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p-Toluidine is an aromatic amine used as an intermediate in the manufacture of dyes, pigments, pharmaceuticals, and agrochemicals.
p-Toluidine belongs to the toluidine family, consisting of isomers with a methyl group attached to the benzene ring along with an amino group.
p-Toluidine is valued for its reactivity in diazotization, coupling, and condensation reactions, making it important in dye and chemical industries.
CAS Number: 106-49-0
EC Number: 203-403-1
Molecular Formula: C7H9N
Molecular Weight: 107.15 g/mol
Synonyms: p-Toluidine, 4-Toluidine, para-Toluidine, 4-Methylaniline, p-Methylaniline, 1-Amino-4-methylbenzene, 4-Amino-1-methylbenzene, 4-Aminotoluene, para-Methylaniline, Dye intermediate p-toluidine, Pigment intermediate para-toluidine, Pharmaceutical intermediate p-toluidine, Agrochemical intermediate p-toluidine, Industrial grade para-toluidine, p-Toluidine base
APPLICATIONS
p-Toluidine is widely used as an intermediate in the manufacture of azo dyes.
p-Toluidine is applied in diazotization and coupling reactions for producing vibrant textile dyes.
p-Toluidine is used in pigments and printing inks.
p-Toluidine is incorporated into rubber chemicals.
p-Toluidine is used in antioxidant and accelerator production for rubber vulcanization.
p-Toluidine is applied in tire and industrial rubber products.
p-Toluidine is employed in pharmaceutical synthesis.
p-Toluidine is used as an intermediate in analgesics and antipyretic drugs.
p-Toluidine is applied in the manufacture of sulfa drugs and other APIs.
p-Toluidine is utilized in agrochemicals.
p-Toluidine is used in the production of herbicides and insecticides.
p-Toluidine is applied in fungicidal intermediates.
p-Toluidine is incorporated into specialty chemicals.
p-Toluidine is used in polymer chemistry as a curing agent precursor.
p-Toluidine is applied in epoxy and resin hardeners.
p-Toluidine is employed in laboratory research.
p-Toluidine is used in organic synthesis as a model aromatic amine.
p-Toluidine is applied in teaching reactions involving aromatic substitution.
p-Toluidine is utilized in hair dye formulations in trace concentrations.
p-Toluidine is included in oxidative dye systems as an intermediate.
p-Toluidine is applied in cosmetic colorant chemistry under strict regulations.
P-Toluidine is used as an intermediate in the manufacture of dyes.
P-Toluidine is incorporated into the synthesis of azo dyes for textiles.
P-Toluidine is applied in the production of pigments for printing inks.
P-Toluidine is used in the pharmaceutical industry as a raw material.
P-Toluidine is incorporated into the synthesis of local anesthetics.
P-Toluidine is applied in the preparation of analgesic compounds.
P-Toluidine is used in agrochemical production.
P-Toluidine is incorporated into the synthesis of herbicides.
P-Toluidine is applied in the manufacture of fungicides and insecticides.
P-Toluidine is used in rubber chemicals manufacturing.
P-Toluidine is incorporated into antioxidant formulations for rubber stabilization.
P-Toluidine is applied in vulcanization accelerators.
P-Toluidine is used in the production of photographic chemicals.
P-Toluidine is incorporated into developing agents.
P-Toluidine is applied in stabilizers for imaging processes.
P-Toluidine is used as a reagent in organic synthesis.
P-Toluidine is incorporated into laboratory experiments involving aromatic amines.
P-Toluidine is applied in the synthesis of heterocyclic compounds.
P-Toluidine is used in polymer chemistry.
P-Toluidine is incorporated into resin production.
P-Toluidine is applied in curing agents for epoxy systems.
P-Toluidine is used in corrosion inhibitor formulations.
P-Toluidine is incorporated into protective coatings for metals.
P-Toluidine is applied in oilfield chemical blends.
P-Toluidine is used in the synthesis of hair dye intermediates.
P-Toluidine is incorporated into permanent hair colorants.
P-Toluidine is applied in cosmetic formulations under controlled regulations.
P-Toluidine is used in adhesive and sealant chemistry.
P-Toluidine is incorporated into curing agents for polyurethane systems.
P-Toluidine is applied in modified epoxy formulations.
P-Toluidine is used in the leather industry for dyeing processes.
P-Toluidine is incorporated into formulations for synthetic leather coloring.
P-Toluidine is applied in natural leather treatment chemicals.
P-Toluidine is used in specialty fine chemicals.
P-Toluidine is incorporated into intermediates for advanced organic synthesis.
P-Toluidine is applied in custom research compounds.
P-Toluidine is used in electroplating formulations.
P-Toluidine is incorporated into baths for surface finishing.
P-Toluidine is applied in processes for improved deposition quality.
P-Toluidine is used in academic research.
P-Toluidine is incorporated into mechanistic studies of aromatic substitution.
P-Toluidine is applied in teaching laboratories as an example of a para-substituted amine.
DESCRIPTION
p-Toluidine is a colorless to pale brown liquid or low-melting solid that darkens upon exposure to air and light.
p-Toluidine has a characteristic amine odor.
p-Toluidine is slightly soluble in water but freely soluble in alcohol, ether, and organic solvents.
p-Toluidine readily undergoes diazotization to form diazonium salts.
p-Toluidine reacts with oxidizing agents, forming colored products.
p-Toluidine is stable under proper storage but oxidizes on exposure to air.
p-Toluidine is toxic and can be absorbed through the skin.
p-Toluidine is classified as harmful due to its potential to cause methemoglobinemia.
p-Toluidine requires controlled handling and protective measures in industrial use.
p-Toluidine is considered a hazardous chemical under international regulations.
P-Toluidine is an aromatic amine with a methyl group in the para position relative to the amino group on the benzene ring.
P-Toluidine appears as a colorless to pale brown solid that may darken upon air exposure.
P-Toluidine has a characteristic aromatic amine odor.
P-Toluidine is slightly soluble in water but readily soluble in alcohol, ether, and acids.
P-Toluidine is flammable and can oxidize, leading to color changes during storage.
P-Toluidine is a versatile chemical intermediate in dyes, pharmaceuticals, and agrochemicals.
P-Toluidine is toxic and must be handled with protective measures in laboratory and industrial environments.
P-Toluidine can undergo diazotization reactions to produce azo compounds.
P-Toluidine is industrially produced by nitration of toluene followed by reduction of p-nitrotoluene.
P-Toluidine is widely used in specialty chemical, dye, pharmaceutical, and agrochemical industries.
PROPERTIES
Chemical Formula: C7H9N
Molecular Weight: 107.15 g/mol
Common Name: p-Toluidine (para-Toluidine)
Appearance: Colorless to pale brown liquid or crystalline solid (darkens on storage)
Odor: Characteristic aromatic amine odor
Density: ~1.03 g/cm³
Melting Point: 43–45°C
Boiling Point: 200–202°C
Flash Point: ~80°C (closed cup)
Solubility: Slightly soluble in water; soluble in alcohol, ether, and organic solvents
Reactivity: Reactive in diazotization and coupling; oxidizes in air
Chemical Stability: Stable when stored away from light and air
Storage Temperature: Store at 2–8°C in tightly sealed containers
FIRST AID
Inhalation:
If p-Toluidine vapors are inhaled, move person to fresh air.
Seek immediate medical attention if symptoms such as dizziness or breathing difficulty occur.
Provide oxygen if necessary.
Skin Contact:
Wash skin immediately with soap and water.
Seek medical attention if irritation or systemic effects occur.
Remove contaminated clothing and wash before reuse.
Eye Contact:
Rinse eyes thoroughly with water for at least 15 minutes.
Seek immediate medical attention if redness, pain, or vision disturbances occur.
Remove contact lenses if present and continue rinsing.
Ingestion:
If p-Toluidine is ingested, rinse mouth thoroughly with water.
Do not induce vomiting unless directed by medical personnel.
Seek immediate medical attention.
Note to Physicians:
Treat symptomatically.
Monitor for methemoglobinemia and provide oxygen or methylene blue as required.
Provide supportive care.
HANDLING AND STORAGE
Handling:
Personal Protection:
Wear chemical-resistant gloves, goggles, and protective clothing when handling p-Toluidine.
Use appropriate respiratory protection in poorly ventilated areas.
Ventilation:
Ensure proper local exhaust ventilation during handling.
Prevent accumulation of vapors.
Avoidance:
Avoid contact with skin, eyes, and clothing.
Do not eat, drink, or smoke while handling.
Wash thoroughly after use.
Spill and Leak Procedures:
Absorb spills with inert material (sand, vermiculite).
Collect into sealed containers for disposal.
Avoid entry into drains and waterways.
Storage:
Store p-Toluidine in a cool, dry, and well-ventilated area.
Keep containers tightly closed and protected from light and air.
Avoid strong oxidizing agents and acids.
Handling Cautions:
Prevent prolonged exposure to air to avoid oxidation.
Maintain containers under inert atmosphere for stability.
Follow strict industrial hygiene measures due to toxicity risks.
