxybispropanediol (diglycerin) attracts moisture to the skin, making it a key ingredient in moisturizers, lotions, and serums.

In cleansers and body washes, Oxybispropanediol (diglycerin) helps maintain hydration while effectively removing impurities.
Oxybispropanediol (diglycerin) also enhances the texture and application of makeup products like foundations and primers.

Additionally, Oxybispropanediol (diglycerin)erves as a stabilizer in emulsions, ensuring even distribution of ingredients.
Oxybispropanediol (diglycerin)'s versatility makes it suitable for a broad range of formulations, contributing to improved skin health and product performance.

Oxybispropanediol (diglycerin) is widely used as a humectant, moisturizer, and solvent in cosmetics, personal care, pharmaceutical, food, and industrial formulations.
In skin- and hair-care products, Oxybispropanediol (diglycerin) improves hydration, enhances skin feel, and provides long-lasting moisture with less tackiness than glycerin.
Oxybispropanediol (diglycerin) is also used in pharmaceutical and oral care products as a stabilizing and moisturizing agent, in foods as a humectant and texture enhancer, and in industrial formulations as a plasticizer or viscosity modifier due to its high water affinity, safety, and formulation compatibility.

Cosmetics and Personal Care:
Oxybispropanediol (diglycerin) is widely used as a humectant and moisturizer in skin-care and hair-care products such as creams, lotions, serums, cleansers, shampoos, and conditioners.
Oxybispropanediol (diglycerin) improves skin hydration, reduces dryness, and provides a smooth, non-sticky feel.

Pharmaceuticals:
In pharmaceutical formulations, Oxybispropanediol (diglycerin) is used as a solvent, stabilizer, and moisturizing agent in oral syrups, topical preparations, and medicinal creams due to its safety and good skin tolerance.

Food Industry:
Oxybispropanediol (diglycerin) is used as a food additive (humectant and texturizer) to retain moisture, improve mouthfeel, and prevent drying in products such as baked goods, confectionery, and processed foods, subject to regulatory approval.

Oral Care Products:
Oxybispropanediol (diglycerin) is commonly used in toothpaste and mouthwash formulations to maintain moisture, enhance texture, and improve product stability.

Industrial Applications:
Oxybispropanediol (diglycerin) is used as a plasticizer, solvent, and viscosity modifier in specialty chemical formulations, resins, adhesives, and coatings where moisture retention and stability are required.

Industry Uses:
Solvent
Intermediates

Consumer Uses:
Other
Plasticizer

Purpose and Benefits of Oxybispropanediol (Diglycerin):
Oxybispropanediol (diglycerin) is a special ingredient that works not only on the surface of the skin, but also deep within its layers.
Oxybispropanediol (diglycerin)'s ability to intensely attract and retain water molecules makes it an extremely effective solution for dry skin problems.

This moisturizing effect is not limited to an immediate effect – Oxybispropanediol (diglycerin) creates a long-lasting moisture balance, helping the skin to recover and maintain its natural radiance.
Oxybispropanediol (diglycerin) also reduces skin flaking, soothes irritations and provides a feeling of comfort, even for sensitive skin.

In addition to skin care, Oxybispropanediol (diglycerin) also plays an important role in hair care products.
Oxybispropanediol (diglycerin) helps protect hair from dryness, giving it flexibility and silky smoothness.

Oxybispropanediol (diglycerin) is especially suitable for chemically or heat-damaged hair, as it strengthens the moisture balance in the hair fiber, restoring its healthy appearance and vitality.
Oxybispropanediol (diglycerin) is not only a functional, but also a subtly elegant solution for taking care of your beauty every day.

What makes Oxybispropanediol (diglycerin)o special is its ability to act as a multifaceted enhancer in cosmetic formulas.
Oxybispropanediol (diglycerin) not only improves the texture and consistency of products, but also increases the effectiveness of other active ingredients, allowing them to be better absorbed into the skin or hair.
This property makes Oxybispropanediol (diglycerin) not only a functional, but also a strategically important element trusted by cosmetic creators around the world.

Oxybispropanediol (diglycerin) is also an excellent choice for those who value naturalness and sustainability.
Often derived from renewable plant sources, Oxybispropanediol (diglycerin) meets the growing need for environmentally friendly ingredients.
Oxybispropanediol (diglycerin) is a subtle expression of the balance between effectiveness and responsibility to nature, which is valued by both cosmetic manufacturers and consumers.

Origin of Oxybispropanediol (Diglycerin):
Oxybispropanediol (diglycerin) is produced through the glycerolysis process, where glycerol undergoes a controlled reaction, often in the presence of a catalyst, to form Oxybispropanediol (diglycerin).
This reaction typically occurs at elevated temperatures and can involve glycerol reacting with itself or with fatty acids.

After the reaction, the mixture is purified to remove impurities.
The final product is then refined to meet the quality standards required for use in cosmetics.

Action Mechanism of Oxybispropanediol (Diglycerin):
Oxybispropanediol (diglycerin) acts primarily as a humectant by attracting and binding water molecules through its multiple hydroxyl (–OH) groups.
These hydroxyl groups form hydrogen bonds with water, allowing Oxybispropanediol (diglycerin) to draw moisture from the surrounding environment and retain it within the formulation or on the skin surface.
This mechanism helps maintain hydration, prevent moisture loss, and improve softness and elasticity.

In topical applications, Oxybispropanediol (diglycerin) penetrates the upper layers of the stratum corneum and supports the skin’s natural moisture balance without causing irritation or stickiness.
In formulations, Oxybispropanediol (diglycerin) also functions as a solvent and stabilizer, improving ingredient solubility, reducing crystallization, and enhancing texture stability.
Through these combined actions, Oxybispropanediol (diglycerin) provides long-lasting moisturization, improved sensory properties, and enhanced formulation performance.

Stability and Reactivity of Oxybispropanediol (Diglycerin):

Chemical stability:
Oxybispropanediol (diglycerin) is chemically stable under normal conditions of use, handling, and storage.
Oxybispropanediol (diglycerin) does not readily decompose or undergo hazardous reactions.

Reactivity:
No hazardous reactions are expected under normal conditions.

Conditions to avoid:
Excessive heat, prolonged exposure to very high temperatures, and strong oxidizing conditions.

Incompatible materials:
Strong oxidizing agents and strong acids at elevated temperatures.

Hazardous decomposition products:
Thermal decomposition may produce carbon oxides (CO, CO₂) and irritating organic vapors.

Handling and Storage of Oxybispropanediol (Diglycerin):

Handling:
Handle in accordance with good industrial hygiene and safety practices.
Avoid unnecessary contact with eyes and prolonged skin exposure.

Hygiene measures:
Wash hands after handling.
Avoid eating, drinking, or smoking in handling areas.

Storage:
Store in a cool, dry, and well-ventilated area.
Keep containers tightly closed when not in use.

Storage conditions:
Protect from excessive heat and contamination.

Packaging materials:
Use clean, inert, and tightly sealed containers.

Shelf life:
Long shelf life when stored under recommended conditions.

First Aid Measures of Oxybispropanediol (Diglycerin):

Inhalation:
Not expected to be hazardous.
If mist or vapor is inhaled and discomfort occurs, move the person to fresh air.

Skin contact:
Wash skin with soap and water.
Oxybispropanediol (diglycerin) is generally non-irritating.
Seek medical advice if irritation develops.

Eye contact:
Rinse cautiously with clean water for several minutes.
Remove contact lenses if present and easy to do.
Seek medical attention if irritation persists.

Ingestion:
Rinse mouth with water.
Generally non-toxic.
Seek medical advice if large quantities are ingested or if discomfort occurs.

Most important symptoms:
Mild eye or skin irritation in sensitive individuals.

Firefighting Measures of Oxybispropanediol (Diglycerin):

Flammability:
Oxybispropanediol (diglycerin) is combustible at high temperatures but does not ignite easily under normal conditions.

Suitable extinguishing media:
Water spray, foam, dry chemical powder, or carbon dioxide (CO₂).

Hazardous combustion products:
Carbon monoxide, carbon dioxide, and organic fumes.

Protective equipment for firefighters:
Self-contained breathing apparatus and full protective clothing.

Special precautions:
Cool exposed containers with water spray to prevent rupture.

Accidental Release Measures of Oxybispropanediol (Diglycerin):

Personal precautions:
Avoid slipping hazard due to the viscous liquid.
Use appropriate personal protective equipment if necessary.

Environmental precautions:
Prevent large quantities from entering drains or watercourses.

Methods for cleanup:
Absorb with inert absorbent material such as sand, vermiculite, or universal absorbents.
Collect into suitable containers for disposal according to local regulations.
Clean affected area with water after removal.

Exposure Controls / Personal Protective Equipment of Oxybispropanediol (Diglycerin):

Occupational exposure limits:
Not established.

Engineering controls:
General ventilation is normally sufficient.

Personal protective equipment (PPE):

Respiratory protection:
Not normally required.

Hand protection:
Protective gloves recommended for prolonged or repeated contact.

Eye protection:
Safety glasses recommended to prevent splashes.

Skin protection:
Protective work clothing if frequent contact is expected.

Hygiene measures:
Wash hands after handling and before breaks.
Maintain good industrial hygiene practices.

Identifiers of Oxybispropanediol (Diglycerin):
CAS number: 59113-36-9
EC number: 261-652-8
Molecular formula: C6H14O5
Molecular weight: 166.17 g/mol
Chemical family: Polyols (glycols / glycerol derivatives)
Physical form: Colorless, viscous liquid

Molecular Weight: 166.17
Exact Mass: 166.084122
EC Number: 211-013-8

CAS Number: 59113-36-9
Other(deleted CASRN): 111569-93-8
ECHA EINECS -
REACH Pre-Reg: 261-605-5
FDA UNII: 3YC120743U
Nikkaji Web: J6.871C
XlogP3-AA: -2.50 (est)
Molecular Weight: 166.17358000
Formula: C6 H14 O5

CAS Number: 59113-36-9 / 25618-55-7
Chem/IUPAC Name: Oxybispropanediol
EINECS/ELINCS No: 261-605-5
COSING REF No: 75728

Properties of Oxybispropanediol (Diglycerin):
Appearance: Colorless, clear, viscous liquid
Odor: Odorless
Taste: Slightly sweet
Solubility: Miscible with water and alcohols
Viscosity: High viscosity (greater than glycerin)
Density: Approximately 1.27 g/cm³ (20 °C)
Boiling point: >300 °C (decomposes)
Flash point: >160 °C
Hygroscopicity: Strongly hygroscopic
Stability: Chemically stable under normal conditions

Appearance: colorless clear viscous liquid (est)
Assay: 95.00 to 100.00
Food Chemicals Codex Listed: No
Boiling Point: 407.00 to 408.00 °C. @ 760.00 mm Hg (est)
Flash Point: 392.00 °F. TCC ( 200.00 °C. ) (est)
logP (o/w): -2.048 (est)

Molecular Weight: 166.17 g/mol
XLogP3-AA: -2.5
Hydrogen Bond Donor Count: 4
Hydrogen Bond Acceptor Count: 5
Rotatable Bond Count: 6
Exact Mass: 166.08412354 Da
Monoisotopic Mass: 166.08412354 Da
Topological Polar Surface Area: 90.2 Ų
Heavy Atom Count: 11
Complexity: 77
Isotope Atom Count: 0
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count: 2
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Covalently-Bonded Unit Count: 1
Compound Is Canonicalized: Yes

PSA: 90.15000
XLogP3: -2.61
Appearance: yellowish viscous liquid
Density: 1.2774 g/cm3 @ Temp: 20 °C
Melting Point: 96-97 °C
Boiling Point: 173 °C @ Press: 14 Torr
Flash Point: 200.0±27.3 °C
Refractive Index: 1.516

Specifications of Oxybispropanediol (Diglycerin):
Appearance: Colorless, clear viscous liquid
Chemical type: Polyol (diglycerol)
Purity: ≥ 98% (typical, grade-dependent)
Water content: ≤ 1.0%
Viscosity (25 °C): High (grade-dependent)
Density (20–25 °C): ~1.26–1.28 g/cm³
pH (aqueous solution): Neutral to slightly acidic
Flash point: >160 °C