PEG (20) SORBITAN MONOLAURATE

PEG (20) sorbitan monolaurate is a polysorbate-type nonionic surfactant formed by the ethoxylation of sorbitan monolaurate.
PEG (20) sorbitan monolaurate is used as a wetting agent in flavored mouth drops such as Ice Drops, helping to provide a spreading feeling to other ingredients like SD alcohol and mint flavor.
PEG (20) sorbitan monolaurate is used in many brands of baby wipes.

CAS Number : 9005-64-5 
EC  Number : 500-018-3
Chemical formula :    C58H114O26
Molar mass     :      1226 g/mol
Density             :      1.1 g/mL
 
Its stability and relative nontoxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications. 
As the name implies the ethoxylation process leaves the molecule with 20 repeat units of polyethylene glycol; in practice these are distributed across 4 different chains, leading to a commercial product containing a range of chemical species.

Food applications of PEG (20) sorbitan monolaurate
The World Health Organization has suggested acceptable daily intake limits of 0–25 mg of polyoxyethylene sorbitan esters per kg body weight.

Biotechnical applications of PEG (20) sorbitan monolaurate
In biological techniques and sciences, PEG (20) sorbitan monolaurate has a broad range of applications. 
For example, it is used:

-as a washing agent in immunoassays, such as Western blots and ELISAs. 
-It helps to prevent non-specific antibody binding. 
-In this major application, it is dissolved in Tris-buffered saline or phosphate buffered saline at dilutions of 0.05% to 0.5% v/v. 
-These buffers are used for washes between each immunoreaction, to remove unbound immunologicals, and eventually for incubating solutions of immunoreagents (labeled antibodies) to reduce nonspecific background.
-to saturate binding sites on surfaces (i.e., to coat polystyrene microplates, generally combined with proteins such as BSA).
-to stabilize proteins purified protein derivative (PPD) solution used in skin testing for tuberculosis exposure as a solubilizing agent of membrane proteins
-for lysing mammalian cells, at a concentration of 0.05% to 0.5% v/v, generally combined with other detergents, salts and additives.

Pharmaceutical applications of PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is used as an excipient in pharmaceutical applications to stabilize emulsions and suspensions.

Industrial and domestic applications of PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is used by philatelists to remove stamps from envelopes and to remove residues from stamps, without harming the stamp itself.
PEG (20) sorbitan monolaurate is also used as wetting agent in rubber balers in the elastomer industry.
PEG (20) sorbitan monolaurate has been used as a shape directing agent to synthesize spheroidal magnetite nanoassemblies.

Use and Manufacturing of PEG (20) sorbitan monolaurate
Complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals. Used as an emulsifier/solubilizer in a wide range of foods, cosmetics, and other products; Also used as a delivery vehicle for other chemicals in animal developmental toxicity studies; Polysorbates are used in cosmetics, foods, pharmacy, the textile industry (antistatic agents, fiber lubricants, and finish emulsifiers), and in biological research;  Used as a flavoring agent, boiler water additive, emulsifier, surface-active agent, and stabilizer or thickener for foods; Permitted for use as an inert ingredient in non-food pesticide products; Polysorbate 20 (common commercial brand names include Alkest TW 20 and Tween 20) is a polysorbate surfactant whose stability and relative non-toxicity allows it to be used as a detergent and emulsifier in a number of domestic, scientific, and pharmacological applications.

PEG (20) sorbitan monolaurate is a ubiquitous nonionic surfactant employed in the formulation of countless cosmetic and personal care products. 
The use of PEG (20) sorbitan monolaurate is reported in 85%, i.e. 68 of 80, of the product categories listed in the Personal Care Product Council’s On-Line INFOBASE, indicating its versatility and utility in a variety of goods.
PEG (20) sorbitan monolaurate can function as a solubilizer, emulsifier, stabilizer, dispersing agent or a wetting agent, among other functions. 
Beyond personal care, PEG (20) sorbitan monolaurate has similar functions in the formulation and processing of pharmaceuticals, food and beverage products, agricultural chemicals and household and industrial cleaning products.

Substance identity

EC / List no.: 500-018-3
CAS no.: 9005-64-5

Hazard classification & labelling of PEG (20) sorbitan monolaurate
According to the notifications provided by companies to ECHA in REACH registrations no hazards have been classified.

About PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 100 to < 1 000 tonnes per annum.
PEG (20) sorbitan monolaurate is used by consumers, in articles, by professional workers (widespread uses), in formulation or re-packing, at industrial sites and in manufacturing.

Consumer Uses of PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is used in the following products: washing & cleaning products, plant protection products, lubricants and greases, adhesives and sealants, fertilisers, polishes and waxes and coating products.
Other release to the environment of PEG (20) sorbitan monolaurate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners), outdoor use, indoor use in close systems with minimal release (e.g. cooling liquids in refrigerators, oil-based electric heaters) and outdoor use in close systems with minimal release (e.g. hydraulic liquids in automotive suspension, lubricants in motor oil and break fluids).

Article service life of PEG (20) sorbitan monolaurate
Other release to the environment of PEG (20) sorbitan monolaurate is likely to occur from: outdoor use in long-life materials with low release rate (e.g. metal, wooden and plastic construction and building materials), indoor use in long-life materials with low release rate (e.g. flooring, furniture, toys, construction materials, curtains, foot-wear, leather products, paper and cardboard products, electronic equipment), outdoor use in long-life materials with high release rate (e.g. tyres, treated wooden products, treated textile and fabric, brake pads in trucks or cars, sanding of buildings (bridges, facades) or vehicles (ships)) and indoor use in long-life materials with high release rate (e.g. release from fabrics, textiles during washing, removal of indoor paints). 
PEG (20) sorbitan monolaurate can be found in complex articles, with no release intended: vehicles. 
PEG (20) sorbitan monolaurate can be found in products with material based on: plastic (e.g. food packaging and storage, toys, mobile phones). This substance is intended to be released from scented: clothes.

Widespread uses by professional workers of PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is used in the following products: washing & cleaning products, polishes and waxes and plant protection products.
ECHA has no public registered data on the types of manufacture using PEG (20) sorbitan monolaurate. 
Other release to the environment of  PEG (20) sorbitan monolaurate is likely to occur from: indoor use (e.g. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use.

Formulation or re-packing of PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is used in the following products: polymers, lubricants and greases and textile treatment products and dyes.
Release to the environment of PEG (20) sorbitan monolaurate can occur from industrial use: formulation of mixtures and formulation in materials.

Uses at industrial sites of PEG (20) sorbitan monolaurate
PEG (20) sorbitan monolaurate is used in the following products: washing & cleaning products, metal surface treatment products, polymers, textile treatment products and dyes, pH regulators and water treatment products and leather treatment products.
ECHA has no public registered data on the types of manufacture using PEG (20) sorbitan monolaurate. 
Release to the environment of PEG (20) sorbitan monolaurate can occur from industrial use: in processing aids at industrial sites, in the production of articles, as an intermediate step in further manufacturing of another substance (use of intermediates) and as processing aid.

Manufacture of PEG (20) sorbitan monolaurate
Release to the environment of PEG (20) sorbitan monolaurate can occur from industrial use: manufacturing of the substance.

Synonyms:
polyethyleneglycol sorbitan monolaurate
Polysorbate 20
Sorbitan monolaurate, ethoxylated
Sorbitan monolaurate, ethoxylated
Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Ethoxy (80) Sorbitan Monolaurate
hetsorb L-20
Not available
Polyoxyethylene (20) sorbitan monolaurate
Polyoxyethylene (20)-sobitanmonolaurate
Polyoxyethylene Sorbitan Mono Laurate.
Polyoxyethylene sorbitan monolaurate
polyoxyethylene sorbitan monolaurate
polysorbate 20
Reaction products resulting from the esterification of Sorbitol with C8-18 (even) and C18 unsaturated fatty acids in the ratio 1:1 and subsequent reaction with ethylene oxide in a molar ratio of 1:1-6.5.
SORBITAN MONOLAURATE
Sorbitan monolaurate ethoxylated
SORBITAN MONOLAURATE POLYETHOXYLATE
Sorbitan monolaurate, eth-oxylated
Sorbitan monolaurate, ethoxylated
Sorbitan monolaurate, ethoxylated (1-6.5 moles ethoxylated)
Sorbitan monolaurate, ethoxylated (1-6.5 moles ethoxylated)
Sorbitan, mono-9-octadecenoate, poly(oxy-1,2-ethanediyl) derivs., (Z)-
Sorbitan, monododecanoat, poly(oxy-1,2-ethandiyl)-Derivate
Sorbitan, monododecanoate, poly(oxy-1,2-ethanediyl) derivs.
Sorbitan, monolaurate ethoxylated (1-6.5 moles ethoxylated)
SORBITAN, MONOLAURATE POLYOXYETHYLENE DERIV.
Leunapon-SML
SORBILENE L/4
118955-39-8
118955-39-8
122304-31-8
122304-31-8
1242241-45-7
1242241-45-7
129428-64-4
129428-64-4
1341-06-6
1341-06-6
1646144-25-3
1646144-25-3
194879-92-0
194879-92-0
37310-96-6
37310-96-6
54174-54-8
54174-54-8
60318-54-9
60318-54-9
62229-28-1
62229-28-1
8036-82-6
8036-82-6
851015-03-7
851015-03-7
861842-35-5
861842-35-5
9011-30-7
9011-30-7
9015-57-0
9015-57-0
93037-36-6
93037-36-6
Tween 20
9005-64-5
2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
1052273-76-3
9005-66-7
Sorbimacrogol laurate 300
2-{2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-(2-(3,4-Bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyl dodecanoate
2-[2-[3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate
Alkest TW 20
Tween(R) 20
tween (R) 20
Tween 20 (TN)
Tween 40 (TN)
Tween 60 (TN)
SCHEMBL118527
POE (6) sorbitol monolaurate
POE(20) sorbitan monolaurate
CHEMBL371631
POE (20) sorbitan monolaurate
DTXSID60922815
MFCD00165986
E432
FT-0645136
D05565
D05566
D05567
2-(2-(3,4-bis(2-hydroxyethoxy)tetrahydrofuran-2-yl)-2-(2-hydroxyethoxy)ethoxy)ethyldodecanoate
2-{2-[3,4-Bis(2-hydroxyethoxy)tetrahydro-2-furanyl]-2-(2-hydroxyethoxy)ethoxy}ethyl dodecanoate
2-Désoxy-3,5-bis-O-(2-hydroxyéthyl)-6-O-{2-[(9E)-9-octadecenoyloxy]éthyl}hexofuranoside de 2-hydroxyéthyle [French] [ACD/IUPAC Name]
2-Hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-9-octadecenoyloxy]ethyl}hexofuranoside [ACD/IUPAC Name]
2-Hydroxyethyl-2-desoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-9-octadecenoyloxy]ethyl}hexofuranosid [German] [ACD/IUPAC Name]
9005-64-5 [RN]
9005-65-6 [RN]
Hexofuranoside, 2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-[2-[[(9E)-1-oxo-9-octadecen-1-yl]oxy]ethyl]- [ACD/Index Name]
hexofuranoside, 2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-[2-[[(9E)-1-oxo-9-octadecenyl]oxy]ethyl]-
2-hydroxyethyl 2-deoxy-3,5-bis-O-(2-hydroxyethyl)-6-O-{2-[(9E)-octadec-9-enoyloxy]ethyl}hexofuranoside
EG Coolant 3
LS-2298 [DBID]
Tween 20 [DBID]
Tween 80 [DBID] [Trade name]