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PEG 16 LANOLIN
CAS NO:
61790-81-6
Lanolin is a soft, wax-like material derived from wool as a by-product in the preparation of raw wool for the spinner. Chemically, it is a mixture of cholesterol esters and higher fatty acid esters. It forms a protective barrier and used as a base for emollients in cosmetics and hair-care products. Lanolin alcohols can be obtained by hydrolysis of lanolin to use as an emulsifying agent in the preparation of water-in-oil emulsions. Modified lanolin products are used as a base for ointments and creams. In industrial field they are used as lubricants, leather finishing and as constituents of varnishes and paints.
SYNONYMS: POE Lanolin; polyoxyethylene lanolin alcohol; Ethoxylated lanolin; Lanolin, ethoxylated; PEG Lanolin; POE lanolin ether and ester; Polyoxyethylene lanolin (ether and ester); Polyoxyethylene lanolins; Water soluble lanolin; 09179OX7TB; 61790-81-6; 4922LE41DY; 687SBQ855W; 419118M77O; 2U8P432R6Z; XG24OGD0II; 8WTH94XZF2; 1Q399RNN9M; K2OI1D27ET; PLH8U521GH; JSB8U68Q2U; PEG-10 Lanolin; PEG-100 lanolin; PEG-20 lanolin; PEG-24 lanolin; PEG-27 Lanolin; PEG-30 lanolin; PEG-35 Lanolin; PEG-40 Lanolin; PEG-5 lanolin; PEG-50 lanolin; PEG-55 Lanolin; PEG-60 lanolin; PEG-75 Lanolin; PEG-85 lanolin; Polyethylene glycol (100) lanolin; Polyethylene glycol 1000 lanolin; Polyethylene glycol 2000 lanolin; Polyethylene glycol (24) lanolin; Polyethylene glycol (27) lanolin; Polyethylene glycol (30) lanolin; Polyethylene glycol (35) lanolin; Polyethylene glycol 4000 lanolin; Polyethylene glycol (5) lanolin; Polyethylene glycol (50) lanolin; Polyethylene glycol 500 lanolin; Polyethylene glycol (55) lanolin; Polyethylene glycol (60) lanolin; Polyethylene glycol (85) lanolin; Polyoxyethylene (10) lanolin; Polyoxyethylene (100) lanolin; Polyoxyethylene (20) lanolin; Polyoxyethylene (24) lanolin; Polyoxyethylene (27) lanolin; Polyoxyethylene (30) lanolin; Polyoxyethylene (35) lanolin; Polyoxyethylene (40) lanolin; Polyoxyethylene (5) lanolin; Polyoxyethylene (50) lanolin; Polyoxyethylene (55) lanolin; Polyoxyethylene (60) lanolin; Polyoxyethylene (75) lanolin; Polyoxyethylene (85) lanolin; Ethoxylated lanolin; Lanolin, ethoxylated; Aqualose L 30; Aqualose DL 12; Caswell No. 427A; CCRIS 2690; EPA Pesticide Chemical Code 031607; Ethylene oxide, lanolin adduct; Ivarlan 3406; Ivarlan 3407; Polyethylene glycol-27 lanolin; Polyethylene glycol-40 lanolin; Polyethylene glycol-75 lanolin; Solulan L 575; Solulan 16; Solulan 25; TW 30; UNII-09179OX7TB; UNII-4922LE41DY; UNII-687SBQ855W; UNII-419118M77O; UNII-K2OI1D27ET; UNII-PLH8U521GH; UNII-JSB8U68Q2U; UNII-1Q399RNN9M; UNII-2U8P432R6Z; UNII-XG24OGD0II; UNII-8WTH94XZF2
Peg-16 lanolin derivative is a complex of ethoxylated lanolin and ethoxylated fatty alcohols. It is 100% active. It is supplied as a pale, tan, waxy solid.
Features and Benefits :
- Oil in water emulsifier
- Foam stabilizer for surfactant systems
- Provides a soft, non-tacky after-feel on skin
Peg-16 lanolin derivative is an effective oil in water emulsifier and foam stabilizer used in a wide range of leave-on and rinse-off applications.
Peg-16 lanolin derivative is recommended for use in hair and skin care products including creams, lotions, shampoos and body washes.
It also provides foam stabilization for surfactant based formulations such as shampoos and body washes. Its soft after-feel makes it an excellent candidate for cream and lotion applications as well as hair care applications such as mousses.
Peg-16 lanolin derivative is derived from lanolin and vegetable based fatty alcohols. It is supplied as an easy-to-use waxy solid form.
Polyethylene glycol is a condensation polymers of ethylene oxide and water with the general formula H(OCH2CH2)nOH, where n is the average number of repeating oxyethylene groups typically from 4 to about 180. The low molecular weight members from n=2 to n=4 are diethylene glycol, triethylene glycol and tetraethylene glycol respectively, which are produced as pure compounds. The low molecular weight compounds upto 700 are colorless, odorless viscous liquids with a freezing point from -10 C (diethylene gycol), while polymerized compounds with higher molecular weight than 1,000 are waxlike solids with melting point upto 67 C for n 180. The abbreviation (PEG) is termed in combination with a numeric suffix which indicates the average molecular weights. One common feature of PEG appears to be the water-soluble. It is soluble also in many organic solvents including aromatic hydrocarbons (not aliphatics). They are used to make emulsifying agents and detergents, and as plasticizers, humectants, and water-soluble textile lubricants.Polyethylene glycol is non-toxic, odorless, neutral, lubricating, nonvolatile and nonirritating and is used in a variety of pharmaceuticals and in medications as a solven, dispensing agent, ointment and suppository bases, vehicle, and tablet excipient. Lipophilic compounds are ethoxylated ethylene oxide (the monomer of polyglycols) so that the target compounds have hydrophilic (soluble in water). The bifunctionality in one molecule provides the basic properties of surfactants. Fatty acids rather lipophilic (or hydrophobic) exhibiting low HLB (Hydrophilic-Lipophilic Balance) values; having an affinity for, tending to combine with, or capable of dissolving in lipids (or water-insoluble). While, the ethoxylated fatty acids are hydrophilics exhibiting high HLB values; having an affinity for water; readily absorbing or dissolving in water. The type of fatty acid and the mole number of ethylene oxide provides diverse HLB values for proper applications. There are almost infinite ethoxylated compounds. In combination with the average molecular weights and water-soluble property of PEG, the wide range of chain lengths of fatty acids provide identical physical and chemical properties for the proper application selections directly or indirectly.
Peg-16 lanolin derivative is a 100% active complex of ethoxylated lanolin and ethoxylated fatty alcohols. It is an effective oil-in-water emulsifier and foam stabilizer used in a wide range of leave-on and rinse-off applications. Its soft after-feel makes it an excellent candidate for cream and lotion applications as well as hair care applications such as shampoos and mousses.
Is obtained by reacting lanolin with ethylene oxide. Superfatting emolienes and has the properties of lanolin, with the advantage of being water soluble.
For a relatively low viscosity of the product the process is carried out to produce a higher glycol content, making it easier to handle the liquid product.
At room temperature, the product is a mobile liquid which can be manipulated without any heating.
It is a water soluble humectant with a mild surfactant action.
It can be used as a conditioner for hair and skin in a wide range of aqueous preparations such as bath foams, shampoos and conditioners, bath gels or hand washing, dyes, nail polish remover, hair sprays, skin toners, lotions capital, children's camps, cosmetic creams and milks, and deodorants.
In addition it acts as nonionic surfactant, emulsifier for O / W systems irriante is nontoxic. Associated with other surfactants, anionic or cationic, has the property of stabilizing the formed foam and helps prevent dryness caused by anionic surfactants.
The product has a long history of safe use and has been classified as non-irritating to the skin and eyes
Dosage; 0.5 to 10%
Wool wax is a natural substance, designed by nature to soften both skin and wool fibres, and to protect them against adverse weather conditions. The best known uses of refined wool wax products (lanolin and lanolin derivatives) are in medicine, cosmetics and toiletries, which build on these natural protective qualities. The wax is separated from the liquid using high speed centrifugation. It is then processed and refined through a number of processes, including:
reducing free fatty acids, soap and water content
eliminating contaminants
deodorising and bleaching
These steps can also be modified to achieve different grades of product purity.
Emollient properties of lanolin
The composition of lanolin resembles the intercellular lipids of the stratum corneum. This is the outermost layer of the skin, which consists of cholesterol, cholesterol derivatives and free fatty acids. These lipids play a crucial role in the skin’s moisture control. Under normal conditions, water continuously evaporates from the skin’s surface. Insufficient rehydration from lower epidermal layers leads to a dry, inflexible and brittle stratum corneum.
Bi-functionality of lanolin
Lanolin Alcohol’s water absorption capacity makes it an excellent sole emulsifier. Blended at 6 % into a petroleum jelly-based ointment, it can achieve a water absorption capacity in excess of 200%. Considering petroleum jelly has a close to zero water absorption capacity, this converts into a comparable water absorption capacity of almost 3000% for lanolin alcohol.
Anhydrous lanolin can absorb more than 200% of its weight in water (WW) to form stable water-in-oil (w/o) emulsions. It is also capable of redistributing this moisture to environments of low relative humidity.
In other words, it can both prevent moisture loss and rehydrate. This can be illustrated with a simple experiment.
Glass sheet experiment
By coating a sheet of glass with a thin film of lanolin and dipping it into a container filled with water, the formerly transparent wax layer grows increasingly opaque because of all the water it has absorbed. When the glass sheet is removed from the container and exposed to the air, the lanolin film gradually becomes transparent again as it releases the water via evaporation and dries out. Hydrocarbon-based emollients such as Vaseline or petrolatum do not possess this bi-directional water transport ability. Instead they form an almost impermeable occlusive film on the surface of the skin. Lanolin, as an auxiliary emulsifier, also helps to improve the smooth feel and silky texture of such oil-based systems.
Similarities between lanolin and human skin
Variations of the glass sheet experiment on the stratum corneum of human skin treated with lanolin have shown similar effects. In addition to the chemical similarity between lanolin and human skin lipids, other physical similarities have been discovered, such as multilamellar structures. These molecular aggregations strongly resemble the liquid crystal structures occurring in skin lipids. Lanolin-based skin-care products owe their superb emollient properties to the unique chemical and physical characteristics of lanolin.
Lanolin in cosmetics
Natural emollient
Lanolin’s beneficial effects on the human skin and hair have been known and valued by humans for thousands of years. The natural emollient is absorbed by the skin, restoring its correct moisture balance and softness without impairing natural skin functions. As such, it is an ideal and widely used ingredient for cosmetics, personal-care products and medical applications.
Emulsifying properties
Because of the polar nature of its compounds, lanolin has powerful emulsifying properties. This means that it can bind high amounts of water by forming stable emulsions.
By applying it to human skin as a cream or ointment, this moisture is distributed into the intercellular space of the stratum corneum, the outermost skin layer.
To prevent the intercellular water from evaporation, lanolin lipids form a semi-occlusive film on the skin and create a protective barrier.
The regained and stored moisture has a noticeable softening effect on the epidermis, as observed and confirmed by leading laboratories.
Natural all-rounder
The emollient care effects of lanolin and its derivatives are harnessed in a wide range of:
skin creams (such as Nivea® Creme, night creams, cold creams, barrier creams and vanishing creams)
ointments
sunscreen lotions.
However, the complex composition of lanolin makes it a real natural all-rounder.
In soaps it acts as a superfatting agent, minimising dehydration of the skin.
Lanolin oil is used as gloss-enhancing agent in lip glosses.
In lipstick it can function as a crystal inhibitor.
In shampoos and shower gels, as a conditioner.
Lanolin is also widely used in:
foundation creams and other skin-cream products as an emulsifier, stabiliser, emollient and skin moisturiser;
oil-based skin lotions and cleansing oils as a skin moisturiser and to control viscosity;
toilet soaps as a superfatting agent, minimising the dehydrating effect of detergents, and to retain perfume;
aftershaves as a skin moisturiser and to control viscosity;
nail polish removers to prevent the defatting of the surrounding skin;
lipsticks and eye make-up as a film modifier and crystal inhibitor, for more uniformly dispersed pigment;
hair dressings and shampoos, as a conditioner against drying, scaling and brittleness of the hair shaft;
hair sprays, as a plasticiser;
hair bleaching agents, as a pH-stable emulsifier.
Lanolin in pharmaceuticals
Superb skin protector
As well as being well tolerated by the body – it is approved for uses in ophthalmic emollients and as a food additive in chewing gum bases – lanolin is also of medical interest. It can act as a carrier for pharmaceutically active ingredients that have to be transported into deeper layers of the skin. In burns dressings, lanolin supports the wound healing process and enhances dermal repair.
The use of lanolin acids in topical products for cutaneous infections (e.g. acne) and deodorising toiletries ultimately underlines the versatility of lanolin and its derivatives. Besides emollient and moisturising characteristics, lanolin’s protective function includes antimicrobial and disinfectant activity on human skin.
Approximately 97% of the pale yellow substance is composed of a complex mixture of esters that are formed by in-situ condensation reaction of high molecular weight (MW) alcohols with high MW fatty acids. The class of esterified lanolin alcohols can be divided into three main sub-groups:
steroids
triterpenoids
aliphatic alcohols.
The lanolin acid fraction consists of various branched and unbranched acids and hydroxy fatty acids. The remaining 3% of the mixture is made up of free lanolin alcohols and small amounts of free fatty acids, hydrocarbons (paraffins), water and ash. Because lanolin is a natural product, the exact composition can vary slightly within a tightly controlled limit.
Lanolin is soluble in organic solvents such as diethyl ether, chloroform and chloroform/methanol mixtures, but poorly soluble in ethanol. It does not dissolve in (but is mixable with) water, forming stable oil-water emulsions.
Anhydrous lanolin has a water absorption rate of more than 200% of its own weight and reluctantly forms water-in-oil (w/o) emulsions. Due to its excellent emollient and emulsifying properties, lanolin restores the skin’s correct moisture balance and softness without impairing natural skin functions.
Lanolin is widely used in cosmetic and medical skin creams and ointment bases, as well as a range of other products. The refining process can be customised according to country and intended use. This flexibility is necessary to meet the different requirements of pharmacopoeias throughout the world. It also allows the supplier to offer economical solutions for technical applications that do not need to adhere to rigid pharmaceutical standard
Lanolin alcohols are the most powerful surface-active natural components of wool wax products. They make up around 50% of the total weight of lanolin anhydrous, in which they are chemically bound in ester compounds. The alcohol fraction is obtained by using an alkaline treatment on the lanolin and then removing the released soaps. It is refined further via a multi-stage molecular distillation process, which improves colour and odour. This produces a purified, semi-crystalline and practically colourless wax.
Composition
Lanolin alcohol is lanolin’s primary derivative. It consists of a refined mixture of high molecular weight (MW) alcohols (the mean MW is 370).The main fraction (75%) is composed of sterols and triterpene alcohols, of which cholesterol is the largest individual component (36%), followed by lanosterol, agnosterol and their dihydric derivatives.
These alcohols are closely related to the physiological lipids of the stratum corneum, the human skin’s ‘horny layer’. This results in the excellent epidermal compatibility of lanolin alcohols in skin-care products. The alcohol mixture also contains branched and unbranched aliphatic alcohols in both mono- and dihydric forms. To avoid surface autoxidation, traces of butylhydroxytoluene (BHT) are added at the end of the refining process
HLB numbers describe following characterestics:
<10 : Lipid soluble (or water-insoluble)
>10 : Water Soluble
4-8 : Antifoaming
7-11 : Water-in-oil emulsion
12-16 : Oil-in-water emulsion
11-14 : Good Wetting
12-15 : Good detergency
16-20 : Stabilizing
HLB values of fatty acid compounds are:
Polyethylene Glycol (PEG) Esters are non-toxic and non-irriting nonionic emulsifiers. They are prepared by the esterification of fatty acids with polyethylene glycols. The low molecular weight ranging PEG Esters are oil-soluble to work in nonaqueous systems. The high molecular esters are water-soluble can be used in aqueous systems. Polyethylene Glycol Esters are used as emulsifiers and in formulating emulsifer blends, thickener, resin plasticizer, emollient, opacifier, spreading agent, wetting and dispersing agent, and viscosity control agents. They also have application in the metalworking, pulp, paper, textile and as defoamers for latex paints.
FUNCTION
Peg-16 lanolin derivative is an effective oil in water emulsifier and foam stabilizer used in a wide range of leave-on and rinse-off applications. It also provides foam stabilization for surfactant based formulations such as shampoos and body washes. Its soft after-feel makes it an excellent candidate for cream and lotion applications as well as hair care applications such as mousses.
GENERAL DESCRIPTION OF NONIONIC SURFACTANTS
Nonionic surfactants are surface active agents which do not dissociate into ions in aqueous solutions, unlike anionic surfactants which have a negative charge and cationic surfactants which have a positive charge in aqueous solution. Nonionic surfactants are more widely used as detergents than ionic surfactants because anionic surfactants are insoluble in many hard water and cationic surfactants are considered to be poor cleaners. In addition to detergency, nonionic surfactants show excellent solvency, low foam properties and chemical stability. It is thought that nonionic surfactants are mild on the skin even at high loadings and long-term exposure. The hydrophilic group of nonionic surfactants is a polymerized alkene oxide (water soluble polyether with 10 to 100 units length typically). They are prepared by polymerization of ethylene oxide, propylene oxide, and butylene oxide in the same molecule. Depending on the ratio and order of oxide addition, together with the number of carbon atoms which vary the chemical and physical properties, nonionic surfactant is used as a wetting agent, a detergent, or an emulsifier. Nonionic surfactants include alcohol ethoxylates, alkylphenol ethoxylates, phenol ethoxylates, amide ethoxylates, glyceride ethoxylates (soya bean oil and caster oil ethoxylates), fatty acid ethoxylates, and fatty amine ethoxylates. Another commercially significant nonionic surfactants are the alkyl glycosides in which the hydrophilic groups are sugars (polysaccharides).
Regulatory process names:
Lanolin, ethoxylated
IUPAC names:
Lanolin, ethoxylated , PEG-10 Lanolin
Other names:
ethoxylated lanolin
Other identifiers:
61790-81-6
