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PEG 600 Oleat is a chemical compound formed by the esterification of polyethylene glycol (PEG) with oleic acid.
PEG 600 Oleat refers to a polyethylene glycol with an average molecular weight of 600, while oleate refers to the fatty acid derived from oleic acid, a monounsaturated omega-9 fatty acid commonly found in plant oils such as olive oil.
PEG 600 Oleat is a mid-range HLB, surface active agent suggested for use in animal feed (emulsifier), cosmetics (emuls chemicals (emulsifier, lubricant, softener, scouring agent), coatings (emulsifier) and industrial degreasers.
CAS Number: 9004-96-0
Molecular Formula: C18H33O2.(C2H4O)n.H
EINECS Number: 500-015-7
Synonyms: PEG-12 Oleate, 668U70616Y, AEC PEG-12 OLEATE, ALKAMULS 600 MO, CHEMAX E-600-MO, ETHOX MO-14, JEEMATE 600-OC, PEGOSPERSE 600 MO, PROTAMATE 600 OC, UNIPEG-600 MOnonisol200,nopalcol1-0,Poly(oxy-1,2-ethanediyl), .alpha.-[(9Z)-1-oxo-9-octadecen-1-yl]-. omega.-hydroxy-,PEG-8 OLEATE,PEG-9 OLEATE,PEG-10 OLEATE,PEG-11 OLEATE,PEG-12 OLEATE
PEG 600 Oleat esters are made by reacting polyethylene glycol (glycol and ethylene oxide) with a fatty acid or a glyc.
The PEG ester family offers the formulator a wide range of HLB’s.
PEG 600 Oleat is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.
PEG 600 Oleat is great co-emulsifier in both water-in-oil and oil-in water systems where lubricity and low foaming.
As a general rule, PEG 600 Oleat helps build viscosity and make good suspending agents.
PEG 600 Oleat is used in various field such as textile industry,pigment manufacturing and cosmetics etc.
PEG 600 Oleat is used in the Textile industry as an Emulsifier for spinning oils
PEG 600 Oleat is used as Mixing material in Shampoo, hand cream and lotion in Cosmetics.
PEG 600 Oleat is used in Soaps & surfactant industry as emulsifier.
PEG 600 Oleat is used in Resin & paint industry as emulsifier.
PEG 600 Oleat is a nonionic surfactant of the fatty acid ethoxylate type.
PEG 600 Oleat is good general purpose emulsifier for vegetable oils and their derivatives as well as mineral oils.
PEG 600 Oleat is a nonionic surfactant of high molecular weight, little odor of fatty acid and non-toxic for body.
PEG 600 Oleat is a nonionic surfactant derived from natural oils of the fatty acid glycol type.
As a good general purpose emulsifier, PEG 600 Oleat is readily biodegradable and has low toxicity characteristics.
PEG 600 Oleats are the products obtained by the esterification of polyethyleneglycols with natural fatty acids.
Depending the molecular weight of the polyethyleneglycol used and the mono- and diesters content, non-ionic esters with different HLB values are obtained.
PEG 600 Oleat are mainly used as emulsifiers for oil in water emulsions.
They find also application in cosmetics, lubricants, textiles, pesticides etc.
PEG 600 Oleat is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine.
PEG 600 Oleat is also known as polyethylene oxide (PEO) or polyoxyethylene (POE), depending on its molecular weight.
The structure of PEG is commonly expressed as H−(O−CH2−CH2)n−OH.
PEG 600 Oleat is a nonionic surfactant because of the combination of the hydrophilic (water-attracting) polyethylene glycol chain and the hydrophobic (water-repelling) oleate group.
It has amphiphilic properties, meaning it can dissolve both in water (due to the PEG part) and in oils or fats (due to the oleic acid part).
This makes PEG 600 Oleat an effective emulsifier and solubilizer.
Typically, PEG 600 Oleat is a pale yellow to amber viscous liquid or semi-solid at room temperature.
PEG 600 Oleat is commonly used in several industrial and consumer products due to its surfactant, emulsifying, and solubilizing properties.
PEG 600 Oleat is used in formulations of creams, lotions, and other cosmetic products to help mix oil and water phases, ensuring a smooth, uniform texture.
Helps reduce surface tension in formulations, improving the spreadability of lotions and creams on the skin.
It assists in dissolving poorly water-soluble ingredients, like essential oils, fragrances, or vitamins, in aqueous-based formulations.
PEG 600 Oleat may be used in topical and transdermal drug formulations to enhance the solubility and delivery of active pharmaceutical ingredients (APIs) into the skin.
It can be used in emulsions or suspensions for drug formulations, improving stability and bioavailability of certain compounds.
In the formulation of lubricants, PEG 600 Oleat can help stabilize oil-in-water emulsions, ensuring consistent performance in industrial processes.
PEG 600 Oleat is used as an antistatic agent in textiles and plastics manufacturing, where it reduces the buildup of static electricity on surfaces.
It can function as a defoamer in various manufacturing processes to prevent excessive foaming in liquids.
Used in household and industrial cleaners to improve the spread of the product over surfaces, enhancing the cleaning efficiency by allowing better penetration into soiled areas.
It helps solubilize fragrances or oils in aqueous cleaning products, making them more effective and giving them pleasant scents.
PEG 600 Oleat sold by Acme-Hardesty are Bio-based and not Petro-based.
They are made from “bagasse” which is the fibrous waste that remains after sugar cane stalks are crushed to extract their juice.
This renewable product is ideal for customers who are committed, as we are, to advancing the sustainability profile of their products.
The "600" refers to the average molecular weight of the polyethylene glycol (PEG) component, which gives the compound a good balance between water solubility and oil compatibility.
PEG 600 Oleat is an ester formed from polyethylene glycol (a polymer of ethylene oxide) and oleic acid (a fatty acid typically derived from vegetable oils).
This structure provides both polar (PEG) and non-polar (oleate) characteristics, making it an effective emulsifier.
This amphiphilic nature allows PEG 600 Oleat to interact with both oil and water, reducing surface tension between the two, which is why it is so effective in stabilizing emulsions.
Boiling point: >260 °C(lit.)
Density: 1.034 g/mL at 25 °C
refractive index: n20/D 1.468
Flash point: 113 °C
storage temp.: Amber Vial, Refrigerator
solubility: toluene, ethanol and acetone: soluble (dispersible in water)
form: Oil
color: Colourless to Light Beige
Hydrophilic-Lipophilic Balance (HLB): 15.1
Stability: Light Sensitive
LogP: 7.185 (est)
PEG 600 Oleat is a nonionic surfactant derived from natural oils of the fatty acid glycol type.
A good general purpose emulsifier PEG 600 Oleat is readily biodegradable and has low toxicity characteristics.
The production of PEG 600 Oleat was first reported in 1859.
PEG 600 Oleat is produced by the interaction of ethylene oxide with water, ethylene glycol, or ethylene glycol oligomers.
The reaction is catalyzed by acidic or basic catalysts.
PEG 600 Oleat and its oligomers are preferable as a starting material instead of water, because they allow the creation of polymers with a low polydispersity (narrow molecular weight distribution).
PEG 600 Oleat refer to an oligomer or polymer of ethylene oxide.
The three names are chemically synonymous, but historically PEG 600 Oleat is preferred in the biomedical field, whereas PEO is more prevalent in the field of polymer chemistry.
Because different applications require different polymer chain lengths, PEG 600 Oleat has tended to refer to oligomers and polymers with a molecular mass below 20,000 g/mol, PEO to polymers with a molecular mass above 20,000 g/mol, and POE to a polymer of any molecular mass.
PEG 600 Oleat are prepared by polymerization of ethylene oxide and are commercially available over a wide range of molecular weights from 300 g/mol to 10,000,000 g/mol.
PEG 600 Oleat is liquids or low-melting solids, depending on their molecular weights.
While PEG 600 Oleat with different molecular weights find use in different applications, and have different physical properties (e.g. viscosity) due to chain length effects, their chemical properties are nearly identical.
PEG 600 Oleat are also available, depending on the initiator used for the polymerization process – the most common initiator is a monofunctional methyl ether PEG, or methoxypoly(ethylene glycol), abbreviated mPEG.
PEG 600 Oleats are also available as purer oligomers, referred to as monodisperse, uniform, or discrete.
PEG 600 Oleat has recently been shown to be crystalline, allowing determination of a crystal structure by x-ray crystallography.
Since purification and separation of pure oligomers is difficult, the price for this type of quality is often 10–1000 fold that of polydisperse PEG.
In the food industry, PEG 600 Oleat may be used as an emulsifier to stabilize emulsions in processed foods, beverages, and other food products.
It can also function as a surfactant to improve the texture, consistency, and stability of certain food formulations.
PEG 600 Oleat is used in agrochemical formulations as an emulsifier and surfactant to enhance the spread and penetration of active ingredients (e.g., pesticides, herbicides) on plants.
PEG-based compounds, including PEG 600 Oleat, are generally considered safe for use in cosmetic and pharmaceutical applications because of their mildness and low toxicity.
At high concentrations, PEG oleates may cause mild irritation to the skin or eyes, but they are generally regarded as non-irritating at typical usage levels in formulations.
PEG 600 Oleats are typically approved for use in personal care products, pharmaceuticals, and certain food applications, though the specific regulatory status might vary by region (e.g., FDA, EU, etc.).
Acts as an emulsifier to mix oil and water phases and create a smooth, homogeneous texture.
Enhances the solubility of oils or other hydrophobic components in aqueous formulations, improving consistency and performance.
PEG 600 Oleat helps incorporate oil-soluble ingredients into water-based formulations, which is important for products like liquid foundations, concealers, and other emulsion-based cosmetics.
In creams, ointments, or gels, it helps solubilize active ingredients and improve their absorption into the skin.
PEG 600 Oleat enhances the permeation of drugs across the skin barrier by acting as a penetration enhancer.
PEG 600 Oleat stabilizes emulsions in liquid pharmaceutical formulations, improving the solubility of poorly water-soluble drugs and enhancing their bioavailability.
PEG 600 Oleat is used as a lubricant and antistatic agent in the textile industry.
It helps reduce the buildup of static electricity during the processing of synthetic fibers, preventing dust accumulation and improving fabric quality.
In industrial applications, it acts as an emulsifier in water-based lubricants, stabilizing the mixture and providing lubrication for machinery parts, reducing friction and wear.
PEG 600 Oleat can also serve as a defoamer in certain industrial processes, preventing the formation of excess foam during manufacturing or mixing.
Uses:
PEG 600 Oleat is widely used in creams, lotions, and other skincare products to help blend water and oil phases, ensuring a smooth and stable formulation.
PEG 600 Oleat improves the texture and spreadability of cosmetics like shampoos, conditioners, body washes, and cleansers by reducing surface tension.
Helps dissolve oil-soluble ingredients like essential oils, vitamins, or fragrances in water-based formulations, improving the consistency and effectiveness of the products.
Due to its PEG component, PEG 600 Oleat can help retain moisture on the skin, enhancing the hydrating properties of lotions and creams.
PEG 600 Oleat is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.
PEG 600 Oleatis a mid-range HLB, surface active agent suggested for use in animal feed (emulsifier), cosmetics (emulsifier), textile chemicals (emulsifier, lubricant, softener, scouring agent), coatings (emulsifier) and industrial degreasers.
PEG 600 Oleat is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms.
PEG 600 Oleat is the basis of a number of laxatives (as MiraLax, RestoraLAX, MoviPrep, etc.).
Whole bowel irrigation with polyethylene glycol and added electrolytes is used for bowel preparation before surgery or colonoscopy or for children with constipation.
PEG 600 Oleat (with brand names such as Laxido, Movicol and Miralax) is the generic name for polyethylene glycol used as a laxative.
The name may be followed by a number which represents the average molecular weight (e.g. macrogol 3350, macrogol 4000 or macrogol 6000).
The possibility that PEG 600 Oleat could be used to fuse axons is being explored by researchers studying peripheral nerve and spinal cord injury.
An example of PEG 600 Oleat hydrogels (see Biological uses section) in a therapeutic has been theorized by Ma et al.
They propose using the hydrogel to address periodontitis (gum disease) by encapsulating stem cells in the gel that promote healing in the gums.
The gel with encapsulated stem cells was to be injected into the site of disease and crosslinked to create the microenvironment required for the stem cells to function.
PEG 600 Oleat of adenoviruses for gene therapy can help prevent adverse reactions due to pre-existing adenovirus immunity.
A PEG 600 Oleat lipid is used as an excipient in both the Moderna and Pfizer–BioNTech vaccines for SARS-CoV-2.
Both RNA vaccines consist of messenger RNA, or mRNA, encased in a bubble of oily molecules called lipids.
Proprietary lipid technology is used for each.
In both vaccines, the bubbles are coated with a stabilizing molecule of polyethylene glycol.
PEG 600 Oleat could trigger allergic reaction, and allergic reactions are the driver for both the United Kingdom and Canadian regulators to issue an advisory, noting that: two "individuals in the U.K. were treated and have recovered" from anaphylactic shock.
The US CDC stated that in their jurisdiction six cases of "severe allergic reaction" had been recorded from more than 250,000 vaccinations, and of those six only one person had a "history of vaccination reactions".
PEG 600 Oleat is also commonly used as a polar stationary phase for gas chromatography, as well as a heat transfer fluid in electronic testers.
PEG 600 Oleat is frequently used to preserve waterlogged wood and other organic artifacts that have been salvaged from underwater archaeological contexts, as was the case with the warship Vasa in Stockholm, and similar cases.
It replaces water in wooden objects, making the wood dimensionally stable and preventing warping or shrinking of the wood when it dries.
In addition, PEG 600 Oleat is used when working with green wood as a stabilizer, and to prevent shrinkage.
PEG 600 Oleat has been used to preserve the painted colors on Terracotta Warriors unearthed at a UNESCO World Heritage site in China.
These painted artifacts were created during the Qin Shi Huang (first emperor of China) era. Within 15 seconds of the terra-cotta pieces being unearthed during excavations, the lacquer beneath the paint begins to curl after being exposed to the dry Xi'an air.
The paint would subsequently flake off in about four minutes.
The German Bavarian State Conservation Office developed a PEG 600 Oleat preservative that when immediately applied to unearthed artifacts has aided in preserving the colors painted on the pieces of clay soldiers.
PEG 600 Oleat is often used (as an internal calibration compound) in mass spectrometry experiments, with its characteristic fragmentation pattern allowing accurate and reproducible tuning.
PEG 600 Oleat derivatives, such as narrow range ethoxylates, are used as surfactants.
PEG 600 Oleat has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
PEG 600 Oleat is a component of the propellent used in UGM-133M Trident II Missiles, in service with the United States Navy.
PEG 600 Oleat has been used as a solvent for aryl thioether synthesis.
An example study was done using PEG 600 Oleat to recreate vascular environments with the encapsulation of endothelial cells and macrophages.
This model furthered vascular disease modeling and isolated macrophage phenotype's effect on blood vessels.
PEG 600 Oleat is commonly used as a crowding agent in in vitro assays to mimic highly crowded cellular conditions.
Although PEG 600 Oleat is considered biologically inert, it can form non-covalent complexes with monovalent cations such as Na+, K+, Rb+, and Cs+, affecting equilibrium constants of biochemical reactions.
PEG 600 Oleat is commonly used as a precipitant for plasmid DNA isolation and protein crystallization.
X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
PEG 600 Oleat is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.
PEG 600 Oleat precipitation is used to concentrate viruses.
PEG 600 Oleat is also used to induce complete fusion (mixing of both inner and outer leaflets) in liposomes reconstituted in vitro.
Gene therapy vectors (such as viruses) can be PEG 600 Oleat-coated to shield them from inactivation by the immune system and to de-target them from organs where they may build up and have a toxic effect.
The size of the PEG 600 Oleat has been shown to be important, with larger polymers achieving the best immune protection.
PEG 600 Oleat is a component of stable nucleic acid lipid particles (SNALPs) used to package siRNA for use in vivo.
In blood banking, PEG 600 Oleat is used as a potentiator to enhance detection of antigens and antibodies.
When working with phenol in a laboratory situation, PEG 600 Oleat can be used on phenol skin burns to deactivate any residual phenol.
In biophysics, PEG 600 Oleats are the molecules of choice for the functioning ion channels diameter studies, because in aqueous solutions they have a spherical shape and can block ion channel conductance.
PEG 600 Oleat is the basis of many skin creams (as cetomacrogol) and personal lubricants.
PEG 600 Oleat is used in a number of toothpastes as a dispersant.
In this application, it binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
PEG 600 Oleat is under investigation for use in liquid body armor, and in tattoos to monitor diabetes.
Polymer segments derived from PEG 600 Oleats impart flexibility to polyurethanes for applications such as elastomeric fibers (spandex) and foam cushions.
In low-molecular-weight formulations (e.g. PEG 400), it is used in Hewlett-Packard designjet printers as an ink solvent and lubricant for the print heads.
PEG 600 Oleat is used as an anti-foaming agent in food and drinks – its INS number is 1521 or E1521 in the EU.
A nitrate ester-plasticized PEG 600 Oleat is used in Trident II submarine-launched ballistic missile solid rocket fuel.
Dimethyl ethers of PEG 600 Oleat are the key ingredient of Selexol, a solvent used by coal-burning, integrated gasification combined cycle (IGCC) power plants to remove carbon dioxide and hydrogen sulfide from the syngas stream.
PEG 600 Oleat has been used as the gate insulator in an electric double-layer transistor to induce superconductivity in an insulator.
PEG 600 Oleat is used as a polymer host for solid polymer electrolytes.
Although not yet in commercial production, many groups around the globe are engaged in research on solid polymer electrolytes involving PEG 600 Oleat, with the aim of improving their properties, and in permitting their use in batteries, electro-chromic display systems, and other products in the future.
PEG 600 Oleat is injected into industrial processes to reduce foaming in separation equipment.
PEG 600 Oleat is used as a binder in the preparation of technical ceramics.
PEG 600 Oleat was used as an additive to silver halide photographic emulsions.
PEG 600 Oleat is used to extend the size and durability of very large soap bubbles.
PEG 600 Oleat is an ingredient in some personal lubricants.[citation needed] (Not to be confused with propylene glycol.)
PEG 600 Oleat is the main ingredient in the paint (known as "fill") in paintballs.
Safety Considerations:
PEG 600 Oleat is generally considered to have low toxicity, making it safe for use in a variety of products, particularly in cosmetics and pharmaceuticals.
It is classified as non-carcinogenic and non-mutagenic.
At normal usage concentrations, PEG 600 Oleat poses minimal risks.
However, like most surfactants, at very high concentrations or prolonged exposure, it can cause some mild irritation to the skin, eyes, or respiratory tract.
Prolonged exposure to undiluted PEG 600 Oleat may cause mild skin or eye irritation, but in most formulations, it is diluted enough to prevent such effects.
It is generally regarded as safe for topical use in personal care products.
PEG 600 Oleat is biodegradable, meaning that it breaks down in the environment over time.
This makes it preferable in eco-friendly formulations, as it reduces the risk of long-term environmental contamination.
While PEG 600 Oleat is biodegradable, care should still be taken with large-scale industrial use and disposal, as surfactants can affect aquatic ecosystems in high concentrations.
PEG 600 Oleat is approved for use in many personal care products by regulatory agencies such as the FDA (U.S. Food and Drug Administration) and EU regulatory bodies.
