PCMX

PARA-CHLORO-META-XYLENOL (PCMX)

CHLOROXYLENOL

CAS Number: 88-04-0    
EC Number: 201-793-8
Molecular Formula: ClC6H2(CH3)2OH
Molecular Weight: 156.61 g/mol

Chloroxylenol, also known as para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant which is used for skin disinfection, and together with alcohol for cleaning surgical instruments. 
PCMX is also used within a number of household disinfectants and wound cleaners. 
PCMX is thought to act by disrupting microbial cell walls and inactivating cellular enzymes, and is less effective than some other available agents. 

Chloroxylenol, or para-chloro-meta-xylenol (PCMX), is an antiseptic and disinfectant agent used for skin disinfection and surgical instruments. 
PCMX is found in antibacterial soaps, wound-cleansing applications, and household antiseptics. 

The halophenol is shown to be most effective against Gram positive bacteria where PCMX disrupts the cell wall due to PCMX phenolic nature. 
PCMX is on the World Health Organization's List of Essential Medicines.

PCMX acts as a broad spectrum low-toxic anti-bacterial agent. 
PCMX is an effective and highly-efficient disinfectant and cleanser. 
PCMX has large potency to gram-positive, gram-negative, epiphyte and mildew micro-organisms. 

PCMX has good chemical stability and doesn’t lose activity in normal storage conditions. 
PCMX is soluble in water, alkaline solution and organic solvents. 

PCMX finds application in formulating anti-bacterial hand soaps, shampoos and personal-care products.
4-chloro-3,5-dimethylphenol is a member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. 
PCMX is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. 

PCMX is ineffective against bacterial spores. 
PCMX has a role as an antiseptic drug, a disinfectant and a molluscicide. 

PCMX is a member of phenols and a member of monochlorobenzenes. 
PCMX derives from a 3,5-xylenol.

Para-Chloro-Meta-Xylenol (PCMX) is an antiseptic and disinfectant. 
PCMX is used for skin disinfection and cleaning surgical instruments. 
PCMX is also used within a number of household disinfectants and wound cleaners.

Chloroxylenol (PCMX) also called 4-Chloro-3, 5-dimethylphenol, is a white crystal. 
PCMX is a secure, high-efficient, broad spectrum and low-toxic antiseptic. 

PCMX has large potency to Gram-positive, Gram-negative, epiphyte and mildew approved by FDA. 
PCMX has good chemical stability and doesn’t lose the activity in normal storage conditions. 
Solubility in water is 0.03 wt%, freely soluble in organic solvent such as alcohols, ethers, polyglycols, etc. and solutions of alkali hydroxides frequently used in personal clean care products.

This product is low-poison antibacterial, frequently used in personal care products such as hand - cleaning detergent, soap, dandruff control shampoo and healthy products, etc. 

4-chloro-3,5-dimethylphenol is a member of the class of phenols that is 3,5-xylenol which is substituted at position 4 by chlorine. 
PCMX is bactericidal against most Gram-positive bacteria but less effective against Staphylococci and Gram-negative bacteria, and often inactive against Pseudomonas species. 

PCMX is ineffective against bacterial spores. 
PCMX has a role as an antiseptic drug, a disinfectant and a molluscicide. 

PCMX is a member of phenols and a member of monochlorobenzenes. 
PCMX derives from a 3,5-xylenol.

PCMX, also known as PCMX, is used as a preservative in cooling fluids, cosmetics, topical medications, urinary antiseptics and metal working fluids. 
Liquids are used for cleaning and disinfecting wounds, abrasions and abscesses. 

The creams are used for cuts, scratches, insect bites, burns and similar problems. 
Powders are used to treat problems of the feet and skin inflammations. 

PCMX is also found in hair conditioners, toilet and deodorants, soaps and paste. 
Further research may identify additional product or industrial usages of this chemical.

Common dosage in lotion as follows: 
0.5~1wt% in liquid detergent, 1wt% in antibacterial handing detergent, 4.5~5 wt% in disinfectant. 
What’s more, PCMX has been used in other fields such as glue, painting, textile, pulp, etc.

Uses of PCMX:
Preservative in cooling fluids, creams, topical and urinary antiseptics. 
PCMX acts against a wide range of bacteria. 

Liquids are used for the cleaning and disinfecting of wounds and abrasions as well as abscesses. 
The creams are used for cuts, scratches, insect bites, burns and similar problems. 

Powders can be used to treat tinea problems of the feet and skin inflammations. 
Also in pharmaceutical products, hair conditioners, toilet and deodorants, soaps, electrocardiogram paste, etc.

PCMX is used in hospitals and households for disinfection and sanitation. 
PCMX is also commonly used in antibacterial soaps, wound-cleansing applications and household antiseptics such as Dettol liquid (to which PCMX contributes its distinctive odor), cream and ointments.

Applications of PCMX:
Antimicrobial personal healthcare products
Disinfectant for agricultural and animal husbandry products
Disinfectants for childcare
Disinfectants for burn or open wounds
Surface disinfectants for clinical and household uses
Laboratory disinfectant
Laundry detergent additive
Anti-acne products

Advantages of PCMX:
Combines of a wide variety of natural antimicrobial and antifungal botanicals for reduced harshness upon topical administration.
Combination of different synthetic compounds allows for disinfection against both gram-positive and gram negative bacteria as well as fungi and viruses.
Broad effectiveness allows for use in clinical and household applications.

Professional Care Antimicrobial Handsoap:
Mild antimicrobial soap with broad spectrum
activity ideal for health care professionals.

7.0 - Alpha Olefin Sulfonate
3.0 - Hexylene glycol
3.0 - Exocide PX ( PCMX )
5.0 - Cocoamidopropyl betaine
82.0 - Water

Procedure: 
Dissolve Exocide PX in Hexylene glycol. 
Mix Alpha Olefin Sulfonate, and Cocoamide propyl betaine and add to chloroxylenol mixture. 
Add water and adjust pH to 5 . 6—5 . 8.

E—2 Hand Sanitizing Soap:
Meets criteria for efficacy as an E—2 hand sanitizing soap authorized for use in federally inspected meatand poultry plants.

22.0 - Sodium Lauryl Sulfate
3.5 - Triethylene glycol
3.0 - Exocide PX (PCMX)
1.0 - Cocoamidopropyi betaine
70.5 - H20

Procedure: 
Place Sodium Lauryl Sulfate, triethylene glycol and cocoamidopropyl Betaine in a container and heat to 65 C while stirring. 
Dissolve chloroxylenol in heated mixture and add water. 
Add citrate buffer solution to adjust pH to 5.6—5.8.

Health Care Personnel Handwash Formulation:
Mild liquid handsoap used in health care applications.

8.0 - Tripropylene glycol
3.0 - Exocide PX ( PCMX )
20.0 - TEA lauryl sulfate
3.0 - Alkyl dimethylainine oxide 30%
65.0 - H20
1.0 - Salt to thicken

Procedure: 
Heat tripropylene glycol, TEA lauryl sulfate and alkyl Dimethylamine oxide 30%. 
Dissolve PCMX in heated mixture. 
Add water and salt to thicken. Add pH to 7. 0—7 . 4.

Surgical Scrub Handsoap:
Effective antimicrobial scrub for health care professional use.

8.0 - Tripropylene glycol
3.0 - Exocide PX (PCMX)
20.0 - Sodium lauryl sulfate
1.0 - Alkyl dimethylainjne oxide 30%
1.0 - Cocamjde DEA
65.0 - 1120
2.0 - Salt to thicken

Procedure: 
Heat Tripropylene Glycol, Sodium Lauryl Sulfate, Cocamide DEA and Alkyl dimethylamine oxide. 
Dissolve chloroxylenol in heated mixture, once dissolved add water and salt to thicken. 
Adjust pH to 5.0 - 5.20. 

This will yield a clear solution that can be mist-sprayed onto hard services to effectively sanitize them within 30 seconds contact time, drying to a clear,non-greasy film. 
PCMX has a pH range of 6.0 - 7.0 ( neutral)

Isopropanol 99 %: 25.00
Propylene glycol:  7.00
TEA Lauryl Sulfate 40 %: 7.00
Phenoxyethanol: 1.00
Exocide PX (PCMX): 3.00

A Broad-spectrum Antimicrobial Disinfectant:
This technology is a disinfectant composed of a combination of naturally antimicrobial botanical blends and popular synthetic antimicrobials like para-chloro-meta-xylenol (PCMX).

Current disinfectants are only somewhat effective in preventing infection, with 5% of hospital patients ending up with healthcare-associated infections. 
While Dettol, a disinfectant composed of PCMX, pine oil and castor oil, is rigorously implemented, these infection statistics imply that there is much room for improvement. 
Improvements in scope of antimicrobial activity, whether PCMX is applicable to a broader range of microbes or has more lasting antimicrobial effects, have positive implications for both general public health and the healthcare system.

The Technology: 
Improved disinfectant combining botanical and synthetic antimicrobials for broad-spectrum disinfection
This disinfectant combines the natural antibacterial and antifungal activities of essential oils and botanicals with a powerful chemical disinfectant such as para-chloro-meta-xylenol (PCMX). 

This technology leverages the observation that many botanical components have inherent antimicrobial and antifungal capabilities but are less harsh then chemical agents. 
As such, they often exhibit reduced risk of skin irritation compared with synthetic disinfectants. 
This technology combines the natural disinfectant properties of essential oils and botanicals with the lasting protection of synthetic disinfectants such as PCMX, chlorhexidine, and quaternary ammonium salts to generate a broad-spectrum disinfectant formulation for superior protection against infection in high-risk environments such as hospitals.

History of PCMX:
PCMX was first made in 1927.
PCMX is on the World Health Organization's List of Essential Medicines.
PCMX is sold in a number of formulations and under a number of brand names, including Dettol.

Soon after PCMX was created parachlorometaxylenol was then called PCMX, but this was thought to be a poor name and PCMX was renamed Dettol. 
Then in 1932 PCMX was marketed in Britain and in India. 

PCMX had a white on green bottle with a white sword depicted.
PCMX is sold, in the same style bottle, in Argentina and Uruguay to this day.

Properties of PCMX:
Side effects are generally few but can include skin irritation.
PCMX may be used mixed with water or alcohol.

PCMX is most effective against gram-positive bacteria.
PCMX works by disruption of the cell wall and stopping the function of enzymes.

Identifiers of PCMX:
Chemical Safety: Irritant
Molecular Formula: C8H9ClO
Molecular Weight: 156.61 g/mol
Formula: C8H9ClO 
MW: 156,61
CAS: 88-04-0
CAS NO.: 88-04-0    
EINECS NO.: 201-793-8
FORMULA: ClC6H2(CH3)2OH
MOL WT.: 156.61
TOXICITY: Oral rat LD50: 3830 mg/kg

Names of PCMX:

Translated names of PCMX:
3,5-dimetyl-4-klorfenol (sv)
4-chloor-3,5-dimethylfenol (nl)
4-chlor-3,5-dimethylfenol (cs)
4-chlor-3,5-dimethylphenol (da)
4-chlor-3,5-dimetilfenolis (lt)
4-Chlor-3,5-xylenol (de)
4-chloro-3,5-dimetylofenol (pl)
4-chloro-3,5-diméthylphénol; (fr)
4-chlór-3,5-dimetylfenol (sk)
4-clor-3,5-dimetilfenol (ro)
4-cloro-3,5-dimetilfenol (es)
4-cloro-3,5-dimetilfenol (pt)
4-cloro-3,5-dimetilfenolo (it)
4-hlor-3,5-dimetilfenols (lv)
4-Kloori-3,5-dimetyylifenoli (fi)
4-klor-3,5-dimetylfenol (no)
4-klor-3,5-xylenol (no)
4-klor-3,5-xylenol (sv)
4-kloro-3,5-dimetil-fenol (hr)
4-kloro-3,5-dimetilfenol (sl)
4-kloro-3,5-dimetüülfenool (et)
4-klór-3,5-dimetilfenol (hu)
4-χλωρο-3,5-ξυλενόλη (el)
4-хлоро-3,5-диметилфенол (bg)

CAS names of PCMX:
Phenol, 4-chloro-3,5-dimethyl-

IUPAC names of PCMX:
4-Chlor-3,5-xylenol
4-chloro-3,5-dimethyl-phenol
4-Chloro-3,5-dimethylphenol
4-chloro-3,5-dimethylphenol
4-chloro-3,5-dimethylphenol;
4-Chloro-3,5-xylenol
4-chloro-3,5-xylenol
chloroxylenol-
para chloro meta xylenol
PCMX
Phenol, 4-chloro-3,5-dimethyl

Trade names of PCMX:
PCMx
Surcide PCMX

Other identifiers of PCMX:
604-038-00-4
Index Number
88-04-0

Synonyms of PCMX:
4-Chloro-3,5-dimethylphenol
4-Chloro-3,5-xylenol;p-Chloro-m-xylenol
4-Chloro-3,5-dimethylphenol, purum, >=98.0% (T)
Chloroxylenol, British Pharmacopoeia (BP) Reference Standard
Chloroxylenol, United States Pharmacopeia (USP) Reference Standard
Chloroxylenol, Pharmaceutica
3,5-Xylenol, 4-chloro-
4-chloro-3,5-dimethylphenol
4-chloro-3,5-xylenol
4-chloro-3,5-xylenol
Chloro-xylenol
Chloroxylenol
2-chloro-5-hydroxy-1,3-dimethylbenzene
3,5-dimethyl-4-chlorophenol
4-chloro-3,5-dimethylphenol
4-chloro-3,5-dimethylphenol sulfonate
chloroxylenol
chloroxylenol, potassium salt
chloroxylenol, sodium salt
Dettol
Ice-O-Derm
Micro-Guard
p-chloro-m-xylenol
parachlorometaxylenol
PCMX
4-Chloro-3,5-dimethylphenol
chloroxylenol
88-04-0
Dettol
4-Chloro-3,5-xylenol
PCMX
Benzytol
p-Chloro-m-xylenol
2-Chloro-m-xylenol
4-Chloro-m-xylenol
Ottasept
Desson
Espadol
Chloro-xylenol
Ottasept Extra
Husept Extra
p-Chloro-3,5-xylenol
Phenol, 4-chloro-3,5-dimethyl-
Willenol V
3,5-Dimethyl-4-chlorophenol
parachlorometaxylenol
Septiderm-Hydrochloride
Chloroxylenolum
Chlorxylenolum
Cloroxilenol
2-Chloro-5-hydroxy-m-xylene
Dettol, liquid antiseptic
Nipacide MX
Parametaxylenol
2-Chloro-5-hydroxy-1,3-dimethylbenzene
4-Chloro-1-hydroxy-3,5-dimethylbenzene
C8H9ClO
3,5-Xylenol, 4-chloro-
Caswell No. 218
Clorossilenolo [DCIT]
NSC 4971
Cloroxilenol [INN-Spanish]
Chloroxylenolum [INN-Latin]
4-chloro-3,5-dimethyl-phenol
HSDB 7427
EINECS 201-793-8
4-Chloro-3, 5-xylenol
4-Chloro-3,5-dimethylphenol, 99%
Clorossilenolo
Vionexus
CAS-88-04-0
Camel (pesticide)
Ayrtol
Chloroxylenol [USAN:INN:BAN]
Nipacide PX
Chloroxylenol(USAN
Chloroxylenol [USAN:USP:INN:BAN]
3, 4-chloro-
m-Xylenol, 4-chloro-
Para-chloro-meta-xylenol
Para Chloro Meta Xylenol
Chloroxylenol (USP/INN)
4-chloro-3,5dimethylphenol
p-Chloro-3,5-dimethylphenol
3,5-Dimethy-4-Chloro phenol
3, 5-Dimethyl-4-chlorophenol
Para Chloro Meta Xylenol (PCMX)
Pharmakon1600-01500182
4-Chloro-3,5-dimethylphenol;PCMX
Chlorodimethylphenol (Chloroxylenol)
0F32U78V2Q
215-316-6
492
4-Chlor-3,5-dimethylphenol [German] [ACD/IUPAC Name]
4-Chloro-3,5-dimethylphenol [ACD/IUPAC Name]
4-Chloro-3,5-diméthylphénol [French] [ACD/IUPAC Name]
4-Chloro-3,5-xylenol
4-Chloro-sym-m-xylenol
88-04-0 [RN]
Chloroxylenol [USP] [Wiki]
p-Chloro-m-xylenol
PCMX
Phenol, 4-chloro-3,5-dimethyl- [ACD/Index Name]
ZE6850000
1-[1-(benzenesulfonyl)-2-pyrrolyl]ethanone
1407521-66-7 [RN]
2-Chloro-5-hydroxy-1,3-dimethylbenzene
2-Chloro-5-hydroxy-m-xylene
2-Chloro-m-xylenol
3, 5-Dimethyl-4-chlorophenol
3,5-Dimethy-4-Chloro phenol
3,5-dimethyl-4-chlorophenol
3,5-Xylenol, 4-chloro-
4-06-00-03152 (Beilstein Handbook Reference) [Beilstein]
4-Chloro-1-hydroxy-3,5-dimethylbenzene
4-chloro-3 5-dimethylphenol
4-Chloro-3, 5-xylenol
4-CHLORO-3,5-DIMETHYL PHENOL
4-chloro-3,5-dimethyl-phenol
4-Chloro-3,5-Dimethylphenol (en)4-Chloro-3,5-Xylenol (en)
4-chloro-3,5-dimethylphenol, ??? 98.0%
4-chloro-3,5-dimethylphenol, 98+%
4-chloro-3,5-dimethylphenol, 99%
4-chloro-3,5-dimethylphenol,99%
4-Chloro-3,5-dimethylphenol;PCMX
4-Chloro-3,5-dimethylphenol|4-Chloro-3,5-xylenol
4-chloro-3???5-dimethylphenol
4-Chloro-m-xylenol
Ayrtol
Benzytol
Benzytol; Dettol
BSPBio_002007
Camel
Chloro-xylenol
Chloroxylenol (USP)
Chloroxylenol [USAN:BAN:INN] [INN] [USAN]
Chloroxylenol(USAN
chloroxylenol-d6
chloroxylenolum
Chloroxylenolum [INN-Latin]
Chlorxylenolum
Clorossilenolo [DCIT]
cloroxilenol
Cloroxilenol [INN-Spanish]
Desson
Dettol [Wiki]
EINECS 201-793-8
Espadol
Husept Extra
IDI1_000801
InChI=1/C8H9ClO/c1-5-3-7(10)4-6(2)8(5)9/h3-4,10H,1-2H
m-Xylenol, 4-chloro-
NCGC00094614-01
NCGC00094614-02
NCGC00094614-03
Nipacide MX
Nipacide PX
Ottasept
Ottasept Extra
PARA CHLORO-META-XYLENOL
Para?Chloro Meta Xylenol (PCMX)?
parachlorometaxylenol
para-chloro-meta-xylenol
Parametaxylenol
p-Chloro-3,5-dimethylphenol
p-Chloro-3,5-xylenol
Pharmakon1600-01500182
SPECTRUM1500182
Spectrum5_000713
UNII:0F32U78V2Q
UNII-0F32U78V2Q
Willenol V
WLN: QR DG C1 E1
-Chloro-3,5-dimethylphenol
chloroxylenol
88-04-0
Dettol
4-Chloro-3,5-xylenol
PCMX
Benzytol
p-Chloro-m-xylenol
2-Chloro-m-xylenol
4-Chloro-m-xylenol
Ottasept
Desson
Espadol
Chloro-xylenol
Ottasept Extra
Husept Extra
p-Chloro-3,5-xylenol
Phenol, 4-chloro-3,5-dimethyl-
Willenol V
3,5-Dimethyl-4-chlorophenol
parachlorometaxylenol
Septiderm-Hydrochloride
Chloroxylenolum
Chlorxylenolum
Cloroxilenol
2-Chloro-5-hydroxy-m-xylene
Dettol, liquid antiseptic
Nipacide MX
Parametaxylenol
RBA 777
2-Chloro-5-hydroxy-1,3-dimethylbenzene
4-Chloro-1-hydroxy-3,5-dimethylbenzene
C8H9ClO
3,5-Xylenol, 4-chloro-
Caswell No. 218
Clorossilenolo [DCIT]
NSC 4971
Cloroxilenol [INN-Spanish]
Chloroxylenolum [INN-Latin]
UNII-0F32U78V2Q
4-chloro-3,5-dimethyl-phenol
HSDB 7427
EINECS 201-793-8
4-Chloro-3, 5-xylenol
EPA Pesticide Chemical Code 086801
4-Chloro-3,5-dimethylphenol, 99%
NCGC00094614-03
Clorossilenolo
Vionexus
CAS-88-04-0
Camel (pesticide)
Ayrtol
Chloroxylenol [USAN:INN:BAN]
Nipacide PX
Chloroxylenol(USAN
Chloroxylenol [USAN:USP:INN:BAN]
PubChem19739
Spectrum_000138
3, 4-chloro-
ACMC-209qqy
m-Xylenol, 4-chloro-
Para-chloro-meta-xylenol
G00014-Watson-Int
Para Chloro Meta Xylenol
Chloroxylenol (USP/INN)
4-chloro-3,5dimethylphenol
p-Chloro-3,5-dimethylphenol
3,5-Dimethy-4-Chloro phenol
3, 5-Dimethyl-4-chlorophenol
Para Chloro Meta Xylenol (PCMX)
Pharmakon1600-01500182
4-Chloro-3,5-dimethylphenol;PCMX
Chlorodimethylphenol (Chloroxylenol)
Name: 4-Chloro-3,5-dimethylphenol
4-Chloro-3,5-xylenol;p-Chloro-m-xylenol
4-Chloro-3,5-dimethylphenol, purum, >=98.0% (T)
Chloroxylenol, British Pharmacopoeia (BP) Reference Standard
Chloroxylenol, United States Pharmacopeia (USP) Reference Standard