PEG 6000

PEG 6000

CAS Number: 25322-68-3
EC Number: 500-038-2
MDL Number :MFCD01779614
Linear Formula: H(OCH2CH2)nOH

PEG 6000, Poly(ethylene glycol) 6000, is a high quality research product used as multipurpose polymer of ethelyne glycol for various biochemical, molecular biology and molecular diagnostic applications. 
PEG 6000 is a polethylene glycol with a mean molecular weight of 6000. 
PEG 6000 is a solid in powder form.

PEG 6000 is a preformulated reagent kit designed to provide a rapid screening method for the crystallization of biological macromolecules
PEG 6000 is a polymer of ethylene oxide with an average molecular weight of 6000. 
PEG 6000 is an excellent solubiliser and can be used in a wide variety of home care and I&I applications.

The numbers that are often included in the names of PEGs indicate their average molecular weights, e.g. a PEG with n=9 would have an average molecular weight of approximately 400 and would be labeled PEG 400. 
Most PEGs include molecules with a distribution of molecular weights, i.e. they are polydisperse.
Polyethylene glycols (PEGs) are condensation polymers of ethylene oxide and water with the general formula H(OCH2CH2)nOH. 

They are the most commercially important type of polyether. 
The low molecular weight compounds up to 700 are colorless, odorless viscous liquids with a freezing point from -10˚C (diethylene gycol), while polymerized compounds with higher molecular weight than 1,000 are wax like solids with melting point up to 67˚C. 

While PEGs with different molecular weights find use in different applications and have different physical properties (e.g. viscosity) due to chain length effects, their chemical properties are nearly identical.
PEG 6000 (Polyethylene Glycol 6000) is a water-soluble, waxy solid that is used in the cosmetic industry. 
PEG 6000 is characterized by less toxicity and less skin irritation. 

There is no damage in case of contact with skin or lips.
PEG 6000 is an ester made from the reaction of vegetable-derived triple-pressed grade stearic acid and a defined high molecular weight polyethylene glycol. 
PEG 6000, referred to as Polyethylene glycol, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments and suppository base, and tablet and capsule lubricant. 

PEG 6000 has low toxicity with systemic absorption less than 0.5%.
PEG 6000 is soluble in water and most organic solvents.
PEG 6000 is a condensation polymer of ethylene oxide and water. 
PEG 6000 is susceptible to oxidative degradation in the presence of air. 

Minimizing the exposure of PEG 6000 to elevated temperatures and/or exposure to oxygen, or addition of an antioxidant can limit the amount of degradation. 
PEG 6000 has been used in many different applications. 

A single-step method is described for the activation of PEG for binding to polypeptides and proteins.
PEG 6000 is incompatible with phenol and may reduce the antimicrobial action of other preservatives. 
Both penicillin and bacitracin are rapidly inactivated by PEG 6000. 
PEG 6000 is also incompatible with sorbitol, tannic acid and salicylic acid and may affect the integrity of plastics.

USES and APPLICATIONS of PEG 6000:
-PEG 6000 for synthesis.
-PEG 6000 can be used in medicine. 
-PEG 6000 is used as a substrate in the production of medicine and cosmetics industry to adjust the viscosity and melting point

-PEG 6000 is used as a finishing agent in the paper industry to increase the gloss and smoothness of paper
-PEG 6000 is used as an additive in the rubber industry to increase the lubricity and plasticity of rubber products , Reduce the power consumption in the processing process, extend the service life of rubber products
-PEG 6000 is used as a lubricant and coolant in the metal processing industry

-Antistatic agent, lubricant, etc.
-Coatings and Paints (Specialty Additives)
-Automatic & hand dishwash
-Fabric & laundry care
-Hard surface cleaning
-Industrial & institutional cleaning
-Waxes & polishes

-Primary or secondary, PEG 6000 is versus pH grid crystallization screen for biological macromolecules
-PEG 6000 is used as a dispersant and emulsifier in the production of pesticides and pigments
-PEG 6000 is used in the textile industry
-The SCF also evaluated the use of PEG 6000 (polyethylene glycol 6000) in preparations for sweetener-based sodas in 1994 (SCF, 1997) and concluded that the use of the food additive as excipient for sweetener tablets was acceptable.

-PEG 6000 by Dow is PEG-150-based plasticizer and mold release agent. 
-PEG 6000 is used in pressure sensitive and thermoplastic adhesives. 
-PEG 6000 possesses lubricity and humectant properties. 
PEG 6000 maintains wet-tack strength.

-PEG 6000 are useful as lubricants, commonly used for soluble tablets such as effervescent tablets. 
-In addition, PEG 6000 can be used for ODT, buccal and chewable tablets.
-PEG 6000 is a compound used to modify therapeutic proteins and peptides to increase their solubility. 
-PEG 6000 is often used as a polar stationary phase for Gas Chromatorgraphy. 

-PEG 6000 is commonly also used in mass spec experiments. 
-PEG 6000 is also used to preserve objects that have been retrieved from the ocean.
-PEG 6000 is a compound used to modify therapeutic proteins and peptides to increase their solubility

-PEG 6000 is particularly effective for the thickening of clear, mild, amphoteric-containing surfactant systems, such as shampoos, body washes, bubble baths, baby baths, vapor baths and shower gels. 
-PEG 6000 can also be used to thicken facial scrubs, facial cleansers, body scrubs and shaving foams, and finds application in color cosmetics as an auxiliary emulsifer (HLB ~18.4). 
-The typical use level is 2 – 4%.

-PEG 6000 is used for such diverse purposes as viral / phage enrichment, plant protoplast fusion, or fractionated protein precipitation. 
-In addition, the ligation efficiency can be increased by macromolecular crowding, that is, a concentration of molecules in solution.

-PEG 6000 is non-toxic, odorless, neutral, lubricating, nonvolatile and nonirritating and are used in a variety of pharmaceuticals and in medications as a solvent, dispersing agent, ointment and suppository bases, vehicle, and tablet excipient.
-PEG 6000, is used as an inactive ingredient in the pharmaceutical industry as a solvent, plasticizer, surfactant, ointments and suppository base, and tablet and capsule lubricant.

-PEG 6000 has been used in the precipitation of proteins, as a fusing agent in enhancing the effect of macrophages on hybridoma, in the separation and purification of biomolecules, and in induction of cell hybridization.
-PEG 6000 is used for protoplast fusion (induction of cell fusion).
-PEG 6000 is used as PVC lubricant, masterbatch additive, textile softener, pigment dispersant, etc

-Reacted with fatty acid to make surfactants of different performance, PEG 6000 series can be used as medical binder, cream and shampoo base material; 
-PEG 6000 is used as lubricants, binders and plasticizers, wetting agents for fiber processing, pottery, metal processing, rubber molding; 
-PEG 6000 is used in water soluble paints and printing inks; and used as a wetting agent in the electroplating industry.

-PEG 6000 is the basis of many skin creams (as cetomacrogol) and personal lubricants (frequently combined with glycerin).
-PEG 6000 is used in a number of toothpastes as a dispersant. 
In this application, PEG 6000 binds water and helps keep xanthan gum uniformly distributed throughout the toothpaste.
-PEG 6000 is used to fuse two different types of cells, most often B-cells and myelomas in order to create hybridomas.

-PEG 6000 is commonly used as a precipitant for plasmid DNA isolation and protein crystallization. 
X-ray diffraction of protein crystals can reveal the atomic structure of the proteins.
-PEG 6000 is often used (as an internal calibration compound) in mass spectrometry experiments, with PEG 6000's characteristic fragmentation pattern allowing accurate and reproducible tuning.

-PEG 6000 derivatives, such as narrow range ethoxylates, are used as surfactants.
-PEG 6000 has been used as the hydrophilic block of amphiphilic block copolymers used to create some polymersomes.
-PEG 6000 is the basis of a number of laxatives. 
-Whole bowel irrigation with PEG 6000 and added electrolytes is used for bowel preparation before surgery or colonoscopy.

-PEG 6000 is also used as an excipient in many pharmaceutical products.
When attached to various protein medications, PEG 6000 allows a slowed clearance of the carried protein from  blood.
-Rubber Auxiliary Agents, Textile Auxiliary Agents, Paper Chemicals, Surfactants
-PEG 6000 can be used in medicine
-PEG 6000 is used as a substrate in the pharmaceutical and cosmetic industries to control viscosity and melting point, 

-PEG 6000 is used as a finishing agent in the paper industry to improve the gloss and smoothness of paper, in the rubber industry as a lubricating additive and plasticity of rubber products, reduce energy consumption in processing, prolong the service life of rubber products.
-PEG 6000 is used as a lubricant and coolant in metal processing industry, dispersant and emulsifier in production. 
-Pesticide and pigment industry Agents and lubricants in the textile industry.

CAN PEG 6000 BE AUTOCLAVED?
PEG 6000 can be dissolved in warm water at 80-90 °C with no adverse affects. 
Sterile filtration of the solution is recommended using a 0.45 µm filter, initially. 
Although autoclaving of PEG 6000 in saline solutions has been reported, it is not recommended.

BENEFITS of PEG 6000:
-Excellent solubility in water
-Very low water content
-Compatible with hard water
-Non-volatile
-Outstanding toxicological safety
-Emulsifying Agent (O/W)
-Thickener (aqueous)

PHYSICAL and CHEMICAL PROPERTIES of PEG 6000:
Molecular Weight: 6000.00
Boiling point: >200 °C (1013 hPa) Not applicable
Density: 1.2 g/cm3 (20 °C)
Flash point: 138.6 °C
Ignition temperature: 420 °C
Melting Point: 58 - 63 °C
pH value: 5 - 7 (100 g/l, H₂O, 20 °C)

Vapor pressure: <0.1 hPa (20 °C)
Solubility: 550 g/l
Storage: Store below +30°C.
Physical State: Solid
Solubility: 
*Soluble in water (500 g/l at 20° C), 
*Aromatic hydrocarbons (very)
*Aliphatic hydrocarbons (slightly).

Storage: Store at room temperature
Melting Point: 60-63° C
Boiling Point: >250° C
Refractive Index: n20D 1.47
Appearance Form: scales
Color: white
Odor: No data available
Odor Threshold: No data available
pH: No data available

Melting point/freezing point:
Freezing point: < -14,08 °C at 973,5 hPa 
Initial boiling point and boiling range: 205,7 °C at 977,6 hPa 
Flash point: 138,6 °C - closed cup
Evaporation rate: No data available
Flammability (solid, gas): No data available
Upper/lower flammability or explosive limits: No data available

Vapor pressure: < 0,1 hPa at 20 °C
Vapor density: No data available
Density: 1,116 g/cm3 at 20 °C at 975,5 hPa 
Relative density: No data available
Water solubility: 256,084 g/l at 25 °C - OECD Test Guideline 105- completely soluble
Partition coefficient: n-octanol/water:
log Pow: -0,698 at 30 °C - Bioaccumulation is not expected.,
Autoignition temperature: 360 °C

Decomposition temperature: No data available
Viscosity 
Viscosity, kinematic: No data available
Viscosity, dynamic: No data available
Explosive properties: No data available
Oxidizing properties: none
Other safety information:
Bulk density: 400 - 500 kg/m3

FIRST AID MEASURES of PEG 6000:
-Description of first-aid measures:
*If inhaled:
After inhalation: 
Fresh air.

*In case of skin contact: 
Take off immediately all contaminated clothing. 
Rinse skin with water/ shower.

*In case of eye contact:
After eye contact: 
Rinse out with plenty of water. 
Remove contact lenses.

*If swallowed:
After swallowing: 
Make victim drink water. 
Consult doctor if feeling unwell.

-Indication of any immediate medical attention and special treatment needed:
No data available

ACCIDENTAL RELEASE MEASURES of PEG 6000:
-Environmental precautions:
Do not let product enter drains.

-Methods and materials for containment and cleaning up:
Cover drains. 
Collect, bind, and pump off spills.  
Dispose of properly. 
Clean up affected area.

FIRE FIGHTING MEASURES of PEG 6000:
-Extinguishing media:
--Suitable extinguishing media:
Water Foam Carbon dioxide (CO2) Dry powder
--Unsuitable extinguishing media:
For this substance/mixture no limitations of extinguishing agents are given.

EXPOSURE CONTROLS/PERSONAL PROTECTION of PEG 6000:
-Control parameters:
--Ingredients with workplace control parameters:
-Exposure controls:
--Personal protective equipment:

*Eye/face protection:
Safety glasses.

*Skin protection:
Full contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

Splash contact:
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min

-Control of environmental exposure:
Do not let product enter drains.

HANDLING and STORAGE of PEG 6000:
-Conditions for safe storage, including any incompatibilities:
Storage conditions:
Tightly closed.
Recommended storage temperature see product label.

STABILITY and REACTIVITY of PEG 6000:
-Chemical stability:
The product is chemically stable under standard ambient conditions (room temperature) .
Contains the following stabilizer(s):
Butylmethoxyphenol (<=0,010,0099 %)

-Incompatible materials: no information available

SYNONYMS:
PEG
Poly(ethylene glycol)
Polyglycol
Polyethylene oxide 
Polyoxy ethylene
Polyethylene glycol
Poly(ethylene glycol)
Polyethylene glycol
polyethylene oxide standard 511000
Poly(ethylene oxide)
macrogol
poly(oxyethylene)
Polyethylene glycol PEG
Aquacide III
PEG 1000
Ethylene glycol 8000 polymer
Polyethyleneglycol
Polyethylene Glycol 5000000
PolyethyleneoxideMW
PEG 200-8000
Tri-(2,3-Dibromopropyl) Phosphate
Polyethylene glycol - 6000 grade
PEG 200
PEG 400
PEG 6000
Poly(ethylene oxide)
PEO
PEG 600
Polyethyleneoxidemonomethacryloxymonotrimethylsiloxyterminated
O-Methacryloxy(polyethyleneoxy)trimethylsilane
PEG
Poly ethylene glycol
Carmowax
carbowax
PEG 8000
Polyethylene glycol series
Polyethylene Glycol
Polyethylene glygcol